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The map label for this gene is dgoD [H]

Identifier: 116622541

GI number: 116622541

Start: 4348076

End: 4349326

Strand: Direct

Name: dgoD [H]

Synonym: Acid_3439

Alternate gene names: 116622541

Gene position: 4348076-4349326 (Clockwise)

Preceding gene: 116622540

Following gene: 116622542

Centisome position: 43.63

GC content: 62.67

Gene sequence:

>1251_bases
ATGAACCGTCGAGAGTTCCTCTGCGCCGCGGGTGCGGCCGGTCTTTTTTGCGGCCCTCTGGCAAGGCGCGCGTCCGCCAT
GGCCAGGAAGGTCAAGATCACGGACGTCAAATGCATGATCGTCCGCGGCACCTGGGATTGGAATCTGATCAAGATTGAAA
CCGATTCCGGCCTGTACGGAATCGGCGAGGCGTATTGGGGCTGGGGCGTCAAGGATCTGGTGGTGAATAAGATGAAGGGG
ATCATCGTGGGTGAGGACCCCCTCAACGTGGACAAGCTGTATACCAAGATGCTGATGCAAAGCGCCGGGGCCGGCGCGAT
CGGCGGGGTCACGATGACGGCGGCGAGCGGCATCGAGATCGCGTTGTGGGATCTCTGCGGCCGCATCCTGGATACGCCGG
TCTGCAATCTGCTGGGCGGCCGCTTCCGCGATCGCATTCGCTTCTACCGGACTACGCAGGCGGTGAAGAACGTGGAAGAC
ACGAAGGAGTGGCGCGCGCTGGCAGAATCGGCGCGCGCGGAGAAGTGGGGCTGGACGGCCTTCAAATTCCAGGGCGATGG
CATCCCGCCGCGAGCCGATCCCGAATTCAAGGAGCCCGGCCACGACCCCTACGCGCGCAATCTCACGCACAAAGACCATC
GCCGCATCGTGACCGCGATGGAGACAGTGCGCGAGACGCTCGGCCCCGACGCCGATTTCGCGGTGGAATGCCACTGGCGC
TACGACACGCAGGATGTGATCAGCCTAGGGAAGGAACTGGAGCCGGTAAAACCGATGTGGCTGGAAGATCCGGTACCGCC
GGACAACATCGAGGCGATGCAAAGGGTGACGCATGCGATCAACGTCCCGGTGTGCACGGGGGAGAATCTCTACGGCCGGC
AGGGCTTCCGCAAGCTGATCGAGATGCAGGCCTGCTCGGGCGTACACATCGATATTCCGAAATCCGGCGGGCTGATGGAA
TCGAAAAAGATCTCGGACCTGGCGGATCTTTACTACATCTGGACGGCATGTCACAATCCGGCGAGTCCGGTGGGCACGAT
CGCGTCCTGCCACGCGTCGGCGGCGATGCGCGAATTCCGCATTCACGAGCTGGCGAACTGGGTGGACTGGTGGCCGGACC
TGGTGATCCGTGAAGGCCCGTTCTGGAAGGACGGGTACTTCACGATCCAGGACAAGCCGGGGTACGGTGTGGAATTGAAT
CCCGATGTCGCCAAGGCGCACCTGGCGCCCGGCGAGACGTGGTGGGGCTAG

Upstream 100 bases:

>100_bases
TCAAGGCCGCGGAGTCGAAGCGAAAGAAACCTGCAGGCAAGCGCAAGGCCGCATAAATCTCCTGCTACAGCTTTCATCGG
ACGGTGATAGGGTAAAGCCT

Downstream 100 bases:

>100_bases
GGCCCGGTTCGGTGATATTGTAGTGCGATGAAAACTTCGCTTCTGATTTCGAGCTTGCTTCTCGCCTCGCTGGCGGCCGC
CGCGGATGTACCGCCGGTGG

Product: mandelate racemase/muconate lactonizing protein

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNRREFLCAAGAAGLFCGPLARRASAMARKVKITDVKCMIVRGTWDWNLIKIETDSGLYGIGEAYWGWGVKDLVVNKMKG
IIVGEDPLNVDKLYTKMLMQSAGAGAIGGVTMTAASGIEIALWDLCGRILDTPVCNLLGGRFRDRIRFYRTTQAVKNVED
TKEWRALAESARAEKWGWTAFKFQGDGIPPRADPEFKEPGHDPYARNLTHKDHRRIVTAMETVRETLGPDADFAVECHWR
YDTQDVISLGKELEPVKPMWLEDPVPPDNIEAMQRVTHAINVPVCTGENLYGRQGFRKLIEMQACSGVHIDIPKSGGLME
SKKISDLADLYYIWTACHNPASPVGTIASCHASAAMREFRIHELANWVDWWPDLVIREGPFWKDGYFTIQDKPGYGVELN
PDVAKAHLAPGETWWG

Sequences:

>Translated_416_residues
MNRREFLCAAGAAGLFCGPLARRASAMARKVKITDVKCMIVRGTWDWNLIKIETDSGLYGIGEAYWGWGVKDLVVNKMKG
IIVGEDPLNVDKLYTKMLMQSAGAGAIGGVTMTAASGIEIALWDLCGRILDTPVCNLLGGRFRDRIRFYRTTQAVKNVED
TKEWRALAESARAEKWGWTAFKFQGDGIPPRADPEFKEPGHDPYARNLTHKDHRRIVTAMETVRETLGPDADFAVECHWR
YDTQDVISLGKELEPVKPMWLEDPVPPDNIEAMQRVTHAINVPVCTGENLYGRQGFRKLIEMQACSGVHIDIPKSGGLME
SKKISDLADLYYIWTACHNPASPVGTIASCHASAAMREFRIHELANWVDWWPDLVIREGPFWKDGYFTIQDKPGYGVELN
PDVAKAHLAPGETWWG
>Mature_416_residues
MNRREFLCAAGAAGLFCGPLARRASAMARKVKITDVKCMIVRGTWDWNLIKIETDSGLYGIGEAYWGWGVKDLVVNKMKG
IIVGEDPLNVDKLYTKMLMQSAGAGAIGGVTMTAASGIEIALWDLCGRILDTPVCNLLGGRFRDRIRFYRTTQAVKNVED
TKEWRALAESARAEKWGWTAFKFQGDGIPPRADPEFKEPGHDPYARNLTHKDHRRIVTAMETVRETLGPDADFAVECHWR
YDTQDVISLGKELEPVKPMWLEDPVPPDNIEAMQRVTHAINVPVCTGENLYGRQGFRKLIEMQACSGVHIDIPKSGGLME
SKKISDLADLYYIWTACHNPASPVGTIASCHASAAMREFRIHELANWVDWWPDLVIREGPFWKDGYFTIQDKPGYGVELN
PDVAKAHLAPGETWWG

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186972148, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994953, Length=366, Percent_Identity=27.0491803278689, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787864, Length=397, Percent_Identity=24.4332493702771, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 46580; Mature: 46580

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00908 MR_MLE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRREFLCAAGAAGLFCGPLARRASAMARKVKITDVKCMIVRGTWDWNLIKIETDSGLYG
CCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCEEEEEEECCCCCEE
IGEAYWGWGVKDLVVNKMKGIIVGEDPLNVDKLYTKMLMQSAGAGAIGGVTMTAASGIEI
CCHHHHCCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
ALWDLCGRILDTPVCNLLGGRFRDRIRFYRTTQAVKNVEDTKEWRALAESARAEKWGWTA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHCCCEE
FKFQGDGIPPRADPEFKEPGHDPYARNLTHKDHRRIVTAMETVRETLGPDADFAVECHWR
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
YDTQDVISLGKELEPVKPMWLEDPVPPDNIEAMQRVTHAINVPVCTGENLYGRQGFRKLI
CCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
EMQACSGVHIDIPKSGGLMESKKISDLADLYYIWTACHNPASPVGTIASCHASAAMREFR
HHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IHELANWVDWWPDLVIREGPFWKDGYFTIQDKPGYGVELNPDVAKAHLAPGETWWG
HHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCCEEECCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MNRREFLCAAGAAGLFCGPLARRASAMARKVKITDVKCMIVRGTWDWNLIKIETDSGLYG
CCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCEEEEEEECCCCCEE
IGEAYWGWGVKDLVVNKMKGIIVGEDPLNVDKLYTKMLMQSAGAGAIGGVTMTAASGIEI
CCHHHHCCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
ALWDLCGRILDTPVCNLLGGRFRDRIRFYRTTQAVKNVEDTKEWRALAESARAEKWGWTA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHCCCEE
FKFQGDGIPPRADPEFKEPGHDPYARNLTHKDHRRIVTAMETVRETLGPDADFAVECHWR
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
YDTQDVISLGKELEPVKPMWLEDPVPPDNIEAMQRVTHAINVPVCTGENLYGRQGFRKLI
CCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
EMQACSGVHIDIPKSGGLMESKKISDLADLYYIWTACHNPASPVGTIASCHASAAMREFR
HHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IHELANWVDWWPDLVIREGPFWKDGYFTIQDKPGYGVELNPDVAKAHLAPGETWWG
HHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCCEEECCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA