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The map label for this gene is eriC [C]

Identifier: 116622756

GI number: 116622756

Start: 4634401

End: 4637025

Strand: Reverse

Name: eriC [C]

Synonym: Acid_3655

Alternate gene names: 116622756

Gene position: 4637025-4634401 (Counterclockwise)

Preceding gene: 116622758

Following gene: 116622755

Centisome position: 46.53

GC content: 65.03

Gene sequence:

>2625_bases
GTGGTGGTGGCCTTCATTCTGCTCACGGAGAGATTGGGCTCGCGGCTATATCCTCCGGGGGGAACAGCGTGGCGCCGGCT
GGTGATTCCGCTGGTGGGGTCTTTCGCCACCGGGCTCCTGATGTTCCGCTATTTTCCGGACGCGCGCGGCAGCGGAATAC
CGCAGACCAAAGTCGCACTGTTTCTGCGCGATGGGTACATCAGCCTGAGAACGGTGCTCGGCAAATTCGGGCTGTGCTCG
GTATCGCTGGCCAGCGGCATCGCGTTGGGCCGCGAGGGTCCGAGTGTACAGGTGAGCGCGGGAATCGCCAGCGTGCTGGG
GCGCCGGCTCGGCCTGGGACCAAGCTCGGTGCGCGCGCTCATTCCCATCGGCGCGTCGGCGGCGCTGGCGGCGGCATTCA
ACACGCCGATCGCCGCGGTCCTGTTCTCGCTGGAAGAGGTGATGGGTGACATGCACGCGCCGGTGCTGGGCTCGATCGTG
CTGAGTTCGGCGACATCATGGATCGTGCTCCACCTGGTGCTGGGTGACGAACCACTTTTCCACGTGCCCTCCTACCAATT
GGTCCATCCGCTGGAATTCGGAATCTACGCCCTGCTGGGAGTGGCGGGCGGATTGGTGTCCGTGGGCTTCGTGAAGCTGC
TGCTGTGGCAGCGCAAGCACTTTCTTTCGCTACCCGCGCGTACGCGGTGGCTGCAGCCGACGATAGGCGGGCTGACGGTG
GGCATTCTCGGTTGGTATTTCCCGGCGGTGCTGGGCGTGGGGTATGGCTTCGTAGGGCAGGCGCTCAACGGGCAAATGTT
GATTGGGGCGATGGCGCTGCTGGTGTGCCTGAAGATCGTGGCCACCTCAACGTGTTACGCGTCTGGTAATGCGGGCGGCA
TCTTCGGACCGAGCCTTTTTATCGGGGCGATGATGGGAGGCGCGGTGGGCGGAGTTGCGCACCAGCTGCTGCCGGACTAC
ACGGGCAGCGCGGGCGCGTACGCCCTGGTGGGAATGGGCGCGGCCTTCGCCGGGATCATTCGCGTGCCGTTGACCAGCGT
GATCATGATCTTCGAAATCACGCGCGACTATACGATTATCGTGCCGCTAATGATTTCGAACCTGGCGAGCTATTGGATCT
CATCCCGCCTGCAGGAGGAGCCGATCTACGAAGCGCTACAGCACCAGGACGGAATTCATCTGCCTTCGGGAGCGAAGGCG
CGGGAAGACCTGCTGATGGTGGGCAACGCATTCCGGCCGGAATCGCTGGCGCTCTCGGCCACGCAGAGCATCGAGCAGGC
GCTGGCCACGGTAGATCGGGAACGCGGCGCGTGGCCGGTGATCGACGGCGCTGGGCTGTGCGGCATGGTCACGCTGGAGC
AACTGGAGGCGGCGCGCGCCTCGGGGCTACCGGCGCTGGCCGGCGACCTGGTGCACGGGAAACCGGCGCACCTGCACGCC
GACGATTCGCTGGATTACGCGATGCGGCGGATCGCGAGCAGCGGAATCAAAGCGCTCCCGGTAGTAAGCCGCGAGAACGA
GCGGGAACTGAAGGGGACGGTGTCGGTGGCGGATATACTGGACGCCTATGGAATCGGGCGGGCGCGCCCGGTGGAGGCGG
CGCCGGAGGAAGGAGTTCCCCGGAAACGGCTATTCGCGATGGCTACGGGCGTGCTGATCGTGCTCGGGATTGTAGCGGGG
CTGGTGAATTATGGATTAGGCGCGGAGCGCGCGGCGCGAGCGGAGCGCGCTTATCAGGCCGGCAACCAGCTGCTGGCGCG
GGAGCGCTACGACGAAGCGATCGAGCAGTACCGCCATGCGCTTTCGATTGAGCACAAGTTTGAATACCGCCTGGCGCTGG
GTAAGGCGCTGACCAGGATGGAACGGCCGGCCGAAGCGCTGATCTATCTGGAAGAGGCGCGCAATGAGAGGCCGACAAGC
GGGCCGGTGAATCTGGCGGCGGCTGAGTCGGAGATGCAGCTGGGCCATGTAGACCGCGCCGTGACACACTACCAGCGCGC
GATTTACGGAACCTGGCCGCCGGGCACAGAGGGTGAGCGGGTGCGGGCCCGTCTGGAATTGATCGATGCGTTGATTAAGG
AAAACAAGCCCCAACAGGCGCAGGCGGAACTGATCTCGCTGGCGAGCGATACGGCCGGGAACGCGCCGGTCCAAAGGCAG
GTGGCACAGCGGCTCTCGGCGATGGGAATGCACGAGAAGGCCGCCGAGGTGTACGGTCGAATTGCGATTCGGAATCCGGA
GGTGCAGGGGGCGCTCGGCGAGGAGGAACTCGCGGCGGGCAATATCGCAGCGGCGTGCAAGGCGTTCGACGCGGGGGGGA
TCACCGATAGGGAGGCGTTGTGCGCGCAGATGCTGTTGATGGACCCCTCGGTTCCCGGTTTGCGTCCGGCAGAGCGGTCC
CTGCGCAGCCGGGCACTACTGGAAGCCGTGGAAGAGGATTTGCAGGCGTGCAGCGGCGCAGCGCCGGTGCGCCCGCCGGC
GAAGCGCAATACGCCGGAGGGCAACGTAGCGTTAGCCGTGGAACTGTGGACGAAGCGAATGGAGACATGTACGGCACCAC
CCTCGGCGGATGCGGCGTTGACAAGGGTTATGAGTACGATGAAGCATGGCGCACACACTGAATGA

Upstream 100 bases:

>100_bases
TTTACGTAAGATAAGACTGGTGGGGAAACCAAAGAGGGCGGCACACGAGGACCAGGTTCTTCTAATCCTGACACTGATCA
TTGGAGCGGTAGTCGGACTG

Downstream 100 bases:

>100_bases
CAAGGTCGCACTGATCACCGGCGCGGCAGGCGGCTTGGGCGTGGCGGTGACGCAGGCGTTTCTCGAAGGAGGCGCGAACG
TGGCCGGAGTGTCGCGTCAC

Product: Cl- channel, voltage-gated family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 874; Mature: 874

Protein sequence:

>874_residues
MVVAFILLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVALFLRDGYISLRTVLGKFGLCS
VSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRALIPIGASAALAAAFNTPIAAVLFSLEEVMGDMHAPVLGSIV
LSSATSWIVLHLVLGDEPLFHVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV
GILGWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLFIGAMMGGAVGGVAHQLLPDY
TGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTIIVPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPSGAKA
REDLLMVGNAFRPESLALSATQSIEQALATVDRERGAWPVIDGAGLCGMVTLEQLEAARASGLPALAGDLVHGKPAHLHA
DDSLDYAMRRIASSGIKALPVVSRENERELKGTVSVADILDAYGIGRARPVEAAPEEGVPRKRLFAMATGVLIVLGIVAG
LVNYGLGAERAARAERAYQAGNQLLARERYDEAIEQYRHALSIEHKFEYRLALGKALTRMERPAEALIYLEEARNERPTS
GPVNLAAAESEMQLGHVDRAVTHYQRAIYGTWPPGTEGERVRARLELIDALIKENKPQQAQAELISLASDTAGNAPVQRQ
VAQRLSAMGMHEKAAEVYGRIAIRNPEVQGALGEEELAAGNIAAACKAFDAGGITDREALCAQMLLMDPSVPGLRPAERS
LRSRALLEAVEEDLQACSGAAPVRPPAKRNTPEGNVALAVELWTKRMETCTAPPSADAALTRVMSTMKHGAHTE

Sequences:

>Translated_874_residues
MVVAFILLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVALFLRDGYISLRTVLGKFGLCS
VSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRALIPIGASAALAAAFNTPIAAVLFSLEEVMGDMHAPVLGSIV
LSSATSWIVLHLVLGDEPLFHVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV
GILGWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLFIGAMMGGAVGGVAHQLLPDY
TGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTIIVPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPSGAKA
REDLLMVGNAFRPESLALSATQSIEQALATVDRERGAWPVIDGAGLCGMVTLEQLEAARASGLPALAGDLVHGKPAHLHA
DDSLDYAMRRIASSGIKALPVVSRENERELKGTVSVADILDAYGIGRARPVEAAPEEGVPRKRLFAMATGVLIVLGIVAG
LVNYGLGAERAARAERAYQAGNQLLARERYDEAIEQYRHALSIEHKFEYRLALGKALTRMERPAEALIYLEEARNERPTS
GPVNLAAAESEMQLGHVDRAVTHYQRAIYGTWPPGTEGERVRARLELIDALIKENKPQQAQAELISLASDTAGNAPVQRQ
VAQRLSAMGMHEKAAEVYGRIAIRNPEVQGALGEEELAAGNIAAACKAFDAGGITDREALCAQMLLMDPSVPGLRPAERS
LRSRALLEAVEEDLQACSGAAPVRPPAKRNTPEGNVALAVELWTKRMETCTAPPSADAALTRVMSTMKHGAHTE
>Mature_874_residues
MVVAFILLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVALFLRDGYISLRTVLGKFGLCS
VSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRALIPIGASAALAAAFNTPIAAVLFSLEEVMGDMHAPVLGSIV
LSSATSWIVLHLVLGDEPLFHVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV
GILGWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLFIGAMMGGAVGGVAHQLLPDY
TGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTIIVPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPSGAKA
REDLLMVGNAFRPESLALSATQSIEQALATVDRERGAWPVIDGAGLCGMVTLEQLEAARASGLPALAGDLVHGKPAHLHA
DDSLDYAMRRIASSGIKALPVVSRENERELKGTVSVADILDAYGIGRARPVEAAPEEGVPRKRLFAMATGVLIVLGIVAG
LVNYGLGAERAARAERAYQAGNQLLARERYDEAIEQYRHALSIEHKFEYRLALGKALTRMERPAEALIYLEEARNERPTS
GPVNLAAAESEMQLGHVDRAVTHYQRAIYGTWPPGTEGERVRARLELIDALIKENKPQQAQAELISLASDTAGNAPVQRQ
VAQRLSAMGMHEKAAEVYGRIAIRNPEVQGALGEEELAAGNIAAACKAFDAGGITDREALCAQMLLMDPSVPGLRPAERS
LRSRALLEAVEEDLQACSGAAPVRPPAKRNTPEGNVALAVELWTKRMETCTAPPSADAALTRVMSTMKHGAHTE

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Homo sapiens, GI153252026, Length=410, Percent_Identity=26.3414634146341, Blast_Score=96, Evalue=2e-19,
Organism=Escherichia coli, GI1786350, Length=361, Percent_Identity=32.409972299169, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI87081943, Length=308, Percent_Identity=31.4935064935065, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17532615, Length=394, Percent_Identity=25.6345177664975, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71985141, Length=219, Percent_Identity=29.2237442922374, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985148, Length=219, Percent_Identity=29.2237442922374, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665008, Length=426, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45551566, Length=412, Percent_Identity=26.4563106796117, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 92955; Mature: 92955

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAFILLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVAL
CEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEE
FLRDGYISLRTVLGKFGLCSVSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRAL
EEECCHHHHHHHHHHCCCHHHHHHHCHHCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHEE
IPIGASAALAAAFNTPIAAVLFSLEEVMGDMHAPVLGSIVLSSATSWIVLHLVLGDEPLF
EECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHEEEEEECCCCCE
HVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHH
GILGWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLF
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHH
IGAMMGGAVGGVAHQLLPDYTGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTII
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPSGAKAREDLLMVGNAFRPESLALSA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
TQSIEQALATVDRERGAWPVIDGAGLCGMVTLEQLEAARASGLPALAGDLVHGKPAHLHA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
DDSLDYAMRRIASSGIKALPVVSRENERELKGTVSVADILDAYGIGRARPVEAAPEEGVP
CCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RKRLFAMATGVLIVLGIVAGLVNYGLGAERAARAERAYQAGNQLLARERYDEAIEQYRHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIEHKFEYRLALGKALTRMERPAEALIYLEEARNERPTSGPVNLAAAESEMQLGHVDRA
HCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHH
VTHYQRAIYGTWPPGTEGERVRARLELIDALIKENKPQQAQAELISLASDTAGNAPVQRQ
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHH
VAQRLSAMGMHEKAAEVYGRIAIRNPEVQGALGEEELAAGNIAAACKAFDAGGITDREAL
HHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCHHHH
CAQMLLMDPSVPGLRPAERSLRSRALLEAVEEDLQACSGAAPVRPPAKRNTPEGNVALAV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
ELWTKRMETCTAPPSADAALTRVMSTMKHGAHTE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVVAFILLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVAL
CEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEE
FLRDGYISLRTVLGKFGLCSVSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRAL
EEECCHHHHHHHHHHCCCHHHHHHHCHHCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHEE
IPIGASAALAAAFNTPIAAVLFSLEEVMGDMHAPVLGSIVLSSATSWIVLHLVLGDEPLF
EECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHEEEEEECCCCCE
HVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHH
GILGWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLF
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHH
IGAMMGGAVGGVAHQLLPDYTGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTII
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPSGAKAREDLLMVGNAFRPESLALSA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
TQSIEQALATVDRERGAWPVIDGAGLCGMVTLEQLEAARASGLPALAGDLVHGKPAHLHA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
DDSLDYAMRRIASSGIKALPVVSRENERELKGTVSVADILDAYGIGRARPVEAAPEEGVP
CCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RKRLFAMATGVLIVLGIVAGLVNYGLGAERAARAERAYQAGNQLLARERYDEAIEQYRHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIEHKFEYRLALGKALTRMERPAEALIYLEEARNERPTSGPVNLAAAESEMQLGHVDRA
HCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHH
VTHYQRAIYGTWPPGTEGERVRARLELIDALIKENKPQQAQAELISLASDTAGNAPVQRQ
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHH
VAQRLSAMGMHEKAAEVYGRIAIRNPEVQGALGEEELAAGNIAAACKAFDAGGITDREAL
HHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCHHHH
CAQMLLMDPSVPGLRPAERSLRSRALLEAVEEDLQACSGAAPVRPPAKRNTPEGNVALAV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
ELWTKRMETCTAPPSADAALTRVMSTMKHGAHTE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]