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The map label for this gene is uxuA [H]

Identifier: 116622448

GI number: 116622448

Start: 4234793

End: 4236109

Strand: Direct

Name: uxuA [H]

Synonym: Acid_3346

Alternate gene names: 116622448

Gene position: 4234793-4236109 (Clockwise)

Preceding gene: 116622447

Following gene: 116622451

Centisome position: 42.49

GC content: 65.15

Gene sequence:

>1317_bases
ATGGAGAACCGGGTTTCCCGAAGAAAGATGATCCAGGGAGTGGGCGCTGCGGCGCTGGCGCAATCTGTCGAGCTGGCGCA
CGCGCAAGCCTCGCGCAAGTGGCCGATTGAGGAAGGTGCAGATACGCCCAAGCTCTGCCTTGCGATGGGCGATGCCGGCA
TGCAGCTTGCCGGCGCGGCGTCGCAACCGCAGGCTCCGGCTGCTGCTCCCGGCGGCCGCGGCGGCGGGTACGGAGGCACC
TTGGCACCGCGTACGGAAGCGGCGTCGAACGCGTACCAGCGGCTGCGCCAGATCGGCGTGACGCACCTGCTGGGCGTCAA
TGCCGGCGGCTTTCCGTGGACGGAGGAGAACGTCCGGCGTACGGTCCAGACCGCGCGCGAGAACGGGATGGTGGCCTACA
ACGCGATGATCAATATCCCGAGTTCGATCATTTATGGCCGCGACGGGCGGGATAAGGATCTGGAACTCGTGCTCGCGTCG
ATCCAGGCCGCCGGCAAGGGCGGACTTACGGTGGTGGAGTACAATTTCTACGCGCACCGCGCGATCGAGGGGTACTTCGA
GCAGGTTGGGCGGGCCAACGCGGGATACACCGGTTTCGACCACGATCTGGAGCTGCTGGTCAACGAGAATGGCGCGGTGC
TGCCGGGCCAGCTGCGCGATGCCCAGGGCCGGCTCACGCCGGAGACGCTGGCGGCGAATCCAAACGCGAAGCGCGTGAAG
TTCCGCGACTTGCCGCCGCTGGGCAACGAGGGCGCGCACAATCTCGGTGAGATGTGGAAGAACATCACGTACCTGCTGAA
GGCCGCGGTGCCCGCCGCCGAGAAGGCGGGCGTGCGCCTGGCGCTGCATCCGAACGATCCGCCCGCACCCATCAGCCGCG
GCTCGCAGCAGATCATGGGGACGGTCGCCGGCTGGAGGCACCTGATCGAAATCGTCGATAGCCCGGCCAATGGAATCACG
TTCGATTGCGGCGTGACGCGCGAGATGGGGGAGGACCCGGTTGCGGTGGCCAATTACTTCGCGAGCCGCAAGCGCATCAA
CCACATTCACTATCGCAACGTGATGGTGGAGCGGCCGTACGAGAAATACTCGGAGTTGTTCATCGATGCCGGCATGGTGG
ACATGTTCGGCGTGATGAAGGCGATCGTGAAAAACAAATATACCGGGACGATCTATCCCGAACATCCGCGCGCGTTGGAT
TACGATCGCGATCGCGGCCGCATCGGCGGCTATCCGGGCGGAGGCGGCTACGCGGGCATCACGTACAGCGTGGCCTACGC
CCGTGCGATGATGCAGGCGGCTTTGGAGAGCGTCTAG

Upstream 100 bases:

>100_bases
ACCAGACCGAGCACCAGATGCTGCCGTTTATTGAAAAGTTCAAGTCCATCAAGGAAGCGGTCGCGAAGTTTGGGCGTATC
TGAAATAGAGAGGTGCTCGC

Downstream 100 bases:

>100_bases
CGATACTTCTCCGGTTCGCGCGTGACGGTGACATTTCCGCGCGCGTCGATCTGGCCGGTCTCCTCGTTCAGGTCGGCTTC
GTCGGCCCGCAGCACCACGG

Product: D-mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MENRVSRRKMIQGVGAAALAQSVELAHAQASRKWPIEEGADTPKLCLAMGDAGMQLAGAASQPQAPAAAPGGRGGGYGGT
LAPRTEAASNAYQRLRQIGVTHLLGVNAGGFPWTEENVRRTVQTARENGMVAYNAMINIPSSIIYGRDGRDKDLELVLAS
IQAAGKGGLTVVEYNFYAHRAIEGYFEQVGRANAGYTGFDHDLELLVNENGAVLPGQLRDAQGRLTPETLAANPNAKRVK
FRDLPPLGNEGAHNLGEMWKNITYLLKAAVPAAEKAGVRLALHPNDPPAPISRGSQQIMGTVAGWRHLIEIVDSPANGIT
FDCGVTREMGEDPVAVANYFASRKRINHIHYRNVMVERPYEKYSELFIDAGMVDMFGVMKAIVKNKYTGTIYPEHPRALD
YDRDRGRIGGYPGGGGYAGITYSVAYARAMMQAALESV

Sequences:

>Translated_438_residues
MENRVSRRKMIQGVGAAALAQSVELAHAQASRKWPIEEGADTPKLCLAMGDAGMQLAGAASQPQAPAAAPGGRGGGYGGT
LAPRTEAASNAYQRLRQIGVTHLLGVNAGGFPWTEENVRRTVQTARENGMVAYNAMINIPSSIIYGRDGRDKDLELVLAS
IQAAGKGGLTVVEYNFYAHRAIEGYFEQVGRANAGYTGFDHDLELLVNENGAVLPGQLRDAQGRLTPETLAANPNAKRVK
FRDLPPLGNEGAHNLGEMWKNITYLLKAAVPAAEKAGVRLALHPNDPPAPISRGSQQIMGTVAGWRHLIEIVDSPANGIT
FDCGVTREMGEDPVAVANYFASRKRINHIHYRNVMVERPYEKYSELFIDAGMVDMFGVMKAIVKNKYTGTIYPEHPRALD
YDRDRGRIGGYPGGGGYAGITYSVAYARAMMQAALESV
>Mature_438_residues
MENRVSRRKMIQGVGAAALAQSVELAHAQASRKWPIEEGADTPKLCLAMGDAGMQLAGAASQPQAPAAAPGGRGGGYGGT
LAPRTEAASNAYQRLRQIGVTHLLGVNAGGFPWTEENVRRTVQTARENGMVAYNAMINIPSSIIYGRDGRDKDLELVLAS
IQAAGKGGLTVVEYNFYAHRAIEGYFEQVGRANAGYTGFDHDLELLVNENGAVLPGQLRDAQGRLTPETLAANPNAKRVK
FRDLPPLGNEGAHNLGEMWKNITYLLKAAVPAAEKAGVRLALHPNDPPAPISRGSQQIMGTVAGWRHLIEIVDSPANGIT
FDCGVTREMGEDPVAVANYFASRKRINHIHYRNVMVERPYEKYSELFIDAGMVDMFGVMKAIVKNKYTGTIYPEHPRALD
YDRDRGRIGGYPGGGGYAGITYSVAYARAMMQAALESV

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1790778, Length=345, Percent_Identity=25.5072463768116, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004628
- InterPro:   IPR013022 [H]

Pfam domain/function: PF03786 UxuA [H]

EC number: =4.2.1.8 [H]

Molecular weight: Translated: 47239; Mature: 47239

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRVSRRKMIQGVGAAALAQSVELAHAQASRKWPIEEGADTPKLCLAMGDAGMQLAGAA
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCC
SQPQAPAAAPGGRGGGYGGTLAPRTEAASNAYQRLRQIGVTHLLGVNAGGFPWTEENVRR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHEEECCCCCCCCCHHHHHH
TVQTARENGMVAYNAMINIPSSIIYGRDGRDKDLELVLASIQAAGKGGLTVVEYNFYAHR
HHHHHHHCCEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHH
AIEGYFEQVGRANAGYTGFDHDLELLVNENGAVLPGQLRDAQGRLTPETLAANPNAKRVK
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEE
FRDLPPLGNEGAHNLGEMWKNITYLLKAAVPAAEKAGVRLALHPNDPPAPISRGSQQIMG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCCHHHHHH
TVAGWRHLIEIVDSPANGITFDCGVTREMGEDPVAVANYFASRKRINHIHYRNVMVERPY
HHHHHHHHHHHHCCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCH
EKYSELFIDAGMVDMFGVMKAIVKNKYTGTIYPEHPRALDYDRDRGRIGGYPGGGGYAGI
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
TYSVAYARAMMQAALESV
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENRVSRRKMIQGVGAAALAQSVELAHAQASRKWPIEEGADTPKLCLAMGDAGMQLAGAA
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCC
SQPQAPAAAPGGRGGGYGGTLAPRTEAASNAYQRLRQIGVTHLLGVNAGGFPWTEENVRR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHEEECCCCCCCCCHHHHHH
TVQTARENGMVAYNAMINIPSSIIYGRDGRDKDLELVLASIQAAGKGGLTVVEYNFYAHR
HHHHHHHCCEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHH
AIEGYFEQVGRANAGYTGFDHDLELLVNENGAVLPGQLRDAQGRLTPETLAANPNAKRVK
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEE
FRDLPPLGNEGAHNLGEMWKNITYLLKAAVPAAEKAGVRLALHPNDPPAPISRGSQQIMG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCCHHHHHH
TVAGWRHLIEIVDSPANGITFDCGVTREMGEDPVAVANYFASRKRINHIHYRNVMVERPY
HHHHHHHHHHHHCCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCH
EKYSELFIDAGMVDMFGVMKAIVKNKYTGTIYPEHPRALDYDRDRGRIGGYPGGGGYAGI
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
TYSVAYARAMMQAALESV
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA