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The map label for this gene is sucD [H]

Identifier: 116622479

GI number: 116622479

Start: 4277955

End: 4278821

Strand: Reverse

Name: sucD [H]

Synonym: Acid_3377

Alternate gene names: 116622479

Gene position: 4278821-4277955 (Counterclockwise)

Preceding gene: 116622480

Following gene: 116622478

Centisome position: 42.94

GC content: 62.17

Gene sequence:

>867_bases
ATGAGCGTACTGGTAGACAAGAATACGAAAGTGATTGTTCAGGGCTTCACCGGTAAGGAAGGCACCTTTCACGCGCAGCA
ATCGATTGCGTACGGCACCAACGTGGTGGGCGGCGTCGTGCCCGGCAAGGGCGGCACGCAGCAGCTGGAGCGGCCGGTCT
TCGATACCGTGGAGCAGGCCGTAAAAGCCACGGGCGCGAATGCGAGCGTGATCTTCGTACCGCCGCCGTTCGCCGCGGAC
GCCATCATGGAAGCGGCGGACGCGGGCGTCGAGCTGGTGGTGTGTATTACGGAAGGCATTCCGGCGCTGGACATGGTGAA
GGCGTGGGCATTCCTGCAGGGTAAGAAGACGCGCCTGATCGGGCCGAACTGCCCGGGGATTATTTCGCCGGGTAAGTGCA
AGATCGGCATCATGCCGGCATCGATTCACCGCGAAGGGCACGTGGGCGTGGTTTCGCGCTCGGGCACTTTGACGTACGAA
GCAGTGGGGCAGTTGACCAAACTCGGAATCGGACAATCGACCTGCATCGGGATCGGCGGCGATCCGATTATCGGCACCAC
GTTCCTGGATGCGCTGGAGTTGTTCAATGCCGACCCGGACACGCACGCGATCATTATGATCGGCGAGATCGGCGGCAACG
CCGAGGAAACTGCCGCGGCGTATGTGAAGGCGCACGTGAAAAAGCCGGTAGTCGGTTTCGTGGCGGGGCAGACCGCGCCG
CCCGGACGCCGCATGGGACACGCGGGCGCGATCATCGCCGGCGGGTCGGGCAAAGCGGAAGACAAGATTGCGGCTATGGC
GGATGCAGGCATCACGATCTGCTCCACGCCGGCCGAACTCGGAGAGAAAGTAAAAAGTCGTTTATGA

Upstream 100 bases:

>100_bases
GGCCGGCAGATTCTGCTGGAATCGGGATTCAACTTTACGGTGGGCGCGGACATGTGGGACGCCGCTCAAAAAGTAGTGAA
GCTGGCTGCGTGAGGAACTA

Downstream 100 bases:

>100_bases
GCGTTGAACGGACATTTTCCATTATTAAGCCGGATGCGGTGAAGGCCGGGCAGGCAGGCGAAATCCTGGCCATGATTCAG
AAGGCCGGGTTCAAGATCAT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha; Vegetative protein 239; VEG239 [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSVLVDKNTKVIVQGFTGKEGTFHAQQSIAYGTNVVGGVVPGKGGTQQLERPVFDTVEQAVKATGANASVIFVPPPFAAD
AIMEAADAGVELVVCITEGIPALDMVKAWAFLQGKKTRLIGPNCPGIISPGKCKIGIMPASIHREGHVGVVSRSGTLTYE
AVGQLTKLGIGQSTCIGIGGDPIIGTTFLDALELFNADPDTHAIIMIGEIGGNAEETAAAYVKAHVKKPVVGFVAGQTAP
PGRRMGHAGAIIAGGSGKAEDKIAAMADAGITICSTPAELGEKVKSRL

Sequences:

>Translated_288_residues
MSVLVDKNTKVIVQGFTGKEGTFHAQQSIAYGTNVVGGVVPGKGGTQQLERPVFDTVEQAVKATGANASVIFVPPPFAAD
AIMEAADAGVELVVCITEGIPALDMVKAWAFLQGKKTRLIGPNCPGIISPGKCKIGIMPASIHREGHVGVVSRSGTLTYE
AVGQLTKLGIGQSTCIGIGGDPIIGTTFLDALELFNADPDTHAIIMIGEIGGNAEETAAAYVKAHVKKPVVGFVAGQTAP
PGRRMGHAGAIIAGGSGKAEDKIAAMADAGITICSTPAELGEKVKSRL
>Mature_287_residues
SVLVDKNTKVIVQGFTGKEGTFHAQQSIAYGTNVVGGVVPGKGGTQQLERPVFDTVEQAVKATGANASVIFVPPPFAADA
IMEAADAGVELVVCITEGIPALDMVKAWAFLQGKKTRLIGPNCPGIISPGKCKIGIMPASIHREGHVGVVSRSGTLTYEA
VGQLTKLGIGQSTCIGIGGDPIIGTTFLDALELFNADPDTHAIIMIGEIGGNAEETAAAYVKAHVKKPVVGFVAGQTAPP
GRRMGHAGAIIAGGSGKAEDKIAAMADAGITICSTPAELGEKVKSRL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=287, Percent_Identity=63.0662020905923, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI38569423, Length=256, Percent_Identity=30.46875, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38569421, Length=256, Percent_Identity=30.46875, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=64.2361111111111, Blast_Score=383, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=60.7017543859649, Blast_Score=327, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=57.5342465753425, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17557344, Length=255, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=290, Percent_Identity=53.7931034482759, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI21356559, Length=285, Percent_Identity=57.8947368421053, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=58.6805555555556, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI281363477, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281363475, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281363473, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29422; Mature: 29291

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVDKNTKVIVQGFTGKEGTFHAQQSIAYGTNVVGGVVPGKGGTQQLERPVFDTVEQA
CEEEEECCCEEEEEECCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VKATGANASVIFVPPPFAADAIMEAADAGVELVVCITEGIPALDMVKAWAFLQGKKTRLI
HHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIISPGKCKIGIMPASIHREGHVGVVSRSGTLTYEAVGQLTKLGIGQSTCIGIGG
CCCCCCCCCCCCEEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIIGTTFLDALELFNADPDTHAIIMIGEIGGNAEETAAAYVKAHVKKPVVGFVAGQTAP
CCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
PGRRMGHAGAIIAGGSGKAEDKIAAMADAGITICSTPAELGEKVKSRL
CCCCCCCCCEEEECCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
SVLVDKNTKVIVQGFTGKEGTFHAQQSIAYGTNVVGGVVPGKGGTQQLERPVFDTVEQA
EEEEECCCEEEEEECCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VKATGANASVIFVPPPFAADAIMEAADAGVELVVCITEGIPALDMVKAWAFLQGKKTRLI
HHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIISPGKCKIGIMPASIHREGHVGVVSRSGTLTYEAVGQLTKLGIGQSTCIGIGG
CCCCCCCCCCCCEEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIIGTTFLDALELFNADPDTHAIIMIGEIGGNAEETAAAYVKAHVKKPVVGFVAGQTAP
CCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
PGRRMGHAGAIIAGGSGKAEDKIAAMADAGITICSTPAELGEKVKSRL
CCCCCCCCCEEEECCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]