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The map label for this gene is czcC [H]

Identifier: 116623975

GI number: 116623975

Start: 6166699

End: 6167994

Strand: Reverse

Name: czcC [H]

Synonym: Acid_4887

Alternate gene names: 116623975

Gene position: 6167994-6166699 (Counterclockwise)

Preceding gene: 116623976

Following gene: 116623974

Centisome position: 61.89

GC content: 61.19

Gene sequence:

>1296_bases
ATGGAGAACGTCTTTGAAGGACATGCACCTGGCCTCCGGATCCGGCGGCTGCTGCTCGGGACATGGCTAGTTGTCTCGAT
GGCCGGCGTGGCCGCGGCGCAGAAGAAGACCTTGACCTGGGACGAGGCCAAGCGGGAGTTGGACGCCGTGAACCCGACGC
TGCGCGCCGCGCGCATCGGAATCCAGCAATCGCGGGCCGATGAGATCACGGCATTTCTGCGGCCGAACCCGGACCTGACG
ATATCGGTGGATCAGGTCAGTCCGCTCTATGAGGCGGATGGGGGACCCTTCCGGCCATTCTCCGATTCCCTGCCATTTCT
CTCCAGCAGCTACCTGATTGAACGGCGGCACAAGCGCGAACTGCGGCGCGACAGCGCCCGGCAAGGCACCGAGATCGCCA
TTTCGGAATTCGACGACCAGAAACGGAACCTGCTTTTCGACCTGCGCGGCGCGTTCATAGACGTGCTTCAGCAGAAGGCC
GTGGTGGAGGTCACGCACGAAAGCCTGGCGTATTACGACCGAATGCTCAGCGTGGGCCGCGAGCGCTACAAGAACGGCGA
CATCGCGCAGGTGGACCTCGACCGATTGGAATTGCAGCGCGTGCAGTTCGAAACCGACGTCCAGACCGCCTTGGTCAATC
TGCGTACGGCGAAGATCCGGCTTGAAGCGCTGCTAAACGATCGGACGCCTTTGGAGCAATTGGATGTGAGCGGGCGATTC
GACTTTTCGGAGATCGTCACTCCGCTGCCGGAGTTCCGGCAGGCCGCGCTGGACTCAAGGGCGGACCTGCGGGCGGCGGT
ACAGTCCGTGGATAAAGCCAGGACCGATTACCGGCTCGCTATTGCCAACGGTTCGACGGATCCGACAGTCGGATTCGACG
TGGCACGACAGTACCCGCTGCGAGCGTATTTCGGAGTCGGCGTTACCATCCCGCTGCGCATCTTCGATCGCAACCAGGGC
GAAAAGGCGCGCACGCGGCTCGATATCCAACGAAGCGAGCGGCTGGTGGAGGCAAACCGGCTGCAGGTATTCAGCGATGT
GGATTCGGCATACGCCACGCTGGAGAGCAACCTGACGCTCCTGCGGCCGTACAAGACCCGATACCTGCAACAGGCTGCGC
GCGTGCGCGAAACGATTTCCTTTTCGTACCAGCATGGCGGGGCTTCACTGCTCGACTTTCTGCAAGCGCAGCAGGATTAC
CGCAATATTCAATTGAGCTATCTGAATCTGGTGGGGTCGTATTTGAGCGCCGCCAACCAAATGAACTTCGCCGTGGGGCG
TGAGGTGATTCCATGA

Upstream 100 bases:

>100_bases
CCAATGCGTTTTGCGGTCAGTGGCCAAGGATGAAAGCAGCCAGCTCTGTCCATCACCGGAGTGTCTCGCGTGTTCCCGCG
GTATTCGGGTCTAAGTTCGA

Downstream 100 bases:

>100_bases
AGCACGTGGCATTTCTACCGGCAGGTCTGGCAGTCGCGTTGAGTCTTTTGCTGGGAAGCTGCGCGCGGAACGTGACGGCC
AAGAATCCCCAGCTCGAGGA

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MENVFEGHAPGLRIRRLLLGTWLVVSMAGVAAAQKKTLTWDEAKRELDAVNPTLRAARIGIQQSRADEITAFLRPNPDLT
ISVDQVSPLYEADGGPFRPFSDSLPFLSSSYLIERRHKRELRRDSARQGTEIAISEFDDQKRNLLFDLRGAFIDVLQQKA
VVEVTHESLAYYDRMLSVGRERYKNGDIAQVDLDRLELQRVQFETDVQTALVNLRTAKIRLEALLNDRTPLEQLDVSGRF
DFSEIVTPLPEFRQAALDSRADLRAAVQSVDKARTDYRLAIANGSTDPTVGFDVARQYPLRAYFGVGVTIPLRIFDRNQG
EKARTRLDIQRSERLVEANRLQVFSDVDSAYATLESNLTLLRPYKTRYLQQAARVRETISFSYQHGGASLLDFLQAQQDY
RNIQLSYLNLVGSYLSAANQMNFAVGREVIP

Sequences:

>Translated_431_residues
MENVFEGHAPGLRIRRLLLGTWLVVSMAGVAAAQKKTLTWDEAKRELDAVNPTLRAARIGIQQSRADEITAFLRPNPDLT
ISVDQVSPLYEADGGPFRPFSDSLPFLSSSYLIERRHKRELRRDSARQGTEIAISEFDDQKRNLLFDLRGAFIDVLQQKA
VVEVTHESLAYYDRMLSVGRERYKNGDIAQVDLDRLELQRVQFETDVQTALVNLRTAKIRLEALLNDRTPLEQLDVSGRF
DFSEIVTPLPEFRQAALDSRADLRAAVQSVDKARTDYRLAIANGSTDPTVGFDVARQYPLRAYFGVGVTIPLRIFDRNQG
EKARTRLDIQRSERLVEANRLQVFSDVDSAYATLESNLTLLRPYKTRYLQQAARVRETISFSYQHGGASLLDFLQAQQDY
RNIQLSYLNLVGSYLSAANQMNFAVGREVIP
>Mature_431_residues
MENVFEGHAPGLRIRRLLLGTWLVVSMAGVAAAQKKTLTWDEAKRELDAVNPTLRAARIGIQQSRADEITAFLRPNPDLT
ISVDQVSPLYEADGGPFRPFSDSLPFLSSSYLIERRHKRELRRDSARQGTEIAISEFDDQKRNLLFDLRGAFIDVLQQKA
VVEVTHESLAYYDRMLSVGRERYKNGDIAQVDLDRLELQRVQFETDVQTALVNLRTAKIRLEALLNDRTPLEQLDVSGRF
DFSEIVTPLPEFRQAALDSRADLRAAVQSVDKARTDYRLAIANGSTDPTVGFDVARQYPLRAYFGVGVTIPLRIFDRNQG
EKARTRLDIQRSERLVEANRLQVFSDVDSAYATLESNLTLLRPYKTRYLQQAARVRETISFSYQHGGASLLDFLQAQQDY
RNIQLSYLNLVGSYLSAANQMNFAVGREVIP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 48892; Mature: 48892

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVFEGHAPGLRIRRLLLGTWLVVSMAGVAAAQKKTLTWDEAKRELDAVNPTLRAARIG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHC
IQQSRADEITAFLRPNPDLTISVDQVSPLYEADGGPFRPFSDSLPFLSSSYLIERRHKRE
HHHCCHHHHEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LRRDSARQGTEIAISEFDDQKRNLLFDLRGAFIDVLQQKAVVEVTHESLAYYDRMLSVGR
HHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERYKNGDIAQVDLDRLELQRVQFETDVQTALVNLRTAKIRLEALLNDRTPLEQLDVSGRF
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
DFSEIVTPLPEFRQAALDSRADLRAAVQSVDKARTDYRLAIANGSTDPTVGFDVARQYPL
CHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCC
RAYFGVGVTIPLRIFDRNQGEKARTRLDIQRSERLVEANRLQVFSDVDSAYATLESNLTL
CEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LRPYKTRYLQQAARVRETISFSYQHGGASLLDFLQAQQDYRNIQLSYLNLVGSYLSAANQ
ECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNFAVGREVIP
HHHHHCCCCCC
>Mature Secondary Structure
MENVFEGHAPGLRIRRLLLGTWLVVSMAGVAAAQKKTLTWDEAKRELDAVNPTLRAARIG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHC
IQQSRADEITAFLRPNPDLTISVDQVSPLYEADGGPFRPFSDSLPFLSSSYLIERRHKRE
HHHCCHHHHEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LRRDSARQGTEIAISEFDDQKRNLLFDLRGAFIDVLQQKAVVEVTHESLAYYDRMLSVGR
HHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERYKNGDIAQVDLDRLELQRVQFETDVQTALVNLRTAKIRLEALLNDRTPLEQLDVSGRF
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
DFSEIVTPLPEFRQAALDSRADLRAAVQSVDKARTDYRLAIANGSTDPTVGFDVARQYPL
CHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCC
RAYFGVGVTIPLRIFDRNQGEKARTRLDIQRSERLVEANRLQVFSDVDSAYATLESNLTL
CEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LRPYKTRYLQQAARVRETISFSYQHGGASLLDFLQAQQDYRNIQLSYLNLVGSYLSAANQ
ECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNFAVGREVIP
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]