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The map label for this gene is yvrD [H]

Identifier: 116622755

GI number: 116622755

Start: 4633740

End: 4634420

Strand: Reverse

Name: yvrD [H]

Synonym: Acid_3654

Alternate gene names: 116622755

Gene position: 4634420-4633740 (Counterclockwise)

Preceding gene: 116622756

Following gene: 116622752

Centisome position: 46.5

GC content: 65.64

Gene sequence:

>681_bases
ATGGCGCACACACTGAATGACAAGGTCGCACTGATCACCGGCGCGGCAGGCGGCTTGGGCGTGGCGGTGACGCAGGCGTT
TCTCGAAGGAGGCGCGAACGTGGCCGGAGTGTCGCGTCACATCAAAGCCGACCAGTTCCAGCACCCGAACTTCAGCGCAT
TTCCCGGCGATCTTGCGAGCGGCGCAGCGGCGCGCAAGATTGTGGAAAGCGTGGTGGCGCAGTTAGGACGCATCGACGCG
CTGGTCCACGTGATGGGCGGGTTCGCAGGAGGACAGAGCGTGGCGGACACGGACGACGCGACGATGGAGCAGATGCTGGA
TCTAAATTTCCGCTCGGGATTCTTCATGGCACGCGCGGTGTTGCCCCTGATGAAGCGGCAAGGGAGCGGGCGGATCCTGG
TAGTGGCGAGCCGCCAGGGCGCGGAGCCGGGGGCGATGGTGGGAGCATACAGCGCGTCCAAAGCGGCGATGATCGCGCTG
GTGAAATCGATCGCGCTGGAGAACAAGGACGCCGGCATTACGGCGAACACCGTGCTCCCCGGCGCGATGGCCACGCCGGG
GAATCAAGGCAGCAACCTGGTGGCGACGGAAGAGGTCGCGGCGCTGTTGGCGCATCTTGCGAGTGACGCGGCGGCGCAGA
TTACGGGCGCTGCGATCCCGGTCTACGGGCGACAGCTTTAG

Upstream 100 bases:

>100_bases
GTAGCGTTAGCCGTGGAACTGTGGACGAAGCGAATGGAGACATGTACGGCACCACCCTCGGCGGATGCGGCGTTGACAAG
GGTTATGAGTACGATGAAGC

Downstream 100 bases:

>100_bases
CGCGGCACTACTTCTGTATGGTCAGAAGTGTGGAGGCGGAGTTGGCGGTGCCAAGCCGCACTACTACGGGCAAATCGCCG
TTCGGGGCATCAGAGGGCAC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MAHTLNDKVALITGAAGGLGVAVTQAFLEGGANVAGVSRHIKADQFQHPNFSAFPGDLASGAAARKIVESVVAQLGRIDA
LVHVMGGFAGGQSVADTDDATMEQMLDLNFRSGFFMARAVLPLMKRQGSGRILVVASRQGAEPGAMVGAYSASKAAMIAL
VKSIALENKDAGITANTVLPGAMATPGNQGSNLVATEEVAALLAHLASDAAAQITGAAIPVYGRQL

Sequences:

>Translated_226_residues
MAHTLNDKVALITGAAGGLGVAVTQAFLEGGANVAGVSRHIKADQFQHPNFSAFPGDLASGAAARKIVESVVAQLGRIDA
LVHVMGGFAGGQSVADTDDATMEQMLDLNFRSGFFMARAVLPLMKRQGSGRILVVASRQGAEPGAMVGAYSASKAAMIAL
VKSIALENKDAGITANTVLPGAMATPGNQGSNLVATEEVAALLAHLASDAAAQITGAAIPVYGRQL
>Mature_225_residues
AHTLNDKVALITGAAGGLGVAVTQAFLEGGANVAGVSRHIKADQFQHPNFSAFPGDLASGAAARKIVESVVAQLGRIDAL
VHVMGGFAGGQSVADTDDATMEQMLDLNFRSGFFMARAVLPLMKRQGSGRILVVASRQGAEPGAMVGAYSASKAAMIALV
KSIALENKDAGITANTVLPGAMATPGNQGSNLVATEEVAALLAHLASDAAAQITGAAIPVYGRQL

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=243, Percent_Identity=31.6872427983539, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=27.7551020408163, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=28.0632411067194, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=27.5590551181102, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4504505, Length=228, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=24.2798353909465, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI31542939, Length=195, Percent_Identity=29.7435897435897, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI59889578, Length=182, Percent_Identity=25.8241758241758, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=244, Percent_Identity=31.5573770491803, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787335, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786812, Length=244, Percent_Identity=30.327868852459, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1789378, Length=190, Percent_Identity=26.8421052631579, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787905, Length=189, Percent_Identity=30.6878306878307, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87082160, Length=190, Percent_Identity=28.9473684210526, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787820, Length=153, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788459, Length=184, Percent_Identity=30.9782608695652, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=244, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=24.6913580246914, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=29.9465240641711, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=220, Percent_Identity=28.6363636363636, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=27.4611398963731, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355319, Length=236, Percent_Identity=26.6949152542373, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=29.7959183673469, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=32.1052631578947, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=28.8, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.1587301587302, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=27.5132275132275, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 22880; Mature: 22748

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHTLNDKVALITGAAGGLGVAVTQAFLEGGANVAGVSRHIKADQFQHPNFSAFPGDLAS
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHCCCCCCCCCCCCHHHH
GAAARKIVESVVAQLGRIDALVHVMGGFAGGQSVADTDDATMEQMLDLNFRSGFFMARAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
LPLMKRQGSGRILVVASRQGAEPGAMVGAYSASKAAMIALVKSIALENKDAGITANTVLP
HHHHHCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
GAMATPGNQGSNLVATEEVAALLAHLASDAAAQITGAAIPVYGRQL
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AHTLNDKVALITGAAGGLGVAVTQAFLEGGANVAGVSRHIKADQFQHPNFSAFPGDLAS
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHCCCCCCCCCCCCHHHH
GAAARKIVESVVAQLGRIDALVHVMGGFAGGQSVADTDDATMEQMLDLNFRSGFFMARAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
LPLMKRQGSGRILVVASRQGAEPGAMVGAYSASKAAMIALVKSIALENKDAGITANTVLP
HHHHHCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
GAMATPGNQGSNLVATEEVAALLAHLASDAAAQITGAAIPVYGRQL
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]