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The map label for this gene is serA [H]

Identifier: 116621260

GI number: 116621260

Start: 2740624

End: 2741634

Strand: Direct

Name: serA [H]

Synonym: Acid_2141

Alternate gene names: 116621260

Gene position: 2740624-2741634 (Clockwise)

Preceding gene: 116621256

Following gene: 116621261

Centisome position: 27.5

GC content: 60.53

Gene sequence:

>1011_bases
ATGAGAATTCGTCTAGTCTCATTCCTGATCTTTTCTTGCGTCCTGCCGGCCCAAACCAAGAAGATCATCGCGAACTTGCC
CGCGGACATGTTGAAGGAACTGGCCGTCTCCGCTCCCAACGTCCGAATCGTTGCGGCGCGCGGCGCGGATCTTGCCAGGG
AGATCGAGGATGCAGACGCCATGGTCGGCGTCACCTTGACCCCGGAACTATTCACCCACGCCCGCCAGTTGAAGTGGCTT
CACATCACCAGTGCAGGCGTTGAGACTCATGGACGCTCCATCGGTCTTTTCCCGGCACTCGTGGAGAGCAGCGTAGTGGT
GACCAACGCCAAGAACATGTACGGTCCGCAGATCGCCGACCATGCCTTCGCCTTTCTCCTGGCCTTGACGCGCAAACTCA
ACGTCACCATCCCGCGCCAGCAGTTGGAGGAATGGCCCTCTGGACGCGACGGCATGTTCGAACTCAACGGCAAGACCGCT
GTGATCATCGGGGTCGGCGGCATCGGCAGCCAGATCGCGCAGCGCGCCCACGGCTTCGGTATGAAAGTGATCGGCGTCGA
TATCCGCGACATCCCCACCAACAACATGATCCAACGCGTCGTGCCGCCCGATATGTTGGATTCCGTGCTGCCGGAAGCCG
ACGTGGTTTTCGTGTCCGTGCCGCACACGCCGAAAAGCGAGGGCATGATGGGCGCGCGCGAGTTCGAGCTGATGAAGAAG
GGCTCGTACTTCATCGCCATGTCCCGCGGCAAGATCTACGACCATCAAGCCCTCGTGAAGGCGCTCGACAATCGCCGCCT
CGCCGGCGTCGGATTGGATGCCACGGACCCGGAGCCCCTGCCGAAAAGCCACCCGCTCTGGAAGTTCCCGAACGTGATCA
TCACTCCGCACGTCTCCGGCGGTTCGGACAATCTGGAGATGCGGCTCTACAACCTCGTGAAGGAGAACATCCGCCGCTTC
GGCGCGGGCCTGCCTTTGCTCAATGTGGTGGATAAGAAGGAAGGTTTCTAA

Upstream 100 bases:

>100_bases
CATCTGAAGGAACGTCTCAGCTCGGAGACTCCCGGGCATTTCAGGTCTATGGCAATGCGGACCATCCCTGGCGCACTACA
ATCGATAGCGGAGGCTCCCA

Downstream 100 bases:

>100_bases
CAGGGCATCCGGCCCTGCCCATGATACACTCGCGCCCATGAGACTGAATTCCCTGGGTAGCGCACTTGCGCGCCCCCGCG
GAGCGCACCTCTGCGGGACC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MRIRLVSFLIFSCVLPAQTKKIIANLPADMLKELAVSAPNVRIVAARGADLAREIEDADAMVGVTLTPELFTHARQLKWL
HITSAGVETHGRSIGLFPALVESSVVVTNAKNMYGPQIADHAFAFLLALTRKLNVTIPRQQLEEWPSGRDGMFELNGKTA
VIIGVGGIGSQIAQRAHGFGMKVIGVDIRDIPTNNMIQRVVPPDMLDSVLPEADVVFVSVPHTPKSEGMMGAREFELMKK
GSYFIAMSRGKIYDHQALVKALDNRRLAGVGLDATDPEPLPKSHPLWKFPNVIITPHVSGGSDNLEMRLYNLVKENIRRF
GAGLPLLNVVDKKEGF

Sequences:

>Translated_336_residues
MRIRLVSFLIFSCVLPAQTKKIIANLPADMLKELAVSAPNVRIVAARGADLAREIEDADAMVGVTLTPELFTHARQLKWL
HITSAGVETHGRSIGLFPALVESSVVVTNAKNMYGPQIADHAFAFLLALTRKLNVTIPRQQLEEWPSGRDGMFELNGKTA
VIIGVGGIGSQIAQRAHGFGMKVIGVDIRDIPTNNMIQRVVPPDMLDSVLPEADVVFVSVPHTPKSEGMMGAREFELMKK
GSYFIAMSRGKIYDHQALVKALDNRRLAGVGLDATDPEPLPKSHPLWKFPNVIITPHVSGGSDNLEMRLYNLVKENIRRF
GAGLPLLNVVDKKEGF
>Mature_336_residues
MRIRLVSFLIFSCVLPAQTKKIIANLPADMLKELAVSAPNVRIVAARGADLAREIEDADAMVGVTLTPELFTHARQLKWL
HITSAGVETHGRSIGLFPALVESSVVVTNAKNMYGPQIADHAFAFLLALTRKLNVTIPRQQLEEWPSGRDGMFELNGKTA
VIIGVGGIGSQIAQRAHGFGMKVIGVDIRDIPTNNMIQRVVPPDMLDSVLPEADVVFVSVPHTPKSEGMMGAREFELMKK
GSYFIAMSRGKIYDHQALVKALDNRRLAGVGLDATDPEPLPKSHPLWKFPNVIITPHVSGGSDNLEMRLYNLVKENIRRF
GAGLPLLNVVDKKEGF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=25.5172413793103, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI6912396, Length=215, Percent_Identity=29.7674418604651, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=27.6422764227642, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=27.6422764227642, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI61743967, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=27.6422764227642, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789279, Length=163, Percent_Identity=39.8773006134969, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082289, Length=214, Percent_Identity=31.3084112149533, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081824, Length=310, Percent_Identity=24.1935483870968, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787645, Length=167, Percent_Identity=30.5389221556886, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=238, Percent_Identity=27.7310924369748, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=270, Percent_Identity=28.8888888888889, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=270, Percent_Identity=28.8888888888889, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=291, Percent_Identity=25.4295532646048, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=25.3807106598985, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=26.4591439688716, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=27.9693486590038, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=27.9693486590038, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=27.9693486590038, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=27.9693486590038, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=27.9693486590038, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571528, Length=154, Percent_Identity=34.4155844155844, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921140, Length=277, Percent_Identity=27.7978339350181, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585516, Length=324, Percent_Identity=24.3827160493827, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=27.2, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36798; Mature: 36798

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRLVSFLIFSCVLPAQTKKIIANLPADMLKELAVSAPNVRIVAARGADLAREIEDADA
CEEHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCC
MVGVTLTPELFTHARQLKWLHITSAGVETHGRSIGLFPALVESSVVVTNAKNMYGPQIAD
EEEEEECHHHHHHHHHEEEEEEEECCCHHCCCEECCHHHHHCCCEEEECCCCCCCCHHHH
HAFAFLLALTRKLNVTIPRQQLEEWPSGRDGMFELNGKTAVIIGVGGIGSQIAQRAHGFG
HHHHHHHHHHHHCCEEECHHHHHHCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHCCC
MKVIGVDIRDIPTNNMIQRVVPPDMLDSVLPEADVVFVSVPHTPKSEGMMGAREFELMKK
EEEEEEEHCCCCCCHHHHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHC
GSYFIAMSRGKIYDHQALVKALDNRRLAGVGLDATDPEPLPKSHPLWKFPNVIITPHVSG
CCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCC
GSDNLEMRLYNLVKENIRRFGAGLPLLNVVDKKEGF
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MRIRLVSFLIFSCVLPAQTKKIIANLPADMLKELAVSAPNVRIVAARGADLAREIEDADA
CEEHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCC
MVGVTLTPELFTHARQLKWLHITSAGVETHGRSIGLFPALVESSVVVTNAKNMYGPQIAD
EEEEEECHHHHHHHHHEEEEEEEECCCHHCCCEECCHHHHHCCCEEEECCCCCCCCHHHH
HAFAFLLALTRKLNVTIPRQQLEEWPSGRDGMFELNGKTAVIIGVGGIGSQIAQRAHGFG
HHHHHHHHHHHHCCEEECHHHHHHCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHCCC
MKVIGVDIRDIPTNNMIQRVVPPDMLDSVLPEADVVFVSVPHTPKSEGMMGAREFELMKK
EEEEEEEHCCCCCCHHHHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHC
GSYFIAMSRGKIYDHQALVKALDNRRLAGVGLDATDPEPLPKSHPLWKFPNVIITPHVSG
CCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCC
GSDNLEMRLYNLVKENIRRFGAGLPLLNVVDKKEGF
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]