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The map label for this gene is purE [H]

Identifier: 116624126

GI number: 116624126

Start: 6367472

End: 6367942

Strand: Direct

Name: purE [H]

Synonym: Acid_5042

Alternate gene names: 116624126

Gene position: 6367472-6367942 (Clockwise)

Preceding gene: 116624121

Following gene: 116624127

Centisome position: 63.89

GC content: 66.45

Gene sequence:

>471_bases
ATGGTCGGCATAATCATGGGCAGCAAATCCGATTGGGAGACCATGCAGCACGCTGCGCAGACGCTGCAACAATTCGACGT
CGCACACGAATGCCGTGTTGTCTCCGCGCACCGCACGCCGCTGCGTATGGCCGAGTACGCCGCCACCGCAGAAGAGCGCG
GCGTCCAGGTGATCATCGCCGGAGCCGGCGGGGCCGCGCACCTTCCCGGCATGGTGGCCGCGCAGACTCTCGTTCCCGTC
CTCGGCGTCCCGGTGGAATCCCACGCTTTGAAAGGCATGGATTCGCTGCTCTCCATCGTCCAGATGCCCAGCGGCATCCC
GGTCGGTACCCTCGCCATCGGCAAGGCCGGCGCCATCAACGCCGCGCTCCTCGCCGTCGCCATCCTCGCCAACACTCGCC
CCGAACTGCGCGAAAAACTCCGCCGTTATCGCCAGGAGCAGACCGCGCGCGTGGAGCGGGAGACGCTATGA

Upstream 100 bases:

>100_bases
CCCGTCCCCTCCTGTGTCTTAAAGTGTAGAACTCCGGCGAACGTCATAAGTTGATTGATTTACAAAACTTTACCCCTCCT
TTTGTACGACAATTGAGTCC

Downstream 100 bases:

>100_bases
AGCCCGTCCTCCCCGGCGCCACCGTCGGCATCCTCGGCGGCGGACAGCTCGGACGCATGTTCGCCATCGCCGCTCGCCGC
ATGGGCTATCGCGTACACAC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MVGIIMGSKSDWETMQHAAQTLQQFDVAHECRVVSAHRTPLRMAEYAATAEERGVQVIIAGAGGAAHLPGMVAAQTLVPV
LGVPVESHALKGMDSLLSIVQMPSGIPVGTLAIGKAGAINAALLAVAILANTRPELREKLRRYRQEQTARVERETL

Sequences:

>Translated_156_residues
MVGIIMGSKSDWETMQHAAQTLQQFDVAHECRVVSAHRTPLRMAEYAATAEERGVQVIIAGAGGAAHLPGMVAAQTLVPV
LGVPVESHALKGMDSLLSIVQMPSGIPVGTLAIGKAGAINAALLAVAILANTRPELREKLRRYRQEQTARVERETL
>Mature_156_residues
MVGIIMGSKSDWETMQHAAQTLQQFDVAHECRVVSAHRTPLRMAEYAATAEERGVQVIIAGAGGAAHLPGMVAAQTLVPV
LGVPVESHALKGMDSLLSIVQMPSGIPVGTLAIGKAGAINAALLAVAILANTRPELREKLRRYRQEQTARVERETL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=150, Percent_Identity=66.6666666666667, Blast_Score=165, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=52.5316455696203, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16613; Mature: 16613

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGIIMGSKSDWETMQHAAQTLQQFDVAHECRVVSAHRTPLRMAEYAATAEERGVQVIIA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCEEEEE
GAGGAAHLPGMVAAQTLVPVLGVPVESHALKGMDSLLSIVQMPSGIPVGTLAIGKAGAIN
CCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHH
AALLAVAILANTRPELREKLRRYRQEQTARVERETL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVGIIMGSKSDWETMQHAAQTLQQFDVAHECRVVSAHRTPLRMAEYAATAEERGVQVIIA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCEEEEE
GAGGAAHLPGMVAAQTLVPVLGVPVESHALKGMDSLLSIVQMPSGIPVGTLAIGKAGAIN
CCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHH
AALLAVAILANTRPELREKLRRYRQEQTARVERETL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]