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The map label for this gene is nuoM [H]

Identifier: 116621438

GI number: 116621438

Start: 2964848

End: 2966398

Strand: Reverse

Name: nuoM [H]

Synonym: Acid_2320

Alternate gene names: 116621438

Gene position: 2966398-2964848 (Counterclockwise)

Preceding gene: 116621442

Following gene: 116621435

Centisome position: 29.77

GC content: 60.09

Gene sequence:

>1551_bases
ATGGATCACATCCTCTCGATTGTCCTGTTCACGCCACTGGTAGGCTTACTGGTGCTGTTGTTCATTCCGTCGTCGAATGT
ACGCGCCATCAAGCTCTGGGCCAATGTGGCAGGGTTTTTGGGCTTTCTGGTCTCGCTGCCGCTGGTCTTCAACTTCGACC
ACACCAAGGACTACCAGTTCGTGGAAAGGGCATCGTGGATCCCTTCGCTGGGCGCGACCTACCACATCGGGATCGACGGG
CTCGGACTGCTGCTGGTGATGCTGACCACGGTGGTCGGGTTCCTGGCGATTCTTTCGAGCTGGAACGCAATCCACGAACG
CTTGAAGGAATACTACGCCTTCTTCCTGCTGCTGCAGACGGGTATGCTGGGCGTCTTCATGGCGCTCGATTTCCTGCTGT
TTTTCGTGTTCTGGGAAACCGTGCTGGTGCCGATGTACTTCATCATCGGGATCTGGGGCGGCCCGCGCCGTGTGTATGCG
GCGATCAAGTTCATGATCTATACGCTGATCGGCAGCGTGCTCATGTTCCTCGGCATCCTGACGCTGTACTACCAGCACAT
GCAGCAGTTCCAGACGCCGAGCTTCGATATCGCCGACCTGATGCGCCTGCAACTCACCGGGCCGACCGCCTGGTGGGTCT
TCTGGGCCTTCTTCGTGGGCTTCGCCGTGAAGGTGCCGATGTTCCCGTTCCACACGTGGCTGCCGGACGCGCACACCGAA
GCGCCGACCGCGGGCAGCGTGGTGCTGGCAAGCGTCCTGCTGAAGATGGGGACATACGGATTCCTGCGGTTCTCGCTGCC
GCTGCTGCCGGAATCGGCGAAGAACCCGGTGATCATCAACGCGATGGGTGTGCTCTCGCTGATCGGGATCGTGTATGGCG
CGCTGGCCTGCCTGATGCAGAAGGATTGGAAAAAGCTGGTGGCCTATTCCTCGGTGAGCCACCTGGGATTCTGCACACTG
GGAATTTTCTCCTTGAATCCGGCGGGGATTTCGGGCTCGATTCTGCAGCAGATCAACCACGGAATTTCGACCGGCATGTT
GTTCCTGATTGTCGGCGTAGTCTACGAGCGCAGGCACACGCGTGAGATTTCCGAGTACGGCGGGCTATTGAAGGTGATGC
CGGTATTTACGATCATCTTTCTGCTGGCGGCGCTGAGCTCGATGGGCATGCCGCCGTTGAACGGCTTCATCGGCGAGCTG
ACGATTTTGGGCGGCGCCTATCAGATGTCCTTCAACTGGGCCGTTTGGGCGGCGATCGGAATCGCACTGGGCGCGGCTTA
CCTGCTGTGGCTGTTCCAGCGCACGATGCTGGGCGAGGTCAAGGAAAAGAACGCGCTGCTGAAGGATCTTTCCTGGCGCG
AGATCGCGGTCTTCGCACCCCTGGTGGCGTGGGCATTCTGGATCGGCCTGAATCCGCAGCCGTACTTCCGCGTGCTGGAG
CGTCCGGTGGCGCAGATCGTCGAACGCGTGCGCCCCGGCTATTACGCGGAGCGCCACTTGACGAATCCCTTGGACACTAC
GGCTCCAGTACCGCGCGCGTCGCTGCGGTAA

Upstream 100 bases:

>100_bases
AAATCATAGCCGCATTGGGTATACGGATGACACCCGGAAAAAGACGCCTCTCGGCGCGGGGGCGCAGTGGTGATAAGATG
AGTCCTTCCTAAGCGGTGTT

Downstream 100 bases:

>100_bases
CGCCCACCCTTTCCATACGCGCCGCCATGGCGAGGATGCCTTCGCCGGCCGGGGCAGGACTCCTCCCGGCGGTCCGGAAT
TCCGGGCGCTCAATGTTGAT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MDHILSIVLFTPLVGLLVLLFIPSSNVRAIKLWANVAGFLGFLVSLPLVFNFDHTKDYQFVERASWIPSLGATYHIGIDG
LGLLLVMLTTVVGFLAILSSWNAIHERLKEYYAFFLLLQTGMLGVFMALDFLLFFVFWETVLVPMYFIIGIWGGPRRVYA
AIKFMIYTLIGSVLMFLGILTLYYQHMQQFQTPSFDIADLMRLQLTGPTAWWVFWAFFVGFAVKVPMFPFHTWLPDAHTE
APTAGSVVLASVLLKMGTYGFLRFSLPLLPESAKNPVIINAMGVLSLIGIVYGALACLMQKDWKKLVAYSSVSHLGFCTL
GIFSLNPAGISGSILQQINHGISTGMLFLIVGVVYERRHTREISEYGGLLKVMPVFTIIFLLAALSSMGMPPLNGFIGEL
TILGGAYQMSFNWAVWAAIGIALGAAYLLWLFQRTMLGEVKEKNALLKDLSWREIAVFAPLVAWAFWIGLNPQPYFRVLE
RPVAQIVERVRPGYYAERHLTNPLDTTAPVPRASLR

Sequences:

>Translated_516_residues
MDHILSIVLFTPLVGLLVLLFIPSSNVRAIKLWANVAGFLGFLVSLPLVFNFDHTKDYQFVERASWIPSLGATYHIGIDG
LGLLLVMLTTVVGFLAILSSWNAIHERLKEYYAFFLLLQTGMLGVFMALDFLLFFVFWETVLVPMYFIIGIWGGPRRVYA
AIKFMIYTLIGSVLMFLGILTLYYQHMQQFQTPSFDIADLMRLQLTGPTAWWVFWAFFVGFAVKVPMFPFHTWLPDAHTE
APTAGSVVLASVLLKMGTYGFLRFSLPLLPESAKNPVIINAMGVLSLIGIVYGALACLMQKDWKKLVAYSSVSHLGFCTL
GIFSLNPAGISGSILQQINHGISTGMLFLIVGVVYERRHTREISEYGGLLKVMPVFTIIFLLAALSSMGMPPLNGFIGEL
TILGGAYQMSFNWAVWAAIGIALGAAYLLWLFQRTMLGEVKEKNALLKDLSWREIAVFAPLVAWAFWIGLNPQPYFRVLE
RPVAQIVERVRPGYYAERHLTNPLDTTAPVPRASLR
>Mature_516_residues
MDHILSIVLFTPLVGLLVLLFIPSSNVRAIKLWANVAGFLGFLVSLPLVFNFDHTKDYQFVERASWIPSLGATYHIGIDG
LGLLLVMLTTVVGFLAILSSWNAIHERLKEYYAFFLLLQTGMLGVFMALDFLLFFVFWETVLVPMYFIIGIWGGPRRVYA
AIKFMIYTLIGSVLMFLGILTLYYQHMQQFQTPSFDIADLMRLQLTGPTAWWVFWAFFVGFAVKVPMFPFHTWLPDAHTE
APTAGSVVLASVLLKMGTYGFLRFSLPLLPESAKNPVIINAMGVLSLIGIVYGALACLMQKDWKKLVAYSSVSHLGFCTL
GIFSLNPAGISGSILQQINHGISTGMLFLIVGVVYERRHTREISEYGGLLKVMPVFTIIFLLAALSSMGMPPLNGFIGEL
TILGGAYQMSFNWAVWAAIGIALGAAYLLWLFQRTMLGEVKEKNALLKDLSWREIAVFAPLVAWAFWIGLNPQPYFRVLE
RPVAQIVERVRPGYYAERHLTNPLDTTAPVPRASLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=370, Percent_Identity=32.1621621621622, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI251831117, Length=345, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788613, Length=452, Percent_Identity=38.2743362831858, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1788831, Length=419, Percent_Identity=29.3556085918854, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788827, Length=281, Percent_Identity=29.8932384341637, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788829, Length=427, Percent_Identity=26.6978922716628, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788614, Length=424, Percent_Identity=25, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI145693160, Length=337, Percent_Identity=25.5192878338279, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI2367154, Length=302, Percent_Identity=27.4834437086093, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 57734; Mature: 57734

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA