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The map label for this gene is phoR [H]

Identifier: 116623412

GI number: 116623412

Start: 5475880

End: 5477712

Strand: Reverse

Name: phoR [H]

Synonym: Acid_4321

Alternate gene names: 116623412

Gene position: 5477712-5475880 (Counterclockwise)

Preceding gene: 116623414

Following gene: 116623411

Centisome position: 54.97

GC content: 68.52

Gene sequence:

>1833_bases
ATGACGCCACTTCGGGAGTGGCTCAAACCGCCGAAGAGTCTGCTGCTGATTCTCTTCCTGCTGACCCTCGTTTCGGTCTC
GGCGCTGGGCTGGTTTGGCTTTAAGCTCCTGGAACAAGACAGGATGGTGCAGGCGCAGCGGCGGCAGGAGCGGCTGGAAC
AGGCGGCCGACCGGATCGCCGCGACGCTGCGGGGCACGCTCGCCGAAACCGGCGAACGGCTGAGCGCGTGGCTGACCGCG
ACGCCCTCCGCGGGGAAGCCCGAGGAAGGGATTCTCCTGATCGGGTCGGACTCGGCGGTGAACGCGTATCCGGAGGGGAA
GCTGCTGTTTTACCCGGTGCCGGAGAGCGATCCGGAGGCGCCGGCGGGACTGTTCGCCGAGGGGGAATCGCTGGAGTTTT
TGCAATCGCAGCCGGCGCGCGCGGCGGAGGTATACCGGCGGCTGGCGGAATCGGCGGACCCGGCACGACGCGCGGGAGCG
TTGCTGCGGCTGGCGCGTGTGCTGGGGAAAGTAGGACGGCGCGAGGAAAGCGCGGCGGCTTATGCGCGCATGGCGACGAT
TGACGACGCGCTGGTGGCGGGTGCGCCGGCGTCGCTGGTGGCGCGGCATGCACTGGGCGACGCCACACTGCGCGACGACC
TGCTGCGCGGACGCTGGCGCGTGACCCGCGGGCAGCTCGAGTTTTATGCGGGCGGCGCGCTGCCGGAAGATCGGATGGCT
ATGGCCGAGGCGGCGTCGCAGGCCTGGAATGCGGCGAACCCGCGCGGTCAAAGCACGCTGTGGGTGGGCGGGCGGCCCTA
TTTTGCGATGTCGCGCAATTCCGGGGCGAAACGCGCGATGCTGATTCAGAGTCCGCGGATTCCGGAGGTGGACCAGGCGG
TATGCGCGGCGGTGGATAGCGAGGGGCGGGTAGTCTACGGACGTCGCGACCGGGCCGATCGCGCGGCGATTCGTCCGGCG
GCGGAGAGCCAGCTTCCGTGGACGCTCTACGTCACCGGGGCGGACAATCCGCCGGGAGCGGGCATGCCGGCAAGCCAGCG
ATTCCTGCTGCTGGGGACCGGAGTGATGGTGCTGTTTCTGATTGCGGGCACGTACTTCATTGCGCGCGCGATCCGTCGCG
AGATGGAAGTTTCACGCATGCAATCGGATTTCGTTTCCGCCGTATCGCACGAGTTCCGCTCGCCGCTGACCTCGATCCGG
CACCTCTCGGAGATTTTGGAATTGGGCCGCGTGCCGAGCGAGGAGCGGCGGCAGGTTTACTACAGCACGCTGGTGCGGGA
GACGCGGCGGCTGCAGCGGCTGGTGGAGGCATTGCTGAATTTCGGCCGCATGGAAGCGGGCGCGCGGCCATACCGCTTCG
AGGAATGCGAAGCATCGGCGCTGATTCATCGCGTGGCGGGCGAGTTCGATGCCGAGCTGGCGGCGGGGCGGCGCCTGGAA
CTGAGCGGCCCGGAAAGGGCCTGCGCGGTGGATGGCGATCCGGACGCGCTTTCGGTGGCACTGCGCAACGTGATCGACAA
CGCGTTCAAGTACTCGCCGGACGGTCCCACGGTGTGGGTGGAGTGGCGGGTGGAGAATGCGCGCGTGGCGATCCAGGTGC
GCGATCAGGGGCTGGGGATTACGGCGGCGGAGCGGCGCGCGATCTTTCGCAAATTCGTGCGCGGCAGCGCGGCGGCGGCG
GCCAACGTGAAGGGATCGGGCGTGGGCTTGGCGATGGTGCGACACATTGTGGCGGCGCACCGCGGGGAGATCCGCCTGGA
GAGCGAGCCGGGAAGCGGCAGCACGTTCGTCATCCTGCTGCCGGCGGCCTTGACCGCGATGGTGGAACCCTGA

Upstream 100 bases:

>100_bases
TCTGTTCAAATACTCCCACTTACTCCGATATCAGGCTGACACAAACGTGACACGGGGGCCGGCGAATCCGGGGCAGCCGC
CGTGTACAATCGGGGGTATC

Downstream 100 bases:

>100_bases
TGATCCGGATCCTGGTGGTGGAAGACGAGCCGGGGATCGCGCTGGGATTGGAGGACGATCTCACGATAGAAGGCTACGAC
GTGGAGGTGGCGCGCGACGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTPLREWLKPPKSLLLILFLLTLVSVSALGWFGFKLLEQDRMVQAQRRQERLEQAADRIAATLRGTLAETGERLSAWLTA
TPSAGKPEEGILLIGSDSAVNAYPEGKLLFYPVPESDPEAPAGLFAEGESLEFLQSQPARAAEVYRRLAESADPARRAGA
LLRLARVLGKVGRREESAAAYARMATIDDALVAGAPASLVARHALGDATLRDDLLRGRWRVTRGQLEFYAGGALPEDRMA
MAEAASQAWNAANPRGQSTLWVGGRPYFAMSRNSGAKRAMLIQSPRIPEVDQAVCAAVDSEGRVVYGRRDRADRAAIRPA
AESQLPWTLYVTGADNPPGAGMPASQRFLLLGTGVMVLFLIAGTYFIARAIRREMEVSRMQSDFVSAVSHEFRSPLTSIR
HLSEILELGRVPSEERRQVYYSTLVRETRRLQRLVEALLNFGRMEAGARPYRFEECEASALIHRVAGEFDAELAAGRRLE
LSGPERACAVDGDPDALSVALRNVIDNAFKYSPDGPTVWVEWRVENARVAIQVRDQGLGITAAERRAIFRKFVRGSAAAA
ANVKGSGVGLAMVRHIVAAHRGEIRLESEPGSGSTFVILLPAALTAMVEP

Sequences:

>Translated_610_residues
MTPLREWLKPPKSLLLILFLLTLVSVSALGWFGFKLLEQDRMVQAQRRQERLEQAADRIAATLRGTLAETGERLSAWLTA
TPSAGKPEEGILLIGSDSAVNAYPEGKLLFYPVPESDPEAPAGLFAEGESLEFLQSQPARAAEVYRRLAESADPARRAGA
LLRLARVLGKVGRREESAAAYARMATIDDALVAGAPASLVARHALGDATLRDDLLRGRWRVTRGQLEFYAGGALPEDRMA
MAEAASQAWNAANPRGQSTLWVGGRPYFAMSRNSGAKRAMLIQSPRIPEVDQAVCAAVDSEGRVVYGRRDRADRAAIRPA
AESQLPWTLYVTGADNPPGAGMPASQRFLLLGTGVMVLFLIAGTYFIARAIRREMEVSRMQSDFVSAVSHEFRSPLTSIR
HLSEILELGRVPSEERRQVYYSTLVRETRRLQRLVEALLNFGRMEAGARPYRFEECEASALIHRVAGEFDAELAAGRRLE
LSGPERACAVDGDPDALSVALRNVIDNAFKYSPDGPTVWVEWRVENARVAIQVRDQGLGITAAERRAIFRKFVRGSAAAA
ANVKGSGVGLAMVRHIVAAHRGEIRLESEPGSGSTFVILLPAALTAMVEP
>Mature_609_residues
TPLREWLKPPKSLLLILFLLTLVSVSALGWFGFKLLEQDRMVQAQRRQERLEQAADRIAATLRGTLAETGERLSAWLTAT
PSAGKPEEGILLIGSDSAVNAYPEGKLLFYPVPESDPEAPAGLFAEGESLEFLQSQPARAAEVYRRLAESADPARRAGAL
LRLARVLGKVGRREESAAAYARMATIDDALVAGAPASLVARHALGDATLRDDLLRGRWRVTRGQLEFYAGGALPEDRMAM
AEAASQAWNAANPRGQSTLWVGGRPYFAMSRNSGAKRAMLIQSPRIPEVDQAVCAAVDSEGRVVYGRRDRADRAAIRPAA
ESQLPWTLYVTGADNPPGAGMPASQRFLLLGTGVMVLFLIAGTYFIARAIRREMEVSRMQSDFVSAVSHEFRSPLTSIRH
LSEILELGRVPSEERRQVYYSTLVRETRRLQRLVEALLNFGRMEAGARPYRFEECEASALIHRVAGEFDAELAAGRRLEL
SGPERACAVDGDPDALSVALRNVIDNAFKYSPDGPTVWVEWRVENARVAIQVRDQGLGITAAERRAIFRKFVRGSAAAAA
NVKGSGVGLAMVRHIVAAHRGEIRLESEPGSGSTFVILLPAALTAMVEP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=27.5109170305677, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=31.1965811965812, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=26.5560165975104, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=26.9387755102041, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=31.1740890688259, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=28.0334728033473, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=299, Percent_Identity=28.0936454849498, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=29.6803652968037, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=29.4642857142857, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=27.5555555555556, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=27.9835390946502, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=26.3392857142857, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=230, Percent_Identity=27.3913043478261, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=230, Percent_Identity=25.2173913043478, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=198, Percent_Identity=29.7979797979798, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66561; Mature: 66430

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLREWLKPPKSLLLILFLLTLVSVSALGWFGFKLLEQDRMVQAQRRQERLEQAADRIA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATLRGTLAETGERLSAWLTATPSAGKPEEGILLIGSDSAVNAYPEGKLLFYPVPESDPEA
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCC
PAGLFAEGESLEFLQSQPARAAEVYRRLAESADPARRAGALLRLARVLGKVGRREESAAA
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
YARMATIDDALVAGAPASLVARHALGDATLRDDLLRGRWRVTRGQLEFYAGGALPEDRMA
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCEEECCCEEEEECCCCCHHHHH
MAEAASQAWNAANPRGQSTLWVGGRPYFAMSRNSGAKRAMLIQSPRIPEVDQAVCAAVDS
HHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCC
EGRVVYGRRDRADRAAIRPAAESQLPWTLYVTGADNPPGAGMPASQRFLLLGTGVMVLFL
CCCEEECCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHH
IAGTYFIARAIRREMEVSRMQSDFVSAVSHEFRSPLTSIRHLSEILELGRVPSEERRQVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YSTLVRETRRLQRLVEALLNFGRMEAGARPYRFEECEASALIHRVAGEFDAELAAGRRLE
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LSGPERACAVDGDPDALSVALRNVIDNAFKYSPDGPTVWVEWRVENARVAIQVRDQGLGI
CCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCEEEEEEECCCCCC
TAAERRAIFRKFVRGSAAAAANVKGSGVGLAMVRHIVAAHRGEIRLESEPGSGSTFVILL
CHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEH
PAALTAMVEP
HHHHHHHCCC
>Mature Secondary Structure 
TPLREWLKPPKSLLLILFLLTLVSVSALGWFGFKLLEQDRMVQAQRRQERLEQAADRIA
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATLRGTLAETGERLSAWLTATPSAGKPEEGILLIGSDSAVNAYPEGKLLFYPVPESDPEA
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCC
PAGLFAEGESLEFLQSQPARAAEVYRRLAESADPARRAGALLRLARVLGKVGRREESAAA
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
YARMATIDDALVAGAPASLVARHALGDATLRDDLLRGRWRVTRGQLEFYAGGALPEDRMA
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCEEECCCEEEEECCCCCHHHHH
MAEAASQAWNAANPRGQSTLWVGGRPYFAMSRNSGAKRAMLIQSPRIPEVDQAVCAAVDS
HHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCC
EGRVVYGRRDRADRAAIRPAAESQLPWTLYVTGADNPPGAGMPASQRFLLLGTGVMVLFL
CCCEEECCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHH
IAGTYFIARAIRREMEVSRMQSDFVSAVSHEFRSPLTSIRHLSEILELGRVPSEERRQVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YSTLVRETRRLQRLVEALLNFGRMEAGARPYRFEECEASALIHRVAGEFDAELAAGRRLE
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LSGPERACAVDGDPDALSVALRNVIDNAFKYSPDGPTVWVEWRVENARVAIQVRDQGLGI
CCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCEEEEEEECCCCCC
TAAERRAIFRKFVRGSAAAAANVKGSGVGLAMVRHIVAAHRGEIRLESEPGSGSTFVILL
CHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEH
PAALTAMVEP
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]