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The map label for this gene is ald [H]

Identifier: 116624502

GI number: 116624502

Start: 6795556

End: 6796611

Strand: Reverse

Name: ald [H]

Synonym: Acid_5426

Alternate gene names: 116624502

Gene position: 6796611-6795556 (Counterclockwise)

Preceding gene: 116624503

Following gene: 116624501

Centisome position: 68.2

GC content: 67.23

Gene sequence:

>1056_bases
ATGAATATCGGAGTTCTTCGCGAGCGGGGTGCGTTTGACCGGCGGGTCGCGCTCACGCCGCCCGTGGTCCGGCGCCTGTG
TGGAGCGGGGCACACCGTATGGATTGAGAGCGGCGCGGGCGATGGCGCGATGTTCAAGGATCCGGAATATCAGCGCGCCG
GCGCCCAGGTAGGCTACACGCCGGCGGAGATCGTCGGCCGAGCGGAACTGGTAGTGAAGATCGGGCGCCCCACCCGCGAA
GAACTCGAATGGTGCAAACCGGAAACGGCCCTGATGGCCTTCTATCACATGGCCGTCGCGGATCGCGGGTTGATCGACGC
ACTGGCGGAGCGCTCCGTCACGGCGATCGGCTGCGAGGTGATCGAGCAGCAGGACGGCAGCCTGCCGGTGCTGGCGGCGA
TCAGCGAGATCGCGGGACAGATGACGGTGCCGATCGCGGCACACCTGATGCGGACCAGTTCGGGAGGTCGCGGCATTCTG
CTGGGCGGGACGCCGGGAGTGCCGCCCGCGCGAGTAGTTGTGTTGGGCGCGGGGTCAGCGGGATTCGCGTCGGCTCGCAG
TGCCGCTGGCTCCGGCGCGCGCGTCACGGCGTTCGATCGCGATCCGCGGAAGCTGCGCCACATGATGGAGCACGTTCCAT
CGGTCGAGACCTGCCTCGCCGATGAGGACGCCATTGCCGAAGCGGTGGCGGCCGCCGACGTGGTGATCGGCGCGGTGCTG
GTAGCGGGCCGGCGGACGCCGCACGTGGTGACCCGCGCGATGGTGGAGCGCATGAAGCCGGGTGCGGCGATGATCGATGT
TTCGATCGACCAGGGCGGCTGCTTCGAGACCAGCCATCCCACCAGCATGGATCAGCCCACGTTCGTCCACCAGGGAGTGA
CGCATTTCTGCGTGCCGAACTTTACGGCCGATCTGGGACGCTCGGCCAGCGTGGCGATCGCGCAGGCGCTGCTGCCTTAC
GTATTGACCATCGCCAAACACGGTGTCGCCGGCGCATTCGAAAAATGCTCGGAACTGGCGCGCGGCGTGTACTTGATCGA
GGGGAAACGGCCATGA

Upstream 100 bases:

>100_bases
GCTTCTGGTTCATGCGCGCCATCCTCAAAGTAATGTCGGGGAGGCTACACGCCATCCGGGCGCAACTGGTGGATAGCTAC
TCTCCGCTGGCAGGCGTCAG

Downstream 100 bases:

>100_bases
GGAACGATTACCGGTCGCGGATCATGCCCGCGGATGTGGCGCTCGCGGAACTGCACAGCGGCCAGCGCGTCTACGTGCAC
AATGGCTGCGGAGAGCCGGT

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNIGVLRERGAFDRRVALTPPVVRRLCGAGHTVWIESGAGDGAMFKDPEYQRAGAQVGYTPAEIVGRAELVVKIGRPTRE
ELEWCKPETALMAFYHMAVADRGLIDALAERSVTAIGCEVIEQQDGSLPVLAAISEIAGQMTVPIAAHLMRTSSGGRGIL
LGGTPGVPPARVVVLGAGSAGFASARSAAGSGARVTAFDRDPRKLRHMMEHVPSVETCLADEDAIAEAVAAADVVIGAVL
VAGRRTPHVVTRAMVERMKPGAAMIDVSIDQGGCFETSHPTSMDQPTFVHQGVTHFCVPNFTADLGRSASVAIAQALLPY
VLTIAKHGVAGAFEKCSELARGVYLIEGKRP

Sequences:

>Translated_351_residues
MNIGVLRERGAFDRRVALTPPVVRRLCGAGHTVWIESGAGDGAMFKDPEYQRAGAQVGYTPAEIVGRAELVVKIGRPTRE
ELEWCKPETALMAFYHMAVADRGLIDALAERSVTAIGCEVIEQQDGSLPVLAAISEIAGQMTVPIAAHLMRTSSGGRGIL
LGGTPGVPPARVVVLGAGSAGFASARSAAGSGARVTAFDRDPRKLRHMMEHVPSVETCLADEDAIAEAVAAADVVIGAVL
VAGRRTPHVVTRAMVERMKPGAAMIDVSIDQGGCFETSHPTSMDQPTFVHQGVTHFCVPNFTADLGRSASVAIAQALLPY
VLTIAKHGVAGAFEKCSELARGVYLIEGKRP
>Mature_351_residues
MNIGVLRERGAFDRRVALTPPVVRRLCGAGHTVWIESGAGDGAMFKDPEYQRAGAQVGYTPAEIVGRAELVVKIGRPTRE
ELEWCKPETALMAFYHMAVADRGLIDALAERSVTAIGCEVIEQQDGSLPVLAAISEIAGQMTVPIAAHLMRTSSGGRGIL
LGGTPGVPPARVVVLGAGSAGFASARSAAGSGARVTAFDRDPRKLRHMMEHVPSVETCLADEDAIAEAVAAADVVIGAVL
VAGRRTPHVVTRAMVERMKPGAAMIDVSIDQGGCFETSHPTSMDQPTFVHQGVTHFCVPNFTADLGRSASVAIAQALLPY
VLTIAKHGVAGAFEKCSELARGVYLIEGKRP

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=340, Percent_Identity=27.9411764705882, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI122939153, Length=340, Percent_Identity=27.9411764705882, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1787887, Length=307, Percent_Identity=31.9218241042345, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=370, Percent_Identity=26.4864864864865, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 36924; Mature: 36924

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGVLRERGAFDRRVALTPPVVRRLCGAGHTVWIESGAGDGAMFKDPEYQRAGAQVGYT
CCCCCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCCC
PAEIVGRAELVVKIGRPTREELEWCKPETALMAFYHMAVADRGLIDALAERSVTAIGCEV
HHHHHCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHH
IEQQDGSLPVLAAISEIAGQMTVPIAAHLMRTSSGGRGILLGGTPGVPPARVVVLGAGSA
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCC
GFASARSAAGSGARVTAFDRDPRKLRHMMEHVPSVETCLADEDAIAEAVAAADVVIGAVL
CCHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
VAGRRTPHVVTRAMVERMKPGAAMIDVSIDQGGCFETSHPTSMDQPTFVHQGVTHFCVPN
HCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHCCCC
FTADLGRSASVAIAQALLPYVLTIAKHGVAGAFEKCSELARGVYLIEGKRP
CHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCC
>Mature Secondary Structure
MNIGVLRERGAFDRRVALTPPVVRRLCGAGHTVWIESGAGDGAMFKDPEYQRAGAQVGYT
CCCCCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCCC
PAEIVGRAELVVKIGRPTREELEWCKPETALMAFYHMAVADRGLIDALAERSVTAIGCEV
HHHHHCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHH
IEQQDGSLPVLAAISEIAGQMTVPIAAHLMRTSSGGRGILLGGTPGVPPARVVVLGAGSA
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCC
GFASARSAAGSGARVTAFDRDPRKLRHMMEHVPSVETCLADEDAIAEAVAAADVVIGAVL
CCHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
VAGRRTPHVVTRAMVERMKPGAAMIDVSIDQGGCFETSHPTSMDQPTFVHQGVTHFCVPN
HCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCHHHCCCC
FTADLGRSASVAIAQALLPYVLTIAKHGVAGAFEKCSELARGVYLIEGKRP
CHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]