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The map label for this gene is betC [H]

Identifier: 116623102

GI number: 116623102

Start: 5077666

End: 5079027

Strand: Direct

Name: betC [H]

Synonym: Acid_4006

Alternate gene names: 116623102

Gene position: 5077666-5079027 (Clockwise)

Preceding gene: 116623100

Following gene: 116623106

Centisome position: 50.95

GC content: 65.49

Gene sequence:

>1362_bases
ATGCCTTCCTCGCGCCGTACGTTCCTGCAGGCCGCCGCCGCGGCCATGCCGCTCGCATCCCAAACGGCGGGCAGGCCGCC
CAACATTCTCTATCTGCACTCGCACGACACCGGGCGCTACCTTCGACCGTACGGGTACGCGACACCCACGCCGCGCATTC
AGCGGCTGGCGGCGGAGGGCGTGCTGTTCCGGCGCGCTTTTAGCGCCGCGCCGACCTGTTCGCCGAGCCGCGCGGCCCTG
TTGACCGGACAGTGCCCTCACCAGAACGGAATGCTCGGGCTGGCGCATCGCGGTTTCGCGATGACCGATTACCGGCGGCA
CATGCTGTACACATTGCGCGATGCGGGATACCGGTCGATTCTGGGCGGATTGCAGCACATCGCGGACAAGCCGGAGCGAA
TCGGCTACGACGAGCTCCTGGGCGCCAAATCGAACCGCGTTGCCGATGTGGCGCCGGCGGCAGCGCGGTTTCTGGAAGGC
CGGCCGAAAGGCCCGTTCTTTCTCGACGTGGGCTTTTTCGAGACGCACCGCGAATTTCATCCGCCGACGCCGGAGGACGA
TCCGCGCTACCTGCAGCCTCCGGTACCGATCCCCGATACCGCGGCCACGCGCCGCGACATGGCGGGATTTCATGCGAGCG
CGCGGGTGTTGGACCAAGGCGTGGGACAGGTGCTGGACGCGCTGGAACGCAGCGGGCTCGCTGGGAATACGCTCGTGATC
AGCACCACCGATCACGGGCTCGCTTTCCCCGACATGAAGTGCAACCTGGTGGACGCGGGCTTCGGAGTCTCGCTGATCAT
GAGAGGCCCGGGCCTGTTCGGCGGTGGCAAGGTGGTGGACGGGATGGTATCCCAGCTGGATCTGTTCCCGACACTCTGCG
ACCTCGCCGAGGTAAAGCATCCCGCTTGGCTGGAGGGCAGGTCTTTGCTGCCGCTGCTGCGCGGAGAGTCGCCGGAGATT
CACGACGAGATCTTCGCCGAGGTCAATTATCACGCGGCGTATGAGCCCAAGCGGGCAGTGCGCACGCAGCGTTGGAAGTA
CATCCGGCGTTACAGCGAGCTGGGAACGACGGTCCTGCCGAATTGCGACGACGGACCGAGCAAGAGCCTGTGGCTGGAGC
ATGGGTGGAGGCAGAAGGCTCTGCCCCGCGAAGATCTTTACGATTTAGTGTTCGACCCGACGGAGCGGCGCAATCTGGCG
GGCGATAAGGCATCGGCGGAAGCGCTGGCGGACATGCGCGGGAGGCTCGACGCATGGATGAAGCGGACCAACGATCCCTT
GCTCTCAGGTGCAGTGCCGCTACCGGCTGGAGCGAAGGTCAACCGGGTGGACGGAATCTCGCCCGGGGAGCCAATCAATT
AG

Upstream 100 bases:

>100_bases
TCACCGGCAAGTACGACAAGGGAATACGTAAAAAACTCGCGGCGGTCCATGGCGGTATTGTATCCGGTGTGGGCGACGGT
AACATGGAGGGGAGGTGACC

Downstream 100 bases:

>100_bases
AGGGCCTTGCGAAAGGTGAGATTGATGCGGAACGGGCCGGTGAGCGGGTGATCGCCCGGTTTGAGAGGCGCAACGCCGTG
ATAGGCGAGACGAGTGGGAC

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPSSRRTFLQAAAAAMPLASQTAGRPPNILYLHSHDTGRYLRPYGYATPTPRIQRLAAEGVLFRRAFSAAPTCSPSRAAL
LTGQCPHQNGMLGLAHRGFAMTDYRRHMLYTLRDAGYRSILGGLQHIADKPERIGYDELLGAKSNRVADVAPAAARFLEG
RPKGPFFLDVGFFETHREFHPPTPEDDPRYLQPPVPIPDTAATRRDMAGFHASARVLDQGVGQVLDALERSGLAGNTLVI
STTDHGLAFPDMKCNLVDAGFGVSLIMRGPGLFGGGKVVDGMVSQLDLFPTLCDLAEVKHPAWLEGRSLLPLLRGESPEI
HDEIFAEVNYHAAYEPKRAVRTQRWKYIRRYSELGTTVLPNCDDGPSKSLWLEHGWRQKALPREDLYDLVFDPTERRNLA
GDKASAEALADMRGRLDAWMKRTNDPLLSGAVPLPAGAKVNRVDGISPGEPIN

Sequences:

>Translated_453_residues
MPSSRRTFLQAAAAAMPLASQTAGRPPNILYLHSHDTGRYLRPYGYATPTPRIQRLAAEGVLFRRAFSAAPTCSPSRAAL
LTGQCPHQNGMLGLAHRGFAMTDYRRHMLYTLRDAGYRSILGGLQHIADKPERIGYDELLGAKSNRVADVAPAAARFLEG
RPKGPFFLDVGFFETHREFHPPTPEDDPRYLQPPVPIPDTAATRRDMAGFHASARVLDQGVGQVLDALERSGLAGNTLVI
STTDHGLAFPDMKCNLVDAGFGVSLIMRGPGLFGGGKVVDGMVSQLDLFPTLCDLAEVKHPAWLEGRSLLPLLRGESPEI
HDEIFAEVNYHAAYEPKRAVRTQRWKYIRRYSELGTTVLPNCDDGPSKSLWLEHGWRQKALPREDLYDLVFDPTERRNLA
GDKASAEALADMRGRLDAWMKRTNDPLLSGAVPLPAGAKVNRVDGISPGEPIN
>Mature_452_residues
PSSRRTFLQAAAAAMPLASQTAGRPPNILYLHSHDTGRYLRPYGYATPTPRIQRLAAEGVLFRRAFSAAPTCSPSRAALL
TGQCPHQNGMLGLAHRGFAMTDYRRHMLYTLRDAGYRSILGGLQHIADKPERIGYDELLGAKSNRVADVAPAAARFLEGR
PKGPFFLDVGFFETHREFHPPTPEDDPRYLQPPVPIPDTAATRRDMAGFHASARVLDQGVGQVLDALERSGLAGNTLVIS
TTDHGLAFPDMKCNLVDAGFGVSLIMRGPGLFGGGKVVDGMVSQLDLFPTLCDLAEVKHPAWLEGRSLLPLLRGESPEIH
DEIFAEVNYHAAYEPKRAVRTQRWKYIRRYSELGTTVLPNCDDGPSKSLWLEHGWRQKALPREDLYDLVFDPTERRNLAG
DKASAEALADMRGRLDAWMKRTNDPLLSGAVPLPAGAKVNRVDGISPGEPIN

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4506919, Length=478, Percent_Identity=29.9163179916318, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI4503899, Length=371, Percent_Identity=29.1105121293801, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI39930577, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356831, Length=482, Percent_Identity=31.5352697095436, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 49788; Mature: 49657

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSRRTFLQAAAAAMPLASQTAGRPPNILYLHSHDTGRYLRPYGYATPTPRIQRLAAEG
CCCCHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VLFRRAFSAAPTCSPSRAALLTGQCPHQNGMLGLAHRGFAMTDYRRHMLYTLRDAGYRSI
HHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHH
LGGLQHIADKPERIGYDELLGAKSNRVADVAPAAARFLEGRPKGPFFLDVGFFETHREFH
HHHHHHHHCCCHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCC
PPTPEDDPRYLQPPVPIPDTAATRRDMAGFHASARVLDQGVGQVLDALERSGLAGNTLVI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
STTDHGLAFPDMKCNLVDAGFGVSLIMRGPGLFGGGKVVDGMVSQLDLFPTLCDLAEVKH
EECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PAWLEGRSLLPLLRGESPEIHDEIFAEVNYHAAYEPKRAVRTQRWKYIRRYSELGTTVLP
CCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC
NCDDGPSKSLWLEHGWRQKALPREDLYDLVFDPTERRNLAGDKASAEALADMRGRLDAWM
CCCCCCCCCCHHHCCCHHCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHH
KRTNDPLLSGAVPLPAGAKVNRVDGISPGEPIN
HHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSSRRTFLQAAAAAMPLASQTAGRPPNILYLHSHDTGRYLRPYGYATPTPRIQRLAAEG
CCCHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
VLFRRAFSAAPTCSPSRAALLTGQCPHQNGMLGLAHRGFAMTDYRRHMLYTLRDAGYRSI
HHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHH
LGGLQHIADKPERIGYDELLGAKSNRVADVAPAAARFLEGRPKGPFFLDVGFFETHREFH
HHHHHHHHCCCHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCC
PPTPEDDPRYLQPPVPIPDTAATRRDMAGFHASARVLDQGVGQVLDALERSGLAGNTLVI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
STTDHGLAFPDMKCNLVDAGFGVSLIMRGPGLFGGGKVVDGMVSQLDLFPTLCDLAEVKH
EECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PAWLEGRSLLPLLRGESPEIHDEIFAEVNYHAAYEPKRAVRTQRWKYIRRYSELGTTVLP
CCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC
NCDDGPSKSLWLEHGWRQKALPREDLYDLVFDPTERRNLAGDKASAEALADMRGRLDAWM
CCCCCCCCCCHHHCCCHHCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHH
KRTNDPLLSGAVPLPAGAKVNRVDGISPGEPIN
HHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]