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The map label for this gene is proA [H]

Identifier: 116622447

GI number: 116622447

Start: 4234053

End: 4234775

Strand: Direct

Name: proA [H]

Synonym: Acid_3345

Alternate gene names: 116622447

Gene position: 4234053-4234775 (Clockwise)

Preceding gene: 116622446

Following gene: 116622448

Centisome position: 42.49

GC content: 61.55

Gene sequence:

>723_bases
ATGAAGCGTAAGCTGCTTCTGGCCGGGCTACCGGCGCTTGTGGTGGGCGGATGGCTGCTGGCGCAGCCATCCGGGGAAGA
GAACATCATCGAGGGTTTTCGGAACGTAGAGGTCGCCTCAGTGTCGGACGCCATCGAACAACTCTACGGCCAGAAAACGT
ACATGTCACACGACATGCGCCCGCTCTTCAAGACCAAGTTCGCGGGCCCGGCGGTGACCGTGCTGCTCAAGAAAGAGGAA
CACAAGGAGGGCTCCGCCGCATCGCAGGGAATGCTGGATGCGATCGACAACGCCGCCCCGGGCTCTGTGTACGTGATGGT
GTTGGAGCAGGGAATCGACTACGCGGGCATGGGCGCGCTGATGGCCACCGCGATGAAGGTTCGCGGCTTCACCGGCGCGG
TGGTCGATGGCTCAATCCGCGACCTTCCGCAGATCGGCAGGATCCAGTTCCCGGTGTACAGCCGCGGTGTGGCGCCTTCG
ACTACGATCAATCACTTTCGGTTTGCCGGTGTCAATGTGCCGGTAACGTGCGCGGGCGCGAAGGTGACGGGCGGTGACCT
GATTGTCGCAGATGAAGATGGCGTGGCGGTGGTGCCGCGCGCGCATGCGGCGGAGGTGTTGAAGAAGGCCCAGGAGTTGG
ACCAGACCGAGCACCAGATGCTGCCGTTTATTGAAAAGTTCAAGTCCATCAAGGAAGCGGTCGCGAAGTTTGGGCGTATC
TGA

Upstream 100 bases:

>100_bases
ACGGATATATACGGCAGTCCGAAGGATCCGGCGCTTAAAAAGGAATACGACGAGTATCTCCAAAAGCGTCGTGCGGAAAT
TCAGAAGGGCGGGAAGTGAG

Downstream 100 bases:

>100_bases
AATAGAGAGGTGCTCGCATGGAGAACCGGGTTTCCCGAAGAAAGATGATCCAGGGAGTGGGCGCTGCGGCGCTGGCGCAA
TCTGTCGAGCTGGCGCACGC

Product: dimethylmenaquinone methyltransferase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKRKLLLAGLPALVVGGWLLAQPSGEENIIEGFRNVEVASVSDAIEQLYGQKTYMSHDMRPLFKTKFAGPAVTVLLKKEE
HKEGSAASQGMLDAIDNAAPGSVYVMVLEQGIDYAGMGALMATAMKVRGFTGAVVDGSIRDLPQIGRIQFPVYSRGVAPS
TTINHFRFAGVNVPVTCAGAKVTGGDLIVADEDGVAVVPRAHAAEVLKKAQELDQTEHQMLPFIEKFKSIKEAVAKFGRI

Sequences:

>Translated_240_residues
MKRKLLLAGLPALVVGGWLLAQPSGEENIIEGFRNVEVASVSDAIEQLYGQKTYMSHDMRPLFKTKFAGPAVTVLLKKEE
HKEGSAASQGMLDAIDNAAPGSVYVMVLEQGIDYAGMGALMATAMKVRGFTGAVVDGSIRDLPQIGRIQFPVYSRGVAPS
TTINHFRFAGVNVPVTCAGAKVTGGDLIVADEDGVAVVPRAHAAEVLKKAQELDQTEHQMLPFIEKFKSIKEAVAKFGRI
>Mature_240_residues
MKRKLLLAGLPALVVGGWLLAQPSGEENIIEGFRNVEVASVSDAIEQLYGQKTYMSHDMRPLFKTKFAGPAVTVLLKKEE
HKEGSAASQGMLDAIDNAAPGSVYVMVLEQGIDYAGMGALMATAMKVRGFTGAVVDGSIRDLPQIGRIQFPVYSRGVAPS
TTINHFRFAGVNVPVTCAGAKVTGGDLIVADEDGVAVVPRAHAAEVLKKAQELDQTEHQMLPFIEKFKSIKEAVAKFGRI

Specific function: Plays a role in protocatechuate degradation. Has a broad substrate specificity and catalyzes the aldol cleavage of 4- hydroxy-4-methyl-2-oxoglutarate, 4-hydroxy-2-oxoglutarate and 4- carboxy-4-hydroxy-2-oxoadipate, and the decarboxylation of oxaloacetate.

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014165
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6 [H]

EC number: =4.1.1.3; =4.1.3.16; =4.1.3.17 [H]

Molecular weight: Translated: 25696; Mature: 25696

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKLLLAGLPALVVGGWLLAQPSGEENIIEGFRNVEVASVSDAIEQLYGQKTYMSHDMR
CCCCEEECCCHHHHHCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCC
PLFKTKFAGPAVTVLLKKEEHKEGSAASQGMLDAIDNAAPGSVYVMVLEQGIDYAGMGAL
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHH
MATAMKVRGFTGAVVDGSIRDLPQIGRIQFPVYSRGVAPSTTINHFRFAGVNVPVTCAGA
HHHHHHHCCCCCEEECCCHHCCCCCCCEECCHHCCCCCCCCCCCCEEEECCCCEEEECCC
KVTGGDLIVADEDGVAVVPRAHAAEVLKKAQELDQTEHQMLPFIEKFKSIKEAVAKFGRI
EECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRKLLLAGLPALVVGGWLLAQPSGEENIIEGFRNVEVASVSDAIEQLYGQKTYMSHDMR
CCCCEEECCCHHHHHCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCC
PLFKTKFAGPAVTVLLKKEEHKEGSAASQGMLDAIDNAAPGSVYVMVLEQGIDYAGMGAL
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHH
MATAMKVRGFTGAVVDGSIRDLPQIGRIQFPVYSRGVAPSTTINHFRFAGVNVPVTCAGA
HHHHHHHCCCCCEEECCCHHCCCCCCCEECCHHCCCCCCCCCCCCEEEECCCCEEEECCC
KVTGGDLIVADEDGVAVVPRAHAAEVLKKAQELDQTEHQMLPFIEKFKSIKEAVAKFGRI
EECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11826967 [H]