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The map label for this gene is baeS [H]

Identifier: 116624117

GI number: 116624117

Start: 6353940

End: 6355265

Strand: Direct

Name: baeS [H]

Synonym: Acid_5033

Alternate gene names: 116624117

Gene position: 6353940-6355265 (Clockwise)

Preceding gene: 116624116

Following gene: 116624118

Centisome position: 63.76

GC content: 67.19

Gene sequence:

>1326_bases
GTGAAGATTAGCCTCCGATTGCGATTCCTGCTGGCCACCATGGCAATCGCCGGCGCCACGCTTACGGCCATCGCACTCTT
CTCCAGCCGGGTTACCCTCAGCGAGATCGAACGCGTCACTTCCCCTTCGCCGGCTGCCGCTCCCAGGCTCGATCTCGACA
CCCTGCGCGGGGCGCTCACGGATTATTGGAACCGGCACCACCGCTGGACCAGCGTCGAGCTGACCCTGCACCGCCTGGCC
GGAGAGTCTGCCGGCTTGCTGCTGCTCTCGGATCAGACCGCCCCGATCGCTTCCTGGCCGCCCGAGCTCGCCCAGTCCCG
CGTCACCCTGCACCCCGATCAATCGCTGGAACTCGACGGCCGCACTGCCGCCGGAGAGACCCGCCGCATGGTCCTGCGCG
GTTCTCCGCGTATCGCGCTCCCCGGCGGCACCACCCTCTACCTGTTGCCGGTCGAATCACCCACCGCCGAATCGCGCAGC
GAGATTACGCGCACCGTGAACCGCTCGCTTTTGCTGGCCGTGCTGCTCGCCTTCACTGCCGCGCTGATCGCCGCGCTCCT
GCTCTCGCGCTACATCCTGCGCCCCGTGCGCGCCCTCACCACCGCCGCCGGCGAAATCGCCGAGGGCCGATTCGATCGAC
GCGTCCCGACCCATGGCCGCGACGAAATCGGCCGCCTCGCCGATACCTTCAACACTATGGCCGACCGCCTGGCGCATACC
GAGCAGCTCCGCCGTAACATGGTCGGCGATATCTCCCACGAGCTCCGAACTCCGCTCACCCGCATGCAGTGCCAGGTCGA
AGCCATTCAGGATGGCCTTGCGCCTTCCACGCCCGAAGCGCTCCACCAGTTGCACGACCAGATCCTCCAGCTCGATCGCC
TGGTCGATGATCTCCAGGATCTTTCCCTCTCCGATGCCGGACAGCTCAAGCTCACGCCCGTTCCCGTGCGGCTCGATATC
CTGATCCGCGAAGTTGCCACCGGCCGCCCCATCTCTCTCGAGATCGCGCCCGATCTCCCGCCCGTCCTCGCCGACCAGCG
CCGCCTCCGGCAGATTCTGGAGAACCTGATCGCCGCGCTCCGCCGCCCGGGGGAAATCGAAGTTCGAGTACAGGATCGCG
GCCCCGGCATTCCGGCCGAACATCTCGCGCGCATCTTCGAACGTTTCCACCGCGTTGACGATTCGCGCACTCGCTCCACC
GGCGGCACAGGTCTCGGCCTCGCGATTGTCAAACACCTCGTGGAAGCCCACGGCGGCCACGTCCGCGCCGAAGGTTCCCC
AGGTACCGGCGCCACCCTCATCTTCACCCTGCCCACGCTGGCGTAG

Upstream 100 bases:

>100_bases
ACATCGCCAACCTGCGCCGCAAAATTGACGACAATCCCGCGCAGCCCGCGCTCATCGCCACGATCTTCGGCGCCGGCTAC
AAATGGATCGGCGGACCCTC

Downstream 100 bases:

>100_bases
TGTCTCTTAACATCTCCTTAACACCTCCCTGCTACCGTCCTCACATGCGCTTTCTTGCATTCCCGCTGCTCGCTGTCGCC
GCCTTCGGCCAGGACTCCAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKISLRLRFLLATMAIAGATLTAIALFSSRVTLSEIERVTSPSPAAAPRLDLDTLRGALTDYWNRHHRWTSVELTLHRLA
GESAGLLLLSDQTAPIASWPPELAQSRVTLHPDQSLELDGRTAAGETRRMVLRGSPRIALPGGTTLYLLPVESPTAESRS
EITRTVNRSLLLAVLLAFTAALIAALLLSRYILRPVRALTTAAGEIAEGRFDRRVPTHGRDEIGRLADTFNTMADRLAHT
EQLRRNMVGDISHELRTPLTRMQCQVEAIQDGLAPSTPEALHQLHDQILQLDRLVDDLQDLSLSDAGQLKLTPVPVRLDI
LIREVATGRPISLEIAPDLPPVLADQRRLRQILENLIAALRRPGEIEVRVQDRGPGIPAEHLARIFERFHRVDDSRTRST
GGTGLGLAIVKHLVEAHGGHVRAEGSPGTGATLIFTLPTLA

Sequences:

>Translated_441_residues
MKISLRLRFLLATMAIAGATLTAIALFSSRVTLSEIERVTSPSPAAAPRLDLDTLRGALTDYWNRHHRWTSVELTLHRLA
GESAGLLLLSDQTAPIASWPPELAQSRVTLHPDQSLELDGRTAAGETRRMVLRGSPRIALPGGTTLYLLPVESPTAESRS
EITRTVNRSLLLAVLLAFTAALIAALLLSRYILRPVRALTTAAGEIAEGRFDRRVPTHGRDEIGRLADTFNTMADRLAHT
EQLRRNMVGDISHELRTPLTRMQCQVEAIQDGLAPSTPEALHQLHDQILQLDRLVDDLQDLSLSDAGQLKLTPVPVRLDI
LIREVATGRPISLEIAPDLPPVLADQRRLRQILENLIAALRRPGEIEVRVQDRGPGIPAEHLARIFERFHRVDDSRTRST
GGTGLGLAIVKHLVEAHGGHVRAEGSPGTGATLIFTLPTLA
>Mature_441_residues
MKISLRLRFLLATMAIAGATLTAIALFSSRVTLSEIERVTSPSPAAAPRLDLDTLRGALTDYWNRHHRWTSVELTLHRLA
GESAGLLLLSDQTAPIASWPPELAQSRVTLHPDQSLELDGRTAAGETRRMVLRGSPRIALPGGTTLYLLPVESPTAESRS
EITRTVNRSLLLAVLLAFTAALIAALLLSRYILRPVRALTTAAGEIAEGRFDRRVPTHGRDEIGRLADTFNTMADRLAHT
EQLRRNMVGDISHELRTPLTRMQCQVEAIQDGLAPSTPEALHQLHDQILQLDRLVDDLQDLSLSDAGQLKLTPVPVRLDI
LIREVATGRPISLEIAPDLPPVLADQRRLRQILENLIAALRRPGEIEVRVQDRGPGIPAEHLARIFERFHRVDDSRTRST
GGTGLGLAIVKHLVEAHGGHVRAEGSPGTGATLIFTLPTLA

Specific function: Member of the two-component regulatory system BaeS/BaeR. May activate BaeR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=313, Percent_Identity=38.0191693290735, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=35.5263157894737, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790346, Length=321, Percent_Identity=29.2834890965732, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789149, Length=336, Percent_Identity=27.6785714285714, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787894, Length=291, Percent_Identity=30.5841924398625, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=31.864406779661, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=26.7782426778243, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=27.6923076923077, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=30.1801801801802, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=30.1492537313433, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789808, Length=376, Percent_Identity=27.3936170212766, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=26.431718061674, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=24.1758241758242, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=309, Percent_Identity=26.8608414239482, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=26.2820512820513, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48271; Mature: 48271

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISLRLRFLLATMAIAGATLTAIALFSSRVTLSEIERVTSPSPAAAPRLDLDTLRGALT
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DYWNRHHRWTSVELTLHRLAGESAGLLLLSDQTAPIASWPPELAQSRVTLHPDQSLELDG
HHHHHCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHCCCEEECCCCCCCCCC
RTAAGETRRMVLRGSPRIALPGGTTLYLLPVESPTAESRSEITRTVNRSLLLAVLLAFTA
CCCCCHHHEEEEECCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALIAALLLSRYILRPVRALTTAAGEIAEGRFDRRVPTHGRDEIGRLADTFNTMADRLAHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQLRRNMVGDISHELRTPLTRMQCQVEAIQDGLAPSTPEALHQLHDQILQLDRLVDDLQD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSLSDAGQLKLTPVPVRLDILIREVATGRPISLEIAPDLPPVLADQRRLRQILENLIAAL
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RRPGEIEVRVQDRGPGIPAEHLARIFERFHRVDDSRTRSTGGTGLGLAIVKHLVEAHGGH
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCE
VRAEGSPGTGATLIFTLPTLA
EEECCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MKISLRLRFLLATMAIAGATLTAIALFSSRVTLSEIERVTSPSPAAAPRLDLDTLRGALT
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DYWNRHHRWTSVELTLHRLAGESAGLLLLSDQTAPIASWPPELAQSRVTLHPDQSLELDG
HHHHHCCCEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHCCCEEECCCCCCCCCC
RTAAGETRRMVLRGSPRIALPGGTTLYLLPVESPTAESRSEITRTVNRSLLLAVLLAFTA
CCCCCHHHEEEEECCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALIAALLLSRYILRPVRALTTAAGEIAEGRFDRRVPTHGRDEIGRLADTFNTMADRLAHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQLRRNMVGDISHELRTPLTRMQCQVEAIQDGLAPSTPEALHQLHDQILQLDRLVDDLQD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSLSDAGQLKLTPVPVRLDILIREVATGRPISLEIAPDLPPVLADQRRLRQILENLIAAL
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RRPGEIEVRVQDRGPGIPAEHLARIFERFHRVDDSRTRSTGGTGLGLAIVKHLVEAHGGH
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCE
VRAEGSPGTGATLIFTLPTLA
EEECCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8282725; 9097040; 9278503 [H]