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The map label for this gene is lig [H]

Identifier: 116622664

GI number: 116622664

Start: 4509807

End: 4511384

Strand: Direct

Name: lig [H]

Synonym: Acid_3563

Alternate gene names: 116622664

Gene position: 4509807-4511384 (Clockwise)

Preceding gene: 116622663

Following gene: 116622665

Centisome position: 45.25

GC content: 65.78

Gene sequence:

>1578_bases
ATGAAGGCCTTCGCCGAACTCTACGCCGCGCTCGATCAAACCACCAAGACCAACGCCAAGGTCGATGCGCTCAAGCGCTA
CCTGGCCGCGGCCGCGCCCGAGGATGCCGCGTGGGCGGTAAACTTCCTCATCGGCCGCCGCCCCAAGCGCCTGCTGGAAT
CGCGCAAGCTCGCGCAATGGGCCATCGAAGAAGCCGGAGTTCCCGACTGGCTGTTCTCCGAGTGTTACCACGCTGTGGGC
GATTTCGCCGAGACTATCGCGCTCCTGCTGCCGCCGGCCGCTGCTTCCAGTGCGCTCGCTCTGCATCACTGGATCGAAGA
CCGCCTCCTTCCCCTGCGCGATGCCGACGATGAAACCCGCCGCCAACACCTGGTGGAGGCCTGGCGCGAGATGGACGAAG
GCCAGCGCTTCGCCTGGAACAAACTCCTCACCGGCGAGTTTCGCGTGGGTGTCTCGCAGACCCTGGTCGTCCGCGCGATC
GCCGAGTTCAGCGGCATCGCCCCCGAAGTCATGGCGCATCGCCTGATGGGCGAGTGGCAGCCGACGCCTGAGTTTTGGCG
GCAGTTGGTAGCGCCCGACACGCGCGACGCCGATATCAGCCGCCCTTACCCCTTCTGTCTGGCCTATCCGGTGGAGGGCG
ATGTCGGCGAACTTGGCGACCCGGGCGAGTGGCAGATCGAGTGGAAGTGGGACGGTATTCGCGCGCAGCTGATCCGCCGC
CAGTGGCGCACCTTCCTGTGGTCGCGCGGCGAGGAGTTGATCACCGACCGCTTTCCCGAACTGGAGGCTCTGGGCGCGCA
GCTTCCCGAAGGCACCGTGATCGACGGCGAAGTGCTCCCGTGGAAGGAGGGCGCGCCGCTGCCGTTCGCGCAGATGCAGC
GGCGCATCGGCCGCAAGGTGCTCGGCCCGAAGATCCTCGCCGAAGTCCCGGTGGTGCTGGTGGCGTACGACCTATTGGAA
CTCAACGGCCAGGATATCCGCGAGCGTCCGCTGGAGTGGCGGCGAGCCAGCCTGCAATCGCTCGCGCCCCCCGATTCCGC
GCTGGTGGTCTCACCAACCGTGAATGAACCCACATGGGATGCACTTCGCCAGTTGCGCGAGCAGTCGCGCGCCCGCAAGG
TCGAGGGCTTCATGCTGAAGCGGCTCGGCTCACCCTATCGCGTGGGGCGCCGCCGCGGTGACTGGTGGAAGTGGAAGATC
AACCCCTACTCCGTGGATTGCGTCCTGATCTACGCGCAGCCCGGCAACGGCCGCCGCGCCAGTCTTTTCACGGACTACAC
CTTCGGTGTCTGGGACGATGGAAAGTTGGTGCCCTTCGCGAAGGCCTATTCCGGCCTGACCGACGAAGAGATCCGCGAAG
TGGACGCCTTCGTGCGGCGTAACACGATTGAAAAGTTCGGCCCGGTCCACGCGGTGAAGCCGGAACTCGTCTTCGAACTG
GCCTTCGAAGCCATCCAGCGCTCCCCGCGCCACAAATCCGGCATCGCCGTCCGCTTCCCCCGCATGGCCCGCTGGCGTAA
AGACAAACCTGCGGAAGAAGCCGACAGCCTCGACACGATCCGGGCACTGTTGGCTTAG

Upstream 100 bases:

>100_bases
GGGTCACGCACGGCTACGTCGCGCCCCTGGTTCGCTGGTTGACCGAGCGTGGCAAGCAGGCCATCCCGGTGGAGTTGAAG
CCTCCCGCGGAGGAAGAGGA

Downstream 100 bases:

>100_bases
GCTGTCCGTTCTTTCTTCTTGGCGTTACTTTGCGGCTTTGCGGTTCTGCGAGAAATGACGCCCTTTCGGTCGGCGGCTCG
CCCTCGGAACAGCGCCTTCT

Product: ATP dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MKAFAELYAALDQTTKTNAKVDALKRYLAAAAPEDAAWAVNFLIGRRPKRLLESRKLAQWAIEEAGVPDWLFSECYHAVG
DFAETIALLLPPAAASSALALHHWIEDRLLPLRDADDETRRQHLVEAWREMDEGQRFAWNKLLTGEFRVGVSQTLVVRAI
AEFSGIAPEVMAHRLMGEWQPTPEFWRQLVAPDTRDADISRPYPFCLAYPVEGDVGELGDPGEWQIEWKWDGIRAQLIRR
QWRTFLWSRGEELITDRFPELEALGAQLPEGTVIDGEVLPWKEGAPLPFAQMQRRIGRKVLGPKILAEVPVVLVAYDLLE
LNGQDIRERPLEWRRASLQSLAPPDSALVVSPTVNEPTWDALRQLREQSRARKVEGFMLKRLGSPYRVGRRRGDWWKWKI
NPYSVDCVLIYAQPGNGRRASLFTDYTFGVWDDGKLVPFAKAYSGLTDEEIREVDAFVRRNTIEKFGPVHAVKPELVFEL
AFEAIQRSPRHKSGIAVRFPRMARWRKDKPAEEADSLDTIRALLA

Sequences:

>Translated_525_residues
MKAFAELYAALDQTTKTNAKVDALKRYLAAAAPEDAAWAVNFLIGRRPKRLLESRKLAQWAIEEAGVPDWLFSECYHAVG
DFAETIALLLPPAAASSALALHHWIEDRLLPLRDADDETRRQHLVEAWREMDEGQRFAWNKLLTGEFRVGVSQTLVVRAI
AEFSGIAPEVMAHRLMGEWQPTPEFWRQLVAPDTRDADISRPYPFCLAYPVEGDVGELGDPGEWQIEWKWDGIRAQLIRR
QWRTFLWSRGEELITDRFPELEALGAQLPEGTVIDGEVLPWKEGAPLPFAQMQRRIGRKVLGPKILAEVPVVLVAYDLLE
LNGQDIRERPLEWRRASLQSLAPPDSALVVSPTVNEPTWDALRQLREQSRARKVEGFMLKRLGSPYRVGRRRGDWWKWKI
NPYSVDCVLIYAQPGNGRRASLFTDYTFGVWDDGKLVPFAKAYSGLTDEEIREVDAFVRRNTIEKFGPVHAVKPELVFEL
AFEAIQRSPRHKSGIAVRFPRMARWRKDKPAEEADSLDTIRALLA
>Mature_525_residues
MKAFAELYAALDQTTKTNAKVDALKRYLAAAAPEDAAWAVNFLIGRRPKRLLESRKLAQWAIEEAGVPDWLFSECYHAVG
DFAETIALLLPPAAASSALALHHWIEDRLLPLRDADDETRRQHLVEAWREMDEGQRFAWNKLLTGEFRVGVSQTLVVRAI
AEFSGIAPEVMAHRLMGEWQPTPEFWRQLVAPDTRDADISRPYPFCLAYPVEGDVGELGDPGEWQIEWKWDGIRAQLIRR
QWRTFLWSRGEELITDRFPELEALGAQLPEGTVIDGEVLPWKEGAPLPFAQMQRRIGRKVLGPKILAEVPVVLVAYDLLE
LNGQDIRERPLEWRRASLQSLAPPDSALVVSPTVNEPTWDALRQLREQSRARKVEGFMLKRLGSPYRVGRRRGDWWKWKI
NPYSVDCVLIYAQPGNGRRASLFTDYTFGVWDDGKLVPFAKAYSGLTDEEIREVDAFVRRNTIEKFGPVHAVKPELVFEL
AFEAIQRSPRHKSGIAVRFPRMARWRKDKPAEEADSLDTIRALLA

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=355, Percent_Identity=26.4788732394366, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985269, Length=330, Percent_Identity=28.4848484848485, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24762424, Length=352, Percent_Identity=26.9886363636364, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 59947; Mature: 59947

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFAELYAALDQTTKTNAKVDALKRYLAAAAPEDAAWAVNFLIGRRPKRLLESRKLAQW
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
AIEEAGVPDWLFSECYHAVGDFAETIALLLPPAAASSALALHHWIEDRLLPLRDADDETR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
RQHLVEAWREMDEGQRFAWNKLLTGEFRVGVSQTLVVRAIAEFSGIAPEVMAHRLMGEWQ
HHHHHHHHHHHCCCCHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PTPEFWRQLVAPDTRDADISRPYPFCLAYPVEGDVGELGDPGEWQIEWKWDGIRAQLIRR
CCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECHHHHHHHHH
QWRTFLWSRGEELITDRFPELEALGAQLPEGTVIDGEVLPWKEGAPLPFAQMQRRIGRKV
HHHHHHHHCCHHHHHHCCCCHHHHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHH
LGPKILAEVPVVLVAYDLLELNGQDIRERPLEWRRASLQSLAPPDSALVVSPTVNEPTWD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHH
ALRQLREQSRARKVEGFMLKRLGSPYRVGRRRGDWWKWKINPYSVDCVLIYAQPGNGRRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCEEEEEEEEEEECCCCCEE
SLFTDYTFGVWDDGKLVPFAKAYSGLTDEEIREVDAFVRRNTIEKFGPVHAVKPELVFEL
EEEECCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AFEAIQRSPRHKSGIAVRFPRMARWRKDKPAEEADSLDTIRALLA
HHHHHHCCCCCCCCCEEECCHHHHHCCCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MKAFAELYAALDQTTKTNAKVDALKRYLAAAAPEDAAWAVNFLIGRRPKRLLESRKLAQW
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
AIEEAGVPDWLFSECYHAVGDFAETIALLLPPAAASSALALHHWIEDRLLPLRDADDETR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
RQHLVEAWREMDEGQRFAWNKLLTGEFRVGVSQTLVVRAIAEFSGIAPEVMAHRLMGEWQ
HHHHHHHHHHHCCCCHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PTPEFWRQLVAPDTRDADISRPYPFCLAYPVEGDVGELGDPGEWQIEWKWDGIRAQLIRR
CCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECHHHHHHHHH
QWRTFLWSRGEELITDRFPELEALGAQLPEGTVIDGEVLPWKEGAPLPFAQMQRRIGRKV
HHHHHHHHCCHHHHHHCCCCHHHHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHH
LGPKILAEVPVVLVAYDLLELNGQDIRERPLEWRRASLQSLAPPDSALVVSPTVNEPTWD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCHHH
ALRQLREQSRARKVEGFMLKRLGSPYRVGRRRGDWWKWKINPYSVDCVLIYAQPGNGRRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCEEEEEEEEEEECCCCCEE
SLFTDYTFGVWDDGKLVPFAKAYSGLTDEEIREVDAFVRRNTIEKFGPVHAVKPELVFEL
EEEECCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AFEAIQRSPRHKSGIAVRFPRMARWRKDKPAEEADSLDTIRALLA
HHHHHHCCCCCCCCCEEECCHHHHHCCCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA