Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 116622583

GI number: 116622583

Start: 4400157

End: 4400789

Strand: Reverse

Name: degU [H]

Synonym: Acid_3481

Alternate gene names: 116622583

Gene position: 4400789-4400157 (Counterclockwise)

Preceding gene: 116622584

Following gene: 116622582

Centisome position: 44.16

GC content: 63.82

Gene sequence:

>633_bases
ATGCCTGAAGCACCGATTTCCGTGCTCCTGGTGGACGACCACAGCCTGGTGCGCCGCGGCTTCCGCCGCATGCTGGAGGA
CGACCCCGCAATCGTCGTGGTGGGTGAAGCCGAAGACGGGCACCAGGCCGTACAGCTCGCCGGCGAACTTCATCCGCGCG
TGGTGGTTATGGATTTCGCGATGCCGAGCATGAACGGCGCGGTGGCGGCGCGGCACATTCTGCGAACCGCTCCGGAGACC
GCCATTCTGATTCTCAGCATGCACGCCGAAGCGTCGTATGTGCGTACCTGCCTGGAGGCCGGCGTCCGCGGGTACCTGCT
GAAGAACGCGCTGGATCTGGAGATGGTGGCCGCCGTGAAGCAGGTGGCGGCAGGCAAGCAGGTGCTCGATCGCCGCCTGG
GAGCGCTCGACCTACCCTCTGGCGCCGCCCCTGCGGGATTGACCACGCGCGAACTCGAAGTGCTGCAATTGATCGTGCAT
GGAAAATCGAACAAAGAAATCGCGGCAGTGCTCAGCCTCAGCGCCAACACCGTAGCCGTGCATCGCGCCAATATCATGCA
GACTCTCGGCATCCACAACACCGCCGAACTGGTGGTTTACGCCATTCGCCAGGGCCTGGTGAGTATCGCGTGA

Upstream 100 bases:

>100_bases
GAGCGCGCCGACCTGGTGAACGGCCGCTTGGATCTGGAGAACTGCAGTTCCGGCGGCGCGCTGGTTCGCCTCACGGTTCC
CGCCGGCACGCAAGAGGTTC

Downstream 100 bases:

>100_bases
CGCGGCGGACGTTTCTCTCGGGGGCCGCCGCACTCCCGCTGGCCGCGGCACCCGGCCTGGACTTCCGCCTCACCGACGTC
ACCGCGGCGGCCGGCATTCA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MPEAPISVLLVDDHSLVRRGFRRMLEDDPAIVVVGEAEDGHQAVQLAGELHPRVVVMDFAMPSMNGAVAARHILRTAPET
AILILSMHAEASYVRTCLEAGVRGYLLKNALDLEMVAAVKQVAAGKQVLDRRLGALDLPSGAAPAGLTTRELEVLQLIVH
GKSNKEIAAVLSLSANTVAVHRANIMQTLGIHNTAELVVYAIRQGLVSIA

Sequences:

>Translated_210_residues
MPEAPISVLLVDDHSLVRRGFRRMLEDDPAIVVVGEAEDGHQAVQLAGELHPRVVVMDFAMPSMNGAVAARHILRTAPET
AILILSMHAEASYVRTCLEAGVRGYLLKNALDLEMVAAVKQVAAGKQVLDRRLGALDLPSGAAPAGLTTRELEVLQLIVH
GKSNKEIAAVLSLSANTVAVHRANIMQTLGIHNTAELVVYAIRQGLVSIA
>Mature_209_residues
PEAPISVLLVDDHSLVRRGFRRMLEDDPAIVVVGEAEDGHQAVQLAGELHPRVVVMDFAMPSMNGAVAARHILRTAPETA
ILILSMHAEASYVRTCLEAGVRGYLLKNALDLEMVAAVKQVAAGKQVLDRRLGALDLPSGAAPAGLTTRELEVLQLIVHG
KSNKEIAAVLSLSANTVAVHRANIMQTLGIHNTAELVVYAIRQGLVSIA

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=38.0952380952381, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1788521, Length=215, Percent_Identity=36.2790697674419, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=38.860103626943, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787473, Length=187, Percent_Identity=35.2941176470588, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786747, Length=202, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=27.8606965174129, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=25.7281553398058, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22413; Mature: 22281

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAPISVLLVDDHSLVRRGFRRMLEDDPAIVVVGEAEDGHQAVQLAGELHPRVVVMDFA
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEEC
MPSMNGAVAARHILRTAPETAILILSMHAEASYVRTCLEAGVRGYLLKNALDLEMVAAVK
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
QVAAGKQVLDRRLGALDLPSGAAPAGLTTRELEVLQLIVHGKSNKEIAAVLSLSANTVAV
HHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEE
HRANIMQTLGIHNTAELVVYAIRQGLVSIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEAPISVLLVDDHSLVRRGFRRMLEDDPAIVVVGEAEDGHQAVQLAGELHPRVVVMDFA
CCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEEC
MPSMNGAVAARHILRTAPETAILILSMHAEASYVRTCLEAGVRGYLLKNALDLEMVAAVK
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
QVAAGKQVLDRRLGALDLPSGAAPAGLTTRELEVLQLIVHGKSNKEIAAVLSLSANTVAV
HHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEE
HRANIMQTLGIHNTAELVVYAIRQGLVSIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]