Click here to switch to the map view.

The map label for this gene is gfo [H]

Identifier: 116624226

GI number: 116624226

Start: 6465506

End: 6466573

Strand: Direct

Name: gfo [H]

Synonym: Acid_5142

Alternate gene names: 116624226

Gene position: 6465506-6466573 (Clockwise)

Preceding gene: 116624225

Following gene: 116624227

Centisome position: 64.88

GC content: 62.83

Gene sequence:

>1068_bases
ATGAAGATCTCGCGGCGAGAATTTGCAGGGGTGATGGCTGGGACCCCTGCCCTGCGGGCGCAGCAAGAGGAGCGCAAGGT
CGGGTACGCGATGGTCGGGCTGGGACGCATCTCGATGCAGCACCTGGCGCCGTCCTTGAAGGTGTCGAAGATCGCGAAGG
TGACGGCCCTCGTTAGCGGACATCGCGAAAAGGCCGAGAAGATGGCGGCCGACTACGGCATCCCGGCCAAGAACATTTAC
AGCTACGAAAACTACGACGCGATCGCCGACAACCCGGACATCGACGCTGTCTACGTCGCGCTGCCCAACAGCATGCACGC
GGAGTACACCATCCGCGCGGCTAAGGCGGGCAAACACGTGCTGTGCGAGAAGCCGATGGCGACGACCGTTGCCGACGCGC
AGGCGATGATCGATGCGTGCCGCCAGGCGAATCGCAAGCTCATGATCGCCTACCGCTGCCAGTTCGAGCCGGCCACGCTG
CGCGCGGTAGAGTTGATTCGCTCGGGAAAGCTGGGCAAGATCCAGGGAATCGAGAGCGCCAACGGCTTCAACATCCGGGC
AGGCGAGTGGCGATTGAATATGAAGCTGGCAGGCGGCGGACCGCTGATGGACATGGGCGTGTATTCGCTGAATGCCTGCC
GTTTTCTGACCGGCGAGGAGCCGGCGGATATCAAGGCCAATTGGAGCGTGATTGACCAGGACGGCCGCTTCGGCGAAGTC
GAGGAAAACATCGGGTGGACCATGCGCTTTCCCTCTGGGACGGTGGCGAGTTGCAATACGACGTACGGCGCCAACATGCC
GGGCTTCTACCGGGTGCACGGGTCGAAGGGGATGCTGCACATGGAGCCGGCATTCGGCTACGAAGGACTGCACCTGACGG
CGCGGATCCAGGGGGAGCCGCCGATCGACGAGTTGAATACCGAGAAGGATCCCGCACAGTTCACGCGCGAGGCGGACCAT
CTGGCGAATGCGATACTGCACGACGGAGAGTTGCGCGCGGGCGGCGAGGAAGGCCTGCGCGATATGAAGCTGATGATGGA
GATTTACCGCTCCTGCGGCCGCCATTGA

Upstream 100 bases:

>100_bases
TGATCGTTGTTTGCGGCGTGCCGCATTTTTGGACGTCCCCCCACCAGTGCCTGGGCTCAATCCGCTGCGGTTCGGTGCGG
ACGCGGGTATGATTGGGAGC

Downstream 100 bases:

>100_bases
GCGGGCCCACGCCTTGATACTGACCGGCCGCGCCGAGCGGCCGGTCGAGGGAGTACTAGCGGCGGAAGTGATCGTCGCGG
TCGTCAATGCGCGCGCGGTT

Product: oxidoreductase domain-containing protein

Products: NA

Alternate protein names: GFOR [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKISRREFAGVMAGTPALRAQQEERKVGYAMVGLGRISMQHLAPSLKVSKIAKVTALVSGHREKAEKMAADYGIPAKNIY
SYENYDAIADNPDIDAVYVALPNSMHAEYTIRAAKAGKHVLCEKPMATTVADAQAMIDACRQANRKLMIAYRCQFEPATL
RAVELIRSGKLGKIQGIESANGFNIRAGEWRLNMKLAGGGPLMDMGVYSLNACRFLTGEEPADIKANWSVIDQDGRFGEV
EENIGWTMRFPSGTVASCNTTYGANMPGFYRVHGSKGMLHMEPAFGYEGLHLTARIQGEPPIDELNTEKDPAQFTREADH
LANAILHDGELRAGGEEGLRDMKLMMEIYRSCGRH

Sequences:

>Translated_355_residues
MKISRREFAGVMAGTPALRAQQEERKVGYAMVGLGRISMQHLAPSLKVSKIAKVTALVSGHREKAEKMAADYGIPAKNIY
SYENYDAIADNPDIDAVYVALPNSMHAEYTIRAAKAGKHVLCEKPMATTVADAQAMIDACRQANRKLMIAYRCQFEPATL
RAVELIRSGKLGKIQGIESANGFNIRAGEWRLNMKLAGGGPLMDMGVYSLNACRFLTGEEPADIKANWSVIDQDGRFGEV
EENIGWTMRFPSGTVASCNTTYGANMPGFYRVHGSKGMLHMEPAFGYEGLHLTARIQGEPPIDELNTEKDPAQFTREADH
LANAILHDGELRAGGEEGLRDMKLMMEIYRSCGRH
>Mature_355_residues
MKISRREFAGVMAGTPALRAQQEERKVGYAMVGLGRISMQHLAPSLKVSKIAKVTALVSGHREKAEKMAADYGIPAKNIY
SYENYDAIADNPDIDAVYVALPNSMHAEYTIRAAKAGKHVLCEKPMATTVADAQAMIDACRQANRKLMIAYRCQFEPATL
RAVELIRSGKLGKIQGIESANGFNIRAGEWRLNMKLAGGGPLMDMGVYSLNACRFLTGEEPADIKANWSVIDQDGRFGEV
EENIGWTMRFPSGTVASCNTTYGANMPGFYRVHGSKGMLHMEPAFGYEGLHLTARIQGEPPIDELNTEKDPAQFTREADH
LANAILHDGELRAGGEEGLRDMKLMMEIYRSCGRH

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Homo sapiens, GI7657212, Length=255, Percent_Identity=23.921568627451, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI87082405, Length=261, Percent_Identity=28.735632183908, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787574, Length=254, Percent_Identity=28.3464566929134, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693182, Length=218, Percent_Identity=28.8990825688073, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789848, Length=189, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24581117, Length=256, Percent_Identity=27.734375, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24581115, Length=219, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008354
- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.99.28 [H]

Molecular weight: Translated: 39047; Mature: 39047

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISRREFAGVMAGTPALRAQQEERKVGYAMVGLGRISMQHLAPSLKVSKIAKVTALVSG
CCCCHHHHHHHHCCCHHHHCCHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHC
HREKAEKMAADYGIPAKNIYSYENYDAIADNPDIDAVYVALPNSMHAEYTIRAAKAGKHV
CHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEE
LCEKPMATTVADAQAMIDACRQANRKLMIAYRCQFEPATLRAVELIRSGKLGKIQGIESA
EECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCEEECCCCC
NGFNIRAGEWRLNMKLAGGGPLMDMGVYSLNACRFLTGEEPADIKANWSVIDQDGRFGEV
CCCEEEECCEEEEEEECCCCCCHHHHHEEECEEEEECCCCCCCCEECCEEEECCCCCCCH
EENIGWTMRFPSGTVASCNTTYGANMPGFYRVHGSKGMLHMEPAFGYEGLHLTARIQGEP
HHCCCEEEECCCCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEECCCC
PIDELNTEKDPAQFTREADHLANAILHDGELRAGGEEGLRDMKLMMEIYRSCGRH
CHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISRREFAGVMAGTPALRAQQEERKVGYAMVGLGRISMQHLAPSLKVSKIAKVTALVSG
CCCCHHHHHHHHCCCHHHHCCHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHC
HREKAEKMAADYGIPAKNIYSYENYDAIADNPDIDAVYVALPNSMHAEYTIRAAKAGKHV
CHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEE
LCEKPMATTVADAQAMIDACRQANRKLMIAYRCQFEPATLRAVELIRSGKLGKIQGIESA
EECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCEEECCCCC
NGFNIRAGEWRLNMKLAGGGPLMDMGVYSLNACRFLTGEEPADIKANWSVIDQDGRFGEV
CCCEEEECCEEEEEEECCCCCCHHHHHEEECEEEEECCCCCCCCEECCEEEECCCCCCCH
EENIGWTMRFPSGTVASCNTTYGANMPGFYRVHGSKGMLHMEPAFGYEGLHLTARIQGEP
HHCCCEEEECCCCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEECCCC
PIDELNTEKDPAQFTREADHLANAILHDGELRAGGEEGLRDMKLMMEIYRSCGRH
CHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1537789; 8472911; 8994968 [H]