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The map label for this gene is clpX [H]

Identifier: 116621145

GI number: 116621145

Start: 2564891

End: 2566165

Strand: Direct

Name: clpX [H]

Synonym: Acid_2026

Alternate gene names: 116621145

Gene position: 2564891-2566165 (Clockwise)

Preceding gene: 116621144

Following gene: 116621146

Centisome position: 25.74

GC content: 56.47

Gene sequence:

>1275_bases
GTGAAGCGTGCCGGATCCGATGATGCTTTACGGTGTTCTTTTTGTCATAAGAGTCAGGACGTAGTCGGAAAGCTGATCTC
CTCCCCCAGCGACTATCCCCGTGCCTATATCTGCGACGAGTGCATCGCCGTCTGTAATTCGATCCTCGAAGACGATAAGG
TCGAGGCTCCGTCGGGAACACCCAACAAGATTCCGAAACCGTTGGAAGTAAAAGAGTTTCTGGATCAGTACGTGATTGGC
CAGGAGGCCACCAAGAAGAAGTTGGCGGTGGCGGTCTACAACCACTGCAAGCGGATTCACATGAACCGCATGCGCAACAG
TGAGGTCGAGCTGCAGAAATCCAACATTCTGCTGATCGGTCCCACCGGCACAGGGAAAACCCTGATGGCGCAGACTTTAG
CCAAAATTCTGGACGTGCCGTTCGCGATTGTCGATGCCACCACGCTGACCGAGGCCGGGTATGTCGGTGAAGACGTCGAG
AACATTATCCTGAAGTTGCTCCAGGCGGCGGACGGAGACGTACAAAAGTGCCAGCAGGGCATCATCTACATCGACGAAAT
CGACAAGATCTGCCGCAAGGACGAGAACCCCTCGATCACCCGTGACGTCTCGGGCGAGGGCGTGCAGCAGGCGCTCCTGA
AGATACTGGAAGGCACGGTCGCCAACGTTCCGCCGCAGGGCGGCCGCAAGCACCCGCACCAGGAATTCACGCCCGTGGAC
ACTACCAACATCCTGTTCATCTGTGGCGGTGCTTTCGTTGGCCTCGAAAAGGTGATTGCCCGGCGCACCGGCAAGAAGTC
CATGGGCTTTTTGCAGGAAGAGGAAAAGGGCACGGGGATTCGCAATACCGGCGTCAGCGGGCGGCGCGATATCGACCTCC
TTACGCAGGCGCAGCCGATCGACCTGATCAAGTTCGGTTTCATCCCGGAATTCATCGGCCGCCTGCCGGTGAGCGCTGTG
CTCGAAGATCTGGACCGCTCGGCCCTGATTCAGATTCTGACCAAGCCGAAGAACGCCATCATCAAGCAGTATCAGAAGCT
GTTCGAGTTCGAAAACGTCCGCTTGAAGTTCAGCGATGAAGCCACGGAAGCGATCGCCGACCTGGCCATGGACCGCAAGG
TGGGCGCGCGCGGCCTGCGCATGATACTCGAAGACCTGATGCTGGATCTGATGTACTACCTGCCTTCGTACAAGAAAGTC
CGCGAGTTCCAGGTCACCAAGGAAATGGTGCTCTCGCAAAAAATCAGTCTTACAATATTAGAAAAGGCCGGTTAA

Upstream 100 bases:

>100_bases
ATTGCTAACGAAGCCCTATTCAGGTGATAATGGAAACGAAAGAGAGTCTAGGTCTCTACTCTGAAGGCGTTGCGCCAGCG
GTGAAAGAGGAGAAAACTGC

Downstream 100 bases:

>100_bases
TACTCAGCGTCCTCAAAAACCGCGCAAAACCTGGGCACGGGGGTTGAACTATACCTCCTGGGGAGAATAATGCTTACTTC
AAAGGAAAAATCCGATACAA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKRAGSDDALRCSFCHKSQDVVGKLISSPSDYPRAYICDECIAVCNSILEDDKVEAPSGTPNKIPKPLEVKEFLDQYVIG
QEATKKKLAVAVYNHCKRIHMNRMRNSEVELQKSNILLIGPTGTGKTLMAQTLAKILDVPFAIVDATTLTEAGYVGEDVE
NIILKLLQAADGDVQKCQQGIIYIDEIDKICRKDENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPHQEFTPVD
TTNILFICGGAFVGLEKVIARRTGKKSMGFLQEEEKGTGIRNTGVSGRRDIDLLTQAQPIDLIKFGFIPEFIGRLPVSAV
LEDLDRSALIQILTKPKNAIIKQYQKLFEFENVRLKFSDEATEAIADLAMDRKVGARGLRMILEDLMLDLMYYLPSYKKV
REFQVTKEMVLSQKISLTILEKAG

Sequences:

>Translated_424_residues
MKRAGSDDALRCSFCHKSQDVVGKLISSPSDYPRAYICDECIAVCNSILEDDKVEAPSGTPNKIPKPLEVKEFLDQYVIG
QEATKKKLAVAVYNHCKRIHMNRMRNSEVELQKSNILLIGPTGTGKTLMAQTLAKILDVPFAIVDATTLTEAGYVGEDVE
NIILKLLQAADGDVQKCQQGIIYIDEIDKICRKDENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPHQEFTPVD
TTNILFICGGAFVGLEKVIARRTGKKSMGFLQEEEKGTGIRNTGVSGRRDIDLLTQAQPIDLIKFGFIPEFIGRLPVSAV
LEDLDRSALIQILTKPKNAIIKQYQKLFEFENVRLKFSDEATEAIADLAMDRKVGARGLRMILEDLMLDLMYYLPSYKKV
REFQVTKEMVLSQKISLTILEKAG
>Mature_424_residues
MKRAGSDDALRCSFCHKSQDVVGKLISSPSDYPRAYICDECIAVCNSILEDDKVEAPSGTPNKIPKPLEVKEFLDQYVIG
QEATKKKLAVAVYNHCKRIHMNRMRNSEVELQKSNILLIGPTGTGKTLMAQTLAKILDVPFAIVDATTLTEAGYVGEDVE
NIILKLLQAADGDVQKCQQGIIYIDEIDKICRKDENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPHQEFTPVD
TTNILFICGGAFVGLEKVIARRTGKKSMGFLQEEEKGTGIRNTGVSGRRDIDLLTQAQPIDLIKFGFIPEFIGRLPVSAV
LEDLDRSALIQILTKPKNAIIKQYQKLFEFENVRLKFSDEATEAIADLAMDRKVGARGLRMILEDLMLDLMYYLPSYKKV
REFQVTKEMVLSQKISLTILEKAG

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP [H]

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=325, Percent_Identity=51.0769230769231, Blast_Score=302, Evalue=5e-82,
Organism=Escherichia coli, GI1786642, Length=427, Percent_Identity=59.4847775175644, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=45.1923076923077, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=321, Percent_Identity=46.417445482866, Blast_Score=287, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI71982905, Length=321, Percent_Identity=46.417445482866, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71988663, Length=393, Percent_Identity=40.9669211195929, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71988660, Length=253, Percent_Identity=42.2924901185771, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319704, Length=413, Percent_Identity=39.225181598063, Blast_Score=252, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24648289, Length=316, Percent_Identity=48.4177215189873, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24648291, Length=316, Percent_Identity=48.4177215189873, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603 [H]

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX [H]

EC number: NA

Molecular weight: Translated: 47102; Mature: 47102

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAGSDDALRCSFCHKSQDVVGKLISSPSDYPRAYICDECIAVCNSILEDDKVEAPSGT
CCCCCCCCCEEEHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PNKIPKPLEVKEFLDQYVIGQEATKKKLAVAVYNHCKRIHMNRMRNSEVELQKSNILLIG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEE
PTGTGKTLMAQTLAKILDVPFAIVDATTLTEAGYVGEDVENIILKLLQAADGDVQKCQQG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
IIYIDEIDKICRKDENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPHQEFTPVD
CEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCC
TTNILFICGGAFVGLEKVIARRTGKKSMGFLQEEEKGTGIRNTGVSGRRDIDLLTQAQPI
CCCEEEEECCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCCCCCCHHHHCCCCCC
DLIKFGFIPEFIGRLPVSAVLEDLDRSALIQILTKPKNAIIKQYQKLFEFENVRLKFSDE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCH
ATEAIADLAMDRKVGARGLRMILEDLMLDLMYYLPSYKKVREFQVTKEMVLSQKISLTIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEE
EKAG
ECCC
>Mature Secondary Structure
MKRAGSDDALRCSFCHKSQDVVGKLISSPSDYPRAYICDECIAVCNSILEDDKVEAPSGT
CCCCCCCCCEEEHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PNKIPKPLEVKEFLDQYVIGQEATKKKLAVAVYNHCKRIHMNRMRNSEVELQKSNILLIG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEE
PTGTGKTLMAQTLAKILDVPFAIVDATTLTEAGYVGEDVENIILKLLQAADGDVQKCQQG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
IIYIDEIDKICRKDENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPHQEFTPVD
CEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCC
TTNILFICGGAFVGLEKVIARRTGKKSMGFLQEEEKGTGIRNTGVSGRRDIDLLTQAQPI
CCCEEEEECCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCCCCCCHHHHCCCCCC
DLIKFGFIPEFIGRLPVSAVLEDLDRSALIQILTKPKNAIIKQYQKLFEFENVRLKFSDE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCH
ATEAIADLAMDRKVGARGLRMILEDLMLDLMYYLPSYKKVREFQVTKEMVLSQKISLTIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEE
EKAG
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA