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The map label for this gene is hemE

Identifier: 116624284

GI number: 116624284

Start: 6528830

End: 6529867

Strand: Direct

Name: hemE

Synonym: Acid_5202

Alternate gene names: 116624284

Gene position: 6528830-6529867 (Clockwise)

Preceding gene: 116624283

Following gene: 116624285

Centisome position: 65.51

GC content: 63.49

Gene sequence:

>1038_bases
ATGCGCGTGGCTCCAATGACAAGCCGTTTCTTAGATGCATGCCGGAGAAGGCCGACCGACGTCAGGCCGGTCTGGTTCAT
GCGTCAAGCCGGGCGATACATGAAGCAGTACCGGCAGATCCGCGAGAAACACGGCATTTTGGAAATTTGCAAGCGGCCGG
ATCTGGCGGCGACCGTCACGCTGCAGCCGATTGAAGTTCTCGACGTGGATGCGGCGATCATCTTCGCGGACCTTCTGCTC
CCCATCGAACCGATGGGATTGAAATTGAAATACGAGAAGGGCGAAGGCCCCGTCATCGGCAACCCGGTGCGGACCTCCGA
TGACGTGGATTCGCTCTCTACCACCAACACCGACGAGCTCGGCTACGTGGGCGAAGCCATTCAGCACGTGGTGCGCGCGC
TCGCCGGCAAGGTGCCGGTGGTGGGCTTTGTGGGCGCTCCCTTCACCATGGCGAGCTACATGATCGAAGGCGGCGCGTCG
CGCAACTTCGTTCGCACCAAGAAGCTGATGTACAGCGACGAAACGCTGTGGCGGCGGCTGATGGGCAAGATCGTGGACGT
GCTCGCCCCCTTCGCGCATTCGCAAGTGGCGGCCGGCGCCCGCGCCATCCAGGTTTTCGATAGCTGGGTGGGCGCGCTCG
GCTCCGACGATTACGTGCGCTTCGCCGCGCCCTATTCGCGCGCGCTGATCGAACGCATCCGCTCTACCGGCGTGCCGGTG
ATTCACTTCGGCACGGGCGCCAGCGGCTTTTTCCGCGAACTGCACGCCGCCGGCGGCGACGTGATGGGCGTGGACTGGCG
CATCAACATCGACCAGGCGTGGATGGATATCAGCTACCGCTCGGCAATCCAGGGCAATCTGGACCCGGTGGCGCTCTTTG
CGCCGCTCCCCGAATTGCGCACCAAGGTCCAGGAACTGCTGAAACGCACGGGCACACGCCCGGGCCATATCTTCAATCTC
GGCCACGGCATTCTGCCGGAAACCCCGGTGGAGAACGTGAAGGCCGTGGTGGAGCTGGTCCGGGAATTCCGGCCGTGA

Upstream 100 bases:

>100_bases
CGTGGGCCAAACCTTATTTCGTGAATGGCCGCCAGTGGGCGGTGAAGCATCGGCCAAAGGACTTTCGAGTGTTCTTTTGC
GAAGACAGGATGGATAAGCC

Downstream 100 bases:

>100_bases
AATCCGCGGTCCTGCTGCTCGCCCACGGAGCGCCGGAACGCATTGAGGACGTGGAGCGTTACCTCGCGTTCGTACGCGGC
GGACAGGTCGTCTCGCCGCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRVAPMTSRFLDACRRRPTDVRPVWFMRQAGRYMKQYRQIREKHGILEICKRPDLAATVTLQPIEVLDVDAAIIFADLLL
PIEPMGLKLKYEKGEGPVIGNPVRTSDDVDSLSTTNTDELGYVGEAIQHVVRALAGKVPVVGFVGAPFTMASYMIEGGAS
RNFVRTKKLMYSDETLWRRLMGKIVDVLAPFAHSQVAAGARAIQVFDSWVGALGSDDYVRFAAPYSRALIERIRSTGVPV
IHFGTGASGFFRELHAAGGDVMGVDWRINIDQAWMDISYRSAIQGNLDPVALFAPLPELRTKVQELLKRTGTRPGHIFNL
GHGILPETPVENVKAVVELVREFRP

Sequences:

>Translated_345_residues
MRVAPMTSRFLDACRRRPTDVRPVWFMRQAGRYMKQYRQIREKHGILEICKRPDLAATVTLQPIEVLDVDAAIIFADLLL
PIEPMGLKLKYEKGEGPVIGNPVRTSDDVDSLSTTNTDELGYVGEAIQHVVRALAGKVPVVGFVGAPFTMASYMIEGGAS
RNFVRTKKLMYSDETLWRRLMGKIVDVLAPFAHSQVAAGARAIQVFDSWVGALGSDDYVRFAAPYSRALIERIRSTGVPV
IHFGTGASGFFRELHAAGGDVMGVDWRINIDQAWMDISYRSAIQGNLDPVALFAPLPELRTKVQELLKRTGTRPGHIFNL
GHGILPETPVENVKAVVELVREFRP
>Mature_345_residues
MRVAPMTSRFLDACRRRPTDVRPVWFMRQAGRYMKQYRQIREKHGILEICKRPDLAATVTLQPIEVLDVDAAIIFADLLL
PIEPMGLKLKYEKGEGPVIGNPVRTSDDVDSLSTTNTDELGYVGEAIQHVVRALAGKVPVVGFVGAPFTMASYMIEGGAS
RNFVRTKKLMYSDETLWRRLMGKIVDVLAPFAHSQVAAGARAIQVFDSWVGALGSDDYVRFAAPYSRALIERIRSTGVPV
IHFGTGASGFFRELHAAGGDVMGVDWRINIDQAWMDISYRSAIQGNLDPVALFAPLPELRTKVQELLKRTGTRPGHIFNL
GHGILPETPVENVKAVVELVREFRP

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=342, Percent_Identity=37.1345029239766, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI2367337, Length=343, Percent_Identity=39.3586005830904, Blast_Score=265, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=32.6647564469914, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=34.0116279069767, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=34.0116279069767, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SOLUE (Q01W10)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826440.1
- ProteinModelPortal:   Q01W10
- SMR:   Q01W10
- STRING:   Q01W10
- GeneID:   4426584
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5202
- NMPDR:   fig|234267.9.peg.4936
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q01W10
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38315; Mature: 38315

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 153-153 BINDING 208-208 BINDING 322-322

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAPMTSRFLDACRRRPTDVRPVWFMRQAGRYMKQYRQIREKHGILEICKRPDLAATVT
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEE
LQPIEVLDVDAAIIFADLLLPIEPMGLKLKYEKGEGPVIGNPVRTSDDVDSLSTTNTDEL
ECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHCCCCCCHHH
GYVGEAIQHVVRALAGKVPVVGFVGAPFTMASYMIEGGASRNFVRTKKLMYSDETLWRRL
HHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHH
MGKIVDVLAPFAHSQVAAGARAIQVFDSWVGALGSDDYVRFAAPYSRALIERIRSTGVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCE
IHFGTGASGFFRELHAAGGDVMGVDWRINIDQAWMDISYRSAIQGNLDPVALFAPLPELR
EEECCCCHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
TKVQELLKRTGTRPGHIFNLGHGILPETPVENVKAVVELVREFRP
HHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVAPMTSRFLDACRRRPTDVRPVWFMRQAGRYMKQYRQIREKHGILEICKRPDLAATVT
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEE
LQPIEVLDVDAAIIFADLLLPIEPMGLKLKYEKGEGPVIGNPVRTSDDVDSLSTTNTDEL
ECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHCCCCCCHHH
GYVGEAIQHVVRALAGKVPVVGFVGAPFTMASYMIEGGASRNFVRTKKLMYSDETLWRRL
HHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHH
MGKIVDVLAPFAHSQVAAGARAIQVFDSWVGALGSDDYVRFAAPYSRALIERIRSTGVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCE
IHFGTGASGFFRELHAAGGDVMGVDWRINIDQAWMDISYRSAIQGNLDPVALFAPLPELR
EEECCCCHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
TKVQELLKRTGTRPGHIFNLGHGILPETPVENVKAVVELVREFRP
HHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA