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The map label for this gene is proY [C]

Identifier: 116622923

GI number: 116622923

Start: 4856899

End: 4858323

Strand: Reverse

Name: proY [C]

Synonym: Acid_3825

Alternate gene names: 116622923

Gene position: 4858323-4856899 (Counterclockwise)

Preceding gene: 116622924

Following gene: 116622922

Centisome position: 48.75

GC content: 64.91

Gene sequence:

>1425_bases
GTGAAGACCACCTATACGGCCGTTGATGCCGCATACCTCGGGGAACGAAAGCTGCGACGGCACGCCCGCGTTTTTCAGCT
TTGGGCTATGGGCGTGGGCGCGGTCATCTCTGGCGATTTCTTCGGGTGGAATTTCGGCCTTACCGCCGGCGGCTTCGGCG
GCATGCTGCTGGCCGTCGCGGTGATGACCGTGATGTACATTGGGTTGTGCTTTTCGATTGCGGAGATGTCGCCGGCGCTG
CCGCACGCGGGCGGTGCCTACTCCTTCGCGCGCACGTCGATGGGGCCGTGGGCAGGCTACATCACGGGACTCGCGGAGAA
TATGGAGTACATTCTGACGCCGGCCGTGATCGTGGTCGGCATCGGCGGCTACCTGGGCGCGGTGTTCGGTACGCCGCACG
CGTGGGAACCTCTGTGGTGGCTGGCGGCATACGGGGTCTTCGTCGCGCTCAACATCTGGGGCGTGGAGATGACCTTCCAC
GTGTCGGTGGTGATCACGTTGGCGGCGATCGCGATCCTGGCGGTCTTCTGGGTGGGAGCTCTGCCGCACTTCGACCTTCA
CCAATGGGCGTCGCCCTATTTTCCAGCGGGCCGCGGAAAGGCGTCGTCGGCACTGGTGGAATTGCCGTTCGCGTTGTGGC
TGTACCTGGGAATCGAGCAGCTCCCGCTGGCCGCGGAAGAGAGTCACGATCCTAAGCGCGACATGCCGCGCGGCATTCTC
TACGGGCTGGTCACGCTGATCGCGATTTCGTTTCTGACGGTGGTGCTGAGCGTGGGAATCGCGCCCGGCGCGGCGGCGAT
CGCCAAATCGAACGAGCCGTTATTCCTGGGCTTCCAGACGATTTTCGGGCATGGCATGCAGGCGCGCTTGCTGGCGCTGA
TCGCGTGCACCGGGTTGATCGCCAGCTTTCACACCATCATCTACGCGTACGGACGGCAGATTTATTCGATCTCGCGCGCC
GGCTATTTTCCGACCTGGCTCTCGGTGACGCACGGCACGCGCCAAACGCCGCAACGCGCGCTGCTGGCCGGGAGCGCGCT
CGGCTTCCTGGCGGCGCTGGTCATTCACCTCGCTCCGCAGGGCAGTCCGGTGGGCGCGGTGCTGCTCAATATGGCGGTCT
TCGGCGCGGTGCTGGCGTACATGCTCCAGATGCTTTCCTTCCTCGTGCTCCGCGTGCGTTTTCCGAAGATGGCGCGGCCG
TATCGGAGTCCGGTAGGGTTGGCTGGCGCGGCGCTCGCGCTCGCGATCGCGGGTATCACGCTGTTCACACTGTTCCGGAA
TCCGGACTACAACAAAGGAGTGATCGGTGCGGCGCTCTGGTTTCTGCTCGGCATCGGCTATCACGCGTTCCACGGACGGC
ACGGACTGGTGCTGGCGCCGGAGGAGGAGGCGGCGATGCGCTTGCGGGCGGAGCGCGCGCCATGA

Upstream 100 bases:

>100_bases
GGCTGGACAAATATCAGCCGGTGGCGAAGGTGGGGAAATCGATCTTGCTGTACCATATTCCAGAGTGACCGCCTTCATCG
CGTACACTGAATAATCCGCT

Downstream 100 bases:

>100_bases
CGCTGCGCGAACTACTCGGCAAGGCATCGCCGGCGCGCTCGGGGGACGAGCTGGCGGGCGTCGCGGCACGGACCGCCGAG
GAGCGCGTGCGTGCGCAGAT

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKTTYTAVDAAYLGERKLRRHARVFQLWAMGVGAVISGDFFGWNFGLTAGGFGGMLLAVAVMTVMYIGLCFSIAEMSPAL
PHAGGAYSFARTSMGPWAGYITGLAENMEYILTPAVIVVGIGGYLGAVFGTPHAWEPLWWLAAYGVFVALNIWGVEMTFH
VSVVITLAAIAILAVFWVGALPHFDLHQWASPYFPAGRGKASSALVELPFALWLYLGIEQLPLAAEESHDPKRDMPRGIL
YGLVTLIAISFLTVVLSVGIAPGAAAIAKSNEPLFLGFQTIFGHGMQARLLALIACTGLIASFHTIIYAYGRQIYSISRA
GYFPTWLSVTHGTRQTPQRALLAGSALGFLAALVIHLAPQGSPVGAVLLNMAVFGAVLAYMLQMLSFLVLRVRFPKMARP
YRSPVGLAGAALALAIAGITLFTLFRNPDYNKGVIGAALWFLLGIGYHAFHGRHGLVLAPEEEAAMRLRAERAP

Sequences:

>Translated_474_residues
MKTTYTAVDAAYLGERKLRRHARVFQLWAMGVGAVISGDFFGWNFGLTAGGFGGMLLAVAVMTVMYIGLCFSIAEMSPAL
PHAGGAYSFARTSMGPWAGYITGLAENMEYILTPAVIVVGIGGYLGAVFGTPHAWEPLWWLAAYGVFVALNIWGVEMTFH
VSVVITLAAIAILAVFWVGALPHFDLHQWASPYFPAGRGKASSALVELPFALWLYLGIEQLPLAAEESHDPKRDMPRGIL
YGLVTLIAISFLTVVLSVGIAPGAAAIAKSNEPLFLGFQTIFGHGMQARLLALIACTGLIASFHTIIYAYGRQIYSISRA
GYFPTWLSVTHGTRQTPQRALLAGSALGFLAALVIHLAPQGSPVGAVLLNMAVFGAVLAYMLQMLSFLVLRVRFPKMARP
YRSPVGLAGAALALAIAGITLFTLFRNPDYNKGVIGAALWFLLGIGYHAFHGRHGLVLAPEEEAAMRLRAERAP
>Mature_474_residues
MKTTYTAVDAAYLGERKLRRHARVFQLWAMGVGAVISGDFFGWNFGLTAGGFGGMLLAVAVMTVMYIGLCFSIAEMSPAL
PHAGGAYSFARTSMGPWAGYITGLAENMEYILTPAVIVVGIGGYLGAVFGTPHAWEPLWWLAAYGVFVALNIWGVEMTFH
VSVVITLAAIAILAVFWVGALPHFDLHQWASPYFPAGRGKASSALVELPFALWLYLGIEQLPLAAEESHDPKRDMPRGIL
YGLVTLIAISFLTVVLSVGIAPGAAAIAKSNEPLFLGFQTIFGHGMQARLLALIACTGLIASFHTIIYAYGRQIYSISRA
GYFPTWLSVTHGTRQTPQRALLAGSALGFLAALVIHLAPQGSPVGAVLLNMAVFGAVLAYMLQMLSFLVLRVRFPKMARP
YRSPVGLAGAALALAIAGITLFTLFRNPDYNKGVIGAALWFLLGIGYHAFHGRHGLVLAPEEEAAMRLRAERAP

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786602, Length=470, Percent_Identity=23.8297872340426, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790653, Length=465, Percent_Identity=23.2258064516129, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081869, Length=393, Percent_Identity=23.4096692111959, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367353, Length=210, Percent_Identity=29.5238095238095, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786789, Length=456, Percent_Identity=22.1491228070175, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50889; Mature: 50889

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTYTAVDAAYLGERKLRRHARVFQLWAMGVGAVISGDFFGWNFGLTAGGFGGMLLAVA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHH
VMTVMYIGLCFSIAEMSPALPHAGGAYSFARTSMGPWAGYITGLAENMEYILTPAVIVVG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
IGGYLGAVFGTPHAWEPLWWLAAYGVFVALNIWGVEMTFHVSVVITLAAIAILAVFWVGA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHC
LPHFDLHQWASPYFPAGRGKASSALVELPFALWLYLGIEQLPLAAEESHDPKRDMPRGIL
CCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
YGLVTLIAISFLTVVLSVGIAPGAAAIAKSNEPLFLGFQTIFGHGMQARLLALIACTGLI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHH
ASFHTIIYAYGRQIYSISRAGYFPTWLSVTHGTRQTPQRALLAGSALGFLAALVIHLAPQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GSPVGAVLLNMAVFGAVLAYMLQMLSFLVLRVRFPKMARPYRSPVGLAGAALALAIAGIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHH
LFTLFRNPDYNKGVIGAALWFLLGIGYHAFHGRHGLVLAPEEEAAMRLRAERAP
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKTTYTAVDAAYLGERKLRRHARVFQLWAMGVGAVISGDFFGWNFGLTAGGFGGMLLAVA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHH
VMTVMYIGLCFSIAEMSPALPHAGGAYSFARTSMGPWAGYITGLAENMEYILTPAVIVVG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHH
IGGYLGAVFGTPHAWEPLWWLAAYGVFVALNIWGVEMTFHVSVVITLAAIAILAVFWVGA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHC
LPHFDLHQWASPYFPAGRGKASSALVELPFALWLYLGIEQLPLAAEESHDPKRDMPRGIL
CCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
YGLVTLIAISFLTVVLSVGIAPGAAAIAKSNEPLFLGFQTIFGHGMQARLLALIACTGLI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHH
ASFHTIIYAYGRQIYSISRAGYFPTWLSVTHGTRQTPQRALLAGSALGFLAALVIHLAPQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GSPVGAVLLNMAVFGAVLAYMLQMLSFLVLRVRFPKMARPYRSPVGLAGAALALAIAGIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHH
LFTLFRNPDYNKGVIGAALWFLLGIGYHAFHGRHGLVLAPEEEAAMRLRAERAP
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]