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The map label for this gene is rsbU [H]

Identifier: 116621325

GI number: 116621325

Start: 2826510

End: 2828255

Strand: Direct

Name: rsbU [H]

Synonym: Acid_2206

Alternate gene names: 116621325

Gene position: 2826510-2828255 (Clockwise)

Preceding gene: 116621324

Following gene: 116621327

Centisome position: 28.36

GC content: 65.01

Gene sequence:

>1746_bases
ATGCAAGCGACTCGCAAAGCGTCGGTCCGGTTCCGGGAACGCAGCGAGCTGCTCGATTTTCTGCTGGAGGTTTCGGCTTC
CATCACGCAGACTCTGGACCTGGACCAACTGCTGGCCAATGTCGCGGAGATGGTGCAGAAGGTGCTGCCGTACGACCTAT
TCGCGATCCTGCTGTACAGCGAGCGGCGACGCGACCTGCGCATTCGCTACGCGGTGGGGCATCGCGACGACGTGGTGCGG
AATCTCTCGATCGCGGAAGGCGAAGGCATCACGGGGACGGCGGCGGCGCGGCGCGAGCCGGTGCTGGTGAGCGACGTGCG
CAACGATCCCCGGTACCTGAACACGGTGGACGCGGTGCGCACGGAGCTGGCTGTGCCGATGACGGCGCGCGGCAAGCTGG
TGGGCGTGATCGATCTGCAATCGACCCGGGTGGATGCGTACACGGAATACGACCGGGCGCTGATGCGGTTGATCGCGGCG
CGGGTGAGTATCGCGATCGACAACGCGCGGCTGTACCGGCGGGCGGACCGGCAGAACCGGACGCTCAAGACGCTGGCCAA
TATCTCGCGCGAGTTCTCTTCGATTCTGGATTTGAACGAGCTGCTCAGCAAGATCGCGAGCACGATGCACGACCTGATCG
CCTACGACGCCTTCAGCATTCTCTCGGTGGACCACGAGGCGAAGGCCTTGAAGCACCTGTTCAGCATCCGCTATGACAAG
CGCGTGAATATCGACAACGTGCCGTTGGGCAAGGGGCTGACGGGCGCGGCGGCGGAATCGCGCGAAGTGGTGCGGGTACA
CGATACGGCGAAGGATCCGCGGTACATCGCGTCGCACGCGGACATTCGCAGCGAGGTGGCGGTACCGCTGATTCTGCAGG
ATCGCGTGGTGGGCGTGATGGACCTGGAGAGCGACCGGGTCGGCTATTTCAACGACGACCAGGTGCGCACGCTGGCGCTG
CTGGCGCCGCAGGTGGCGAGTTCCGTGGAGAACGCGCGGCTGTACGCGGAGCTGGCGCAGCGCGAGAGGCGCATGGAGCA
GGACCTGGAAGCGGCGCGCGAATTGCAGCGGATCCTGCTGCCTGATGCGGCGCCGGAGATCGCGGGACTGGAAGCGGCCG
TGCGGCTGCGTCCGGCGCGGGAAATCTCGGGCGATATTTACGATATCTTCGAGCAGCGCGAAGGGCAGACCGTGATCGCG
ATGGGCGACGTCAGCGGCAAGGGTGCGGCGGCGGCGCTATACGGCGGGTTGATGAGTGGGCTACTGCGCACGCTGGCTCC
GCGGCGTCCGCGTCCGGCGGAACTGATGAAGGCGTTGAACGACGCGCTGGTGGAACGCAAAGTCGAGGCGCGCTACGTGA
CGCTGGGTGTGATGCTCTGGGACGCGTCCACGCGGCGCATCGTGATGGCGAACGCGGGCGCGCTGCCGCCGATGATTTGC
CGCGGGACGGAGATCCTCAAGATCCGCGTGGAGGGCGTGCCGCTGGGCCTTTTGGAATCGCGCGAGTACGAGGAAGTCAC
GTTCCAGGCGGAGCCCGGCGATACGATCGTGCTGTACTCCGACGGGATAACGGATCACGTGAACGCGGCGGGGACGGAAT
TCGGACGCGGCAGGCTGGCGCAGATCGTGCGCGCGCATTGCGGGGGCACGGCGGACGGCTTGATACTCAAGATATTCGAA
GAGCTGGATAAGTTTTCGAAGGTGGCGTTCGACGATCAATCGATCTTCGTGATGAAGGTTCTCTAG

Upstream 100 bases:

>100_bases
CAGACGATGACGGCCGCTGGCGCTTCGCGAATCGGGGCGAGCGCGAGCGTAAAGATCGTAGAGGCTACCGCTGCCTGATC
AATTTCCGTTAGGGAAGTCT

Downstream 100 bases:

>100_bases
ACCTAATTCGACGCGCGGCCCAGCGGGTAGCCGCGAATCAACTTGAAAGTCCGGGACCAACGGGTCTTGGTGAAGAAATG
GGTGATGACGTCGATGATGT

Product: serine phosphatase

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MQATRKASVRFRERSELLDFLLEVSASITQTLDLDQLLANVAEMVQKVLPYDLFAILLYSERRRDLRIRYAVGHRDDVVR
NLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVRTELAVPMTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAA
RVSIAIDNARLYRRADRQNRTLKTLANISREFSSILDLNELLSKIASTMHDLIAYDAFSILSVDHEAKALKHLFSIRYDK
RVNIDNVPLGKGLTGAAAESREVVRVHDTAKDPRYIASHADIRSEVAVPLILQDRVVGVMDLESDRVGYFNDDQVRTLAL
LAPQVASSVENARLYAELAQRERRMEQDLEAARELQRILLPDAAPEIAGLEAAVRLRPAREISGDIYDIFEQREGQTVIA
MGDVSGKGAAAALYGGLMSGLLRTLAPRRPRPAELMKALNDALVERKVEARYVTLGVMLWDASTRRIVMANAGALPPMIC
RGTEILKIRVEGVPLGLLESREYEEVTFQAEPGDTIVLYSDGITDHVNAAGTEFGRGRLAQIVRAHCGGTADGLILKIFE
ELDKFSKVAFDDQSIFVMKVL

Sequences:

>Translated_581_residues
MQATRKASVRFRERSELLDFLLEVSASITQTLDLDQLLANVAEMVQKVLPYDLFAILLYSERRRDLRIRYAVGHRDDVVR
NLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVRTELAVPMTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAA
RVSIAIDNARLYRRADRQNRTLKTLANISREFSSILDLNELLSKIASTMHDLIAYDAFSILSVDHEAKALKHLFSIRYDK
RVNIDNVPLGKGLTGAAAESREVVRVHDTAKDPRYIASHADIRSEVAVPLILQDRVVGVMDLESDRVGYFNDDQVRTLAL
LAPQVASSVENARLYAELAQRERRMEQDLEAARELQRILLPDAAPEIAGLEAAVRLRPAREISGDIYDIFEQREGQTVIA
MGDVSGKGAAAALYGGLMSGLLRTLAPRRPRPAELMKALNDALVERKVEARYVTLGVMLWDASTRRIVMANAGALPPMIC
RGTEILKIRVEGVPLGLLESREYEEVTFQAEPGDTIVLYSDGITDHVNAAGTEFGRGRLAQIVRAHCGGTADGLILKIFE
ELDKFSKVAFDDQSIFVMKVL
>Mature_581_residues
MQATRKASVRFRERSELLDFLLEVSASITQTLDLDQLLANVAEMVQKVLPYDLFAILLYSERRRDLRIRYAVGHRDDVVR
NLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVRTELAVPMTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAA
RVSIAIDNARLYRRADRQNRTLKTLANISREFSSILDLNELLSKIASTMHDLIAYDAFSILSVDHEAKALKHLFSIRYDK
RVNIDNVPLGKGLTGAAAESREVVRVHDTAKDPRYIASHADIRSEVAVPLILQDRVVGVMDLESDRVGYFNDDQVRTLAL
LAPQVASSVENARLYAELAQRERRMEQDLEAARELQRILLPDAAPEIAGLEAAVRLRPAREISGDIYDIFEQREGQTVIA
MGDVSGKGAAAALYGGLMSGLLRTLAPRRPRPAELMKALNDALVERKVEARYVTLGVMLWDASTRRIVMANAGALPPMIC
RGTEILKIRVEGVPLGLLESREYEEVTFQAEPGDTIVLYSDGITDHVNAAGTEFGRGRLAQIVRAHCGGTADGLILKIFE
ELDKFSKVAFDDQSIFVMKVL

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

Organism=Homo sapiens, GI194595488, Length=349, Percent_Identity=22.9226361031519, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI5729972, Length=349, Percent_Identity=22.9226361031519, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 64579; Mature: 64579

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATRKASVRFRERSELLDFLLEVSASITQTLDLDQLLANVAEMVQKVLPYDLFAILLYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
ERRRDLRIRYAVGHRDDVVRNLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVR
HCCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCHHHHHHHHH
TELAVPMTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAARVSIAIDNARLYRRADRQNR
HHHCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCH
TLKTLANISREFSSILDLNELLSKIASTMHDLIAYDAFSILSVDHEAKALKHLFSIRYDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RVNIDNVPLGKGLTGAAAESREVVRVHDTAKDPRYIASHADIRSEVAVPLILQDRVVGVM
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
DLESDRVGYFNDDQVRTLALLAPQVASSVENARLYAELAQRERRMEQDLEAARELQRILL
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDAAPEIAGLEAAVRLRPAREISGDIYDIFEQREGQTVIAMGDVSGKGAAAALYGGLMSG
CCCCCCHHCCHHHHHCCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LLRTLAPRRPRPAELMKALNDALVERKVEARYVTLGVMLWDASTRRIVMANAGALPPMIC
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCHHH
RGTEILKIRVEGVPLGLLESREYEEVTFQAEPGDTIVLYSDGITDHVNAAGTEFGRGRLA
CCCEEEEEEECCCCEEHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHH
QIVRAHCGGTADGLILKIFEELDKFSKVAFDDQSIFVMKVL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MQATRKASVRFRERSELLDFLLEVSASITQTLDLDQLLANVAEMVQKVLPYDLFAILLYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
ERRRDLRIRYAVGHRDDVVRNLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVR
HCCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCHHHHHHHHH
TELAVPMTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAARVSIAIDNARLYRRADRQNR
HHHCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCH
TLKTLANISREFSSILDLNELLSKIASTMHDLIAYDAFSILSVDHEAKALKHLFSIRYDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RVNIDNVPLGKGLTGAAAESREVVRVHDTAKDPRYIASHADIRSEVAVPLILQDRVVGVM
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
DLESDRVGYFNDDQVRTLALLAPQVASSVENARLYAELAQRERRMEQDLEAARELQRILL
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDAAPEIAGLEAAVRLRPAREISGDIYDIFEQREGQTVIAMGDVSGKGAAAALYGGLMSG
CCCCCCHHCCHHHHHCCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LLRTLAPRRPRPAELMKALNDALVERKVEARYVTLGVMLWDASTRRIVMANAGALPPMIC
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCHHH
RGTEILKIRVEGVPLGLLESREYEEVTFQAEPGDTIVLYSDGITDHVNAAGTEFGRGRLA
CCCEEEEEEECCCCEEHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHH
QIVRAHCGGTADGLILKIFEELDKFSKVAFDDQSIFVMKVL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]