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The map label for this gene is htpX [H]

Identifier: 116621452

GI number: 116621452

Start: 2978722

End: 2979570

Strand: Direct

Name: htpX [H]

Synonym: Acid_2334

Alternate gene names: 116621452

Gene position: 2978722-2979570 (Clockwise)

Preceding gene: 116621451

Following gene: 116621453

Centisome position: 29.89

GC content: 62.07

Gene sequence:

>849_bases
ATGAGTAAGAATGCTCTCAAGACTGCTGCACTTCTCGGCTTCCTGACCGCCCTCCTGCTGGTGGGCGGTCAGGCCCTCGC
GGGACGCCAGGGCCTCTACTTGGCGCTGGTGATTTCGGGCCTCATGAACTTCGTGAGTTACTTCTTCTCCGACAAGATCG
CCCTCGCTACTTACCGCGCACAACCGGTGAGCGAGACCGAAAACCCGGAGGCTTACCGGAGGGTGGGTCCCATCGTTCAG
CGTCTCGCCGAACGCATGAACCTGCCTATGCCGAAGCTTTACATCATCCCCGAGGATTCGCCCAACGCCTTCGCGACGGG
CCGCAATCCGCAGCACGCGTCGGTGGCATTCACGTCGGGCATTCTGCAGCTGATGAGCGATAGCGAGCTCGAAGGCGTGA
TCGCCCACGAGCTCGGCCACGTGCTGCACCGCGACATTCTGATCAGCTCCGTGGCCGCGATGATCGCCGGCACCATAACG
TTCGTCGCCCGCATGGCCTTCTGGTTTGGCGGGAGCCGCGACGAGGAAGGCCGCGGCGGCAACCCGATCGCCGCCATCGC
CATGCTGATTCTGGCGCCGATCGCGGCTATGCTGATTCAGATGGCCATTTCCCGTTCGCGCGAATACGATGCCGATGCCG
CCAGCGCCAAGTACATCGGCTCGCCCTACCCGCTGATCGGCGGCCTGCAAAAACTCGAAAGCTGGTCCAAGCAGATTCCC
ATGGACGCCTCGCCCTCTACTGCTCACATGTTCATCATCAAGCCCTTCAGCGGACAGAGCCTCATGAAGCTCTTCTCCAC
GCACCCCGCCACGGAAGATCGCATCGCCCGCCTTCAGGAGATGCGATGA

Upstream 100 bases:

>100_bases
TCCGGACGGAGCCGAACTCACGTTCGCAAAGCTGGTTCCGATAACGGAACCAGCGGTTCCCATCTCCAGGTAATTAACCA
GGTGATCAACCAGGTGATTT

Downstream 100 bases:

>100_bases
ACGAAGTCCGGGTGAACCGCAAGGCGGCCGGCCGGGTCGCCGGCGGCCATCCCTGGATTTTCGCCAGTGATATTGACGAT
CGCGATGGCGCGCAGGGCGG

Product: HtpX-2 peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSKNALKTAALLGFLTALLLVGGQALAGRQGLYLALVISGLMNFVSYFFSDKIALATYRAQPVSETENPEAYRRVGPIVQ
RLAERMNLPMPKLYIIPEDSPNAFATGRNPQHASVAFTSGILQLMSDSELEGVIAHELGHVLHRDILISSVAAMIAGTIT
FVARMAFWFGGSRDEEGRGGNPIAAIAMLILAPIAAMLIQMAISRSREYDADAASAKYIGSPYPLIGGLQKLESWSKQIP
MDASPSTAHMFIIKPFSGQSLMKLFSTHPATEDRIARLQEMR

Sequences:

>Translated_282_residues
MSKNALKTAALLGFLTALLLVGGQALAGRQGLYLALVISGLMNFVSYFFSDKIALATYRAQPVSETENPEAYRRVGPIVQ
RLAERMNLPMPKLYIIPEDSPNAFATGRNPQHASVAFTSGILQLMSDSELEGVIAHELGHVLHRDILISSVAAMIAGTIT
FVARMAFWFGGSRDEEGRGGNPIAAIAMLILAPIAAMLIQMAISRSREYDADAASAKYIGSPYPLIGGLQKLESWSKQIP
MDASPSTAHMFIIKPFSGQSLMKLFSTHPATEDRIARLQEMR
>Mature_281_residues
SKNALKTAALLGFLTALLLVGGQALAGRQGLYLALVISGLMNFVSYFFSDKIALATYRAQPVSETENPEAYRRVGPIVQR
LAERMNLPMPKLYIIPEDSPNAFATGRNPQHASVAFTSGILQLMSDSELEGVIAHELGHVLHRDILISSVAAMIAGTITF
VARMAFWFGGSRDEEGRGGNPIAAIAMLILAPIAAMLIQMAISRSREYDADAASAKYIGSPYPLIGGLQKLESWSKQIPM
DASPSTAHMFIIKPFSGQSLMKLFSTHPATEDRIARLQEMR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=283, Percent_Identity=32.1554770318021, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 30611; Mature: 30480

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNALKTAALLGFLTALLLVGGQALAGRQGLYLALVISGLMNFVSYFFSDKIALATYRA
CCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEECC
QPVSETENPEAYRRVGPIVQRLAERMNLPMPKLYIIPEDSPNAFATGRNPQHASVAFTSG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHH
ILQLMSDSELEGVIAHELGHVLHRDILISSVAAMIAGTITFVARMAFWFGGSRDEEGRGG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NPIAAIAMLILAPIAAMLIQMAISRSREYDADAASAKYIGSPYPLIGGLQKLESWSKQIP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCC
MDASPSTAHMFIIKPFSGQSLMKLFSTHPATEDRIARLQEMR
CCCCCCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SKNALKTAALLGFLTALLLVGGQALAGRQGLYLALVISGLMNFVSYFFSDKIALATYRA
CCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEECC
QPVSETENPEAYRRVGPIVQRLAERMNLPMPKLYIIPEDSPNAFATGRNPQHASVAFTSG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHH
ILQLMSDSELEGVIAHELGHVLHRDILISSVAAMIAGTITFVARMAFWFGGSRDEEGRGG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NPIAAIAMLILAPIAAMLIQMAISRSREYDADAASAKYIGSPYPLIGGLQKLESWSKQIP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCC
MDASPSTAHMFIIKPFSGQSLMKLFSTHPATEDRIARLQEMR
CCCCCCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA