Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 116622441

GI number: 116622441

Start: 4224880

End: 4226025

Strand: Direct

Name: hisC [H]

Synonym: Acid_3339

Alternate gene names: 116622441

Gene position: 4224880-4226025 (Clockwise)

Preceding gene: 116622438

Following gene: 116622442

Centisome position: 42.39

GC content: 59.86

Gene sequence:

>1146_bases
ATGACGATTCTGAACGAAGAATTGAAACGCGACCTGATTAACCGCGGTTTTTCGCGCCGGAATTTCGGCCGCATCGCCGC
GATGGTAACCGCCGGAGCTACTCTGCCCTTCTACAATGAACCGGCTCTGGCCCAACTTTCAAAAGTCAATGCACCCCCGG
ACGCCGTTCTCATCAATGCCAACGAGAATCCGCTGGGACCGTGTCCGGAAGCGCGCGAAGCCGCCGCGAAGATGATTGAG
TTTGGCGGACGCTATCGTTATAGCGAAGCCGACAAGGTGAAACAGCTTTTGGCCGAGCAGGAAGGCGTGAAGGAAAGCCA
CGTCACGATCCATCCCGGCTCGAGCGGTCCGCTGCATCAAGCCGTGCTGGCATTCTGTTCGCCGACAAAGCCGTTCGTCA
TGGCCGATCCCGGCTATGAAGCCGGCGGGCGCGCCGCGGATTTCATCGGCGCGAAGACATACCGGATTCCATTGATGGCG
GACAAGGGCTACTGCCACGATGTGAAAGCGATGGTGGCCGCCAGTCCCGATGCGGGGCTAATTTATATTTGCAATCCCAA
CAATCCGACGGGCACGCTAACGCCGCAGGCCGATATCGAATGGCTGGTCGCGAATAAGCCGAAGGATGCCATCGTGATGG
TGGACGAGGCTTACACGCACATTGCAGGCGCGCCGTTCCAGTCGCCGATGGTGGCCGCGGGCAAGGACGTGATCCTGCTG
CGGACGTTCTCTAAGATTTACGGCATGGCGGGCTTGCGCGCCGGCGCGGCGATCGCGCGGCCGGACCTGCTGCAGAAGAT
TTCGAATTTCAGCTCGACCATGATGCCGATCACCGGCATGGCGGCGGCCAGCGCCAGCCTGCAGGTGAAGGATCTTGTGC
CGAAGCGCCGCAAGCTGATGGGCGAGGTTCGCGAGGAGACGTTCAGCTTCCTCGAGAAGCACAAGTTCACGTTCGTGCCG
TCGGTTTCGAACTGCTTCATGATCGACGTGAAACGTCCGGGCGGCCAGATTGTGCAGGCGATGGCGGCAGAGAAGATTTA
CATCGGCCGCGTATGGAAGGCCTGGCCCAATCACGTGCGCGTCACCGTGGGCACCGCCGAAGAGATGAAGAAGTTCCAGA
CGGCGTTCCTTAAGGTGATGGCTTGA

Upstream 100 bases:

>100_bases
TTGGTTGCGGCTGTTTCAAATCCGTCCAATCAAGATTTTCTTCTCGACAGCATCGTCAGAAACTGGTAAACTCCCCGGAA
TAGCGCACTTAAGGGGGCCT

Downstream 100 bases:

>100_bases
ACCTTCGCGCCAAGTTGGGACTCGGGTCCCACGGCGCGGAACGGTACGGTTGGACGCAGCTCCTTGGCGATTGTTCCGGC
GGGGTCATCGCAGCGCTCAT

Product: aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTILNEELKRDLINRGFSRRNFGRIAAMVTAGATLPFYNEPALAQLSKVNAPPDAVLINANENPLGPCPEAREAAAKMIE
FGGRYRYSEADKVKQLLAEQEGVKESHVTIHPGSSGPLHQAVLAFCSPTKPFVMADPGYEAGGRAADFIGAKTYRIPLMA
DKGYCHDVKAMVAASPDAGLIYICNPNNPTGTLTPQADIEWLVANKPKDAIVMVDEAYTHIAGAPFQSPMVAAGKDVILL
RTFSKIYGMAGLRAGAAIARPDLLQKISNFSSTMMPITGMAAASASLQVKDLVPKRRKLMGEVREETFSFLEKHKFTFVP
SVSNCFMIDVKRPGGQIVQAMAAEKIYIGRVWKAWPNHVRVTVGTAEEMKKFQTAFLKVMA

Sequences:

>Translated_381_residues
MTILNEELKRDLINRGFSRRNFGRIAAMVTAGATLPFYNEPALAQLSKVNAPPDAVLINANENPLGPCPEAREAAAKMIE
FGGRYRYSEADKVKQLLAEQEGVKESHVTIHPGSSGPLHQAVLAFCSPTKPFVMADPGYEAGGRAADFIGAKTYRIPLMA
DKGYCHDVKAMVAASPDAGLIYICNPNNPTGTLTPQADIEWLVANKPKDAIVMVDEAYTHIAGAPFQSPMVAAGKDVILL
RTFSKIYGMAGLRAGAAIARPDLLQKISNFSSTMMPITGMAAASASLQVKDLVPKRRKLMGEVREETFSFLEKHKFTFVP
SVSNCFMIDVKRPGGQIVQAMAAEKIYIGRVWKAWPNHVRVTVGTAEEMKKFQTAFLKVMA
>Mature_380_residues
TILNEELKRDLINRGFSRRNFGRIAAMVTAGATLPFYNEPALAQLSKVNAPPDAVLINANENPLGPCPEAREAAAKMIEF
GGRYRYSEADKVKQLLAEQEGVKESHVTIHPGSSGPLHQAVLAFCSPTKPFVMADPGYEAGGRAADFIGAKTYRIPLMAD
KGYCHDVKAMVAASPDAGLIYICNPNNPTGTLTPQADIEWLVANKPKDAIVMVDEAYTHIAGAPFQSPMVAAGKDVILLR
TFSKIYGMAGLRAGAAIARPDLLQKISNFSSTMMPITGMAAASASLQVKDLVPKRRKLMGEVREETFSFLEKHKFTFVPS
VSNCFMIDVKRPGGQIVQAMAAEKIYIGRVWKAWPNHVRVTVGTAEEMKKFQTAFLKVMA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=339, Percent_Identity=24.7787610619469, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322075, Length=369, Percent_Identity=25.2032520325203, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41462; Mature: 41330

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILNEELKRDLINRGFSRRNFGRIAAMVTAGATLPFYNEPALAQLSKVNAPPDAVLINA
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
NENPLGPCPEAREAAAKMIEFGGRYRYSEADKVKQLLAEQEGVKESHVTIHPGSSGPLHQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
AVLAFCSPTKPFVMADPGYEAGGRAADFIGAKTYRIPLMADKGYCHDVKAMVAASPDAGL
HHHHHHCCCCCEEEECCCCCCCCCCHHHCCCEEEEEEEEECCCCCHHHHHHEECCCCCCE
IYICNPNNPTGTLTPQADIEWLVANKPKDAIVMVDEAYTHIAGAPFQSPMVAAGKDVILL
EEEECCCCCCCEECCCCCEEEEEECCCCCEEEEEECHHHHHCCCCCCCCHHHCCCCEEEE
RTFSKIYGMAGLRAGAAIARPDLLQKISNFSSTMMPITGMAAASASLQVKDLVPKRRKLM
EEHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEHHHHHHHHHHHH
GEVREETFSFLEKHKFTFVPSVSNCFMIDVKRPGGQIVQAMAAEKIYIGRVWKAWPNHVR
HHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHEEEEHHHHCCCCCEE
VTVGTAEEMKKFQTAFLKVMA
EEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILNEELKRDLINRGFSRRNFGRIAAMVTAGATLPFYNEPALAQLSKVNAPPDAVLINA
CCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
NENPLGPCPEAREAAAKMIEFGGRYRYSEADKVKQLLAEQEGVKESHVTIHPGSSGPLHQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
AVLAFCSPTKPFVMADPGYEAGGRAADFIGAKTYRIPLMADKGYCHDVKAMVAASPDAGL
HHHHHHCCCCCEEEECCCCCCCCCCHHHCCCEEEEEEEEECCCCCHHHHHHEECCCCCCE
IYICNPNNPTGTLTPQADIEWLVANKPKDAIVMVDEAYTHIAGAPFQSPMVAAGKDVILL
EEEECCCCCCCEECCCCCEEEEEECCCCCEEEEEECHHHHHCCCCCCCCHHHCCCCEEEE
RTFSKIYGMAGLRAGAAIARPDLLQKISNFSSTMMPITGMAAASASLQVKDLVPKRRKLM
EEHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEHHHHHHHHHHHH
GEVREETFSFLEKHKFTFVPSVSNCFMIDVKRPGGQIVQAMAAEKIYIGRVWKAWPNHVR
HHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHEEEEHHHHCCCCCEE
VTVGTAEEMKKFQTAFLKVMA
EEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA