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The map label for this gene is tkt [H]

Identifier: 116622962

GI number: 116622962

Start: 4898299

End: 4900416

Strand: Direct

Name: tkt [H]

Synonym: Acid_3864

Alternate gene names: 116622962

Gene position: 4898299-4900416 (Clockwise)

Preceding gene: 116622960

Following gene: 116622963

Centisome position: 49.15

GC content: 62.51

Gene sequence:

>2118_bases
ATGCCCACCGACAGCAAAACACTCGAAGAACTCTGCATCAATACGATCCGCATCCTGGCGGCAGACGCCGTGCAAAACGC
AAACTCCGGACATCCCGGCATGCCCATGGGAGCGGCCGCCATGGCCTACACTCTCTGGTCGCGTTATTTGAAGCACAATC
CGAAGAACCCCGGGTGGTTCGATCGCGACCGCTTCGTGCTTTCGGCGGGCCACGGCTCGATGCTGTTGTACGGCCTGCTG
CACCTCACCGGATATGACCTGCCGCTCGAGGAAATCAAGCGTTTCAGGCAGCTTGGCAGCAAGACGCCGGGCCACCCGGA
GCGCGGGTTGACTCCAGGCGTGGAGGTTTCGACCGGTCCGCTGGGACAGGGCTTCAGCAACGGCGTTGGCATGGCGATCG
CGCAGAATTTCCTGGCTGCGCGGTTTAACAGGCCGGGGCACAACATTATCGATCACTACATCTATGCAATTTGCGGCGAT
GGCGACCTGATGGAGGGCATCACCCAGGAAGCGGCATCGCTGGCCGGGCATCTGCAGTTGGGAAAGTTGGTCTATTTGTA
CGATAACAACCATATTTCCCTGGCCGGGCAGACCAGCCTGTGTTTCACCGAAAATGTGCAGGAACGCTTTAATGCCTATC
AGTGGCATACGCATGCGGTGGCGGACGGCAATGATACGGCGGAGATCGCGGCAGCCATCGAAGAGGCGCGCAAGGATCCG
CGGCCCTCGCTGATCCTGGTGCGAACGCACATCGGCTATGGGAGTCCGCATAAGCACGACAACTTCGGGTCGCACGGCAG
TCCGCTGGGCGAAGAGGAACTGTCAGCGACCAAGAAGGCGCTGGGCTGGCCGACTTTGGACAAGTTTTATATTCCCGATG
AAGCACGAGCGCAGTTCCGCGGAGCGATCGAGAAGGGTGCCGCGGCGGAGGCGGAGTGGAGCGGGCGACTGAATGCGTAT
CGCGCGGCATTCCCCACGGAATGCGCCCAGCTCGAGAGCATGATGGCCGGGCAACTACCGGAGGGCTGGGACGCCGATCT
GCCGAAGTGGAAGCTGAGCGACAAGGCGATTGCGACACGAGTCGCGGGCGGCCAGGCGCTCAATGCGATTGCCAAGCGCA
TGACGAACCTGATCGGCGGGTCCGCTGACCTCAACCCGTCTACCGAGACCGCGCTGAAAGGGCTGGGCGATTTCCAGCCG
CCGAATACGGACGGGACGAACGTGCAAGGCGAGGTCGGCGGCGTGTGGAGTTACGCAGGGCAGAACGTCGCCTTCGGAGT
CCGCGAACATGCGATGGGGGCGGCAGTCAACGGCATGGCGGCGCACGGCGGCGTGCATCCGTTCAGCGCCACCTTCCTGG
TGTTCAGTGACTACATGAAGCCGGCGATCCGCCTGGGTGCGCTCAGTGATCTGAAGGCGCTCTACATTTTCACGCACGAC
AGCATCGGGGTGGGCGAGGATGGTCCGACGCACGAGCCGGTGGAACAGCTCGCGGGGCTGCGTGCGATCCCGGGGCTGGT
GGTGATCCGGCCGGCGGATCCGAATGAGACAAGCGAGGCGTACCGATTTGCGATCCCGCACGATGGTCCGGTGCTGATCG
CGCTGACACGGCAGAACGTGCCGCATGTTTCGCAGAATCCGCCGGTGGCAAAGGGGGCGTACGTGCTCGCCGATTCGGAA
GGCACGCCCGATGTGATTCTGGTGGGCACGGGCAGCGAAGTCGCACTTTGTGTGAAGGCGCAGGAGAAGTTGAAGCAATT
CGGCGTGAAGGCGCGGGTGGTCAGCATGCCAAGCTGGGAACTCTTCGAAAAGCAGGATGCCGCGTATCGGGAACAGGTGC
TGCCCAAAACAGTGCGAAAGCGCGTATGCGTGGAGGCCGAGTCTCCGTTCGGGTGGGAGCGCTGGGCTGGCGACGAAGGT
GCGATCATCGGCATAAATCGTTATGGCCTGAGCGCACCGGGCGCGGAGGTGATGAAGTACTTCGGGTTCACGGTGGAGCG
GGTGACGTCTACCGCGCTGCGGCTGTTAGGGAAGGTTCGCGAGGCTGAGGAGGTCGAGCCGGGCTTTGGCGGTGAGACTG
CGGTAAAGCCGACCTCTCCGCAGGAAGGGCACTCGTAA

Upstream 100 bases:

>100_bases
GATTATAGTACGGGTTCTTACCCGCTTCAATGGAGCAAAGGTTGTGGGAAGAACGCTCTAGGATTCGTCTGGGAGCACGG
TTTTTGTTACTGTCAAAGGA

Downstream 100 bases:

>100_bases
GGCGAGCGACAGCACGAAGAATGGGTGCTGAGAGATCGCACCCTTAATGGTCACGGCTCTGATTGAAGGTGACGTTTAGT
TCTCGGTGGGCTTTTCGACG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 705; Mature: 704

Protein sequence:

>705_residues
MPTDSKTLEELCINTIRILAADAVQNANSGHPGMPMGAAAMAYTLWSRYLKHNPKNPGWFDRDRFVLSAGHGSMLLYGLL
HLTGYDLPLEEIKRFRQLGSKTPGHPERGLTPGVEVSTGPLGQGFSNGVGMAIAQNFLAARFNRPGHNIIDHYIYAICGD
GDLMEGITQEAASLAGHLQLGKLVYLYDNNHISLAGQTSLCFTENVQERFNAYQWHTHAVADGNDTAEIAAAIEEARKDP
RPSLILVRTHIGYGSPHKHDNFGSHGSPLGEEELSATKKALGWPTLDKFYIPDEARAQFRGAIEKGAAAEAEWSGRLNAY
RAAFPTECAQLESMMAGQLPEGWDADLPKWKLSDKAIATRVAGGQALNAIAKRMTNLIGGSADLNPSTETALKGLGDFQP
PNTDGTNVQGEVGGVWSYAGQNVAFGVREHAMGAAVNGMAAHGGVHPFSATFLVFSDYMKPAIRLGALSDLKALYIFTHD
SIGVGEDGPTHEPVEQLAGLRAIPGLVVIRPADPNETSEAYRFAIPHDGPVLIALTRQNVPHVSQNPPVAKGAYVLADSE
GTPDVILVGTGSEVALCVKAQEKLKQFGVKARVVSMPSWELFEKQDAAYREQVLPKTVRKRVCVEAESPFGWERWAGDEG
AIIGINRYGLSAPGAEVMKYFGFTVERVTSTALRLLGKVREAEEVEPGFGGETAVKPTSPQEGHS

Sequences:

>Translated_705_residues
MPTDSKTLEELCINTIRILAADAVQNANSGHPGMPMGAAAMAYTLWSRYLKHNPKNPGWFDRDRFVLSAGHGSMLLYGLL
HLTGYDLPLEEIKRFRQLGSKTPGHPERGLTPGVEVSTGPLGQGFSNGVGMAIAQNFLAARFNRPGHNIIDHYIYAICGD
GDLMEGITQEAASLAGHLQLGKLVYLYDNNHISLAGQTSLCFTENVQERFNAYQWHTHAVADGNDTAEIAAAIEEARKDP
RPSLILVRTHIGYGSPHKHDNFGSHGSPLGEEELSATKKALGWPTLDKFYIPDEARAQFRGAIEKGAAAEAEWSGRLNAY
RAAFPTECAQLESMMAGQLPEGWDADLPKWKLSDKAIATRVAGGQALNAIAKRMTNLIGGSADLNPSTETALKGLGDFQP
PNTDGTNVQGEVGGVWSYAGQNVAFGVREHAMGAAVNGMAAHGGVHPFSATFLVFSDYMKPAIRLGALSDLKALYIFTHD
SIGVGEDGPTHEPVEQLAGLRAIPGLVVIRPADPNETSEAYRFAIPHDGPVLIALTRQNVPHVSQNPPVAKGAYVLADSE
GTPDVILVGTGSEVALCVKAQEKLKQFGVKARVVSMPSWELFEKQDAAYREQVLPKTVRKRVCVEAESPFGWERWAGDEG
AIIGINRYGLSAPGAEVMKYFGFTVERVTSTALRLLGKVREAEEVEPGFGGETAVKPTSPQEGHS
>Mature_704_residues
PTDSKTLEELCINTIRILAADAVQNANSGHPGMPMGAAAMAYTLWSRYLKHNPKNPGWFDRDRFVLSAGHGSMLLYGLLH
LTGYDLPLEEIKRFRQLGSKTPGHPERGLTPGVEVSTGPLGQGFSNGVGMAIAQNFLAARFNRPGHNIIDHYIYAICGDG
DLMEGITQEAASLAGHLQLGKLVYLYDNNHISLAGQTSLCFTENVQERFNAYQWHTHAVADGNDTAEIAAAIEEARKDPR
PSLILVRTHIGYGSPHKHDNFGSHGSPLGEEELSATKKALGWPTLDKFYIPDEARAQFRGAIEKGAAAEAEWSGRLNAYR
AAFPTECAQLESMMAGQLPEGWDADLPKWKLSDKAIATRVAGGQALNAIAKRMTNLIGGSADLNPSTETALKGLGDFQPP
NTDGTNVQGEVGGVWSYAGQNVAFGVREHAMGAAVNGMAAHGGVHPFSATFLVFSDYMKPAIRLGALSDLKALYIFTHDS
IGVGEDGPTHEPVEQLAGLRAIPGLVVIRPADPNETSEAYRFAIPHDGPVLIALTRQNVPHVSQNPPVAKGAYVLADSEG
TPDVILVGTGSEVALCVKAQEKLKQFGVKARVVSMPSWELFEKQDAAYREQVLPKTVRKRVCVEAESPFGWERWAGDEGA
IIGINRYGLSAPGAEVMKYFGFTVERVTSTALRLLGKVREAEEVEPGFGGETAVKPTSPQEGHS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=697, Percent_Identity=24.8206599713056, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4507521, Length=697, Percent_Identity=24.8206599713056, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI133778974, Length=599, Percent_Identity=25.2086811352254, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI225637459, Length=588, Percent_Identity=23.1292517006803, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI225637461, Length=512, Percent_Identity=23.4375, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=512, Percent_Identity=23.4375, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI48994911, Length=673, Percent_Identity=49.479940564636, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=675, Percent_Identity=48.1481481481481, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17539652, Length=586, Percent_Identity=26.962457337884, Blast_Score=165, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=693, Percent_Identity=45.8874458874459, Blast_Score=577, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319593, Length=689, Percent_Identity=43.6865021770682, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45551847, Length=597, Percent_Identity=26.9681742043551, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45550715, Length=597, Percent_Identity=26.9681742043551, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24645119, Length=555, Percent_Identity=26.8468468468468, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666278, Length=595, Percent_Identity=27.7310924369748, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75932; Mature: 75800

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDSKTLEELCINTIRILAADAVQNANSGHPGMPMGAAAMAYTLWSRYLKHNPKNPGWF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DRDRFVLSAGHGSMLLYGLLHLTGYDLPLEEIKRFRQLGSKTPGHPERGLTPGVEVSTGP
CCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCC
LGQGFSNGVGMAIAQNFLAARFNRPGHNIIDHYIYAICGDGDLMEGITQEAASLAGHLQL
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHEEE
GKLVYLYDNNHISLAGQTSLCFTENVQERFNAYQWHTHAVADGNDTAEIAAAIEEARKDP
CCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCC
RPSLILVRTHIGYGSPHKHDNFGSHGSPLGEEELSATKKALGWPTLDKFYIPDEARAQFR
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCHHHHHHH
GAIEKGAAAEAEWSGRLNAYRAAFPTECAQLESMMAGQLPEGWDADLPKWKLSDKAIATR
HHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
VAGGQALNAIAKRMTNLIGGSADLNPSTETALKGLGDFQPPNTDGTNVQGEVGGVWSYAG
HCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHCC
QNVAFGVREHAMGAAVNGMAAHGGVHPFSATFLVFSDYMKPAIRLGALSDLKALYIFTHD
CCEEEHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEEEC
SIGVGEDGPTHEPVEQLAGLRAIPGLVVIRPADPNETSEAYRFAIPHDGPVLIALTRQNV
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCEEEEEECCCC
PHVSQNPPVAKGAYVLADSEGTPDVILVGTGSEVALCVKAQEKLKQFGVKARVVSMPSWE
CCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCEEEEEECCCHH
LFEKQDAAYREQVLPKTVRKRVCVEAESPFGWERWAGDEGAIIGINRYGLSAPGAEVMKY
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHH
FGFTVERVTSTALRLLGKVREAEEVEPGFGGETAVKPTSPQEGHS
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTDSKTLEELCINTIRILAADAVQNANSGHPGMPMGAAAMAYTLWSRYLKHNPKNPGWF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DRDRFVLSAGHGSMLLYGLLHLTGYDLPLEEIKRFRQLGSKTPGHPERGLTPGVEVSTGP
CCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCC
LGQGFSNGVGMAIAQNFLAARFNRPGHNIIDHYIYAICGDGDLMEGITQEAASLAGHLQL
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHEEE
GKLVYLYDNNHISLAGQTSLCFTENVQERFNAYQWHTHAVADGNDTAEIAAAIEEARKDP
CCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCC
RPSLILVRTHIGYGSPHKHDNFGSHGSPLGEEELSATKKALGWPTLDKFYIPDEARAQFR
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCHHHHHHH
GAIEKGAAAEAEWSGRLNAYRAAFPTECAQLESMMAGQLPEGWDADLPKWKLSDKAIATR
HHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
VAGGQALNAIAKRMTNLIGGSADLNPSTETALKGLGDFQPPNTDGTNVQGEVGGVWSYAG
HCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHCC
QNVAFGVREHAMGAAVNGMAAHGGVHPFSATFLVFSDYMKPAIRLGALSDLKALYIFTHD
CCEEEHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEEEC
SIGVGEDGPTHEPVEQLAGLRAIPGLVVIRPADPNETSEAYRFAIPHDGPVLIALTRQNV
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCEEEEEECCCC
PHVSQNPPVAKGAYVLADSEGTPDVILVGTGSEVALCVKAQEKLKQFGVKARVVSMPSWE
CCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCEEEEEECCCHH
LFEKQDAAYREQVLPKTVRKRVCVEAESPFGWERWAGDEGAIIGINRYGLSAPGAEVMKY
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHH
FGFTVERVTSTALRLLGKVREAEEVEPGFGGETAVKPTSPQEGHS
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]