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The map label for this gene is coaBC [H]

Identifier: 116621469

GI number: 116621469

Start: 2997788

End: 2998987

Strand: Reverse

Name: coaBC [H]

Synonym: Acid_2351

Alternate gene names: 116621469

Gene position: 2998987-2997788 (Counterclockwise)

Preceding gene: 116621470

Following gene: 116621468

Centisome position: 30.09

GC content: 66.75

Gene sequence:

>1200_bases
ATGAAAGTCCTCCTCGGAGTCGGCGGCGGCATCGCGGCGTATAAATCCGCGGAGCTCGCCCGCCTCCTGATGCAGCAGGG
CCATCACGTGCAAGTCGTCATGACCCACGCGGCCGAGGAATTCGTCCGCCCCCTCACCTTCGCCGCCCTCACCGGCCGTA
AAGTCCTCACCAACCTCTTCGCCATCGAATCCGCGATCGAGCATATCTCGGTCGCCGAGGAACACGAAATCCTCGTCGTC
GCCCCCGCTACCGCAGACCTCATGGCGAGGCTCGCCCACGGCGCCGCCGACGATTTCCTCACCACCCTCTACCTCGCCTT
CACCGGCCCCGTGGTCATCGCGCCCGCCATGAACGTCAACATGTGGCAGCACCCCGCCACGCAGGCCAACCTGGAGACCC
TCGTCAAGCGCGGCCACATCATCGTAGAACCCGGCAGCGGCTATCTGGCCTGCGGCATGACCGGACCCGGGCGCCTCGCC
GATCCCGAAGCCATCGCGGCCGCCATCGAGCGCAGCGCCAACCAGCGCCGCGATCTGGAAGGCGAAACCGTCCTGATCAC
CGCCGGCCCCACCCAGGAGCCGCTCGACCCCGTCCGCTACATTTCCAACCGCTCCAGCGGCAAGATGGGCTACGCGCTCG
CCGAAGCTGCCGCCGCACGCGGCGCCCGCGTCATCCTGGTCTCCGGCCCGGTTCACCTTGCGCCACCGCGCGGCGTCGAA
GTCATCCACGTGCGCACCGCGGTCGAAATGCGCGACCAGGTGATGGCCAACCTCCAGCTCGCCGGTATCGTCATCAAGGC
CGCCGCCGTCGCCGATTTCCACCTCTCCAAGGTCCCCGACCAGAAGGTCAAGAAGACCGCTGCTCGCATCTCGCTCGAGC
TCGACCCGACTCCGGATATCCTCGCCGAGCTCGGCCGTAAAAAGGGTAACTACCTGCTGGTCGGCTTCGCCGCCGAGACC
CAGAACCTGCAGCAGGAAGCGCGCCGCAAGCTCGAAACCAAGAACTGCGACATGGTGGTCGGCAACCTGGTCGGCGGCAG
CGAACTCGGCTTCGAATCCGACGAAAACGAGGTCGTGCTCACCCGCCGCCAGGGCGAACCGATCCAGATTCCCCGCGCCT
CCAAGCGCCACATCGCGGACCGCATCTTCGACGAAATCCTGGCCCTGCGCCTGACCCTACACGCCACCGATGGACGCTGA

Upstream 100 bases:

>100_bases
ACCTGGAACCGCCCCCCGAACCCGCAGCGTAACGCGATCGCTCCCTGACGGATCGCCCACAGAACCGCGACCGTTGGGGA
ACGTCCTCTTCTCCTAGCCT

Downstream 100 bases:

>100_bases
CTCTCTCCGCCAATATCTCGAGTTCTACCAGGATCTGCACATACAGACCCTCTACCGCCGCACCGCGCCGCCCGTAGCCG
CGGTGACGCCGGCACCCATC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKVLLGVGGGIAAYKSAELARLLMQQGHHVQVVMTHAAEEFVRPLTFAALTGRKVLTNLFAIESAIEHISVAEEHEILVV
APATADLMARLAHGAADDFLTTLYLAFTGPVVIAPAMNVNMWQHPATQANLETLVKRGHIIVEPGSGYLACGMTGPGRLA
DPEAIAAAIERSANQRRDLEGETVLITAGPTQEPLDPVRYISNRSSGKMGYALAEAAAARGARVILVSGPVHLAPPRGVE
VIHVRTAVEMRDQVMANLQLAGIVIKAAAVADFHLSKVPDQKVKKTAARISLELDPTPDILAELGRKKGNYLLVGFAAET
QNLQQEARRKLETKNCDMVVGNLVGGSELGFESDENEVVLTRRQGEPIQIPRASKRHIADRIFDEILALRLTLHATDGR

Sequences:

>Translated_399_residues
MKVLLGVGGGIAAYKSAELARLLMQQGHHVQVVMTHAAEEFVRPLTFAALTGRKVLTNLFAIESAIEHISVAEEHEILVV
APATADLMARLAHGAADDFLTTLYLAFTGPVVIAPAMNVNMWQHPATQANLETLVKRGHIIVEPGSGYLACGMTGPGRLA
DPEAIAAAIERSANQRRDLEGETVLITAGPTQEPLDPVRYISNRSSGKMGYALAEAAAARGARVILVSGPVHLAPPRGVE
VIHVRTAVEMRDQVMANLQLAGIVIKAAAVADFHLSKVPDQKVKKTAARISLELDPTPDILAELGRKKGNYLLVGFAAET
QNLQQEARRKLETKNCDMVVGNLVGGSELGFESDENEVVLTRRQGEPIQIPRASKRHIADRIFDEILALRLTLHATDGR
>Mature_399_residues
MKVLLGVGGGIAAYKSAELARLLMQQGHHVQVVMTHAAEEFVRPLTFAALTGRKVLTNLFAIESAIEHISVAEEHEILVV
APATADLMARLAHGAADDFLTTLYLAFTGPVVIAPAMNVNMWQHPATQANLETLVKRGHIIVEPGSGYLACGMTGPGRLA
DPEAIAAAIERSANQRRDLEGETVLITAGPTQEPLDPVRYISNRSSGKMGYALAEAAAARGARVILVSGPVHLAPPRGVE
VIHVRTAVEMRDQVMANLQLAGIVIKAAAVADFHLSKVPDQKVKKTAARISLELDPTPDILAELGRKKGNYLLVGFAAET
QNLQQEARRKLETKNCDMVVGNLVGGSELGFESDENEVVLTRRQGEPIQIPRASKRHIADRIFDEILALRLTLHATDGR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=164, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082301, Length=392, Percent_Identity=44.8979591836735, Blast_Score=290, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322762, Length=199, Percent_Identity=26.6331658291457, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24657262, Length=177, Percent_Identity=27.683615819209, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42933; Mature: 42933

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLGVGGGIAAYKSAELARLLMQQGHHVQVVMTHAAEEFVRPLTFAALTGRKVLTNLF
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AIESAIEHISVAEEHEILVVAPATADLMARLAHGAADDFLTTLYLAFTGPVVIAPAMNVN
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCC
MWQHPATQANLETLVKRGHIIVEPGSGYLACGMTGPGRLADPEAIAAAIERSANQRRDLE
CCCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GETVLITAGPTQEPLDPVRYISNRSSGKMGYALAEAAAARGARVILVSGPVHLAPPRGVE
CCEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCEEECCCCCCE
VIHVRTAVEMRDQVMANLQLAGIVIKAAAVADFHLSKVPDQKVKKTAARISLELDPTPDI
EEEEHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHCCCHHHHHHHHHEEEEEECCCHHH
LAELGRKKGNYLLVGFAAETQNLQQEARRKLETKNCDMVVGNLVGGSELGFESDENEVVL
HHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEE
TRRQGEPIQIPRASKRHIADRIFDEILALRLTLHATDGR
EECCCCCEECCCCHHHHHHHHHHHHHHHHEEEEEECCCC
>Mature Secondary Structure
MKVLLGVGGGIAAYKSAELARLLMQQGHHVQVVMTHAAEEFVRPLTFAALTGRKVLTNLF
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AIESAIEHISVAEEHEILVVAPATADLMARLAHGAADDFLTTLYLAFTGPVVIAPAMNVN
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCC
MWQHPATQANLETLVKRGHIIVEPGSGYLACGMTGPGRLADPEAIAAAIERSANQRRDLE
CCCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GETVLITAGPTQEPLDPVRYISNRSSGKMGYALAEAAAARGARVILVSGPVHLAPPRGVE
CCEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCEEECCCCCCE
VIHVRTAVEMRDQVMANLQLAGIVIKAAAVADFHLSKVPDQKVKKTAARISLELDPTPDI
EEEEHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHCCCHHHHHHHHHEEEEEECCCHHH
LAELGRKKGNYLLVGFAAETQNLQQEARRKLETKNCDMVVGNLVGGSELGFESDENEVVL
HHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEE
TRRQGEPIQIPRASKRHIADRIFDEILALRLTLHATDGR
EECCCCCEECCCCHHHHHHHHHHHHHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]