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The map label for this gene is kdgA [H]

Identifier: 116624368

GI number: 116624368

Start: 6629445

End: 6630128

Strand: Direct

Name: kdgA [H]

Synonym: Acid_5289

Alternate gene names: 116624368

Gene position: 6629445-6630128 (Clockwise)

Preceding gene: 116624365

Following gene: 116624370

Centisome position: 66.52

GC content: 63.3

Gene sequence:

>684_bases
GTGTCGCGTGATAGCGTAAAGGCAATGACCTCAAAAGAGATTCTCGCCTTCATCACCGAAGTCGGCATCGTTCCCGTGGT
GCGCGTCGCGAGCGCGGACGCCGCCGTCCAGGCCGTGCAAGCCATCTACAAAGGCGGCGTTCGCGCCGCTGAGATCACCA
TGACCGTCCCCGGCGCTATCCGGGCTCTGGAAAAAGTGGCCGACCTTTTTGGCGATAAAATCATGCTCGGCGCCGGCACC
GTGCTCGACCCCGAGACCGCCCGCGCCTGCATGCTCGCCGGCGCCCAATTCTTCGTCACCCCCGCGCTGCGCATCTCCAC
CATCGAAATCTGCAAACGCTATTCGAAAGTCATCTGCCCCGGCGCTCTCACCCCCACCGAAGTGCTCACTGCCTGGGAGG
CCGGCGCCGACGTCGTAAAAGTCTTTCCCTGCGGCAATGTCGGCGGCGCCAAGTACATCAAAGCGCTCAAAGGACCTTTC
CCGCAAATCGAGATGATTCCGACCGGCGGCGTCAACCTCGATACCGCAGGCGATTTCCTCAAGGCCGGCGCGTGCGCCAT
CGCCGTCGGCGGCGAGCTGGTAGACGCCAAAACCATCAAGGAAGGCCGCTTCGACGTTATCGAAGACCGCGCCCGCCAGT
ACCTGACCTGCGTCGCCAAAGCCCGCGCCGAAATGGCCGCGTAG

Upstream 100 bases:

>100_bases
CTTTCCAGCTGTTCGTTTACCGGCATGGGATTTGACAATATGACGCGCCACTACGCATTTTGTCCCGCTTAACCGGTGCA
ACATTGTCCTTTCTCCCACC

Downstream 100 bases:

>100_bases
GAGAGGCCTCCCGGCCTCCTGATGAGCCGAGACCGTCAGCCTCAGGGAGCGTCGAGCCTTCCTCGGACTGTGTAGCCCGG
TCTGAGCGATCTCACACCCG

Product: 2-keto-3-deoxy-phosphogluconate aldolase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSRDSVKAMTSKEILAFITEVGIVPVVRVASADAAVQAVQAIYKGGVRAAEITMTVPGAIRALEKVADLFGDKIMLGAGT
VLDPETARACMLAGAQFFVTPALRISTIEICKRYSKVICPGALTPTEVLTAWEAGADVVKVFPCGNVGGAKYIKALKGPF
PQIEMIPTGGVNLDTAGDFLKAGACAIAVGGELVDAKTIKEGRFDVIEDRARQYLTCVAKARAEMAA

Sequences:

>Translated_227_residues
MSRDSVKAMTSKEILAFITEVGIVPVVRVASADAAVQAVQAIYKGGVRAAEITMTVPGAIRALEKVADLFGDKIMLGAGT
VLDPETARACMLAGAQFFVTPALRISTIEICKRYSKVICPGALTPTEVLTAWEAGADVVKVFPCGNVGGAKYIKALKGPF
PQIEMIPTGGVNLDTAGDFLKAGACAIAVGGELVDAKTIKEGRFDVIEDRARQYLTCVAKARAEMAA
>Mature_226_residues
SRDSVKAMTSKEILAFITEVGIVPVVRVASADAAVQAVQAIYKGGVRAAEITMTVPGAIRALEKVADLFGDKIMLGAGTV
LDPETARACMLAGAQFFVTPALRISTIEICKRYSKVICPGALTPTEVLTAWEAGADVVKVFPCGNVGGAKYIKALKGPFP
QIEMIPTGGVNLDTAGDFLKAGACAIAVGGELVDAKTIKEGRFDVIEDRARQYLTCVAKARAEMAA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0800

COG function: function code G; 2-keto-3-deoxy-6-phosphogluconate aldolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI48994954, Length=183, Percent_Identity=34.4262295081967, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788156, Length=181, Percent_Identity=32.0441988950276, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 23751; Mature: 23620

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDSVKAMTSKEILAFITEVGIVPVVRVASADAAVQAVQAIYKGGVRAAEITMTVPGAI
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
RALEKVADLFGDKIMLGAGTVLDPETARACMLAGAQFFVTPALRISTIEICKRYSKVICP
HHHHHHHHHHCCEEEECCCCEECHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHCCC
GALTPTEVLTAWEAGADVVKVFPCGNVGGAKYIKALKGPFPQIEMIPTGGVNLDTAGDFL
CCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHH
KAGACAIAVGGELVDAKTIKEGRFDVIEDRARQYLTCVAKARAEMAA
HCCCEEEEECCEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRDSVKAMTSKEILAFITEVGIVPVVRVASADAAVQAVQAIYKGGVRAAEITMTVPGAI
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHH
RALEKVADLFGDKIMLGAGTVLDPETARACMLAGAQFFVTPALRISTIEICKRYSKVICP
HHHHHHHHHHCCEEEECCCCEECHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHCCC
GALTPTEVLTAWEAGADVVKVFPCGNVGGAKYIKALKGPFPQIEMIPTGGVNLDTAGDFL
CCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHH
KAGACAIAVGGELVDAKTIKEGRFDVIEDRARQYLTCVAKARAEMAA
HCCCEEEEECCEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]