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The map label for this gene is tdcB [H]

Identifier: 116621435

GI number: 116621435

Start: 2962443

End: 2963384

Strand: Reverse

Name: tdcB [H]

Synonym: Acid_2317

Alternate gene names: 116621435

Gene position: 2963384-2962443 (Counterclockwise)

Preceding gene: 116621438

Following gene: 116621434

Centisome position: 29.74

GC content: 68.47

Gene sequence:

>942_bases
GTGATGCCGATTACGCTCGAGGATGTGGAGGAGGCGCGCCGCAACATCGCGGGTACGGCGCTGCGTACGCCGCTGGTGCC
GTTGGCCGCCGAAGGACCAGCCGCGGTGTGGTTGAAGCTGGAGAACCTGCAGCCGATCGGCGCATTTAAGATTCGCGGCG
CAGCCAACGTGATGGCGCGGACTCCGCGCGAGCGGCTGGCGCGCGGCGTGCTCACAGCGTCGGCGGGCAACATGGCGCAG
GGCGTGGCCTTCTGCGCGCGCCGCATGGGCGTGCCGGCGACGATCGTGGCGCCGGATACCGCGCCGGCCACCAAGATCCG
CGCGGTGGAACGGCTCGGCGGACGCGTCATCCTGGCGCCGTTCGCCGACTGGTGGCGCACTTTCGAGACGCGTACGTACC
CCGGCGTGGACGCGACCTTCATCCACGCCTTCGACGATCCGGATGTGATGGCGGGTAACGGGACAATCGCGCTCGAGCTG
CTGGAGGATCTGCCAGACCTCGACGCGGTGGTGATTCCCTGGGGCGGCGGCGGACTTTCGTGCGGGATCGCGGAGGTGCT
GCGCAAGCTGGCGCCGCGCGTGAAGATCTACGCCGCGGAAGTGGAGACGGCGGCGCCGCTCGCGGCATCGCTGGCTGCCG
GCTCACTACAGACGGTGGCTTATCAGCCTTCCTTCGTGGATGGCATCGGCAGCAAGATGGTCTTCGCCAATATGTTCGAG
CAGGCGCAGCGGCTGCTGGACGGCTCGCTGGTGGTCACACTCTCGGAAGCGGCGGCGGCGATGAAACTGGCGGCGGAGCG
CAATCGCGTAATCGTGGAAGGTGCGTCGGCCTGCGCCATCGCGGCGGCATTCTCCGGGCGCGCCGGCAGCGGGAGAGTGG
CGGCCATCGTCAGCGGCGGAAATATCGACCTGGAGAAGTTTTCGCAACTGACGGCGGCGTGA

Upstream 100 bases:

>100_bases
GTCCGCCGGCTTGCCATCGAGCAACATCGCTCCGGAGGCAAGCACGCTGATTTTGAGCCGCATTGTTGGTCTATCGTGAG
TGTACAGGAATTAAGATAGG

Downstream 100 bases:

>100_bases
AGGCGTAGGTATCCGGTATGAAATCCGGTATGACATCCGGTGTGACATCGACGGCGGTGGTAGCCCTTGCTCTCCTGGTG
GCGATGCCGTGCGTGGCGCA

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MMPITLEDVEEARRNIAGTALRTPLVPLAAEGPAAVWLKLENLQPIGAFKIRGAANVMARTPRERLARGVLTASAGNMAQ
GVAFCARRMGVPATIVAPDTAPATKIRAVERLGGRVILAPFADWWRTFETRTYPGVDATFIHAFDDPDVMAGNGTIALEL
LEDLPDLDAVVIPWGGGGLSCGIAEVLRKLAPRVKIYAAEVETAAPLAASLAAGSLQTVAYQPSFVDGIGSKMVFANMFE
QAQRLLDGSLVVTLSEAAAAMKLAAERNRVIVEGASACAIAAAFSGRAGSGRVAAIVSGGNIDLEKFSQLTAA

Sequences:

>Translated_313_residues
MMPITLEDVEEARRNIAGTALRTPLVPLAAEGPAAVWLKLENLQPIGAFKIRGAANVMARTPRERLARGVLTASAGNMAQ
GVAFCARRMGVPATIVAPDTAPATKIRAVERLGGRVILAPFADWWRTFETRTYPGVDATFIHAFDDPDVMAGNGTIALEL
LEDLPDLDAVVIPWGGGGLSCGIAEVLRKLAPRVKIYAAEVETAAPLAASLAAGSLQTVAYQPSFVDGIGSKMVFANMFE
QAQRLLDGSLVVTLSEAAAAMKLAAERNRVIVEGASACAIAAAFSGRAGSGRVAAIVSGGNIDLEKFSQLTAA
>Mature_313_residues
MMPITLEDVEEARRNIAGTALRTPLVPLAAEGPAAVWLKLENLQPIGAFKIRGAANVMARTPRERLARGVLTASAGNMAQ
GVAFCARRMGVPATIVAPDTAPATKIRAVERLGGRVILAPFADWWRTFETRTYPGVDATFIHAFDDPDVMAGNGTIALEL
LEDLPDLDAVVIPWGGGGLSCGIAEVLRKLAPRVKIYAAEVETAAPLAASLAAGSLQTVAYQPSFVDGIGSKMVFANMFE
QAQRLLDGSLVVTLSEAAAAMKLAAERNRVIVEGASACAIAAAFSGRAGSGRVAAIVSGGNIDLEKFSQLTAA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=34.3949044585987, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI33469958, Length=259, Percent_Identity=33.5907335907336, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923959, Length=261, Percent_Identity=32.5670498084291, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1789505, Length=320, Percent_Identity=34.0625, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790207, Length=278, Percent_Identity=38.8489208633094, Blast_Score=140, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71991565, Length=309, Percent_Identity=34.3042071197411, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=273, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17508781, Length=276, Percent_Identity=26.8115942028986, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322631, Length=323, Percent_Identity=34.0557275541796, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320930, Length=265, Percent_Identity=37.3584905660377, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319788, Length=296, Percent_Identity=26.6891891891892, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355833, Length=311, Percent_Identity=32.1543408360129, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 32666; Mature: 32666

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPITLEDVEEARRNIAGTALRTPLVPLAAEGPAAVWLKLENLQPIGAFKIRGAANVMAR
CCCCCHHHHHHHHHHHCCHHHHCCCCEEECCCCEEEEEEECCCCCCCEEEECCCHHHHHC
TPRERLARGVLTASAGNMAQGVAFCARRMGVPATIVAPDTAPATKIRAVERLGGRVILAP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEEC
FADWWRTFETRTYPGVDATFIHAFDDPDVMAGNGTIALELLEDLPDLDAVVIPWGGGGLS
CHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCCEEEEEEHHCCCCCCEEEEECCCCCCC
CGIAEVLRKLAPRVKIYAAEVETAAPLAASLAAGSLQTVAYQPSFVDGIGSKMVFANMFE
CCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCHHHCCCHHHHHHHHHH
QAQRLLDGSLVVTLSEAAAAMKLAAERNRVIVEGASACAIAAAFSGRAGSGRVAAIVSGG
HHHHHHCCCEEEEEHHHHHHHHHHHCCCEEEEECCCCEEEEEHHCCCCCCCCEEEEEECC
NIDLEKFSQLTAA
CCCHHHHHHHHCC
>Mature Secondary Structure
MMPITLEDVEEARRNIAGTALRTPLVPLAAEGPAAVWLKLENLQPIGAFKIRGAANVMAR
CCCCCHHHHHHHHHHHCCHHHHCCCCEEECCCCEEEEEEECCCCCCCEEEECCCHHHHHC
TPRERLARGVLTASAGNMAQGVAFCARRMGVPATIVAPDTAPATKIRAVERLGGRVILAP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEEC
FADWWRTFETRTYPGVDATFIHAFDDPDVMAGNGTIALELLEDLPDLDAVVIPWGGGGLS
CHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCCEEEEEEHHCCCCCCEEEEECCCCCCC
CGIAEVLRKLAPRVKIYAAEVETAAPLAASLAAGSLQTVAYQPSFVDGIGSKMVFANMFE
CCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCHHHCCCHHHHHHHHHH
QAQRLLDGSLVVTLSEAAAAMKLAAERNRVIVEGASACAIAAAFSGRAGSGRVAAIVSGG
HHHHHHCCCEEEEEHHHHHHHHHHHCCCEEEEECCCCEEEEEHHCCCCCCCCEEEEEECC
NIDLEKFSQLTAA
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA