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The map label for this gene is exuT [H]

Identifier: 116621467

GI number: 116621467

Start: 2995802

End: 2997043

Strand: Direct

Name: exuT [H]

Synonym: Acid_2349

Alternate gene names: 116621467

Gene position: 2995802-2997043 (Clockwise)

Preceding gene: 116621465

Following gene: 116621477

Centisome position: 30.06

GC content: 68.04

Gene sequence:

>1242_bases
ATGCGTGAAGCCAAAGGCGGCGCGGTGGCCCGCTGGACTCCGGCGGGGGCGATGATGGCGGTGTCGCTGATCAGCTATAT
CGACCGCAATACGCTGGCTCTACTGGCGCCGACGATACTCCACGATACGGGGCTGAGCGTGCAGCAGTACGGGTTCATTG
TTTCGGCATTCTCGATTGCCTACTCGGTGGCGAACCCGATCTGGGGTCGAATTCTGGATCGCGCGGGGCTGCGGCGCGGA
ATGACGGTGGCGGTCTCGTGCTGGACGGTGGCTTCTGTGGCGCATGCCTTCGCGGGCGGTTTGTGGAGCTTCGCGGCGGC
GCGCGCGGCGCTTGGGTTCGGCGAGGGCGCGACCTTTCCGGGCGGGCTGCGCACGGTGGTGCAGACTCTGCCCGAGGAGC
GTCGCGGACGCGGGCTCGCGGTGGCGTATAGCGGCGGATCGCTGGGGGCGGTAATCACTCCGCTGGTGGTGACGCCGATC
TTTCTGTGGTGGGGTTGGCGCGGCGCGTTCTGGTTCACGGGACTGGTGGGGCTGGGATGGCTCGCGCTGTGGGCGGCGGT
GAGCCGCCGCCCGGATATCCGGCGGAAACGCGCGGCGGGCGCGAGCCTGACGCCGGGGCCGCGCCTGCGGGATCGACCGC
TGTGGGCGTTCTTATGCGCGTATGGGTTGGGTGCGCTGCCGCTGGGCTTCGTGCTATACAGCGCGTCGCTTTACCTGGCG
CAGCCGCTGGGATGCACGCAGAAATTCATCGGGCAGGTGCTGTGGATTCCGCCGCTCGGCTGGGAGGCCGGCTACTTCTT
CTGGGGCTGGTTGAGCGACCGGGCAGGTTCGGGGCGGGCCGCGCTGCGGCCGCTGATGATGTGGTGCGCGCTGCTCAACC
TGCCGTTCTTCGCGGTCCCGCTGGTGGGCAGCACGGCGGTGGTGCTGGCACTGATGTTTCTGGCGATGTTCGTGGCGTCG
GGTTTTGTGGTGGTGTCGGTGGCGTACGCGACCGGAGTTTACGGCGGGGACCACGCGGGGCTGATCGCCGGGGCGGGCGC
GGGGTCATGGAGCGCAATGGTGGCGCTGGTGATGCCGTACTTCGGGCGGCTGTTCGATTTGCACGCGTACCCGACCGCGT
TTTGGATCGCGGCGTCGATTCCGGTATTCGGATTCTTCGGCTGGTTGGCGTGGAGCAGGGAAGAGAGTGTAGATCGCTCC
CTGACCGTCGCGGTTCGCGGTGGGGGCGACACAAGGGACTAG

Upstream 100 bases:

>100_bases
TCACGAGTTGTTTGGAGATGTAGGTTACGAACTCTCTGGCAAGAAGCATGCTGTGTGCGCGAAAGCGTAGTTTATCACGT
ATAGGGTATGATCTCAGCTT

Downstream 100 bases:

>100_bases
GGCTCGGGCTGTGAAGGTGATCAGTCGTAGACGAAGTGGAGGACTTTCTTGAGGTCTTCCCAGGCTTCGCGCTTGGCGTT
TTCGTTGAACGGGCGCAGCA

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MREAKGGAVARWTPAGAMMAVSLISYIDRNTLALLAPTILHDTGLSVQQYGFIVSAFSIAYSVANPIWGRILDRAGLRRG
MTVAVSCWTVASVAHAFAGGLWSFAAARAALGFGEGATFPGGLRTVVQTLPEERRGRGLAVAYSGGSLGAVITPLVVTPI
FLWWGWRGAFWFTGLVGLGWLALWAAVSRRPDIRRKRAAGASLTPGPRLRDRPLWAFLCAYGLGALPLGFVLYSASLYLA
QPLGCTQKFIGQVLWIPPLGWEAGYFFWGWLSDRAGSGRAALRPLMMWCALLNLPFFAVPLVGSTAVVLALMFLAMFVAS
GFVVVSVAYATGVYGGDHAGLIAGAGAGSWSAMVALVMPYFGRLFDLHAYPTAFWIAASIPVFGFFGWLAWSREESVDRS
LTVAVRGGGDTRD

Sequences:

>Translated_413_residues
MREAKGGAVARWTPAGAMMAVSLISYIDRNTLALLAPTILHDTGLSVQQYGFIVSAFSIAYSVANPIWGRILDRAGLRRG
MTVAVSCWTVASVAHAFAGGLWSFAAARAALGFGEGATFPGGLRTVVQTLPEERRGRGLAVAYSGGSLGAVITPLVVTPI
FLWWGWRGAFWFTGLVGLGWLALWAAVSRRPDIRRKRAAGASLTPGPRLRDRPLWAFLCAYGLGALPLGFVLYSASLYLA
QPLGCTQKFIGQVLWIPPLGWEAGYFFWGWLSDRAGSGRAALRPLMMWCALLNLPFFAVPLVGSTAVVLALMFLAMFVAS
GFVVVSVAYATGVYGGDHAGLIAGAGAGSWSAMVALVMPYFGRLFDLHAYPTAFWIAASIPVFGFFGWLAWSREESVDRS
LTVAVRGGGDTRD
>Mature_413_residues
MREAKGGAVARWTPAGAMMAVSLISYIDRNTLALLAPTILHDTGLSVQQYGFIVSAFSIAYSVANPIWGRILDRAGLRRG
MTVAVSCWTVASVAHAFAGGLWSFAAARAALGFGEGATFPGGLRTVVQTLPEERRGRGLAVAYSGGSLGAVITPLVVTPI
FLWWGWRGAFWFTGLVGLGWLALWAAVSRRPDIRRKRAAGASLTPGPRLRDRPLWAFLCAYGLGALPLGFVLYSASLYLA
QPLGCTQKFIGQVLWIPPLGWEAGYFFWGWLSDRAGSGRAALRPLMMWCALLNLPFFAVPLVGSTAVVLALMFLAMFVAS
GFVVVSVAYATGVYGGDHAGLIAGAGAGSWSAMVALVMPYFGRLFDLHAYPTAFWIAASIPVFGFFGWLAWSREESVDRS
LTVAVRGGGDTRD

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Escherichia coli, GI2367193, Length=289, Percent_Identity=27.3356401384083, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082320, Length=335, Percent_Identity=27.7611940298507, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI2367379, Length=280, Percent_Identity=26.4285714285714, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789515, Length=357, Percent_Identity=25.7703081232493, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789152, Length=350, Percent_Identity=23.7142857142857, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44158; Mature: 44158

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure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HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]