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The map label for this gene is fkpA [H]

Identifier: 116623240

GI number: 116623240

Start: 5258503

End: 5259411

Strand: Reverse

Name: fkpA [H]

Synonym: Acid_4147

Alternate gene names: 116623240

Gene position: 5259411-5258503 (Counterclockwise)

Preceding gene: 116623241

Following gene: 116623237

Centisome position: 52.78

GC content: 62.71

Gene sequence:

>909_bases
ATGCTCGCGGCCCTTTGCGCTTTGTGCGCCAGCGCCCAAAGCTTCGATCCCAAGATGCCGCCAGCGGTTCCCGCGGCCGC
CGGCAGCGTCGTGGAAACCGCGCCGCTCCGCTACATCGAAATTAAGGAAGGCACCGGTGCTCCCGCCAAGCCCGCGCAGG
AATACACCGTCCACTACACCGGCTGGCTCCGCGACGGCACCAAGTTCGATTCCTCCGTGGATCGCGGCACGCCCCTCAAA
TTCGTCCAGGGCCGCCGCCAGGTGATCTCCGGCTGGGAGATCGGCTTTGAAGGCATGAAAGTCGGCGGCAAGCGCCGCCT
CTTCCTGCCTTACACACTCGCTTACGGAGAACTCGGCAACGGCCGTATCCCGGGCAAAGCCGAACTGATCTTCGACGTCG
AACTGCTCGGCGTTCGCGACGTACCCAACGTGACCGGCGGCGCCATCTTCCTCCTCCCCTTCAACGACCTCGAGAAGCAG
GTGCTCGCTCTTGCCAAAGCCATCCCGGAAGAAAAATACTCCTGGCGTCCCGGCCCCGGCGTGCGCTCCTTCAAGGAAGT
CTTCCTCCACATCGCCTTCGGCAATCAACTCCTGCTCAACATCGCCAACAAGTCGCCGAAGAAGGAAGAGCTGATGAAGC
AGATCGAAGAGAATGCCAAGGGCGAAACCGACACCGCCACCAAGGAGAAGGTGATCGCCCAGCTCACCGAGAGCTTTGCG
CTGGTTCGCAAGACGTTGGATGGCGTCCGCTCCGCCGGCTCCCTCACTCGCGAAGTCGATCTCTTCGGCACTCCCGCCAC
GTTTGGCGGCGTCCTCGCCCAAATCGACACGCACATCGCCGAACACCTCGGCCAGTCCATCGCCTACGCGCGCGTCAATA
ACATCGTCCCGCCCTGGTCGCCGAAATAA

Upstream 100 bases:

>100_bases
CGCACATCTATCCCGGCTCCTACCTCGAGTACGTCCAGCGCATCGGCCACGAAGCCCCCGGCATCTACGCCTGACTTATA
ATCTGGGAATGCGCCTTCCC

Downstream 100 bases:

>100_bases
GCTCACGCTCGCAGGCGTGCCAGATACTGTTTCGCCGATGTTTTGATGTCCGCACTGCCAAACCAGAGCCGCGTCCCGTA
CCAATCAATGCGAAACTCGC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLAALCALCASAQSFDPKMPPAVPAAAGSVVETAPLRYIEIKEGTGAPAKPAQEYTVHYTGWLRDGTKFDSSVDRGTPLK
FVQGRRQVISGWEIGFEGMKVGGKRRLFLPYTLAYGELGNGRIPGKAELIFDVELLGVRDVPNVTGGAIFLLPFNDLEKQ
VLALAKAIPEEKYSWRPGPGVRSFKEVFLHIAFGNQLLLNIANKSPKKEELMKQIEENAKGETDTATKEKVIAQLTESFA
LVRKTLDGVRSAGSLTREVDLFGTPATFGGVLAQIDTHIAEHLGQSIAYARVNNIVPPWSPK

Sequences:

>Translated_302_residues
MLAALCALCASAQSFDPKMPPAVPAAAGSVVETAPLRYIEIKEGTGAPAKPAQEYTVHYTGWLRDGTKFDSSVDRGTPLK
FVQGRRQVISGWEIGFEGMKVGGKRRLFLPYTLAYGELGNGRIPGKAELIFDVELLGVRDVPNVTGGAIFLLPFNDLEKQ
VLALAKAIPEEKYSWRPGPGVRSFKEVFLHIAFGNQLLLNIANKSPKKEELMKQIEENAKGETDTATKEKVIAQLTESFA
LVRKTLDGVRSAGSLTREVDLFGTPATFGGVLAQIDTHIAEHLGQSIAYARVNNIVPPWSPK
>Mature_302_residues
MLAALCALCASAQSFDPKMPPAVPAAAGSVVETAPLRYIEIKEGTGAPAKPAQEYTVHYTGWLRDGTKFDSSVDRGTPLK
FVQGRRQVISGWEIGFEGMKVGGKRRLFLPYTLAYGELGNGRIPGKAELIFDVELLGVRDVPNVTGGAIFLLPFNDLEKQ
VLALAKAIPEEKYSWRPGPGVRSFKEVFLHIAFGNQLLLNIANKSPKKEELMKQIEENAKGETDTATKEKVIAQLTESFA
LVRKTLDGVRSAGSLTREVDLFGTPATFGGVLAQIDTHIAEHLGQSIAYARVNNIVPPWSPK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=88, Percent_Identity=52.2727272727273, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4503725, Length=88, Percent_Identity=52.2727272727273, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI206725530, Length=83, Percent_Identity=51.8072289156626, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI17149844, Length=83, Percent_Identity=51.8072289156626, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI17149842, Length=83, Percent_Identity=51.8072289156626, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4758380, Length=90, Percent_Identity=48.8888888888889, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503729, Length=96, Percent_Identity=43.75, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI8923659, Length=89, Percent_Identity=42.6966292134831, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI192448443, Length=121, Percent_Identity=37.1900826446281, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=79, Percent_Identity=45.5696202531646, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224809329, Length=84, Percent_Identity=45.2380952380952, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI224809327, Length=84, Percent_Identity=45.2380952380952, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758384, Length=84, Percent_Identity=45.2380952380952, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI224809331, Length=84, Percent_Identity=45.2380952380952, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI87082390, Length=105, Percent_Identity=47.6190476190476, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789745, Length=108, Percent_Identity=43.5185185185185, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=48.3516483516484, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=97, Percent_Identity=42.2680412371134, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=98, Percent_Identity=45.9183673469388, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561778, Length=96, Percent_Identity=43.75, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=93, Percent_Identity=52.6881720430108, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=49.5049504950495, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=97, Percent_Identity=41.2371134020619, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=96, Percent_Identity=40.625, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281363946, Length=126, Percent_Identity=43.6507936507937, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17352457, Length=126, Percent_Identity=43.6507936507937, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655568, Length=105, Percent_Identity=46.6666666666667, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356629, Length=136, Percent_Identity=37.5, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24647110, Length=117, Percent_Identity=36.7521367521368, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583150, Length=100, Percent_Identity=44, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32819; Mature: 32819

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAALCALCASAQSFDPKMPPAVPAAAGSVVETAPLRYIEIKEGTGAPAKPAQEYTVHYT
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCCEEEEEE
GWLRDGTKFDSSVDRGTPLKFVQGRRQVISGWEIGFEGMKVGGKRRLFLPYTLAYGELGN
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCEEECCCEEEEEEEEEEECCCCC
GRIPGKAELIFDVELLGVRDVPNVTGGAIFLLPFNDLEKQVLALAKAIPEEKYSWRPGPG
CCCCCCEEEEEEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCC
VRSFKEVFLHIAFGNQLLLNIANKSPKKEELMKQIEENAKGETDTATKEKVIAQLTESFA
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LVRKTLDGVRSAGSLTREVDLFGTPATFGGVLAQIDTHIAEHLGQSIAYARVNNIVPPWS
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PK
CC
>Mature Secondary Structure
MLAALCALCASAQSFDPKMPPAVPAAAGSVVETAPLRYIEIKEGTGAPAKPAQEYTVHYT
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCCEEEEEE
GWLRDGTKFDSSVDRGTPLKFVQGRRQVISGWEIGFEGMKVGGKRRLFLPYTLAYGELGN
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCEEECCCEEEEEEEEEEECCCCC
GRIPGKAELIFDVELLGVRDVPNVTGGAIFLLPFNDLEKQVLALAKAIPEEKYSWRPGPG
CCCCCCEEEEEEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCC
VRSFKEVFLHIAFGNQLLLNIANKSPKKEELMKQIEENAKGETDTATKEKVIAQLTESFA
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LVRKTLDGVRSAGSLTREVDLFGTPATFGGVLAQIDTHIAEHLGQSIAYARVNNIVPPWS
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]