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The map label for this gene is ndk [H]

Identifier: 116622478

GI number: 116622478

Start: 4277539

End: 4277958

Strand: Reverse

Name: ndk [H]

Synonym: Acid_3376

Alternate gene names: 116622478

Gene position: 4277958-4277539 (Counterclockwise)

Preceding gene: 116622479

Following gene: 116622477

Centisome position: 42.93

GC content: 59.05

Gene sequence:

>420_bases
ATGAGCGTTGAACGGACATTTTCCATTATTAAGCCGGATGCGGTGAAGGCCGGGCAGGCAGGCGAAATCCTGGCCATGAT
TCAGAAGGCCGGGTTCAAGATCATCGGGCTGCGGATGACGCGGCTCACCGAATTGCAAGCGGGCGGATTTTACGCCGTGC
ATAAGGAACGGCCCTTTTATCAGGGGCTGGTGAAGTTCATGACGGAGGGGCCGATCATCGTCATGGCGCTGGAGCGCGAG
GATGCGGTGAAGGGTCTGCGCGAAGTCATGGGCGCGACCAATCCGGCGAATGCGGCGGAAGGGACGATCCGGAAAAAGTT
CGCGGAGAACATCGAGCGCAACTGCATTCACGGGTCGGACGCGCCGGAGACGGCGGCGGTCGAGCTGGCCTTCTTCTTTA
GTAGTGCAGAGTTATTGTAG

Upstream 100 bases:

>100_bases
GGTCGGGCAAAGCGGAAGACAAGATTGCGGCTATGGCGGATGCAGGCATCACGATCTGCTCCACGCCGGCCGAACTCGGA
GAGAAAGTAAAAAGTCGTTT

Downstream 100 bases:

>100_bases
AGGGTAAGAGTCATTTCTCGCAGAGACGCAGAGCCGCAGAGTAACGCCAAGAAGAACAGGCCAAGAATTTCTTTGCGTGA
CTCTGCGGCTCTGCGGCTCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSVERTFSIIKPDAVKAGQAGEILAMIQKAGFKIIGLRMTRLTELQAGGFYAVHKERPFYQGLVKFMTEGPIIVMALERE
DAVKGLREVMGATNPANAAEGTIRKKFAENIERNCIHGSDAPETAAVELAFFFSSAELL

Sequences:

>Translated_139_residues
MSVERTFSIIKPDAVKAGQAGEILAMIQKAGFKIIGLRMTRLTELQAGGFYAVHKERPFYQGLVKFMTEGPIIVMALERE
DAVKGLREVMGATNPANAAEGTIRKKFAENIERNCIHGSDAPETAAVELAFFFSSAELL
>Mature_138_residues
SVERTFSIIKPDAVKAGQAGEILAMIQKAGFKIIGLRMTRLTELQAGGFYAVHKERPFYQGLVKFMTEGPIIVMALERED
AVKGLREVMGATNPANAAEGTIRKKFAENIERNCIHGSDAPETAAVELAFFFSSAELL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=43.3823529411765, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4557797, Length=138, Percent_Identity=42.0289855072464, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=138, Percent_Identity=42.0289855072464, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=40.5797101449275, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=40.5797101449275, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=40.5797101449275, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=40.5797101449275, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=40.5797101449275, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=36.0294117647059, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=40.4411764705882, Blast_Score=102, Evalue=7e-23,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=40.4411764705882, Blast_Score=102, Evalue=7e-23,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI30023828, Length=144, Percent_Identity=36.1111111111111, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=53.6231884057971, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17506807, Length=137, Percent_Identity=37.956204379562, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=37.2262773722628, Blast_Score=111, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=42.6470588235294, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15192; Mature: 15061

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVERTFSIIKPDAVKAGQAGEILAMIQKAGFKIIGLRMTRLTELQAGGFYAVHKERPFY
CCCCHHHEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHCCCCEEEECCCCCHH
QGLVKFMTEGPIIVMALEREDAVKGLREVMGATNPANAAEGTIRKKFAENIERNCIHGSD
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
APETAAVELAFFFSSAELL
CCCHHHHHHHEEECCCCCC
>Mature Secondary Structure 
SVERTFSIIKPDAVKAGQAGEILAMIQKAGFKIIGLRMTRLTELQAGGFYAVHKERPFY
CCCHHHEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHCCCCEEEECCCCCHH
QGLVKFMTEGPIIVMALEREDAVKGLREVMGATNPANAAEGTIRKKFAENIERNCIHGSD
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
APETAAVELAFFFSSAELL
CCCHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA