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The map label for this gene is clpB [H]

Identifier: 116621451

GI number: 116621451

Start: 2976043

End: 2978694

Strand: Direct

Name: clpB [H]

Synonym: Acid_2333

Alternate gene names: 116621451

Gene position: 2976043-2978694 (Clockwise)

Preceding gene: 116621450

Following gene: 116621452

Centisome position: 29.86

GC content: 61.54

Gene sequence:

>2652_bases
ATGTTTCGATTGGACAAACTGACTCAAAAGGCGCAGGATGCCCTGCAGCAAACGCAGGCCCTGGCCGAGAAAAATGACAG
CCAGATCATGTTCCCACTGCACCTGTTGATCGCCCTGGCTGAAGAACAGGAAGGCATCGTGCGCCCCGTGCTCGAAAAGT
GCGGCGTGCAGCCCGAAGCCGTCATCACCGAGGCGCAGCACCTCGCGGTATCCCTGCCGAAGACCAACGGCATGCAGCCT
GGCATGTACCTTGCCCCGCAGCTCAACAAAATCATGGAGCGCGCCTTCGATGAGGCCATCCGCTTCAAAGACGAATTTGT
CTCTACCGAGCACCTGCTGCTCTCGATCGCCGAGGAGACCAGCGATCCGGCCGGACAGCTTCTGAAACAGGCCGGCGCCA
GCCATGATGCGATTTTGAAGGCCCTGGTCTCCGTCCGCGGCACGCAGCGCATCACGGACCAGAATCCGGAGACCAAATAC
CAGGCGTTGGAGCGCTATGCGCACGACCTGACCGAATCCGCGCGTCTCGGGAAGCTCGATCCCGTGATCGGGCGCGACGA
TGAGATTCGCCGCGTCATGCAGGTTCTCAGCCGCCGCACCAAGAACAACCCGGTGCTGATCGGCGAACCCGGCGTCGGCA
AGACCGCCATCGTCGAAGGACTTGCGCAGCGGATCATCCGCGGCGACGTGCCGGATCAGCTCAAGAACAAGAAGCTGGTC
GCGATCGATCTCGGCAGCATGATCGCCGGCACCAAGTTCCGCGGCGAATTCGAAGATCGCCTTAAAGCCGTGGTCAAGGA
AATCATCGATTCCAACGGCGAGATCATCTGCTTCATCGACGAGCTGCACACGCTCGTGGGCGCCGGCTCCGCAGAAGGCG
CGATCGATGCCGCCAACCTGCTGAAACCGGCGCTGGCTCGCGGCGAGCTGCGCTGCATCGGCGCTACTACGCTGAACGAG
TACAAGAAGCACGTCGAGAAGGACGCCGCCCTGGCGCGCCGCTTCCAGACCGTCATGGTCGGCGAGCCGAGCGTGGATGA
TACGATTGCGATTCTGCGCGGGCTCAAGGAGAAGTTCGAGATCCACCATGGCGTGCGCATCAAGGACTCGGCAATCCTCG
CGGCCGCCGTGCTTTCGCAGCGCTACATTGCCGACCGCTTCCTGCCCGATAAGGCCATCGATCTGATCGACGAGGCCGGC
AGCGCGCTGCGTCTCCAGATCGGCTCCATGCCGATCGAGATCGACAACCTGGAGCGCCGCATCTCGCATCTCGAGATCGA
GCGCCAGGCCTTGAGCAAGGAGCGCGATCACGCGTCCCACGACCGCCTGCGCCATGTCGAGAACGAACTGGAATCGCTGC
GTGGCGAAGCCGCCGGTTTGAAAGAGCGGTGGAGCCGCGAAAAAGGCGCGATCGATCGGGTCCGCACCCTCAAAGAGCAG
CAGGATTCCCTGCGGCAGGAAGAGGAAAAGGCCAGCCGCGCGGGCGATTGGGAGAAGGCTGCCCAGCTTCGCTACGGCCA
GCTCTCGCAGATCGAGAAGGACATTCAGGCCGCCGAGCAGGAGATGGAGTCCGTCAAATCGCACGCTCTTCTGAAGGAAG
AGATCGATGAAGACGATATCGCCGCCATCGTTGCCAAGTGGACCGGAATCCCCGTGACCCGCATGCTCGAAGGCGAAGTC
CAGAAGCTGGTTCAGATGCCCGACCGGCTCAAAGACCGGGTTATCGGCCAGGACGAAGCCGTCCGGCTGGTGGCCAACGC
CATCCTGCGCAATCGCGCCGGACTCGGCGATCCGCAGCGGCCGATCGGCAGCTTCATTTTCCTCGGGCCCACCGGCGTCG
GTAAAACCGAGCTGGTGCGGGCTCTCGCTCAATACCTGTTTGACGACAGCAAAGCCATGATCCGCGTCGATATGAGCGAG
TACATGGAGAAGCATGCCGTCGCCCGGATGGTTGGCTCGCCTCCCGGATACGTCGGCTACGATGAGGGCGGACAGCTCAC
CGAACAGGTGCGCCGCCGGCCTTATTCGGTGGTCCTTTTCGATGAAATCGAGAAGGCGCACCCCGATGTCTTCCACATGC
TCCTGCAGATACTCGACGACGGCCGCCTGACCGATGGCCAGGGCCGTACCGTGAGTTTCAAGAACACGGTCATCGTCATG
ACCAGCAACGTCGGCACCGGAATGGTCGAGCGCAATACCATCGGCTTCTCGGTGCATGCCAAGAACACTCGCAACGCGGA
CACTCAGAAGCGCCTGCTCGAAGCTCTGCGCGCCCAGTTCCGGCCCGAGTTCCTCAACCGCGTTGACGATATCATTGTCT
TTAACTCGCTGACTCGCGATCATCTCGCTCGCATCGTGGATATCCAGTTGGCCAACGTGGGCAAACTCTTGAAAGATCGC
AAGCTGAATATCGAAATCACTCCCGCGGCCAAAGACCGGATCATCTCCGAAGGTTACGATCCCGATTACGGCGCACGGCC
CATGCGTCGCGCCATACAGCGCCTCGTCCAGGACCCGCTCGCCCTCAAGGTGATCAGCGGCGAATTCGAGGAAGGTGACA
CCATCCTGGTGGACGCCGCTCCGGACGGAGCCGAACTCACGTTCGCAAAGCTGGTTCCGATAACGGAACCAGCGGTTCCC
ATCTCCAGGTAA

Upstream 100 bases:

>100_bases
GGGCGCTTCGCATCTATATAAGTACAGAATCGCGCCGAAACAGAGCGCGAGAAAGGGGGCAGGCGAAGAGCCTGCCCCGT
TGTTTCATTGGGGGACCCAT

Downstream 100 bases:

>100_bases
TTAACCAGGTGATCAACCAGGTGATTTATGAGTAAGAATGCTCTCAAGACTGCTGCACTTCTCGGCTTCCTGACCGCCCT
CCTGCTGGTGGGCGGTCAGG

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 883; Mature: 883

Protein sequence:

>883_residues
MFRLDKLTQKAQDALQQTQALAEKNDSQIMFPLHLLIALAEEQEGIVRPVLEKCGVQPEAVITEAQHLAVSLPKTNGMQP
GMYLAPQLNKIMERAFDEAIRFKDEFVSTEHLLLSIAEETSDPAGQLLKQAGASHDAILKALVSVRGTQRITDQNPETKY
QALERYAHDLTESARLGKLDPVIGRDDEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIIRGDVPDQLKNKKLV
AIDLGSMIAGTKFRGEFEDRLKAVVKEIIDSNGEIICFIDELHTLVGAGSAEGAIDAANLLKPALARGELRCIGATTLNE
YKKHVEKDAALARRFQTVMVGEPSVDDTIAILRGLKEKFEIHHGVRIKDSAILAAAVLSQRYIADRFLPDKAIDLIDEAG
SALRLQIGSMPIEIDNLERRISHLEIERQALSKERDHASHDRLRHVENELESLRGEAAGLKERWSREKGAIDRVRTLKEQ
QDSLRQEEEKASRAGDWEKAAQLRYGQLSQIEKDIQAAEQEMESVKSHALLKEEIDEDDIAAIVAKWTGIPVTRMLEGEV
QKLVQMPDRLKDRVIGQDEAVRLVANAILRNRAGLGDPQRPIGSFIFLGPTGVGKTELVRALAQYLFDDSKAMIRVDMSE
YMEKHAVARMVGSPPGYVGYDEGGQLTEQVRRRPYSVVLFDEIEKAHPDVFHMLLQILDDGRLTDGQGRTVSFKNTVIVM
TSNVGTGMVERNTIGFSVHAKNTRNADTQKRLLEALRAQFRPEFLNRVDDIIVFNSLTRDHLARIVDIQLANVGKLLKDR
KLNIEITPAAKDRIISEGYDPDYGARPMRRAIQRLVQDPLALKVISGEFEEGDTILVDAAPDGAELTFAKLVPITEPAVP
ISR

Sequences:

>Translated_883_residues
MFRLDKLTQKAQDALQQTQALAEKNDSQIMFPLHLLIALAEEQEGIVRPVLEKCGVQPEAVITEAQHLAVSLPKTNGMQP
GMYLAPQLNKIMERAFDEAIRFKDEFVSTEHLLLSIAEETSDPAGQLLKQAGASHDAILKALVSVRGTQRITDQNPETKY
QALERYAHDLTESARLGKLDPVIGRDDEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIIRGDVPDQLKNKKLV
AIDLGSMIAGTKFRGEFEDRLKAVVKEIIDSNGEIICFIDELHTLVGAGSAEGAIDAANLLKPALARGELRCIGATTLNE
YKKHVEKDAALARRFQTVMVGEPSVDDTIAILRGLKEKFEIHHGVRIKDSAILAAAVLSQRYIADRFLPDKAIDLIDEAG
SALRLQIGSMPIEIDNLERRISHLEIERQALSKERDHASHDRLRHVENELESLRGEAAGLKERWSREKGAIDRVRTLKEQ
QDSLRQEEEKASRAGDWEKAAQLRYGQLSQIEKDIQAAEQEMESVKSHALLKEEIDEDDIAAIVAKWTGIPVTRMLEGEV
QKLVQMPDRLKDRVIGQDEAVRLVANAILRNRAGLGDPQRPIGSFIFLGPTGVGKTELVRALAQYLFDDSKAMIRVDMSE
YMEKHAVARMVGSPPGYVGYDEGGQLTEQVRRRPYSVVLFDEIEKAHPDVFHMLLQILDDGRLTDGQGRTVSFKNTVIVM
TSNVGTGMVERNTIGFSVHAKNTRNADTQKRLLEALRAQFRPEFLNRVDDIIVFNSLTRDHLARIVDIQLANVGKLLKDR
KLNIEITPAAKDRIISEGYDPDYGARPMRRAIQRLVQDPLALKVISGEFEEGDTILVDAAPDGAELTFAKLVPITEPAVP
ISR
>Mature_883_residues
MFRLDKLTQKAQDALQQTQALAEKNDSQIMFPLHLLIALAEEQEGIVRPVLEKCGVQPEAVITEAQHLAVSLPKTNGMQP
GMYLAPQLNKIMERAFDEAIRFKDEFVSTEHLLLSIAEETSDPAGQLLKQAGASHDAILKALVSVRGTQRITDQNPETKY
QALERYAHDLTESARLGKLDPVIGRDDEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIIRGDVPDQLKNKKLV
AIDLGSMIAGTKFRGEFEDRLKAVVKEIIDSNGEIICFIDELHTLVGAGSAEGAIDAANLLKPALARGELRCIGATTLNE
YKKHVEKDAALARRFQTVMVGEPSVDDTIAILRGLKEKFEIHHGVRIKDSAILAAAVLSQRYIADRFLPDKAIDLIDEAG
SALRLQIGSMPIEIDNLERRISHLEIERQALSKERDHASHDRLRHVENELESLRGEAAGLKERWSREKGAIDRVRTLKEQ
QDSLRQEEEKASRAGDWEKAAQLRYGQLSQIEKDIQAAEQEMESVKSHALLKEEIDEDDIAAIVAKWTGIPVTRMLEGEV
QKLVQMPDRLKDRVIGQDEAVRLVANAILRNRAGLGDPQRPIGSFIFLGPTGVGKTELVRALAQYLFDDSKAMIRVDMSE
YMEKHAVARMVGSPPGYVGYDEGGQLTEQVRRRPYSVVLFDEIEKAHPDVFHMLLQILDDGRLTDGQGRTVSFKNTVIVM
TSNVGTGMVERNTIGFSVHAKNTRNADTQKRLLEALRAQFRPEFLNRVDDIIVFNSLTRDHLARIVDIQLANVGKLLKDR
KLNIEITPAAKDRIISEGYDPDYGARPMRRAIQRLVQDPLALKVISGEFEEGDTILVDAAPDGAELTFAKLVPITEPAVP
ISR

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=39.7993311036789, Blast_Score=208, Evalue=1e-53,
Organism=Escherichia coli, GI1788943, Length=861, Percent_Identity=52.1486643437863, Blast_Score=894, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=427, Percent_Identity=39.8126463700234, Blast_Score=282, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=705, Percent_Identity=51.6312056737589, Blast_Score=738, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=867, Percent_Identity=41.522491349481, Blast_Score=649, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 98362; Mature: 98362

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLDKLTQKAQDALQQTQALAEKNDSQIMFPLHLLIALAEEQEGIVRPVLEKCGVQPEA
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCHHH
VITEAQHLAVSLPKTNGMQPGMYLAPQLNKIMERAFDEAIRFKDEFVSTEHLLLSIAEET
HHHHHHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDPAGQLLKQAGASHDAILKALVSVRGTQRITDQNPETKYQALERYAHDLTESARLGKLD
CCHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
PVIGRDDEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIIRGDVPDQLKNKKLV
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
AIDLGSMIAGTKFRGEFEDRLKAVVKEIIDSNGEIICFIDELHTLVGAGSAEGAIDAANL
EEECCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHH
LKPALARGELRCIGATTLNEYKKHVEKDAALARRFQTVMVGEPSVDDTIAILRGLKEKFE
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHH
IHHGVRIKDSAILAAAVLSQRYIADRFLPDKAIDLIDEAGSALRLQIGSMPIEIDNLERR
HHCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHH
ISHLEIERQALSKERDHASHDRLRHVENELESLRGEAAGLKERWSREKGAIDRVRTLKEQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHH
QDSLRQEEEKASRAGDWEKAAQLRYGQLSQIEKDIQAAEQEMESVKSHALLKEEIDEDDI
HHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAIVAKWTGIPVTRMLEGEVQKLVQMPDRLKDRVIGQDEAVRLVANAILRNRAGLGDPQR
HHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
PIGSFIFLGPTGVGKTELVRALAQYLFDDSKAMIRVDMSEYMEKHAVARMVGSPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
DEGGQLTEQVRRRPYSVVLFDEIEKAHPDVFHMLLQILDDGRLTDGQGRTVSFKNTVIVM
CCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNVGTGMVERNTIGFSVHAKNTRNADTQKRLLEALRAQFRPEFLNRVDDIIVFNSLTRD
ECCCCCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HLARIVDIQLANVGKLLKDRKLNIEITPAAKDRIISEGYDPDYGARPMRRAIQRLVQDPL
HHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
ALKVISGEFEEGDTILVDAAPDGAELTFAKLVPITEPAVPISR
EEEEECCCCCCCCEEEEECCCCCCCEEHEEECCCCCCCCCCCC
>Mature Secondary Structure
MFRLDKLTQKAQDALQQTQALAEKNDSQIMFPLHLLIALAEEQEGIVRPVLEKCGVQPEA
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCHHH
VITEAQHLAVSLPKTNGMQPGMYLAPQLNKIMERAFDEAIRFKDEFVSTEHLLLSIAEET
HHHHHHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDPAGQLLKQAGASHDAILKALVSVRGTQRITDQNPETKYQALERYAHDLTESARLGKLD
CCHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
PVIGRDDEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIIRGDVPDQLKNKKLV
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
AIDLGSMIAGTKFRGEFEDRLKAVVKEIIDSNGEIICFIDELHTLVGAGSAEGAIDAANL
EEECCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHH
LKPALARGELRCIGATTLNEYKKHVEKDAALARRFQTVMVGEPSVDDTIAILRGLKEKFE
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHH
IHHGVRIKDSAILAAAVLSQRYIADRFLPDKAIDLIDEAGSALRLQIGSMPIEIDNLERR
HHCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHH
ISHLEIERQALSKERDHASHDRLRHVENELESLRGEAAGLKERWSREKGAIDRVRTLKEQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHH
QDSLRQEEEKASRAGDWEKAAQLRYGQLSQIEKDIQAAEQEMESVKSHALLKEEIDEDDI
HHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAIVAKWTGIPVTRMLEGEVQKLVQMPDRLKDRVIGQDEAVRLVANAILRNRAGLGDPQR
HHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
PIGSFIFLGPTGVGKTELVRALAQYLFDDSKAMIRVDMSEYMEKHAVARMVGSPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
DEGGQLTEQVRRRPYSVVLFDEIEKAHPDVFHMLLQILDDGRLTDGQGRTVSFKNTVIVM
CCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNVGTGMVERNTIGFSVHAKNTRNADTQKRLLEALRAQFRPEFLNRVDDIIVFNSLTRD
ECCCCCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HLARIVDIQLANVGKLLKDRKLNIEITPAAKDRIISEGYDPDYGARPMRRAIQRLVQDPL
HHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
ALKVISGEFEEGDTILVDAAPDGAELTFAKLVPITEPAVPISR
EEEEECCCCCCCCEEEEECCCCCCCEEHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA