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The map label for this gene is dxs [C]

Identifier: 116621570

GI number: 116621570

Start: 3114204

End: 3115184

Strand: Reverse

Name: dxs [C]

Synonym: Acid_2452

Alternate gene names: 116621570

Gene position: 3115184-3114204 (Counterclockwise)

Preceding gene: 116621571

Following gene: 116621569

Centisome position: 31.26

GC content: 64.73

Gene sequence:

>981_bases
ATGGCCACCGAAACCAAGACTGCCAAGAGCAAATTCGAGATCAAGCCGGGCGCCGCCACGCGCGAGGCTTTCGGGCGCAC
GCTGGTGGAGCTGGGCCGGGAAAACAAGGACGTGGTGGTGGTGGACGCCGATCTATCGAAATCCACGATGACCACCTATT
TCGCGAAGGAGTTTCCAGACCGCTTCTTCTCGTGCGGGATCGCGGAATCGAACATGGTGGGTGTGGGCGCGGGCCTGGCG
ATGGCGGGGAAGATTCCGTTCGTGGCCAGCTTCAGCGTGTTCGCGGTCAACAAGGGCTTCGAACAGATGCGCGTTTGCGC
GGCCTACGGGCGCAGCAATCTCAAGGTAGTGGGCACGCACAGCGGGATTTCGATCGGCGAAGACGGGCCTTCGCAGATGA
GCGTGGAAGAGATCGCGCTGGCGTGCTCGCTGGCGGGATTCGTGGTAATCGCTCCGGCCGATGAGACGGCGACGAAGGCG
CTGGTGCGGGCGGCGGCGGCATACGACGGGCCGGTTTTCCTGCGCACGGGACGTCCGAAGGCCCCGGTGATTTACGGCGC
GGCGCAGAAGTTCGAGATCGGAAAGTCGATCGAAGTGACTGCGGGAACGGACATCACGATCATCGCCAACGGACTGCTGG
TGGCGCAGGCGATGCTGGCAGCGGATGCGCTCGAAGGCGAGGGCATCTCGGTGCGGGTGATCGATATGCACACGGTGAAG
CCGCTGGATCGCGATGCGATCGCGCGGGCGGCGGCGGAGACAGGCGCCATCGTGGTGGCGGAGGAGCACCTGGTGGACGG
CGGACTTGGCGTGCGGGTGGCGCAGGTCACGGCGGAGACGAACCCGTGCGTGATGGAGTTCGTGGGGATTCACGACCGCT
ACGCGGAATCGGGGCAGCCGGAGGAGTTGCTGGAGAAATACCACCTGGTGGCTCCGGACATCGCCGACGCGGCACGCAAA
GCGCTATCGCGTAAGCGGTAA

Upstream 100 bases:

>100_bases
TGAAAGGCAAAGGCGTGTCCTTCATGGAAAACAATCCGAAGTATCACGGCATGGCGCCGACCAAGGATGAGCGCGAACTG
GCGCTTCAGGAGCTGAACTA

Downstream 100 bases:

>100_bases
TCTGTAGAGATGCCCGACGCGCAAAGCCAGTCTGAAGAAAATCTGGCGGAACTATTTCTGGAGCAGACTCCTGCCTGCCA
GTGGATGGTTTCAGCGTCGG

Product: transketolase subunit B

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MATETKTAKSKFEIKPGAATREAFGRTLVELGRENKDVVVVDADLSKSTMTTYFAKEFPDRFFSCGIAESNMVGVGAGLA
MAGKIPFVASFSVFAVNKGFEQMRVCAAYGRSNLKVVGTHSGISIGEDGPSQMSVEEIALACSLAGFVVIAPADETATKA
LVRAAAAYDGPVFLRTGRPKAPVIYGAAQKFEIGKSIEVTAGTDITIIANGLLVAQAMLAADALEGEGISVRVIDMHTVK
PLDRDAIARAAAETGAIVVAEEHLVDGGLGVRVAQVTAETNPCVMEFVGIHDRYAESGQPEELLEKYHLVAPDIADAARK
ALSRKR

Sequences:

>Translated_326_residues
MATETKTAKSKFEIKPGAATREAFGRTLVELGRENKDVVVVDADLSKSTMTTYFAKEFPDRFFSCGIAESNMVGVGAGLA
MAGKIPFVASFSVFAVNKGFEQMRVCAAYGRSNLKVVGTHSGISIGEDGPSQMSVEEIALACSLAGFVVIAPADETATKA
LVRAAAAYDGPVFLRTGRPKAPVIYGAAQKFEIGKSIEVTAGTDITIIANGLLVAQAMLAADALEGEGISVRVIDMHTVK
PLDRDAIARAAAETGAIVVAEEHLVDGGLGVRVAQVTAETNPCVMEFVGIHDRYAESGQPEELLEKYHLVAPDIADAARK
ALSRKR
>Mature_325_residues
ATETKTAKSKFEIKPGAATREAFGRTLVELGRENKDVVVVDADLSKSTMTTYFAKEFPDRFFSCGIAESNMVGVGAGLAM
AGKIPFVASFSVFAVNKGFEQMRVCAAYGRSNLKVVGTHSGISIGEDGPSQMSVEEIALACSLAGFVVIAPADETATKAL
VRAAAAYDGPVFLRTGRPKAPVIYGAAQKFEIGKSIEVTAGTDITIIANGLLVAQAMLAADALEGEGISVRVIDMHTVKP
LDRDAIARAAAETGAIVVAEEHLVDGGLGVRVAQVTAETNPCVMEFVGIHDRYAESGQPEELLEKYHLVAPDIADAARKA
LSRKR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=317, Percent_Identity=36.2776025236593, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4507521, Length=317, Percent_Identity=36.2776025236593, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI225637463, Length=320, Percent_Identity=36.25, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI225637459, Length=320, Percent_Identity=36.25, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI225637461, Length=320, Percent_Identity=36.25, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI133778974, Length=316, Percent_Identity=36.0759493670886, Blast_Score=181, Evalue=6e-46,
Organism=Escherichia coli, GI1786622, Length=283, Percent_Identity=28.6219081272085, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788808, Length=326, Percent_Identity=28.2208588957055, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539652, Length=319, Percent_Identity=36.0501567398119, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI45551847, Length=315, Percent_Identity=35.2380952380952, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI45550715, Length=315, Percent_Identity=35.2380952380952, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24645119, Length=315, Percent_Identity=35.2380952380952, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24666278, Length=312, Percent_Identity=33.0128205128205, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34353; Mature: 34222

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATETKTAKSKFEIKPGAATREAFGRTLVELGRENKDVVVVDADLSKSTMTTYFAKEFPD
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHH
RFFSCGIAESNMVGVGAGLAMAGKIPFVASFSVFAVNKGFEQMRVCAAYGRSNLKVVGTH
HHHCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEC
SGISIGEDGPSQMSVEEIALACSLAGFVVIAPADETATKALVRAAAAYDGPVFLRTGRPK
CCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCC
APVIYGAAQKFEIGKSIEVTAGTDITIIANGLLVAQAMLAADALEGEGISVRVIDMHTVK
CCEEECCCCCEECCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
PLDRDAIARAAAETGAIVVAEEHLVDGGLGVRVAQVTAETNPCVMEFVGIHDRYAESGQP
CCCHHHHHHHHHHCCEEEEEECCEECCCCCEEEEEEEECCCCEEEEEECCHHHHHCCCCH
EELLEKYHLVAPDIADAARKALSRKR
HHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATETKTAKSKFEIKPGAATREAFGRTLVELGRENKDVVVVDADLSKSTMTTYFAKEFPD
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHH
RFFSCGIAESNMVGVGAGLAMAGKIPFVASFSVFAVNKGFEQMRVCAAYGRSNLKVVGTH
HHHCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEC
SGISIGEDGPSQMSVEEIALACSLAGFVVIAPADETATKALVRAAAAYDGPVFLRTGRPK
CCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCC
APVIYGAAQKFEIGKSIEVTAGTDITIIANGLLVAQAMLAADALEGEGISVRVIDMHTVK
CCEEECCCCCEECCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
PLDRDAIARAAAETGAIVVAEEHLVDGGLGVRVAQVTAETNPCVMEFVGIHDRYAESGQP
CCCHHHHHHHHHHCCEEEEEECCEECCCCCEEEEEEEECCCCEEEEEECCHHHHHCCCCH
EELLEKYHLVAPDIADAARKALSRKR
HHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]