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The map label for this gene is pchF [H]

Identifier: 116621157

GI number: 116621157

Start: 2584003

End: 2585640

Strand: Reverse

Name: pchF [H]

Synonym: Acid_2038

Alternate gene names: 116621157

Gene position: 2585640-2584003 (Counterclockwise)

Preceding gene: 116621158

Following gene: 116621156

Centisome position: 25.95

GC content: 63.43

Gene sequence:

>1638_bases
ATGGTAGCAATGACCATCAGCGATCCGGCAGTGCGGGAATGGTGCTCGGTGGTCGGCCCCGAGCACGTACTGACCGCGCC
GGAAAAGTTGCGCGCCGCCGAACGTACCACGTTCGCCACCAGCCAGCACATTCCGGCCATCATCCGTCCGGCCGATCGCG
CCCAGGTGCAGGAGTGCATCCGCATCGCCAACCGCTGGGGACGTCCCGTCTATCCCATCAGCGGCGGCCGCAACTGGGGC
TACGGGTCGAAAGTGCCCACTGCCGATGACTGCGCCCTGCTGGACTTGGGCCGCATGAACCGCATCGTTGATTTCGACGA
GAACCTGGGGTACGTCACGGTGGAGCCTGGCGTCACCCAGGCCCAGCTCCAGACGTTCCTCGCCGACCGCAAGTCCAACC
TGTGGATGGATTCCACCGGCGCCAGCCCACATTGCAGCCTGATCGGAAATACCCTGGAACGCGGCTTCGGCCATACTCCC
TACGGCGACCACTTCGCCCACAGCTGCGCGCTCGAAGTGGTCCTGCCCCAGGGAGACGTCATCGAAACCGGTTTCGGGCG
CTTCAACTCGCCGCACGCGGCGCCGCTTTTTCGCTGGGGCGTCGGCCCCGTGCTCGATGGCCTGTTTTCGCAGTCCAATT
TCGGCGTGGTCACGCGCATGACCCTCTGGCTCATGCCCGCCCCCGAGTACTTCCAGGCCTACTTCTTCCAGTGTCCCGGC
CACCAGGATCTGCTGCCGTTGATCGACGCGCTTCGCCCCCTGCGCATGAACGGCACCATCCGCAGTTCCTCCCATATCGC
CAACGATTACAAAGTCCTCTCCGCGTTGTATCAATACCCTTGGGACCGGACCGGGGAGCGCACTCCGCTCGAAGCGCCCC
TGATGGAAACCATGCGCGGCGAGCTGCGCATCGGCGCCTGGAACGGCTCCGGCGCCCTCTACGGCACCAAAGCCCAAGTC
AAGGAAGCGCGCCGTCTCCTGCGCGGCGCTCTCAAGGGGAAGGCCACTCGCCTCCAGTTCCTCGACGATCGCAAACTCGC
CCTGGCGGAGCGCTTCGCGCGCATTTACCAGTGGGCCAGCGGTTGGGACTTGACCCGCACTCTCGCGGTGCTCCGCCCGG
TCTACGGTCTGATGAAGGGGATCCCTACCGCTCACCCGCTGGCGAGCACCTACTGGCGCAAACGCACTCCGCCGCCCGAG
GACATGGACCCCGACCGCGATGGCTGCGGACTCCTCTGGTGCAGTCCCGTCGCCCCCAATGATGGCCGGCACGCCGAACG
AATCGTAGCTATCGCGAGTGAGTGCATGTTACGTCACACTTTCGAGCCGATGATCTCGATTACGGTGCTCACCGACCGCA
CGCTTTCCTGTATTCTTGCGCTGGAATACGATCGGGATGTACCCGGCGAAGACAAACGTGCGATAACGTGCTATCTCGAA
CTACTGGACTTACTAGCCGCTCAGGGGTATTACTCATACCGCCTGAGCATCGCTGGCATGTCTTCCCTAGGCGAATCTGG
CACTTACCAGGACCTCCTCTCCTCCCTGAAGCATCTCCTCGACCCCAATCAAATCCTTTCCCCCGGACGATATGTGAGCC
GAGACCCACAACCGCGCCGCCACTCGTGCTGCGATTAA

Upstream 100 bases:

>100_bases
TGCCGCCAGGTTCCGGTGGTTCGGGAAAGCCCGGCGGTCGATAGTCTGCCGGCCCGCCTGTTGCGCGGGTTTGAACTCGC
CCCTCCGCTTCCGGCTTAGA

Downstream 100 bases:

>100_bases
CAACCTCAATTTTCCCGGCAATAAAGGTGTTCCAAGGTTCACAGACACGTACTAACTAAGTGCAGCAGAATAGGGCTTAC
CCAGCGCAGGGTACGCGCTG

Product: FAD linked oxidase domain-containing protein

Products: NA

Alternate protein names: P-cresol methylhydroxylase; PCMH [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MVAMTISDPAVREWCSVVGPEHVLTAPEKLRAAERTTFATSQHIPAIIRPADRAQVQECIRIANRWGRPVYPISGGRNWG
YGSKVPTADDCALLDLGRMNRIVDFDENLGYVTVEPGVTQAQLQTFLADRKSNLWMDSTGASPHCSLIGNTLERGFGHTP
YGDHFAHSCALEVVLPQGDVIETGFGRFNSPHAAPLFRWGVGPVLDGLFSQSNFGVVTRMTLWLMPAPEYFQAYFFQCPG
HQDLLPLIDALRPLRMNGTIRSSSHIANDYKVLSALYQYPWDRTGERTPLEAPLMETMRGELRIGAWNGSGALYGTKAQV
KEARRLLRGALKGKATRLQFLDDRKLALAERFARIYQWASGWDLTRTLAVLRPVYGLMKGIPTAHPLASTYWRKRTPPPE
DMDPDRDGCGLLWCSPVAPNDGRHAERIVAIASECMLRHTFEPMISITVLTDRTLSCILALEYDRDVPGEDKRAITCYLE
LLDLLAAQGYYSYRLSIAGMSSLGESGTYQDLLSSLKHLLDPNQILSPGRYVSRDPQPRRHSCCD

Sequences:

>Translated_545_residues
MVAMTISDPAVREWCSVVGPEHVLTAPEKLRAAERTTFATSQHIPAIIRPADRAQVQECIRIANRWGRPVYPISGGRNWG
YGSKVPTADDCALLDLGRMNRIVDFDENLGYVTVEPGVTQAQLQTFLADRKSNLWMDSTGASPHCSLIGNTLERGFGHTP
YGDHFAHSCALEVVLPQGDVIETGFGRFNSPHAAPLFRWGVGPVLDGLFSQSNFGVVTRMTLWLMPAPEYFQAYFFQCPG
HQDLLPLIDALRPLRMNGTIRSSSHIANDYKVLSALYQYPWDRTGERTPLEAPLMETMRGELRIGAWNGSGALYGTKAQV
KEARRLLRGALKGKATRLQFLDDRKLALAERFARIYQWASGWDLTRTLAVLRPVYGLMKGIPTAHPLASTYWRKRTPPPE
DMDPDRDGCGLLWCSPVAPNDGRHAERIVAIASECMLRHTFEPMISITVLTDRTLSCILALEYDRDVPGEDKRAITCYLE
LLDLLAAQGYYSYRLSIAGMSSLGESGTYQDLLSSLKHLLDPNQILSPGRYVSRDPQPRRHSCCD
>Mature_545_residues
MVAMTISDPAVREWCSVVGPEHVLTAPEKLRAAERTTFATSQHIPAIIRPADRAQVQECIRIANRWGRPVYPISGGRNWG
YGSKVPTADDCALLDLGRMNRIVDFDENLGYVTVEPGVTQAQLQTFLADRKSNLWMDSTGASPHCSLIGNTLERGFGHTP
YGDHFAHSCALEVVLPQGDVIETGFGRFNSPHAAPLFRWGVGPVLDGLFSQSNFGVVTRMTLWLMPAPEYFQAYFFQCPG
HQDLLPLIDALRPLRMNGTIRSSSHIANDYKVLSALYQYPWDRTGERTPLEAPLMETMRGELRIGAWNGSGALYGTKAQV
KEARRLLRGALKGKATRLQFLDDRKLALAERFARIYQWASGWDLTRTLAVLRPVYGLMKGIPTAHPLASTYWRKRTPPPE
DMDPDRDGCGLLWCSPVAPNDGRHAERIVAIASECMLRHTFEPMISITVLTDRTLSCILALEYDRDVPGEDKRAITCYLE
LLDLLAAQGYYSYRLSIAGMSSLGESGTYQDLLSSLKHLLDPNQILSPGRYVSRDPQPRRHSCCD

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=219, Percent_Identity=32.4200913242009, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI119964728, Length=234, Percent_Identity=27.3504273504274, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR006094
- InterPro:   IPR016170
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: =1.17.99.1 [H]

Molecular weight: Translated: 60838; Mature: 60838

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAMTISDPAVREWCSVVGPEHVLTAPEKLRAAERTTFATSQHIPAIIRPADRAQVQECI
CEEEEECCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHH
RIANRWGRPVYPISGGRNWGYGSKVPTADDCALLDLGRMNRIVDFDENLGYVTVEPGVTQ
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCCEEEECCCCCH
AQLQTFLADRKSNLWMDSTGASPHCSLIGNTLERGFGHTPYGDHFAHSCALEVVLPQGDV
HHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEEECCCCE
IETGFGRFNSPHAAPLFRWGVGPVLDGLFSQSNFGVVTRMTLWLMPAPEYFQAYFFQCPG
EECCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCCC
HQDLLPLIDALRPLRMNGTIRSSSHIANDYKVLSALYQYPWDRTGERTPLEAPLMETMRG
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
ELRIGAWNGSGALYGTKAQVKEARRLLRGALKGKATRLQFLDDRKLALAERFARIYQWAS
CEEEEEECCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHHHCC
GWDLTRTLAVLRPVYGLMKGIPTAHPLASTYWRKRTPPPEDMDPDRDGCGLLWCSPVAPN
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
DGRHAERIVAIASECMLRHTFEPMISITVLTDRTLSCILALEYDRDVPGEDKRAITCYLE
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHH
LLDLLAAQGYYSYRLSIAGMSSLGESGTYQDLLSSLKHLLDPNQILSPGRYVSRDPQPRR
HHHHHHHCCCEEEEEEECCHHHCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC
HSCCD
CCCCC
>Mature Secondary Structure
MVAMTISDPAVREWCSVVGPEHVLTAPEKLRAAERTTFATSQHIPAIIRPADRAQVQECI
CEEEEECCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHH
RIANRWGRPVYPISGGRNWGYGSKVPTADDCALLDLGRMNRIVDFDENLGYVTVEPGVTQ
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCCEEEECCCCCH
AQLQTFLADRKSNLWMDSTGASPHCSLIGNTLERGFGHTPYGDHFAHSCALEVVLPQGDV
HHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEEECCCCE
IETGFGRFNSPHAAPLFRWGVGPVLDGLFSQSNFGVVTRMTLWLMPAPEYFQAYFFQCPG
EECCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCCC
HQDLLPLIDALRPLRMNGTIRSSSHIANDYKVLSALYQYPWDRTGERTPLEAPLMETMRG
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
ELRIGAWNGSGALYGTKAQVKEARRLLRGALKGKATRLQFLDDRKLALAERFARIYQWAS
CEEEEEECCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHHHCC
GWDLTRTLAVLRPVYGLMKGIPTAHPLASTYWRKRTPPPEDMDPDRDGCGLLWCSPVAPN
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
DGRHAERIVAIASECMLRHTFEPMISITVLTDRTLSCILALEYDRDVPGEDKRAITCYLE
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHH
LLDLLAAQGYYSYRLSIAGMSSLGESGTYQDLLSSLKHLLDPNQILSPGRYVSRDPQPRR
HHHHHHHCCCEEEEEEECCHHHCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC
HSCCD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929007; 10565539; 3790500; 1846290; 10623531 [H]