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The map label for this gene is lon

Identifier: 116621146

GI number: 116621146

Start: 2566235

End: 2568655

Strand: Direct

Name: lon

Synonym: Acid_2027

Alternate gene names: 116621146

Gene position: 2566235-2568655 (Clockwise)

Preceding gene: 116621145

Following gene: 116621147

Centisome position: 25.75

GC content: 59.56

Gene sequence:

>2421_bases
ATGCTTACTTCAAAGGAAAAATCCGATACAAAACGTCTGCCGATGATGCCCATTCGCGACGTGGTCATCTTTCCGTACAT
GATGACCCCCTTCGTAGTGGGACGTGAATCGAGCGTGCGGGCGTTGGAAGAGGCGATGGCCGGCGACAAGAAGATCTTTC
TCGCCACTCAGCACGACGCCTCCATCGACGAACCCAAACCCAACGAGATTTACAGCGTCGGCACCATCGTCAACATCGTC
CAGAGCCTCAAGCTGCCGGACGGCAACATCAAAGTACTGGTGGAAGGCGTCGAGCGCGCCAAGGTGGTTTCGGTCGCCGA
CGACGAAGGCTTCTTCCGCGCCACCGTGCGGACGTCGGGCTTCAAGGTAGAAACCGGTCCGCAGCTGGACGCGCTGATCA
GCCGCGTGACCACCCTGTTTGAGCAGTATGTAAAGCTCAGCCAGAACCTCAACTACGAGACCATGGTGGCCGCGATCCGG
GTGGATGAACCCGGCAAGCTGGCCGATACCGTGGGCGCCAACCTGCAGCTCACCATCGAAGAGAAGCAGGAGCTGCTCGA
AATCTTCGACCCCATCGATAGACTGACGCGAGTCGCGGAGATGCTCGATATCGAAATCGAGAAGCTCAACGTGGACCGCA
CCATTCAGGGCCGCGTCAAGCGGCAGATGGAAAAGGCGCAAAAAGAGTATTACCTCAACGAAAAGATCAAGGCCATCCAG
AAGGAGCTGGGCCGCGGCGAGAAGAGCGAAATCGATGAGCTGAAGCGGCGCATCGAAGAAGCCGGCATGACCGCCGATGC
GCAGGAAAAGGCCATGGCGGAGCTCAAGCGGCTGGAGAACATGCCGCCCATGTCCGCCGAGAGCACGGTCAGCCGCAACT
ATCTCGACTGGCTGCTGGCGGTGCCGTGGAAGAAAAAATCCAAGGAAATCCGCGATCTCAAATTCGCCGAGGGCGTGCTC
GAAGCCGACCACTACGGCCTCGAAAAGATCAAGGAGCGCATCCTGGAGTTCCTGGCGGTGCGCCGCCTGGTAAAGAATCC
CAAGGGCAGCATCCTCTGTTTCGTGGGACCTCCGGGCGTGGGCAAGACCTCGCTCGGGATGTCGATCGCGAAGGCCACCG
GCCGCAAGTTCGTCCGCATGTCGCTCGGCGGCGTGCGCGATGAAGCCGAAGTCCGCGGGCACCGCCGCACCTACATCGGC
GCGCTGCCGGGGCAGATCATCCAGATGATGAAAAAGGCGGGGACTCGCAACCCGGTCTTCATGCTGGACGAAGTCGATAA
AATGTCGATGGATTTCCGCGGCGACCCGAGCGCGGCGCTGCTCGAAGTGCTCGACCCCGAACAGAATTTCATGTTCGTGG
ACCATTACCTGGACGTCGAATACGACCTCAGCCAGGTCTTCTTCGTGGCCACCGCCAACGTGATGCACACCATCCCGGCG
GCCCTGCAGGACCGCATGGAAGTCATCCGTCTCTCCGGCTACACCGAGCTTGAGAAAATGGAAATCGCCAAGCGCTTCCT
GGTGAAGAAGCAGATTGAAGCCACCGGCCTGGACAGCAAGCAGATCGATTTCCAGGACGATGGCATCAACAGCCTGATTC
AGTACTACACGCGCGAAGCCGGCGTGCGCAACCTGGAACGCGAAATCGGCAACGTCTGCCGCAAAGTAGCGCGGCAGGTG
GTCAACGCCGAGAGCGGCAAGGATAAGAAGGCGCCCGCCAAAGCCGTGATCAACGGGGATAAGGTGCCGGAGCTGCTCGG
TCCGTGGAAATTCCGCGACCTGGTGGTTGAGAAAAAGAACGAAATCGGCGCCGCCACCGGCCTGGCCTGGACCGAAGTGG
GCGGACAATTGCTCACTGTGGAATGCACGCTGATGGAAGGCAAGGGAAAGCTGACCATCACCGGAAAGCTGGGCGAGGTG
ATGCAGGAATCGGCGCAGGCCGCGATGAGCTATATTCGTTCGCGCGCCATGTCGCTCGGAATTCCGCGGGATTTCTATCG
CAACCTGGATTTGCACATTCACATTCCCGAGGGAGCCATTCCGAAAGATGGTCCGTCGGCCGGTATCACGCTCGCGACCA
CGATTTGCAGCGCATTGACCAAGATTCCGGTGCGCGGCGATCTGGCGATGACGGGCGAGATCACGCTGCGCGGCAAGGTG
CTGCCGATCGGCGGATTGAAAGAGAAGTTGATGGCGGCCCATCGCCATGGCATCCTGGAAGCGATCATGCCGAAGGAGAA
CGAAAAGGATCTCCCGGACATTCCAGATGCCATCAAGAAGACCATGAAGCTTCACTTCGTGGAGTCGATGGACGAAGTTT
TAAAGATCGCGCTGGAGCGGGAGATTGTGGCTCTTCCGATTCCGGGCGCCGAGCTCCCGGTGGAAGCTGGCAAGCCCGCC
GAAGAGACGGTCGCGCACTAG

Upstream 100 bases:

>100_bases
CAGTCTTACAATATTAGAAAAGGCCGGTTAATACTCAGCGTCCTCAAAAACCGCGCAAAACCTGGGCACGGGGGTTGAAC
TATACCTCCTGGGGAGAATA

Downstream 100 bases:

>100_bases
TTTTGGGGGGCCGGACCGCAAAATCCGGCCCCTGCCCTAATTCGCGGCGGTACCGCGAAAGGTACGAATGAGTTCCTTGA
AAGCCGAATTTGTAGTAAGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MLTSKEKSDTKRLPMMPIRDVVIFPYMMTPFVVGRESSVRALEEAMAGDKKIFLATQHDASIDEPKPNEIYSVGTIVNIV
QSLKLPDGNIKVLVEGVERAKVVSVADDEGFFRATVRTSGFKVETGPQLDALISRVTTLFEQYVKLSQNLNYETMVAAIR
VDEPGKLADTVGANLQLTIEEKQELLEIFDPIDRLTRVAEMLDIEIEKLNVDRTIQGRVKRQMEKAQKEYYLNEKIKAIQ
KELGRGEKSEIDELKRRIEEAGMTADAQEKAMAELKRLENMPPMSAESTVSRNYLDWLLAVPWKKKSKEIRDLKFAEGVL
EADHYGLEKIKERILEFLAVRRLVKNPKGSILCFVGPPGVGKTSLGMSIAKATGRKFVRMSLGGVRDEAEVRGHRRTYIG
ALPGQIIQMMKKAGTRNPVFMLDEVDKMSMDFRGDPSAALLEVLDPEQNFMFVDHYLDVEYDLSQVFFVATANVMHTIPA
ALQDRMEVIRLSGYTELEKMEIAKRFLVKKQIEATGLDSKQIDFQDDGINSLIQYYTREAGVRNLEREIGNVCRKVARQV
VNAESGKDKKAPAKAVINGDKVPELLGPWKFRDLVVEKKNEIGAATGLAWTEVGGQLLTVECTLMEGKGKLTITGKLGEV
MQESAQAAMSYIRSRAMSLGIPRDFYRNLDLHIHIPEGAIPKDGPSAGITLATTICSALTKIPVRGDLAMTGEITLRGKV
LPIGGLKEKLMAAHRHGILEAIMPKENEKDLPDIPDAIKKTMKLHFVESMDEVLKIALEREIVALPIPGAELPVEAGKPA
EETVAH

Sequences:

>Translated_806_residues
MLTSKEKSDTKRLPMMPIRDVVIFPYMMTPFVVGRESSVRALEEAMAGDKKIFLATQHDASIDEPKPNEIYSVGTIVNIV
QSLKLPDGNIKVLVEGVERAKVVSVADDEGFFRATVRTSGFKVETGPQLDALISRVTTLFEQYVKLSQNLNYETMVAAIR
VDEPGKLADTVGANLQLTIEEKQELLEIFDPIDRLTRVAEMLDIEIEKLNVDRTIQGRVKRQMEKAQKEYYLNEKIKAIQ
KELGRGEKSEIDELKRRIEEAGMTADAQEKAMAELKRLENMPPMSAESTVSRNYLDWLLAVPWKKKSKEIRDLKFAEGVL
EADHYGLEKIKERILEFLAVRRLVKNPKGSILCFVGPPGVGKTSLGMSIAKATGRKFVRMSLGGVRDEAEVRGHRRTYIG
ALPGQIIQMMKKAGTRNPVFMLDEVDKMSMDFRGDPSAALLEVLDPEQNFMFVDHYLDVEYDLSQVFFVATANVMHTIPA
ALQDRMEVIRLSGYTELEKMEIAKRFLVKKQIEATGLDSKQIDFQDDGINSLIQYYTREAGVRNLEREIGNVCRKVARQV
VNAESGKDKKAPAKAVINGDKVPELLGPWKFRDLVVEKKNEIGAATGLAWTEVGGQLLTVECTLMEGKGKLTITGKLGEV
MQESAQAAMSYIRSRAMSLGIPRDFYRNLDLHIHIPEGAIPKDGPSAGITLATTICSALTKIPVRGDLAMTGEITLRGKV
LPIGGLKEKLMAAHRHGILEAIMPKENEKDLPDIPDAIKKTMKLHFVESMDEVLKIALEREIVALPIPGAELPVEAGKPA
EETVAH
>Mature_806_residues
MLTSKEKSDTKRLPMMPIRDVVIFPYMMTPFVVGRESSVRALEEAMAGDKKIFLATQHDASIDEPKPNEIYSVGTIVNIV
QSLKLPDGNIKVLVEGVERAKVVSVADDEGFFRATVRTSGFKVETGPQLDALISRVTTLFEQYVKLSQNLNYETMVAAIR
VDEPGKLADTVGANLQLTIEEKQELLEIFDPIDRLTRVAEMLDIEIEKLNVDRTIQGRVKRQMEKAQKEYYLNEKIKAIQ
KELGRGEKSEIDELKRRIEEAGMTADAQEKAMAELKRLENMPPMSAESTVSRNYLDWLLAVPWKKKSKEIRDLKFAEGVL
EADHYGLEKIKERILEFLAVRRLVKNPKGSILCFVGPPGVGKTSLGMSIAKATGRKFVRMSLGGVRDEAEVRGHRRTYIG
ALPGQIIQMMKKAGTRNPVFMLDEVDKMSMDFRGDPSAALLEVLDPEQNFMFVDHYLDVEYDLSQVFFVATANVMHTIPA
ALQDRMEVIRLSGYTELEKMEIAKRFLVKKQIEATGLDSKQIDFQDDGINSLIQYYTREAGVRNLEREIGNVCRKVARQV
VNAESGKDKKAPAKAVINGDKVPELLGPWKFRDLVVEKKNEIGAATGLAWTEVGGQLLTVECTLMEGKGKLTITGKLGEV
MQESAQAAMSYIRSRAMSLGIPRDFYRNLDLHIHIPEGAIPKDGPSAGITLATTICSALTKIPVRGDLAMTGEITLRGKV
LPIGGLKEKLMAAHRHGILEAIMPKENEKDLPDIPDAIKKTMKLHFVESMDEVLKIALEREIVALPIPGAELPVEAGKPA
EETVAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=46.2765957446808, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=636, Percent_Identity=43.0817610062893, Blast_Score=511, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=778, Percent_Identity=54.3701799485861, Blast_Score=843, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=687, Percent_Identity=39.3013100436681, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17556486, Length=546, Percent_Identity=38.8278388278388, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=702, Percent_Identity=39.1737891737892, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI221513036, Length=638, Percent_Identity=44.2006269592476, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24666867, Length=638, Percent_Identity=44.2006269592476, Blast_Score=501, Evalue=1e-142,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_SOLUE (Q026Q2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_823302.1
- ProteinModelPortal:   Q026Q2
- STRING:   Q026Q2
- MEROPS:   S16.001
- GeneID:   4429773
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_2027
- NMPDR:   fig|234267.9.peg.1929
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   HTFQDHY
- PhylomeDB:   Q026Q2
- ProtClustDB:   CLSK774578
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 89837; Mature: 89837

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 686-686 ACT_SITE 729-729

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSKEKSDTKRLPMMPIRDVVIFPYMMTPFVVGRESSVRALEEAMAGDKKIFLATQHDA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCEEEEEECCCC
SIDEPKPNEIYSVGTIVNIVQSLKLPDGNIKVLVEGVERAKVVSVADDEGFFRATVRTSG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEECCC
FKVETGPQLDALISRVTTLFEQYVKLSQNLNYETMVAAIRVDEPGKLADTVGANLQLTIE
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCHHHHCCCCEEEEHH
EKQELLEIFDPIDRLTRVAEMLDIEIEKLNVDRTIQGRVKRQMEKAQKEYYLNEKIKAIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGRGEKSEIDELKRRIEEAGMTADAQEKAMAELKRLENMPPMSAESTVSRNYLDWLLA
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
VPWKKKSKEIRDLKFAEGVLEADHYGLEKIKERILEFLAVRRLVKNPKGSILCFVGPPGV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GKTSLGMSIAKATGRKFVRMSLGGVRDEAEVRGHRRTYIGALPGQIIQMMKKAGTRNPVF
CCHHHHHHHHHHHHHHEEHHHHCCCCCHHHHCCCCHHEEECCHHHHHHHHHHCCCCCCEE
MLDEVDKMSMDFRGDPSAALLEVLDPEQNFMFVDHYLDVEYDLSQVFFVATANVMHTIPA
EEECHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCEECHHHHHHHHHHHHHHHHHH
ALQDRMEVIRLSGYTELEKMEIAKRFLVKKQIEATGLDSKQIDFQDDGINSLIQYYTREA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
GVRNLEREIGNVCRKVARQVVNAESGKDKKAPAKAVINGDKVPELLGPWKFRDLVVEKKN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHCCCHHHHHHHHHCC
EIGAATGLAWTEVGGQLLTVECTLMEGKGKLTITGKLGEVMQESAQAAMSYIRSRAMSLG
CCCHHCCCHHHHCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
IPRDFYRNLDLHIHIPEGAIPKDGPSAGITLATTICSALTKIPVRGDLAMTGEITLRGKV
CCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEE
LPIGGLKEKLMAAHRHGILEAIMPKENEKDLPDIPDAIKKTMKLHFVESMDEVLKIALER
EECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
EIVALPIPGAELPVEAGKPAEETVAH
CEEEEECCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MLTSKEKSDTKRLPMMPIRDVVIFPYMMTPFVVGRESSVRALEEAMAGDKKIFLATQHDA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCEEEEEECCCC
SIDEPKPNEIYSVGTIVNIVQSLKLPDGNIKVLVEGVERAKVVSVADDEGFFRATVRTSG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEECCC
FKVETGPQLDALISRVTTLFEQYVKLSQNLNYETMVAAIRVDEPGKLADTVGANLQLTIE
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCHHHHCCCCEEEEHH
EKQELLEIFDPIDRLTRVAEMLDIEIEKLNVDRTIQGRVKRQMEKAQKEYYLNEKIKAIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGRGEKSEIDELKRRIEEAGMTADAQEKAMAELKRLENMPPMSAESTVSRNYLDWLLA
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
VPWKKKSKEIRDLKFAEGVLEADHYGLEKIKERILEFLAVRRLVKNPKGSILCFVGPPGV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GKTSLGMSIAKATGRKFVRMSLGGVRDEAEVRGHRRTYIGALPGQIIQMMKKAGTRNPVF
CCHHHHHHHHHHHHHHEEHHHHCCCCCHHHHCCCCHHEEECCHHHHHHHHHHCCCCCCEE
MLDEVDKMSMDFRGDPSAALLEVLDPEQNFMFVDHYLDVEYDLSQVFFVATANVMHTIPA
EEECHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCEECHHHHHHHHHHHHHHHHHH
ALQDRMEVIRLSGYTELEKMEIAKRFLVKKQIEATGLDSKQIDFQDDGINSLIQYYTREA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
GVRNLEREIGNVCRKVARQVVNAESGKDKKAPAKAVINGDKVPELLGPWKFRDLVVEKKN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHCCCHHHHHHHHHCC
EIGAATGLAWTEVGGQLLTVECTLMEGKGKLTITGKLGEVMQESAQAAMSYIRSRAMSLG
CCCHHCCCHHHHCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
IPRDFYRNLDLHIHIPEGAIPKDGPSAGITLATTICSALTKIPVRGDLAMTGEITLRGKV
CCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEE
LPIGGLKEKLMAAHRHGILEAIMPKENEKDLPDIPDAIKKTMKLHFVESMDEVLKIALER
EECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
EIVALPIPGAELPVEAGKPAEETVAH
CEEEEECCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA