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The map label for this gene is ampC [C]

Identifier: 116621628

GI number: 116621628

Start: 3184645

End: 3185850

Strand: Reverse

Name: ampC [C]

Synonym: Acid_2510

Alternate gene names: 116621628

Gene position: 3185850-3184645 (Counterclockwise)

Preceding gene: 116621629

Following gene: 116621627

Centisome position: 31.97

GC content: 64.43

Gene sequence:

>1206_bases
ATGCGCAACGCCCTCTTCGTGCTCGCCCTGTTCGCCGCGGCCGCCTTTACCCAAACCGCCGGACTTAACGCCGATCGCCT
CAAGTTGATCCGCCCCCGCCTGCAGGAGCTCGTCGAAAACCAATCCATCCCCGGCGCGGTCGCGCTTGTCGCCCGCCACG
GGAAGGTCGCCACGCTCGAAGCCGCCGGCTGGCGCGACGTGGAAGCCAGGAAGCCGATGACCACGGACTCCATCTTCCAG
ATCATGTCCATGACCAAGAACTTCACCGGCGTCGGCATCATGATGCTGGTGGAGGAAGGCAGGCTCGAGCTTCGCCGTCC
TGTCTCCGACTATCTCCCCGAGTTCCGCAACCAGATGATCGAAGAGCGCCTGCCCAACGGCAATACCGCGCTCCATCCGC
CGGCCCAGCCTCCCACGGTCGCCCAGCTCATGTCCCACACCTCCGGCCTCGCAGGCGATCCCGATGGCGAGCTCGCCGAC
AACCCACGAACCCTGCGCGTCCCGCTCGCCGAAGCCGTGCGTTTCTATGGCCGGCAGCACCTGCAGTTCGAGCCAGGCAC
GCGCTGGCGTTACAGCAACATGGGTATCGCCGCCCTCGGCCGCATCATCGAGGTCGTAACCGGCGAGGACTACGTTCACT
TCATCGAATCCCGCCTGCTGACTCCGCTCGGCATGAAAGACACCTTCTTCTTCCCGCCCGATGCCAAGAAGGACCGCATA
GCCCTGGTCTACAAACACAGCGCCGGCAAACTGGTCCGCTCCGGTGACGAGATCCTCGCCGGCGATTCGGCCAAGTACCG
CGCCGGCGCAAAATATCCCGCGCCGGAGTTCGGCCTCTACTCCACGGCTCCCGACCTGTTCAACTTCTACGAGATGCTGC
TCGAAGGCGGCACGTACAAGGACCACCGCTATCTCTCGCACCAATCCATCGACACCATGACCCGCGTCTTCACTCCGGAC
GTGAGCCCTTCCGGCTGGCTCGGCGGCACCGGTTACGGCCTCACCTTCGAGATCGTGAACAGGCCCGAAGGCACTCTCCT
TCTGCACTCCCCGGGCACCTTCGGCCACGGCGGCGCTTTCGGCACCGAAGGCTGGATCGATCCGCACAACGATCTCATCC
GCATCTCGATGGTCCAGCTCTCCGACGGCACCGGCTCCCACCCGCGCTCCGTAATTATGCAGATCGGCGAATCCGCAGTC
CAGTAG

Upstream 100 bases:

>100_bases
GTTCACCGCCGTTACGTATTTTCTTCAGTCTGTTTTGCGGAATGCCGTCGCTTCCGAATCGGATTGAGTCTCTTGCCGCC
TCGCGATACACTCACAGGCA

Downstream 100 bases:

>100_bases
GACGGGCCTCCTGGCCGATCGTGCTCTAAGGTTCTCCCACGCACAAATCTTCCGCCGGCATGGCCCCCTGCTTGCTCCTA
CCTTTCACCAGATGCTCGCC

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRNALFVLALFAAAAFTQTAGLNADRLKLIRPRLQELVENQSIPGAVALVARHGKVATLEAAGWRDVEARKPMTTDSIFQ
IMSMTKNFTGVGIMMLVEEGRLELRRPVSDYLPEFRNQMIEERLPNGNTALHPPAQPPTVAQLMSHTSGLAGDPDGELAD
NPRTLRVPLAEAVRFYGRQHLQFEPGTRWRYSNMGIAALGRIIEVVTGEDYVHFIESRLLTPLGMKDTFFFPPDAKKDRI
ALVYKHSAGKLVRSGDEILAGDSAKYRAGAKYPAPEFGLYSTAPDLFNFYEMLLEGGTYKDHRYLSHQSIDTMTRVFTPD
VSPSGWLGGTGYGLTFEIVNRPEGTLLLHSPGTFGHGGAFGTEGWIDPHNDLIRISMVQLSDGTGSHPRSVIMQIGESAV
Q

Sequences:

>Translated_401_residues
MRNALFVLALFAAAAFTQTAGLNADRLKLIRPRLQELVENQSIPGAVALVARHGKVATLEAAGWRDVEARKPMTTDSIFQ
IMSMTKNFTGVGIMMLVEEGRLELRRPVSDYLPEFRNQMIEERLPNGNTALHPPAQPPTVAQLMSHTSGLAGDPDGELAD
NPRTLRVPLAEAVRFYGRQHLQFEPGTRWRYSNMGIAALGRIIEVVTGEDYVHFIESRLLTPLGMKDTFFFPPDAKKDRI
ALVYKHSAGKLVRSGDEILAGDSAKYRAGAKYPAPEFGLYSTAPDLFNFYEMLLEGGTYKDHRYLSHQSIDTMTRVFTPD
VSPSGWLGGTGYGLTFEIVNRPEGTLLLHSPGTFGHGGAFGTEGWIDPHNDLIRISMVQLSDGTGSHPRSVIMQIGESAV
Q
>Mature_401_residues
MRNALFVLALFAAAAFTQTAGLNADRLKLIRPRLQELVENQSIPGAVALVARHGKVATLEAAGWRDVEARKPMTTDSIFQ
IMSMTKNFTGVGIMMLVEEGRLELRRPVSDYLPEFRNQMIEERLPNGNTALHPPAQPPTVAQLMSHTSGLAGDPDGELAD
NPRTLRVPLAEAVRFYGRQHLQFEPGTRWRYSNMGIAALGRIIEVVTGEDYVHFIESRLLTPLGMKDTFFFPPDAKKDRI
ALVYKHSAGKLVRSGDEILAGDSAKYRAGAKYPAPEFGLYSTAPDLFNFYEMLLEGGTYKDHRYLSHQSIDTMTRVFTPD
VSPSGWLGGTGYGLTFEIVNRPEGTLLLHSPGTFGHGGAFGTEGWIDPHNDLIRISMVQLSDGTGSHPRSVIMQIGESAV
Q

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=232, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082101, Length=395, Percent_Identity=24.3037974683544, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786574, Length=226, Percent_Identity=26.1061946902655, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=206, Percent_Identity=26.2135922330097, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=238, Percent_Identity=25.2100840336134, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 44199; Mature: 44199

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNALFVLALFAAAAFTQTAGLNADRLKLIRPRLQELVENQSIPGAVALVARHGKVATLE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEE
AAGWRDVEARKPMTTDSIFQIMSMTKNFTGVGIMMLVEEGRLELRRPVSDYLPEFRNQMI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHHHHH
EERLPNGNTALHPPAQPPTVAQLMSHTSGLAGDPDGELADNPRTLRVPLAEAVRFYGRQH
HHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCC
LQFEPGTRWRYSNMGIAALGRIIEVVTGEDYVHFIESRLLTPLGMKDTFFFPPDAKKDRI
EEECCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCE
ALVYKHSAGKLVRSGDEILAGDSAKYRAGAKYPAPEFGLYSTAPDLFNFYEMLLEGGTYK
EEEEECCCCCHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DHRYLSHQSIDTMTRVFTPDVSPSGWLGGTGYGLTFEIVNRPEGTLLLHSPGTFGHGGAF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCC
GTEGWIDPHNDLIRISMVQLSDGTGSHPRSVIMQIGESAVQ
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRNALFVLALFAAAAFTQTAGLNADRLKLIRPRLQELVENQSIPGAVALVARHGKVATLE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEE
AAGWRDVEARKPMTTDSIFQIMSMTKNFTGVGIMMLVEEGRLELRRPVSDYLPEFRNQMI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHHHHH
EERLPNGNTALHPPAQPPTVAQLMSHTSGLAGDPDGELADNPRTLRVPLAEAVRFYGRQH
HHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCC
LQFEPGTRWRYSNMGIAALGRIIEVVTGEDYVHFIESRLLTPLGMKDTFFFPPDAKKDRI
EEECCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCE
ALVYKHSAGKLVRSGDEILAGDSAKYRAGAKYPAPEFGLYSTAPDLFNFYEMLLEGGTYK
EEEEECCCCCHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DHRYLSHQSIDTMTRVFTPDVSPSGWLGGTGYGLTFEIVNRPEGTLLLHSPGTFGHGGAF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCC
GTEGWIDPHNDLIRISMVQLSDGTGSHPRSVIMQIGESAVQ
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]