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The map label for this gene is gmk [H]

Identifier: 116621471

GI number: 116621471

Start: 2999326

End: 2999940

Strand: Reverse

Name: gmk [H]

Synonym: Acid_2353

Alternate gene names: 116621471

Gene position: 2999940-2999326 (Counterclockwise)

Preceding gene: 116621472

Following gene: 116621470

Centisome position: 30.1

GC content: 59.67

Gene sequence:

>615_bases
ATGCACACGACCACCGTCTACATCATTTCCGCCCCTTCCGGCTCCGGCAAATCGACGCTGGTCGCACGCCTGCTCGAGTC
CGTTCCGAACCTGATGTTCTCCGTGTCCTACACCACCCGCCCGCCCCGCGGCGTTGAGGTGGAGGGCGCGGAGTATCGCT
TTGTGACCCGCGAGGAATTCGAGGCGATGCTGGCCGGCGACGAGTTTCTCGAATGGGCTGAAGTATTTGGCAACTATTAC
GGCACCCACCGCTGCATTCTGGAGGAGGCCCGGAAGCAGGGGAAAGACCTGGTACTCGACATCGATGTCCAAGGTGCGAG
ACAATTGATAGAGAAGATTCCGCAGGCCGTAACCATTTTCGTCCTGGCCCCTTCGCGGCAGGTCCTCGAACAGAGGCTGC
GTTCGCGAGGCGAAGACCGCGAAGAAGTGATCAAGCGGCGGCTCAGGGCGGCGGCGGAAGAGATCCGGAATTACGAGGCT
TACGATTACGTTTTGATTAACCGGGAGCTGTCCGAAGCCGAGGCAACCTTGTGCGGCATTATCCGCGCCGAACGCGCGCG
GCGGACCCGAATCGAAGATCAGCTCCGGCCCATATTAGACACTTTTCAAAGTTGA

Upstream 100 bases:

>100_bases
CGGCGATCTCGGCCTCACTATCACCGACCTTGCTCTCAGCGCCAAGTCGGAAATCGATAAGATCAGGGAGCAGAGCCTCA
ACCTCGAGTAGCGATTCTCC

Downstream 100 bases:

>100_bases
GGTATCGAAGTAATGGCTGACAAAGCACCCCGCAATAACGCGCACTGCACCCTGCCCGACGATCCGGAGCAGAGCACTTA
CCGCTTCATCATCGTGGCCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MHTTTVYIISAPSGSGKSTLVARLLESVPNLMFSVSYTTRPPRGVEVEGAEYRFVTREEFEAMLAGDEFLEWAEVFGNYY
GTHRCILEEARKQGKDLVLDIDVQGARQLIEKIPQAVTIFVLAPSRQVLEQRLRSRGEDREEVIKRRLRAAAEEIRNYEA
YDYVLINRELSEAEATLCGIIRAERARRTRIEDQLRPILDTFQS

Sequences:

>Translated_204_residues
MHTTTVYIISAPSGSGKSTLVARLLESVPNLMFSVSYTTRPPRGVEVEGAEYRFVTREEFEAMLAGDEFLEWAEVFGNYY
GTHRCILEEARKQGKDLVLDIDVQGARQLIEKIPQAVTIFVLAPSRQVLEQRLRSRGEDREEVIKRRLRAAAEEIRNYEA
YDYVLINRELSEAEATLCGIIRAERARRTRIEDQLRPILDTFQS
>Mature_204_residues
MHTTTVYIISAPSGSGKSTLVARLLESVPNLMFSVSYTTRPPRGVEVEGAEYRFVTREEFEAMLAGDEFLEWAEVFGNYY
GTHRCILEEARKQGKDLVLDIDVQGARQLIEKIPQAVTIFVLAPSRQVLEQRLRSRGEDREEVIKRRLRAAAEEIRNYEA
YDYVLINRELSEAEATLCGIIRAERARRTRIEDQLRPILDTFQS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=40.4255319148936, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=40.4255319148936, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=40.4255319148936, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4505237, Length=171, Percent_Identity=32.1637426900585, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118255, Length=171, Percent_Identity=32.1637426900585, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=171, Percent_Identity=32.1637426900585, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118263, Length=171, Percent_Identity=32.1637426900585, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI21361598, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=50, Blast_Score=189, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=37.7659574468085, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=37.7659574468085, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71988048, Length=124, Percent_Identity=29.8387096774194, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988041, Length=124, Percent_Identity=29.8387096774194, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.1693989071038, Blast_Score=148, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21356141, Length=149, Percent_Identity=45.6375838926174, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI85816281, Length=122, Percent_Identity=36.0655737704918, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85816106, Length=122, Percent_Identity=36.0655737704918, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551002, Length=122, Percent_Identity=36.0655737704918, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23413; Mature: 23413

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTTTVYIISAPSGSGKSTLVARLLESVPNLMFSVSYTTRPPRGVEVEGAEYRFVTREEF
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCEECCCCEEEECHHHH
EAMLAGDEFLEWAEVFGNYYGTHRCILEEARKQGKDLVLDIDVQGARQLIEKIPQAVTIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCHHHEEEE
VLAPSRQVLEQRLRSRGEDREEVIKRRLRAAAEEIRNYEAYDYVLINRELSEAEATLCGI
EECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEEECHHHHHHHHHHHH
IRAERARRTRIEDQLRPILDTFQS
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTTTVYIISAPSGSGKSTLVARLLESVPNLMFSVSYTTRPPRGVEVEGAEYRFVTREEF
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCEECCCCEEEECHHHH
EAMLAGDEFLEWAEVFGNYYGTHRCILEEARKQGKDLVLDIDVQGARQLIEKIPQAVTIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCHHHEEEE
VLAPSRQVLEQRLRSRGEDREEVIKRRLRAAAEEIRNYEAYDYVLINRELSEAEATLCGI
EECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEEECHHHHHHHHHHHH
IRAERARRTRIEDQLRPILDTFQS
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA