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The map label for this gene is tolC [C]

Identifier: 116624559

GI number: 116624559

Start: 6874044

End: 6875462

Strand: Direct

Name: tolC [C]

Synonym: Acid_5483

Alternate gene names: 116624559

Gene position: 6874044-6875462 (Clockwise)

Preceding gene: 116624554

Following gene: 116624560

Centisome position: 68.98

GC content: 64.48

Gene sequence:

>1419_bases
ATGCCGCGTATACTCCCGACCCTCGGCCTCGCATTGGCCTTGCGCTGCGGCGCACAGACACCCCCGCCTGTCACGGGGCG
GCCTCCGTCGTCGCTGACTCAGACGAAGACGCCGGCGACGGGCTTCGGAGTGATGCCGATGCCTCCGGTCGGACAGATGC
CCATGCCGGTGCTGGGGCAGGCGCCGCCGGTCACGATGACGCTGACCTTGAAAGAGGCCATGGATCGCGCCCGAGTCAAC
AGCCAGCAATTGCTCTCCGCCGACATCGCGGCGCGCATCGCGCATGAAGACCGCGTGCAGGCCAAGGCCGCGCTGCTGCC
CACGGCGACGCTGCTCAACGGCTTTGACTACACGCAGCCCAACGGACCGGACAACAGCATCGTCTTCGTGACGAACGATG
GCCCACGCGTGTATAACCAACAGATCAACGTGCACGCCGACGTCTGGTCGCCCGCGAAGCGCGCCGATTATCAGATGGCG
ATCGCAGCCGAAGCCGTGGCGCGCGCCAGGGTGGAAATCGCCGGGCGAGGCCTGATCGCAACCGTGTTTCAGAATTTCTA
TGGGATGGCGGTGGCGCAGCGGCACCTTCGGAACGCACAGCGCAGCCTGCAGGAGGCGCGCGAATTTACCGACATCACGC
GCAAGATGGAGGCCGGCGGAGAGGTCGCGCACTCCGACGTGGTAAAGGCGCAGATCACGCTGGACCAGCGGGAGCGCGAT
TTGCAGGACGCCCAACTCGCGGCGGACAAGGCGCGGATCGGCTTCGCGGTCTTCCTGTTCCCGGACTTCCGCCAGGACTT
CAACGTCGCTGACGATCTGGATACCCTCGCCGCTCTGCCGCCATTTCCGGAAATCGAGACGATGGCGCGCACCAACAACC
CGGAACTCCGCGCCGCGGAGGCCACGATCACGCAGGAGAACTACGGAATTCGAAGCGCGCGCGCCGCCTACCTGCCGGAG
CTCTCGGTGGACTACTTCTATGGCATCCAGGCGCGTCAGTACGCCTTGCATGACGAATTCGGCCAGAACAACCTGGGCAG
CGCGGTGTTCGCCACGCTCAACGTGCCGTTGTGGAACTGGGGTGCGACGCGCAGCAAGGTAAAGCAGGCCGAGTTGAGGC
TGCAGCAGGCGCATATCGACCTCAGTTTTACGCAGCGACAGTTGCTCGCGAACCTGAATGCGTTCTATCTGGAGGCGAAC
GTGGCGTCCAGCCAATTGGTTTCTCTCAAGCGCTCGCTCGATCTGGCCGAGGAAAGTCTCAAGCTCACCGTCCTGCGCTA
CGAGGCCGGCGAAGTCAGCGTGCTCGAAGTGGTGGACGCGCAGACCACGGTGGCGGGCGCGCGCAATGCGTATGACGATG
GGCTGGTGCGCTACCGTGCTGCTATCGCCAACATTCAAACCCTGACGGGGGCCTTCTAG

Upstream 100 bases:

>100_bases
GACGTATTGTGCATACGTCAAGCGCGTCGCGCACACGGAGAGCAACCCCTCGCTGGTTCATCGTCTGTTCATGTCATGAT
TTTTATACTGGACGAGAACG

Downstream 100 bases:

>100_bases
CCGATGAAAAAGATGCCTTCCACAACTACTCAACTCGGCCTCGCCCTGTTGCTTCCCTTGCTGTTTACCTCCTGCTCGAA
GAAGGAAGAGAAGGAAGCCG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: RND Efflux System Outer Membrane Lipoprotein; Outer Membrane Transport/Efflux Protein; Outer Membrane Multidrug Efflux Protein OprB

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MPRILPTLGLALALRCGAQTPPPVTGRPPSSLTQTKTPATGFGVMPMPPVGQMPMPVLGQAPPVTMTLTLKEAMDRARVN
SQQLLSADIAARIAHEDRVQAKAALLPTATLLNGFDYTQPNGPDNSIVFVTNDGPRVYNQQINVHADVWSPAKRADYQMA
IAAEAVARARVEIAGRGLIATVFQNFYGMAVAQRHLRNAQRSLQEAREFTDITRKMEAGGEVAHSDVVKAQITLDQRERD
LQDAQLAADKARIGFAVFLFPDFRQDFNVADDLDTLAALPPFPEIETMARTNNPELRAAEATITQENYGIRSARAAYLPE
LSVDYFYGIQARQYALHDEFGQNNLGSAVFATLNVPLWNWGATRSKVKQAELRLQQAHIDLSFTQRQLLANLNAFYLEAN
VASSQLVSLKRSLDLAEESLKLTVLRYEAGEVSVLEVVDAQTTVAGARNAYDDGLVRYRAAIANIQTLTGAF

Sequences:

>Translated_472_residues
MPRILPTLGLALALRCGAQTPPPVTGRPPSSLTQTKTPATGFGVMPMPPVGQMPMPVLGQAPPVTMTLTLKEAMDRARVN
SQQLLSADIAARIAHEDRVQAKAALLPTATLLNGFDYTQPNGPDNSIVFVTNDGPRVYNQQINVHADVWSPAKRADYQMA
IAAEAVARARVEIAGRGLIATVFQNFYGMAVAQRHLRNAQRSLQEAREFTDITRKMEAGGEVAHSDVVKAQITLDQRERD
LQDAQLAADKARIGFAVFLFPDFRQDFNVADDLDTLAALPPFPEIETMARTNNPELRAAEATITQENYGIRSARAAYLPE
LSVDYFYGIQARQYALHDEFGQNNLGSAVFATLNVPLWNWGATRSKVKQAELRLQQAHIDLSFTQRQLLANLNAFYLEAN
VASSQLVSLKRSLDLAEESLKLTVLRYEAGEVSVLEVVDAQTTVAGARNAYDDGLVRYRAAIANIQTLTGAF
>Mature_471_residues
PRILPTLGLALALRCGAQTPPPVTGRPPSSLTQTKTPATGFGVMPMPPVGQMPMPVLGQAPPVTMTLTLKEAMDRARVNS
QQLLSADIAARIAHEDRVQAKAALLPTATLLNGFDYTQPNGPDNSIVFVTNDGPRVYNQQINVHADVWSPAKRADYQMAI
AAEAVARARVEIAGRGLIATVFQNFYGMAVAQRHLRNAQRSLQEAREFTDITRKMEAGGEVAHSDVVKAQITLDQRERDL
QDAQLAADKARIGFAVFLFPDFRQDFNVADDLDTLAALPPFPEIETMARTNNPELRAAEATITQENYGIRSARAAYLPEL
SVDYFYGIQARQYALHDEFGQNNLGSAVFATLNVPLWNWGATRSKVKQAELRLQQAHIDLSFTQRQLLANLNAFYLEANV
ASSQLVSLKRSLDLAEESLKLTVLRYEAGEVSVLEVVDAQTTVAGARNAYDDGLVRYRAAIANIQTLTGAF

Specific function: Required For Proper Expression Of Outer Membrane Protein Genes Such As Ompf, Nmpc, Protein 2, Hemolysin, Colicin V, Or Colicin E1. May Be Specialized For Signal Sequence Independent, Extracellular Secretion In Gram-Negative Bacteria. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Outer Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 51703; Mature: 51572

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRILPTLGLALALRCGAQTPPPVTGRPPSSLTQTKTPATGFGVMPMPPVGQMPMPVLGQ
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APPVTMTLTLKEAMDRARVNSQQLLSADIAARIAHEDRVQAKAALLPTATLLNGFDYTQP
CCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
NGPDNSIVFVTNDGPRVYNQQINVHADVWSPAKRADYQMAIAAEAVARARVEIAGRGLIA
CCCCCEEEEEECCCCEEECCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
TVFQNFYGMAVAQRHLRNAQRSLQEAREFTDITRKMEAGGEVAHSDVVKAQITLDQRERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECHHHHH
LQDAQLAADKARIGFAVFLFPDFRQDFNVADDLDTLAALPPFPEIETMARTNNPELRAAE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCHHCHHHHHCCCCCCCHHHHHCCCCCCEEEEE
ATITQENYGIRSARAAYLPELSVDYFYGIQARQYALHDEFGQNNLGSAVFATLNVPLWNW
EEEECCCCCCCHHHHHHCCCCCCHHEECCCHHHHHHHHHCCCCCCCCEEEEEECCCEECC
GATRSKVKQAELRLQQAHIDLSFTQRQLLANLNAFYLEANVASSQLVSLKRSLDLAEESL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCE
KLTVLRYEAGEVSVLEVVDAQTTVAGARNAYDDGLVRYRAAIANIQTLTGAF
EEEEEEECCCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRILPTLGLALALRCGAQTPPPVTGRPPSSLTQTKTPATGFGVMPMPPVGQMPMPVLGQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APPVTMTLTLKEAMDRARVNSQQLLSADIAARIAHEDRVQAKAALLPTATLLNGFDYTQP
CCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
NGPDNSIVFVTNDGPRVYNQQINVHADVWSPAKRADYQMAIAAEAVARARVEIAGRGLIA
CCCCCEEEEEECCCCEEECCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
TVFQNFYGMAVAQRHLRNAQRSLQEAREFTDITRKMEAGGEVAHSDVVKAQITLDQRERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECHHHHH
LQDAQLAADKARIGFAVFLFPDFRQDFNVADDLDTLAALPPFPEIETMARTNNPELRAAE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCHHCHHHHHCCCCCCCHHHHHCCCCCCEEEEE
ATITQENYGIRSARAAYLPELSVDYFYGIQARQYALHDEFGQNNLGSAVFATLNVPLWNW
EEEECCCCCCCHHHHHHCCCCCCHHEECCCHHHHHHHHHCCCCCCCCEEEEEECCCEECC
GATRSKVKQAELRLQQAHIDLSFTQRQLLANLNAFYLEANVASSQLVSLKRSLDLAEESL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCE
KLTVLRYEAGEVSVLEVVDAQTTVAGARNAYDDGLVRYRAAIANIQTLTGAF
EEEEEEECCCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA