Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 116621568

GI number: 116621568

Start: 3112492

End: 3113169

Strand: Reverse

Name: degU [H]

Synonym: Acid_2450

Alternate gene names: 116621568

Gene position: 3113169-3112492 (Counterclockwise)

Preceding gene: 116621569

Following gene: 116621567

Centisome position: 31.24

GC content: 59.73

Gene sequence:

>678_bases
ATGCCGTTCGACATTGTTCTTGTCGATGATCACAAGCTGGTTCGGGATGGAGTGCGAATGATCCTCGAGAGGGGATCGGA
ATTCCTGGTGGTGGGCGAGGCAGAGAACGGCGCGGACGCCGTGCAGCTCTGCAAGAAATCGTCGCCGGATATCGTCTTAA
TGGATATCGGGCTGCCGGGAATGAACGGGATCGAGGCCACCACGGAATTACTGCGCCACTGCCCGAGCGTCAAAGTCATC
ATTCTTTCGATGTACGACGATGAGAACTCGGTGGTGAGCGCGATTCGGAGCGGGGCGCGGGCATTCGTGCTGAAGAAGGC
GTCCTCGAACGAATTGCTGGATGCGCTGCGCACGGTAGCGCGGGGCGGGAGCTATTTGAGTTCGCAGGTATCGGACCGGC
TGCTGCAGCGGATTCAACGGGGCGACCTGGAGACGCACGATCGGAGCCCGCTGGAATCGCTATCGCCGCGCGAACTGCAG
GTGCTGCGGCTGGTGGCAGAGGGTAAGACCAGCAAGGATATCGCGGTGCTGCTGGACCTCGGGCTGCAGACGGTGCGCAG
CTATCGGAAGACGATGATGAAGAAACTCGGCGTGAACAATGTCGCCGGGCTAACGCAGCTTGCGCTTGCCGCAGGCATTA
CTCACTGGAATAAACCCGATGCAAACACCATGGGGTGA

Upstream 100 bases:

>100_bases
ATTACGCAGCGGAGGCGGGCCTGGAACTTTCGATCACGAGTACGCGGGAATTTGGAACTACGGTGCGGGCCGCGACGCCG
GAAGCCGCCGAGAGATAAAT

Downstream 100 bases:

>100_bases
AATTGCCGTGGCCGACGCGCACGTGCATTTTTTCTCTCGAAACTTCTTTGCCACGCTGGCCGCGCAATGCGGAAAAACCG
CGGAGGAGGTGGCGACCGCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MPFDIVLVDDHKLVRDGVRMILERGSEFLVVGEAENGADAVQLCKKSSPDIVLMDIGLPGMNGIEATTELLRHCPSVKVI
ILSMYDDENSVVSAIRSGARAFVLKKASSNELLDALRTVARGGSYLSSQVSDRLLQRIQRGDLETHDRSPLESLSPRELQ
VLRLVAEGKTSKDIAVLLDLGLQTVRSYRKTMMKKLGVNNVAGLTQLALAAGITHWNKPDANTMG

Sequences:

>Translated_225_residues
MPFDIVLVDDHKLVRDGVRMILERGSEFLVVGEAENGADAVQLCKKSSPDIVLMDIGLPGMNGIEATTELLRHCPSVKVI
ILSMYDDENSVVSAIRSGARAFVLKKASSNELLDALRTVARGGSYLSSQVSDRLLQRIQRGDLETHDRSPLESLSPRELQ
VLRLVAEGKTSKDIAVLLDLGLQTVRSYRKTMMKKLGVNNVAGLTQLALAAGITHWNKPDANTMG
>Mature_224_residues
PFDIVLVDDHKLVRDGVRMILERGSEFLVVGEAENGADAVQLCKKSSPDIVLMDIGLPGMNGIEATTELLRHCPSVKVII
LSMYDDENSVVSAIRSGARAFVLKKASSNELLDALRTVARGGSYLSSQVSDRLLQRIQRGDLETHDRSPLESLSPRELQV
LRLVAEGKTSKDIAVLLDLGLQTVRSYRKTMMKKLGVNNVAGLTQLALAAGITHWNKPDANTMG

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=214, Percent_Identity=36.9158878504673, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=35.7142857142857, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787473, Length=187, Percent_Identity=34.7593582887701, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=32.6530612244898, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1788546, Length=209, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=30.5418719211823, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=26.5700483091787, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=36.6071428571429, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24536; Mature: 24405

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFDIVLVDDHKLVRDGVRMILERGSEFLVVGEAENGADAVQLCKKSSPDIVLMDIGLPG
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCC
MNGIEATTELLRHCPSVKVIILSMYDDENSVVSAIRSGARAFVLKKASSNELLDALRTVA
CCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RGGSYLSSQVSDRLLQRIQRGDLETHDRSPLESLSPRELQVLRLVAEGKTSKDIAVLLDL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
GLQTVRSYRKTMMKKLGVNNVAGLTQLALAAGITHWNKPDANTMG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PFDIVLVDDHKLVRDGVRMILERGSEFLVVGEAENGADAVQLCKKSSPDIVLMDIGLPG
CEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCC
MNGIEATTELLRHCPSVKVIILSMYDDENSVVSAIRSGARAFVLKKASSNELLDALRTVA
CCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
RGGSYLSSQVSDRLLQRIQRGDLETHDRSPLESLSPRELQVLRLVAEGKTSKDIAVLLDL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
GLQTVRSYRKTMMKKLGVNNVAGLTQLALAAGITHWNKPDANTMG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]