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The map label for this gene is yhdN [H]

Identifier: 116623237

GI number: 116623237

Start: 5256383

End: 5257366

Strand: Reverse

Name: yhdN [H]

Synonym: Acid_4144

Alternate gene names: 116623237

Gene position: 5257366-5256383 (Counterclockwise)

Preceding gene: 116623240

Following gene: 116623234

Centisome position: 52.75

GC content: 63.92

Gene sequence:

>984_bases
ATGAACTATCGCGAGTTAGGACGTACCGGCTGGAAGGTTTCCGACATCAGCTTCGGCGCATGGGCCATCGGCGGCAGTTG
GGGCAGCGTGGACGATGGCGAATCGCTCGCCGCGCTGCACAGCGCGATCGATTCGGGCGTCAACTTCATCGACACCGCCG
ACGTCTACGGCATGGGCCGCAGCGAGCGCCTGATCGCGCAGTTGAAGCGCGAGCGCAAAGAGGAGATCATTGTCGCCACC
AAGGCCGGCCGCCGCCTCTCGCCGCATACCGCCGATGGCTACAACGAGAGCAACATCGCGGGCTTCATCGAGGACAGCCT
GCGCAATCTCGCAACCGACTGCCTCGACCTCGTGCAGCTCCACTGCCCGCCGACCGACGTCTATTACCGCCCCGAATTAT
TCGGCGCGCTCGATCGTCTCGTGAAGGCCGGAAAGGTCCGCTACTACGGCGTCAGCGTGGAGCGAGTTGAAGAGGCGCTC
AAGGCCATCGAGTACCCGAACGTTCAATCCGTGCAGATTATCTTCAACTGCTTCCGCCAGCGTCCCGCCGATCTCTTCTT
TGCGCAAGCCATGCAGAAGCATGTGGGCATTTTGGCGCGCGTGCCGCTCGCCAGTGGAATGCTCAGCGGCAAACTCACGC
CCGATTCGCAATTCGCGCCCGATGACCATCGCCAGTTCAACCGCCACGGCGAAGCCTTCGACAAGGGCGAGACCTTTTCC
GGCGTCGATTACCAGACCGGGCTGGATGCCGTGGAAGAGCTCCGCCAGCTTCTTCCCGACGGCGTGACCATGGCGCAGTT
CGCGCTGCGCTGGATCCTGATGTTCCCTGCCGTCACCTGCGCCATTCCCGGCGGCAAGCGCCCCTCGCAGGTGCGCGACA
ATTGCGCGGCGTCCGGTCTTCCGCCGCTCTCCACGGCCGCGATGGATGCCGTACGTCGCATCTACGGCGCCAAGATCCGC
GCGTCCGTTCACCAGCGCTGGTAG

Upstream 100 bases:

>100_bases
TCCGATGCACCGCCAACCGCGGTGAGGAACCCCGGGGTCGCTCCACTTGCCCCTTAGTCGTTCCGGCACCTTACAATTAT
GACCTGATACTTTGGAAGGG

Downstream 100 bases:

>100_bases
CTACTTCTTCGGACCGCCGCCCGTTGGACGCTGATAGATCGTCTCGAAGTCCGGCCGCGAACCCACCGAGATGCCGCTCG
AAGTCGAATTGCCGGACCCC

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNYRELGRTGWKVSDISFGAWAIGGSWGSVDDGESLAALHSAIDSGVNFIDTADVYGMGRSERLIAQLKRERKEEIIVAT
KAGRRLSPHTADGYNESNIAGFIEDSLRNLATDCLDLVQLHCPPTDVYYRPELFGALDRLVKAGKVRYYGVSVERVEEAL
KAIEYPNVQSVQIIFNCFRQRPADLFFAQAMQKHVGILARVPLASGMLSGKLTPDSQFAPDDHRQFNRHGEAFDKGETFS
GVDYQTGLDAVEELRQLLPDGVTMAQFALRWILMFPAVTCAIPGGKRPSQVRDNCAASGLPPLSTAAMDAVRRIYGAKIR
ASVHQRW

Sequences:

>Translated_327_residues
MNYRELGRTGWKVSDISFGAWAIGGSWGSVDDGESLAALHSAIDSGVNFIDTADVYGMGRSERLIAQLKRERKEEIIVAT
KAGRRLSPHTADGYNESNIAGFIEDSLRNLATDCLDLVQLHCPPTDVYYRPELFGALDRLVKAGKVRYYGVSVERVEEAL
KAIEYPNVQSVQIIFNCFRQRPADLFFAQAMQKHVGILARVPLASGMLSGKLTPDSQFAPDDHRQFNRHGEAFDKGETFS
GVDYQTGLDAVEELRQLLPDGVTMAQFALRWILMFPAVTCAIPGGKRPSQVRDNCAASGLPPLSTAAMDAVRRIYGAKIR
ASVHQRW
>Mature_327_residues
MNYRELGRTGWKVSDISFGAWAIGGSWGSVDDGESLAALHSAIDSGVNFIDTADVYGMGRSERLIAQLKRERKEEIIVAT
KAGRRLSPHTADGYNESNIAGFIEDSLRNLATDCLDLVQLHCPPTDVYYRPELFGALDRLVKAGKVRYYGVSVERVEEAL
KAIEYPNVQSVQIIFNCFRQRPADLFFAQAMQKHVGILARVPLASGMLSGKLTPDSQFAPDDHRQFNRHGEAFDKGETFS
GVDYQTGLDAVEELRQLLPDGVTMAQFALRWILMFPAVTCAIPGGKRPSQVRDNCAASGLPPLSTAAMDAVRRIYGAKIR
ASVHQRW

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=329, Percent_Identity=25.2279635258359, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4504825, Length=327, Percent_Identity=25.0764525993884, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI27436964, Length=328, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI27436962, Length=328, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI27436966, Length=328, Percent_Identity=24.6951219512195, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI27436971, Length=336, Percent_Identity=25.297619047619, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87081735, Length=332, Percent_Identity=28.3132530120482, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789375, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788070, Length=310, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789199, Length=357, Percent_Identity=25.7703081232493, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788081, Length=136, Percent_Identity=32.3529411764706, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645785, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646155, Length=158, Percent_Identity=37.3417721518987, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646159, Length=220, Percent_Identity=32.7272727272727, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24640980, Length=346, Percent_Identity=23.121387283237, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45549126, Length=346, Percent_Identity=23.121387283237, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36138; Mature: 36138

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYRELGRTGWKVSDISFGAWAIGGSWGSVDDGESLAALHSAIDSGVNFIDTADVYGMGR
CCHHHHCCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCCC
SERLIAQLKRERKEEIIVATKAGRRLSPHTADGYNESNIAGFIEDSLRNLATDCLDLVQL
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HCPPTDVYYRPELFGALDRLVKAGKVRYYGVSVERVEEALKAIEYPNVQSVQIIFNCFRQ
CCCCCCCEECHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RPADLFFAQAMQKHVGILARVPLASGMLSGKLTPDSQFAPDDHRQFNRHGEAFDKGETFS
CCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
GVDYQTGLDAVEELRQLLPDGVTMAQFALRWILMFPAVTCAIPGGKRPSQVRDNCAASGL
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PPLSTAAMDAVRRIYGAKIRASVHQRW
CCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYRELGRTGWKVSDISFGAWAIGGSWGSVDDGESLAALHSAIDSGVNFIDTADVYGMGR
CCHHHHCCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCCC
SERLIAQLKRERKEEIIVATKAGRRLSPHTADGYNESNIAGFIEDSLRNLATDCLDLVQL
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HCPPTDVYYRPELFGALDRLVKAGKVRYYGVSVERVEEALKAIEYPNVQSVQIIFNCFRQ
CCCCCCCEECHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RPADLFFAQAMQKHVGILARVPLASGMLSGKLTPDSQFAPDDHRQFNRHGEAFDKGETFS
CCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
GVDYQTGLDAVEELRQLLPDGVTMAQFALRWILMFPAVTCAIPGGKRPSQVRDNCAASGL
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PPLSTAAMDAVRRIYGAKIRASVHQRW
CCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]