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The map label for this gene is serS

Identifier: 116621601

GI number: 116621601

Start: 3151655

End: 3152929

Strand: Reverse

Name: serS

Synonym: Acid_2483

Alternate gene names: 116621601

Gene position: 3152929-3151655 (Counterclockwise)

Preceding gene: 116621602

Following gene: 116621600

Centisome position: 31.64

GC content: 62.98

Gene sequence:

>1275_bases
ATGCACGATCTCTCTCACTTCCGGAACAACTTCGAGAAATTGGCGGAACGTCTCGCGACCCGTGGCGGCGCGATCAACCT
GGATGGCTTCCGCGACCTGGACCTCAAGCGCCGTTCCGCCATCTCGCAAGCCGAGCAGCTCAAGGCGCGCAAGAATCAGG
AATCCCTCGAGATCGGCAAACTCAAGCGCGAAGGCGCCGATACCGCCGAGCGCCAGAAGGAAGTTCGCGCCATCGCCGAC
CAGATCGTCGCCCTCGATGAACAGGTCAAGACCGTTGACGAGGAGTTTCAGAAACTCCTCTCCGGTATCCCCAACATCCC
GCACGAATCCGTGCCCGTCGGCAAATCCGCCGACGATAACGTCGAGGTCCGCCGCTCCGGTGAGCCCGCCAAATTCGACT
TCGAACCCAAGGCCCACTGGGACCTCGGACCCGAGCTCGGCATTCTGGATTTCGAACGCGCCGTGAAAATCACCGGCGCC
CGTTTCGCCCTCTATTGGGGCGCCGGCGCCCGCCTCGAACGTGCGCTCGTGAACTTTTTCCTCGACGTCCACACGCAGCA
GCACGGCTACACCGAGGTCCTGCCGCCCTTCATGGTGAACTCCGCCAGCCTCTACGGCACCGGCCAGCTCCCCAAATTCG
CAGAGGACCTGTTTAAGATCGAGAACAGCGATTTCTGGCTTATCCCCACCGCCGAAGTCCCGGTCACCAACATCTACCGC
GACGAAACCCTCGAGGGCGAGCAGCTCCCCGTCAAGCTCTGCGCCTACACTCCCTGCTTCCGCAGCGAGGCCGGCTCCTA
CGGCCGCGACGTCCGCGGCATCATCCGCCAGCACCAGTTCCAGAAGGTGGAGCTGGTGAAATTCACACGCCCCGAACAAA
GCTACGACGAGCTCGATAAACTCACCGCCGACGCCGAGGATATCCTCGTCCGCCTCGGCCTCCCCTTCCGCACTGTCGTG
CTCTGCACCGGCGACATGGGCCCCAGCTCCGCCAAGACCTACGATATCGAGGTCTGGCTCCCCGGCCAGAACAACTACAA
GGAAATCTCGTCCTGCTCCAACTTCGAGGCCTTCCAGGCCCGCCGCGCCGGCATCCGCTACCGCACAGGCAAGAAGTCCG
AGTTCGCCCACACCATCAACGGCAGCGGCCTCGCCGTCGGCCGCACCTGGGTCGCCATCATCGAAAACTACCAGCAAATG
GACGGCAGCGTCATCATCCCCGAGGCCCTCCGCCCCTACATGAACGCCGAAATCATCCGGCCTGAGCGCCCCTAA

Upstream 100 bases:

>100_bases
TGCCTCGATTGCCGCCAGATCTTCGAGGCCGAAGACCTTGAACCCGTGAAAGTCGAGGACGAGGAAGAATAGCCCTCCCC
TGCGATAGCATGGAAGGGTA

Downstream 100 bases:

>100_bases
CGAGCCGCGACTGTAAAGTAAGGGACGCTACCCACTCGCACGCCCATCGTGACGCACCCATCAGAGCCGCGACCGCAAGG
GAGCGATCACCTTCGCCCCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MHDLSHFRNNFEKLAERLATRGGAINLDGFRDLDLKRRSAISQAEQLKARKNQESLEIGKLKREGADTAERQKEVRAIAD
QIVALDEQVKTVDEEFQKLLSGIPNIPHESVPVGKSADDNVEVRRSGEPAKFDFEPKAHWDLGPELGILDFERAVKITGA
RFALYWGAGARLERALVNFFLDVHTQQHGYTEVLPPFMVNSASLYGTGQLPKFAEDLFKIENSDFWLIPTAEVPVTNIYR
DETLEGEQLPVKLCAYTPCFRSEAGSYGRDVRGIIRQHQFQKVELVKFTRPEQSYDELDKLTADAEDILVRLGLPFRTVV
LCTGDMGPSSAKTYDIEVWLPGQNNYKEISSCSNFEAFQARRAGIRYRTGKKSEFAHTINGSGLAVGRTWVAIIENYQQM
DGSVIIPEALRPYMNAEIIRPERP

Sequences:

>Translated_424_residues
MHDLSHFRNNFEKLAERLATRGGAINLDGFRDLDLKRRSAISQAEQLKARKNQESLEIGKLKREGADTAERQKEVRAIAD
QIVALDEQVKTVDEEFQKLLSGIPNIPHESVPVGKSADDNVEVRRSGEPAKFDFEPKAHWDLGPELGILDFERAVKITGA
RFALYWGAGARLERALVNFFLDVHTQQHGYTEVLPPFMVNSASLYGTGQLPKFAEDLFKIENSDFWLIPTAEVPVTNIYR
DETLEGEQLPVKLCAYTPCFRSEAGSYGRDVRGIIRQHQFQKVELVKFTRPEQSYDELDKLTADAEDILVRLGLPFRTVV
LCTGDMGPSSAKTYDIEVWLPGQNNYKEISSCSNFEAFQARRAGIRYRTGKKSEFAHTINGSGLAVGRTWVAIIENYQQM
DGSVIIPEALRPYMNAEIIRPERP
>Mature_424_residues
MHDLSHFRNNFEKLAERLATRGGAINLDGFRDLDLKRRSAISQAEQLKARKNQESLEIGKLKREGADTAERQKEVRAIAD
QIVALDEQVKTVDEEFQKLLSGIPNIPHESVPVGKSADDNVEVRRSGEPAKFDFEPKAHWDLGPELGILDFERAVKITGA
RFALYWGAGARLERALVNFFLDVHTQQHGYTEVLPPFMVNSASLYGTGQLPKFAEDLFKIENSDFWLIPTAEVPVTNIYR
DETLEGEQLPVKLCAYTPCFRSEAGSYGRDVRGIIRQHQFQKVELVKFTRPEQSYDELDKLTADAEDILVRLGLPFRTVV
LCTGDMGPSSAKTYDIEVWLPGQNNYKEISSCSNFEAFQARRAGIRYRTGKKSEFAHTINGSGLAVGRTWVAIIENYQQM
DGSVIIPEALRPYMNAEIIRPERP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=361, Percent_Identity=34.0720221606648, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI8923421, Length=351, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI225579074, Length=335, Percent_Identity=33.7313432835821, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1787120, Length=425, Percent_Identity=50.1176470588235, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539260, Length=437, Percent_Identity=29.7482837528604, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17542084, Length=324, Percent_Identity=29.9382716049383, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=31.9095477386935, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=370, Percent_Identity=29.4594594594595, Blast_Score=189, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24581334, Length=368, Percent_Identity=31.5217391304348, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI17737985, Length=372, Percent_Identity=30.3763440860215, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SOLUE (Q024V4)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_823757.1
- ProteinModelPortal:   Q024V4
- SMR:   Q024V4
- STRING:   Q024V4
- GeneID:   4429327
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_2483
- NMPDR:   fig|234267.9.peg.2377
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q024V4
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47894; Mature: 47894

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 382-382

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLSHFRNNFEKLAERLATRGGAINLDGFRDLDLKRRSAISQAEQLKARKNQESLEIGK
CCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
LKREGADTAERQKEVRAIADQIVALDEQVKTVDEEFQKLLSGIPNIPHESVPVGKSADDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRSGEPAKFDFEPKAHWDLGPELGILDFERAVKITGARFALYWGAGARLERALVNFF
EEEEECCCCCEECCCCCCCCCCCCCCCCEEHHHHHEECCCEEEEEECCCHHHHHHHHHHH
LDVHTQQHGYTEVLPPFMVNSASLYGTGQLPKFAEDLFKIENSDFWLIPTAEVPVTNIYR
HHHHCCCCCCHHHCCHHHCCCCCEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCHHCCC
DETLEGEQLPVKLCAYTPCFRSEAGSYGRDVRGIIRQHQFQKVELVKFTRPEQSYDELDK
CCCCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LTADAEDILVRLGLPFRTVVLCTGDMGPSSAKTYDIEVWLPGQNNYKEISSCSNFEAFQA
HHCCHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHCCCCHHHHHH
RRAGIRYRTGKKSEFAHTINGSGLAVGRTWVAIIENYQQMDGSVIIPEALRPYMNAEIIR
HHCCCEECCCCCCCHHEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCEEEC
PERP
CCCC
>Mature Secondary Structure
MHDLSHFRNNFEKLAERLATRGGAINLDGFRDLDLKRRSAISQAEQLKARKNQESLEIGK
CCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
LKREGADTAERQKEVRAIADQIVALDEQVKTVDEEFQKLLSGIPNIPHESVPVGKSADDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRSGEPAKFDFEPKAHWDLGPELGILDFERAVKITGARFALYWGAGARLERALVNFF
EEEEECCCCCEECCCCCCCCCCCCCCCCEEHHHHHEECCCEEEEEECCCHHHHHHHHHHH
LDVHTQQHGYTEVLPPFMVNSASLYGTGQLPKFAEDLFKIENSDFWLIPTAEVPVTNIYR
HHHHCCCCCCHHHCCHHHCCCCCEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCHHCCC
DETLEGEQLPVKLCAYTPCFRSEAGSYGRDVRGIIRQHQFQKVELVKFTRPEQSYDELDK
CCCCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LTADAEDILVRLGLPFRTVVLCTGDMGPSSAKTYDIEVWLPGQNNYKEISSCSNFEAFQA
HHCCHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHCCCCHHHHHH
RRAGIRYRTGKKSEFAHTINGSGLAVGRTWVAIIENYQQMDGSVIIPEALRPYMNAEIIR
HHCCCEECCCCCCCHHEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCEEEC
PERP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA