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The map label for this gene is ppiA [C]

Identifier: 116621514

GI number: 116621514

Start: 3053937

End: 3054599

Strand: Reverse

Name: ppiA [C]

Synonym: Acid_2396

Alternate gene names: 116621514

Gene position: 3054599-3053937 (Counterclockwise)

Preceding gene: 116621516

Following gene: 116621511

Centisome position: 30.65

GC content: 58.52

Gene sequence:

>663_bases
ATGCCATACTGGGTGACGATGCGGAGAATCTGCTGGCTTGCCCTGAGCGCGGCCGCCTGCCTGGCGCTCACCGGTTGTTC
GTCGCCCGACGAAGCGAAGAAATCCGAACCGCCAAAAGCGGCGCTGCCGGAAAAGCCGCCGGATGTTTTTCAGGCGGCCT
TCGATACTTCCAAGGGGCCCGTAGTGGTGGAGATTCACCGCGGCTGGGCGCCGGTCGGAGTCGATCACTTCTACTCCCTC
GCCAAGACCGGATACTTCGATGGCAATCGTTTTTTCCGCGTGACGCGCGCCTACGCGCAGTTCGGCATCAACGGAAATCC
GCAGACCACTTCGCTGTGGTCTACGGCCTATCTGCCGGACGACCCCGTCAAACAGAGCAACGTCAAAGGCACCCTGACTT
ACGCGCATCTGGGCGCGAACAACCGTACGACGCAACTGTTTTTCAACCGGAAGGACAACAAGGATCTGGATAAGTCCGGG
TTCGCACCCATCGGAAAAGTGACCAGCGGAATGGAGGTGCTGGAGAGCCTCTACGACTCCTACGGAGACATGCCGCCGCG
CGGCCAGGGGCCCGATCCGTCAAAAATCGAGCTACAGGGAAATTCATACCTGGAAAGTCATTTTCCGCGTCTCGACTCTA
TCAAGAAATTGACGATTCAGTGA

Upstream 100 bases:

>100_bases
CAAATGCGCTCCAGAATCGGGAACGCCAGGCTGTGGAAGTCCTCGTTCCAATAGCGGTTGTAGAACCAGGAAAAGTCGTC
GTAGAGAGCCAAATTTCAGC

Downstream 100 bases:

>100_bases
TATATTGAAAAAGACCCTGTCCCCGACGCGAAGGGGACCAGGAAGTTACCAATACAGGGTCAAATTGAAACGACGCGGCC
CGGCGGTGAAATACCGCCGG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: Peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase A; Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin Type

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPYWVTMRRICWLALSAAACLALTGCSSPDEAKKSEPPKAALPEKPPDVFQAAFDTSKGPVVVEIHRGWAPVGVDHFYSL
AKTGYFDGNRFFRVTRAYAQFGINGNPQTTSLWSTAYLPDDPVKQSNVKGTLTYAHLGANNRTTQLFFNRKDNKDLDKSG
FAPIGKVTSGMEVLESLYDSYGDMPPRGQGPDPSKIELQGNSYLESHFPRLDSIKKLTIQ

Sequences:

>Translated_220_residues
MPYWVTMRRICWLALSAAACLALTGCSSPDEAKKSEPPKAALPEKPPDVFQAAFDTSKGPVVVEIHRGWAPVGVDHFYSL
AKTGYFDGNRFFRVTRAYAQFGINGNPQTTSLWSTAYLPDDPVKQSNVKGTLTYAHLGANNRTTQLFFNRKDNKDLDKSG
FAPIGKVTSGMEVLESLYDSYGDMPPRGQGPDPSKIELQGNSYLESHFPRLDSIKKLTIQ
>Mature_219_residues
PYWVTMRRICWLALSAAACLALTGCSSPDEAKKSEPPKAALPEKPPDVFQAAFDTSKGPVVVEIHRGWAPVGVDHFYSLA
KTGYFDGNRFFRVTRAYAQFGINGNPQTTSLWSTAYLPDDPVKQSNVKGTLTYAHLGANNRTTQLFFNRKDNKDLDKSGF
APIGKVTSGMEVLESLYDSYGDMPPRGQGPDPSKIELQGNSYLESHFPRLDSIKKLTIQ

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 24326; Mature: 24194

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYWVTMRRICWLALSAAACLALTGCSSPDEAKKSEPPKAALPEKPPDVFQAAFDTSKGP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
VVVEIHRGWAPVGVDHFYSLAKTGYFDGNRFFRVTRAYAQFGINGNPQTTSLWSTAYLPD
EEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
DPVKQSNVKGTLTYAHLGANNRTTQLFFNRKDNKDLDKSGFAPIGKVTSGMEVLESLYDS
CCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YGDMPPRGQGPDPSKIELQGNSYLESHFPRLDSIKKLTIQ
HCCCCCCCCCCCCCEEEECCCCHHHHHCCCHHCHHEEECC
>Mature Secondary Structure 
PYWVTMRRICWLALSAAACLALTGCSSPDEAKKSEPPKAALPEKPPDVFQAAFDTSKGP
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
VVVEIHRGWAPVGVDHFYSLAKTGYFDGNRFFRVTRAYAQFGINGNPQTTSLWSTAYLPD
EEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
DPVKQSNVKGTLTYAHLGANNRTTQLFFNRKDNKDLDKSGFAPIGKVTSGMEVLESLYDS
CCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YGDMPPRGQGPDPSKIELQGNSYLESHFPRLDSIKKLTIQ
HCCCCCCCCCCCCCEEEECCCCHHHHHCCCHHCHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA