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The map label for this gene is hemH [H]

Identifier: 116624285

GI number: 116624285

Start: 6529864

End: 6530709

Strand: Direct

Name: hemH [H]

Synonym: Acid_5203

Alternate gene names: 116624285

Gene position: 6529864-6530709 (Clockwise)

Preceding gene: 116624284

Following gene: 116624286

Centisome position: 65.52

GC content: 64.54

Gene sequence:

>846_bases
GTGAAATCCGCGGTCCTGCTGCTCGCCCACGGAGCGCCGGAACGCATTGAGGACGTGGAGCGTTACCTCGCGTTCGTACG
CGGCGGACAGGTCGTCTCGCCGCGCGTCCTGGAAGAAGTCACCAGCCGCTACGCCGCTATCGGCGGCAGCTCGCCCTTGA
CGCTGTGGACGCGCGCGCAAGCCGAAGCGCTCGAAACCATGCTCGGAATCCCCGTATTTTTCGGGATGAGAAATTGGCAT
CCGTTCGTCAAAGAGACAATGGATCAAGTGCGCGCCGCGGGCGTGGGTCGTCTGGCCTGCCTTTGCCTGGCGCCGCAGTA
TTCCGAGATGAGCGTCGGTCTCTACATGAAGCACGCGCGCGAAGCCGCGGGTGCGATCGAGCTGGCCTGGGCGCACAGTT
ACCACGATGAACCGCTATTGATCGAGGCCTTCGCGGAGCGCCTTCAGGGCATGTCCGGCAAGGTGCTCTTCACGGCGCAC
AGTCTTCCCTCGCCCAACGAAATCTACGATGCCGAATCGCGCGCTACCGCGAGCGCCGTCGCGGCAAAACTCGGGCTCGC
CGATTGGGAATTCGCCTACCAAAGCCAGGGCATGAGCGGCGGCACCTGGCTTGGACCGACGGTGGAAAGCTGCATCGAGC
GCTACGCCGCCGCGGGCATCCGCGACCTGGTGATCGCGCCCATCGGTTTCGTCTGCGACCACGTCGAGGTCCTGTACGAT
ATCGACGTGCACTTCCGCGATTTCGCTGCCGCGCGCGGCATACGGATCAGGCGCCCGGAAAGCCTCAATGGCTCGCCGTT
ATTCACGCGGGCACTGGCCAAGGTAGCCGGCACATGCCTCGCGTAG

Upstream 100 bases:

>100_bases
CACGCCCGGGCCATATCTTCAATCTCGGCCACGGCATTCTGCCGGAAACCCCGGTGGAGAACGTGAAGGCCGTGGTGGAG
CTGGTCCGGGAATTCCGGCC

Downstream 100 bases:

>100_bases
TCATCGTCGGTGGAGGCATTTCCGGTCTTTCCGCGGCGTATTATCTGGCGAAGGGCGGAGTCTCCTCCACCATCATCGAA
TCGCGGCCGCGCCTGGGCGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKSAVLLLAHGAPERIEDVERYLAFVRGGQVVSPRVLEEVTSRYAAIGGSSPLTLWTRAQAEALETMLGIPVFFGMRNWH
PFVKETMDQVRAAGVGRLACLCLAPQYSEMSVGLYMKHAREAAGAIELAWAHSYHDEPLLIEAFAERLQGMSGKVLFTAH
SLPSPNEIYDAESRATASAVAAKLGLADWEFAYQSQGMSGGTWLGPTVESCIERYAAAGIRDLVIAPIGFVCDHVEVLYD
IDVHFRDFAAARGIRIRRPESLNGSPLFTRALAKVAGTCLA

Sequences:

>Translated_281_residues
MKSAVLLLAHGAPERIEDVERYLAFVRGGQVVSPRVLEEVTSRYAAIGGSSPLTLWTRAQAEALETMLGIPVFFGMRNWH
PFVKETMDQVRAAGVGRLACLCLAPQYSEMSVGLYMKHAREAAGAIELAWAHSYHDEPLLIEAFAERLQGMSGKVLFTAH
SLPSPNEIYDAESRATASAVAAKLGLADWEFAYQSQGMSGGTWLGPTVESCIERYAAAGIRDLVIAPIGFVCDHVEVLYD
IDVHFRDFAAARGIRIRRPESLNGSPLFTRALAKVAGTCLA
>Mature_281_residues
MKSAVLLLAHGAPERIEDVERYLAFVRGGQVVSPRVLEEVTSRYAAIGGSSPLTLWTRAQAEALETMLGIPVFFGMRNWH
PFVKETMDQVRAAGVGRLACLCLAPQYSEMSVGLYMKHAREAAGAIELAWAHSYHDEPLLIEAFAERLQGMSGKVLFTAH
SLPSPNEIYDAESRATASAVAAKLGLADWEFAYQSQGMSGGTWLGPTVESCIERYAAAGIRDLVIAPIGFVCDHVEVLYD
IDVHFRDFAAARGIRIRRPESLNGSPLFTRALAKVAGTCLA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=318, Percent_Identity=26.7295597484277, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI60499021, Length=318, Percent_Identity=26.7295597484277, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6324750, Length=329, Percent_Identity=24.0121580547112, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17864156, Length=323, Percent_Identity=27.8637770897833, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45552018, Length=160, Percent_Identity=33.125, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651774, Length=254, Percent_Identity=26.3779527559055, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 30583; Mature: 30583

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAVLLLAHGAPERIEDVERYLAFVRGGQVVSPRVLEEVTSRYAAIGGSSPLTLWTRAQ
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHH
AEALETMLGIPVFFGMRNWHPFVKETMDQVRAAGVGRLACLCLAPQYSEMSVGLYMKHAR
HHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
EAAGAIELAWAHSYHDEPLLIEAFAERLQGMSGKVLFTAHSLPSPNEIYDAESRATASAV
HHCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHH
AAKLGLADWEFAYQSQGMSGGTWLGPTVESCIERYAAAGIRDLVIAPIGFVCDHVEVLYD
HHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
IDVHFRDFAAARGIRIRRPESLNGSPLFTRALAKVAGTCLA
CCCHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSAVLLLAHGAPERIEDVERYLAFVRGGQVVSPRVLEEVTSRYAAIGGSSPLTLWTRAQ
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHH
AEALETMLGIPVFFGMRNWHPFVKETMDQVRAAGVGRLACLCLAPQYSEMSVGLYMKHAR
HHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
EAAGAIELAWAHSYHDEPLLIEAFAERLQGMSGKVLFTAHSLPSPNEIYDAESRATASAV
HHCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHH
AAKLGLADWEFAYQSQGMSGGTWLGPTVESCIERYAAAGIRDLVIAPIGFVCDHVEVLYD
HHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
IDVHFRDFAAARGIRIRRPESLNGSPLFTRALAKVAGTCLA
CCCHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA