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The map label for this gene is phoP [H]

Identifier: 116623411

GI number: 116623411

Start: 5475203

End: 5475880

Strand: Reverse

Name: phoP [H]

Synonym: Acid_4320

Alternate gene names: 116623411

Gene position: 5475880-5475203 (Counterclockwise)

Preceding gene: 116623412

Following gene: 116623410

Centisome position: 54.95

GC content: 63.57

Gene sequence:

>678_bases
ATGATCCGGATCCTGGTGGTGGAAGACGAGCCGGGGATCGCGCTGGGATTGGAGGACGATCTCACGATAGAAGGCTACGA
CGTGGAGGTGGCGCGCGACGGCGTCACGGCGGCGCGGCGCGGGCGGGAAGGCAACTTCGACCTGATTCTTCTGGACGTAA
TGCTGCCCGGCAAGGACGGCCTGGAAGTCTGCCGCGAGCTGCGGCGGGCGGGGTTGAAGACGCCGATTCTGATGCTGACG
GCCAAGGCTCGCGAGACGGAGAAGGTGATGGGGCTCGAGATCGGCGCCGACGATTACGTCACCAAGCCCTTCGGCACCAA
GGAACTGCGTGCGCGCATCAAGGCGCTGTTGCGGCGAGCGTCAGGGGATACCGACCTGGAAACGTGCAGCTTCGGCGATG
TGGAGGTGGATTTTGCGCGCGGCGAACTGCGATTGAAGGGCAAGGCCGTGGAGCTGACGCCGATCGAGTTCAAGCTGCTG
GATGTTTTCATTCGCGCGCGGGGGCGTGTGTTGAGCCGCGATCAACTGATTGCCGCGACCTGGGGGCGGGACACGTTCAC
CTCGGCGCGTATTGTGGACAATCACATTGCGAATTTGCGGCGCAAGATCGGTGACGATCCGGCGGAGCCGCGCTATCTGC
GGAATGTCCGCGGGTTGGGGTACAGGTTCGATGGTTGA

Upstream 100 bases:

>100_bases
CGGCGCACCGCGGGGAGATCCGCCTGGAGAGCGAGCCGGGAAGCGGCAGCACGTTCGTCATCCTGCTGCCGGCGGCCTTG
ACCGCGATGGTGGAACCCTG

Downstream 100 bases:

>100_bases
CTTAGTCAGGACAGCGGCGCTATTTACTCTCTCGTTTACGCTGCTCGCACAGGGCGATCCGGCACGGCAATTGGAAGCGG
CGATCCATCGCGAGATGGTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIRILVVEDEPGIALGLEDDLTIEGYDVEVARDGVTAARRGREGNFDLILLDVMLPGKDGLEVCRELRRAGLKTPILMLT
AKARETEKVMGLEIGADDYVTKPFGTKELRARIKALLRRASGDTDLETCSFGDVEVDFARGELRLKGKAVELTPIEFKLL
DVFIRARGRVLSRDQLIAATWGRDTFTSARIVDNHIANLRRKIGDDPAEPRYLRNVRGLGYRFDG

Sequences:

>Translated_225_residues
MIRILVVEDEPGIALGLEDDLTIEGYDVEVARDGVTAARRGREGNFDLILLDVMLPGKDGLEVCRELRRAGLKTPILMLT
AKARETEKVMGLEIGADDYVTKPFGTKELRARIKALLRRASGDTDLETCSFGDVEVDFARGELRLKGKAVELTPIEFKLL
DVFIRARGRVLSRDQLIAATWGRDTFTSARIVDNHIANLRRKIGDDPAEPRYLRNVRGLGYRFDG
>Mature_225_residues
MIRILVVEDEPGIALGLEDDLTIEGYDVEVARDGVTAARRGREGNFDLILLDVMLPGKDGLEVCRELRRAGLKTPILMLT
AKARETEKVMGLEIGADDYVTKPFGTKELRARIKALLRRASGDTDLETCSFGDVEVDFARGELRLKGKAVELTPIEFKLL
DVFIRARGRVLSRDQLIAATWGRDTFTSARIVDNHIANLRRKIGDDPAEPRYLRNVRGLGYRFDG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=41.0714285714286, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.7665198237885, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=40.9691629955947, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=37.8854625550661, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=36.7713004484305, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.9464285714286, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.6681614349776, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.0350877192982, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=36.1607142857143, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=35.2678571428571, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=34.6320346320346, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=31.5315315315315, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=34.5971563981043, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.0512820512821, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=32.7731092436975, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=35.6521739130435, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=38, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=137, Percent_Identity=34.3065693430657, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788191, Length=95, Percent_Identity=31.5789473684211, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25142; Mature: 25142

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRILVVEDEPGIALGLEDDLTIEGYDVEVARDGVTAARRGREGNFDLILLDVMLPGKDG
CEEEEEEECCCCEEEECCCCCEEECEEEEEECCCCHHHHCCCCCCCCEEEEEEEECCCCH
LEVCRELRRAGLKTPILMLTAKARETEKVMGLEIGADDYVTKPFGTKELRARIKALLRRA
HHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEECCCCCEECCCCHHHHHHHHHHHHHHC
SGDTDLETCSFGDVEVDFARGELRLKGKAVELTPIEFKLLDVFIRARGRVLSRDQLIAAT
CCCCCCCCCCCCCEEEEEECCEEEECCCEEEECCHHHHHHHHHHHHCCCEECCCCEEEEE
WGRDTFTSARIVDNHIANLRRKIGDDPAEPRYLRNVRGLGYRFDG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECC
>Mature Secondary Structure
MIRILVVEDEPGIALGLEDDLTIEGYDVEVARDGVTAARRGREGNFDLILLDVMLPGKDG
CEEEEEEECCCCEEEECCCCCEEECEEEEEECCCCHHHHCCCCCCCCEEEEEEEECCCCH
LEVCRELRRAGLKTPILMLTAKARETEKVMGLEIGADDYVTKPFGTKELRARIKALLRRA
HHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEECCCCCEECCCCHHHHHHHHHHHHHHC
SGDTDLETCSFGDVEVDFARGELRLKGKAVELTPIEFKLLDVFIRARGRVLSRDQLIAAT
CCCCCCCCCCCCCEEEEEECCEEEECCCEEEECCHHHHHHHHHHHHCCCEECCCCEEEEE
WGRDTFTSARIVDNHIANLRRKIGDDPAEPRYLRNVRGLGYRFDG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]