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The map label for this gene is fabL [H]

Identifier: 116621275

GI number: 116621275

Start: 2758735

End: 2759520

Strand: Reverse

Name: fabL [H]

Synonym: Acid_2156

Alternate gene names: 116621275

Gene position: 2759520-2758735 (Counterclockwise)

Preceding gene: 116621276

Following gene: 116621274

Centisome position: 27.69

GC content: 63.23

Gene sequence:

>786_bases
ATGAGCAAACAACCGTGGGCACTGATATTGGGCGCGAGCAGCGGGTTCGGCGAAGCCACCGCGATTGAGCTGGCGCGCGC
CGGGATGAATATCTTCGGCGTCCACATGGATCGGCGCGACAAGGTGCCTCATGTGGCCGAGGTGCAGGAGCGCATCCGCG
CGGCGGGGCGCGAGTGTGAATTCTTCAACATGAACGCGGCCGATGAAGAGAAGCGCAAGGAGTGCGTCGAGCAGATCCGG
CAGCGGGTCACCGATTCAACGGGCACGCTGCGGGTGCTGCTTCACTCGCTCGCCTGGGGCTCGCTCAAACCGCTGGCCGG
CGCCGAAATTGTCGCCAATAAGAAGCAGATCGAATCTACCGCCGATATCATGGGCCACTCGTTGGTCTACTGGGTGCAGG
AGTGTCTGCTCGCGGGGTTGTTCGACAAAGGGGCGCGCATCTTCGCCATGACCAGCTCAGGCAGCACGCGCGCGATTCCT
GAGTACGGACCGGTGAGCGCCGCCAAGGCCATCCTCGAAGCTCACATCCGGCAGCTCGCGCTCGAGCTCGCGCCCGCCGG
AATCACCGCCAACGCGATTCTCGCCGGCGTCACCGATACGCCGGCGCTGCGCCTGATTCCGGGACACGAGAAGATTATGG
AGATCGCGCGCACGCGCAATCCCAACCGGCGCCTGACTACGCCTGAAGACGTGGCGCGCTCGATCGCCGTGCTCTGCCAT
CCTGCCACGTATTGGATGACAGGCAACACCATCCATGTTGATGGCGGTGAGAACATTGTAGGATGA

Upstream 100 bases:

>100_bases
TCGGTTTGAGGGCGATGCCGAAGATGAAGGGCACATTGCTTCGGAGAGATCTTCGCGGCCTGCGAGCAAACAAGAGCTGT
GTAATACGAGAGGAATTCCG

Downstream 100 bases:

>100_bases
AGCTGATGGACGATAATGGTCTTCCCTGCCTCGACCTGCTCGAATCGACGCCCGGCATCCTCCGCGGGCTCATGGCCGAA
CTCACCGAAGAGGATGTCCG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSKQPWALILGASSGFGEATAIELARAGMNIFGVHMDRRDKVPHVAEVQERIRAAGRECEFFNMNAADEEKRKECVEQIR
QRVTDSTGTLRVLLHSLAWGSLKPLAGAEIVANKKQIESTADIMGHSLVYWVQECLLAGLFDKGARIFAMTSSGSTRAIP
EYGPVSAAKAILEAHIRQLALELAPAGITANAILAGVTDTPALRLIPGHEKIMEIARTRNPNRRLTTPEDVARSIAVLCH
PATYWMTGNTIHVDGGENIVG

Sequences:

>Translated_261_residues
MSKQPWALILGASSGFGEATAIELARAGMNIFGVHMDRRDKVPHVAEVQERIRAAGRECEFFNMNAADEEKRKECVEQIR
QRVTDSTGTLRVLLHSLAWGSLKPLAGAEIVANKKQIESTADIMGHSLVYWVQECLLAGLFDKGARIFAMTSSGSTRAIP
EYGPVSAAKAILEAHIRQLALELAPAGITANAILAGVTDTPALRLIPGHEKIMEIARTRNPNRRLTTPEDVARSIAVLCH
PATYWMTGNTIHVDGGENIVG
>Mature_260_residues
SKQPWALILGASSGFGEATAIELARAGMNIFGVHMDRRDKVPHVAEVQERIRAAGRECEFFNMNAADEEKRKECVEQIRQ
RVTDSTGTLRVLLHSLAWGSLKPLAGAEIVANKKQIESTADIMGHSLVYWVQECLLAGLFDKGARIFAMTSSGSTRAIPE
YGPVSAAKAILEAHIRQLALELAPAGITANAILAGVTDTPALRLIPGHEKIMEIARTRNPNRRLTTPEDVARSIAVLCHP
ATYWMTGNTIHVDGGENIVG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=168, Percent_Identity=32.1428571428571, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324126, Length=115, Percent_Identity=36.5217391304348, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 28329; Mature: 28198

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQPWALILGASSGFGEATAIELARAGMNIFGVHMDRRDKVPHVAEVQERIRAAGRECE
CCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCE
FFNMNAADEEKRKECVEQIRQRVTDSTGTLRVLLHSLAWGSLKPLAGAEIVANKKQIEST
EEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ADIMGHSLVYWVQECLLAGLFDKGARIFAMTSSGSTRAIPEYGPVSAAKAILEAHIRQLA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LELAPAGITANAILAGVTDTPALRLIPGHEKIMEIARTRNPNRRLTTPEDVARSIAVLCH
HHHCCCCCCHHHEEECCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
PATYWMTGNTIHVDGGENIVG
CCEEEEECCEEEECCCCCCCC
>Mature Secondary Structure 
SKQPWALILGASSGFGEATAIELARAGMNIFGVHMDRRDKVPHVAEVQERIRAAGRECE
CCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCE
FFNMNAADEEKRKECVEQIRQRVTDSTGTLRVLLHSLAWGSLKPLAGAEIVANKKQIEST
EEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ADIMGHSLVYWVQECLLAGLFDKGARIFAMTSSGSTRAIPEYGPVSAAKAILEAHIRQLA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LELAPAGITANAILAGVTDTPALRLIPGHEKIMEIARTRNPNRRLTTPEDVARSIAVLCH
HHHCCCCCCHHHEEECCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
PATYWMTGNTIHVDGGENIVG
CCEEEEECCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]