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The map label for this gene is ppiD [C]

Identifier: 116621076

GI number: 116621076

Start: 2455424

End: 2457976

Strand: Direct

Name: ppiD [C]

Synonym: Acid_1957

Alternate gene names: 116621076

Gene position: 2455424-2457976 (Clockwise)

Preceding gene: 116621075

Following gene: 116621077

Centisome position: 24.64

GC content: 60.2

Gene sequence:

>2553_bases
ATGTCTCGCGTGCTCCTCTGTGCGCTGTTTGCTCTCGTCGTCTTTGCCCCAGGCCAGCTACGAACTTCCACTGGTATTCC
GCTGCGGATACTGGTGCTTAATTCAGCCGAGGAGTCGGCTCGCGTCCGGGCGCAACTCGCGAATGGCGCCGATTTCGCCG
TGCTCGCCCGCGAGAAATCCGTGGATGCGACATCGCTCGATGGCGGCCTGCTGGGTAATGTCGATCCCTCCACACTGCGC
GAAGAGATCCGAACCGCGCTGCAAGGGCTCGCCCCCGGTCAGATTTCGCCGGTGTTCCGGCTTCCTACCGGTTTCGCAAT
CGTCAAGGTGCTGGCGCCGGACGAACTCGCCGGAATCGCAGAGTTCCAGCGCTCCCGTCAGGCCGCGATTCGCGCCGAAG
GCAGCATCCGGTTTGACGTGAACGTCTCTGGGTTCAGTGAAGCGGCCGCGGCTCTGGCGAGCTATGCCAAGCCTGCCAAT
TGGAATACCGATCTGAGACAGTCCTGCGCCATGCGGAAGCAATCGTTCGCCGATTTGAAGGCCCGGGCAGAGAAACTGGC
AGCAGGCGCGGACGACCCCGGCCACTCGCCTGCCGATGGCGTGGCGCTGCACCTCGGAGTGGCGCAGGTATATGCCTATC
AGGGAGACATGGATCGGGCCATCGCCCAGTTCGAAGCGGCTCTCCGCACTGCGTCTGCCGGGGCGCCAAAGCTACTGCCC
GAGGTAGAAGAGATGCTAGGCGTGGGATACCTTCACCGGGCGGGAGCGGTGAACGACGTATACCGCCATCCCGGGGAGCG
CTGCCTCTTTCCGATTCGTCCCGAATTCAGTTACACCAAGGGTGCGGATTCCCAAAAAGCCATCCAGCACTTTCTCGCAT
CGCTCAAGTTGCGGCCCAACGATCTCGAGACCAGGTGGCTGTTGAACCTTGCCTATATGACGCTGGGCAAATATCCGGCC
GGTGTACCCAAAGAGCACCTGTTGGCGCCTTCGCACTTCGACTCCGCCGAAGACATCGGCCGCTTTACCGACGTGGCGCC
GCGAGTGGGACTCGGCGCAGTCAATTTTGAAGTGGGCGGGCTGATCGTCGACGACTTCGATAACGATGGTCTCTTCGACA
TCGTTACTTCCAACTGGGACTTTTGCGCGCCCATGCATTTCTTCCACAACAACGGGGATGGCACGTTTGCCGACCGCAGC
GCGCAATCGGGGCTGGCAACCCAGTTCGGTGGAAACAACATTACCCAGACCGATTACAACAATGACGGCTGCCTGGATGT
CCTGGTCCTGCGCGGCGGCTGGGAAACGGCAATGCGGAAATCCCTGCTGCGCAACAACTGTAATGGCACCTTCACCGATG
TCACCGTGGAAGCCGGCCTGGGCACGCCAACGACAACGGAATTTGCCGTGTGGGTGGACATCAATAACGACGGATTCCTC
GATCTCTACGTCGGTAACGAAAACGAGCCGAATCAGCTTTTCCTGAACAACGGCAACGGCACATTTAAGGACATCTCACG
CTCGTCGGGGACGGACCTGTCAGTGCTTAGCAAGGCGGTGGTGGCGGCCGATTATGACAATGACGGCTATGCCGATCTGT
TCGTGTCCAACTACCGCGGCGACAGCGTGCTGTTCCACAACAATCACGATGGCACTTTCACCAACGTAGCGCCTCAGGCG
GGTGTCCAGGCCTCAGGCCATGGATTCGCCGCCTGGTTTTTCGACTACGACAACGACGGTTGGCCAGACCTTCTGGCGAG
CAGCTACGCGATGTCGATTGACGAAAGCGTGCGCACGTACCTGGGGTTGCCCCACCTCTCTCCCACCATGAAGCTCTACC
GCAACCTGGGCAACGGCGCCTTTCGCGATGTGACCGAAGAAACCGGGCTGAACAAAGTCTTCATGCCGATGGGTGCGAAT
TTCGGCGATGTGGATAACGATGGATATCCAGACATCTATTTCGGGACCGGAGAACTGTCTTTTGCCTCTCTGCTGCCCAA
TGTGCTCTTGCATAACAAAGGGGGAAAGAAGTTTGTGGACATCACTACCTCCTCCGGCACGGGCGAGTTGCACAAAGGGC
ACGGCGTGGCATTCGCGGATATCGACAATGACGGAGACGAAGACCTGCTGGAGGTGGTCGGTGGAGGTGTTCCAGGCGAC
CCCCATACGTTCCGCCTTTTCGAGAACCCGGGCCACGGCAACGATTGGATCAGCGTGCGGCTGGTAGGTGTCAAGGCGAA
CCGCGCGGCCATCGGCGCCAGGGTCAAAGTGACCGTAAAGAACGGAACGGAGACGCGAGCCGTTTATCGGACCGTGGGAA
GCGGCGGCTCGTTCGGCGCCTCGCCACTGGAACAGCACATGGGGCTGGGTAAATCGGCGGAGATCGTAGGCCTGGAGATT
CAGTGGCCCGGAGACGCCCAGGCGCAGCGGTTTGCGTCCGTGCCCAAGAACCAGGCGATCGAAATCCGGCAGTCCGCAAG
CGACTACCGCGTGATCGAGCGGCACCGGTTCAAGTTGGGTGGCGATCAGTTGGGTGGGGATCATGGGCAATAG

Upstream 100 bases:

>100_bases
TTCTTTGAACGGTTGGTGCCTGATGCAGAAACCTTTGCACCCGATCCTAACGTGAATCTCGTGCGTTTTGTGATATTATT
CCCGCACTATGAGGGTATCG

Downstream 100 bases:

>100_bases
TCTATCGGGCCGCATCGGGGTTTGCCGGCGGCTAGCTCCATTCCTGATTGGCGTGAGCCTTGCTGCCGCCACACGTTACC
CGGTCACCGGGGTTGTTCTG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: FG-GAP Repeat Domain Protein; ASPIC/UnbV Domain Protein; FG-GAP Repeat-Containing Protein; ASPIC/UnbV; FG-GAP Repeat Protein; Integrin-Like Protein; TPR Repeat-Containing Protein; Fg-Gap Repeat Protein; PpiC-Type Peptidyl-Prolyl Cis-Trans Isomerase; Aspic/Unbv; Rhs Family Protein; Aspic/Unbv Domain Protein; FG-GAP Repeat- ASPIC/UnbV Domain-Containing Protein; Integrin Like Protein; Integrins Alpha Chain; Protein Containing FG-GAP Repeats; Secreted Protein Containing FG-GAP Repeats; Fg-Gap; ASPIC And UnbV Domain Protein; Invasin/Intimin Cell-Adhesion Domain Protein; Immunoglobulin I-Set Domain-Containing Protein; Protein Tyrosine Kinase Family; FG-GAP Repeat Protein/ASPIC/UnbV Domain Protein

Number of amino acids: Translated: 850; Mature: 849

Protein sequence:

>850_residues
MSRVLLCALFALVVFAPGQLRTSTGIPLRILVLNSAEESARVRAQLANGADFAVLAREKSVDATSLDGGLLGNVDPSTLR
EEIRTALQGLAPGQISPVFRLPTGFAIVKVLAPDELAGIAEFQRSRQAAIRAEGSIRFDVNVSGFSEAAAALASYAKPAN
WNTDLRQSCAMRKQSFADLKARAEKLAAGADDPGHSPADGVALHLGVAQVYAYQGDMDRAIAQFEAALRTASAGAPKLLP
EVEEMLGVGYLHRAGAVNDVYRHPGERCLFPIRPEFSYTKGADSQKAIQHFLASLKLRPNDLETRWLLNLAYMTLGKYPA
GVPKEHLLAPSHFDSAEDIGRFTDVAPRVGLGAVNFEVGGLIVDDFDNDGLFDIVTSNWDFCAPMHFFHNNGDGTFADRS
AQSGLATQFGGNNITQTDYNNDGCLDVLVLRGGWETAMRKSLLRNNCNGTFTDVTVEAGLGTPTTTEFAVWVDINNDGFL
DLYVGNENEPNQLFLNNGNGTFKDISRSSGTDLSVLSKAVVAADYDNDGYADLFVSNYRGDSVLFHNNHDGTFTNVAPQA
GVQASGHGFAAWFFDYDNDGWPDLLASSYAMSIDESVRTYLGLPHLSPTMKLYRNLGNGAFRDVTEETGLNKVFMPMGAN
FGDVDNDGYPDIYFGTGELSFASLLPNVLLHNKGGKKFVDITTSSGTGELHKGHGVAFADIDNDGDEDLLEVVGGGVPGD
PHTFRLFENPGHGNDWISVRLVGVKANRAAIGARVKVTVKNGTETRAVYRTVGSGGSFGASPLEQHMGLGKSAEIVGLEI
QWPGDAQAQRFASVPKNQAIEIRQSASDYRVIERHRFKLGGDQLGGDHGQ

Sequences:

>Translated_850_residues
MSRVLLCALFALVVFAPGQLRTSTGIPLRILVLNSAEESARVRAQLANGADFAVLAREKSVDATSLDGGLLGNVDPSTLR
EEIRTALQGLAPGQISPVFRLPTGFAIVKVLAPDELAGIAEFQRSRQAAIRAEGSIRFDVNVSGFSEAAAALASYAKPAN
WNTDLRQSCAMRKQSFADLKARAEKLAAGADDPGHSPADGVALHLGVAQVYAYQGDMDRAIAQFEAALRTASAGAPKLLP
EVEEMLGVGYLHRAGAVNDVYRHPGERCLFPIRPEFSYTKGADSQKAIQHFLASLKLRPNDLETRWLLNLAYMTLGKYPA
GVPKEHLLAPSHFDSAEDIGRFTDVAPRVGLGAVNFEVGGLIVDDFDNDGLFDIVTSNWDFCAPMHFFHNNGDGTFADRS
AQSGLATQFGGNNITQTDYNNDGCLDVLVLRGGWETAMRKSLLRNNCNGTFTDVTVEAGLGTPTTTEFAVWVDINNDGFL
DLYVGNENEPNQLFLNNGNGTFKDISRSSGTDLSVLSKAVVAADYDNDGYADLFVSNYRGDSVLFHNNHDGTFTNVAPQA
GVQASGHGFAAWFFDYDNDGWPDLLASSYAMSIDESVRTYLGLPHLSPTMKLYRNLGNGAFRDVTEETGLNKVFMPMGAN
FGDVDNDGYPDIYFGTGELSFASLLPNVLLHNKGGKKFVDITTSSGTGELHKGHGVAFADIDNDGDEDLLEVVGGGVPGD
PHTFRLFENPGHGNDWISVRLVGVKANRAAIGARVKVTVKNGTETRAVYRTVGSGGSFGASPLEQHMGLGKSAEIVGLEI
QWPGDAQAQRFASVPKNQAIEIRQSASDYRVIERHRFKLGGDQLGGDHGQ
>Mature_849_residues
SRVLLCALFALVVFAPGQLRTSTGIPLRILVLNSAEESARVRAQLANGADFAVLAREKSVDATSLDGGLLGNVDPSTLRE
EIRTALQGLAPGQISPVFRLPTGFAIVKVLAPDELAGIAEFQRSRQAAIRAEGSIRFDVNVSGFSEAAAALASYAKPANW
NTDLRQSCAMRKQSFADLKARAEKLAAGADDPGHSPADGVALHLGVAQVYAYQGDMDRAIAQFEAALRTASAGAPKLLPE
VEEMLGVGYLHRAGAVNDVYRHPGERCLFPIRPEFSYTKGADSQKAIQHFLASLKLRPNDLETRWLLNLAYMTLGKYPAG
VPKEHLLAPSHFDSAEDIGRFTDVAPRVGLGAVNFEVGGLIVDDFDNDGLFDIVTSNWDFCAPMHFFHNNGDGTFADRSA
QSGLATQFGGNNITQTDYNNDGCLDVLVLRGGWETAMRKSLLRNNCNGTFTDVTVEAGLGTPTTTEFAVWVDINNDGFLD
LYVGNENEPNQLFLNNGNGTFKDISRSSGTDLSVLSKAVVAADYDNDGYADLFVSNYRGDSVLFHNNHDGTFTNVAPQAG
VQASGHGFAAWFFDYDNDGWPDLLASSYAMSIDESVRTYLGLPHLSPTMKLYRNLGNGAFRDVTEETGLNKVFMPMGANF
GDVDNDGYPDIYFGTGELSFASLLPNVLLHNKGGKKFVDITTSSGTGELHKGHGVAFADIDNDGDEDLLEVVGGGVPGDP
HTFRLFENPGHGNDWISVRLVGVKANRAAIGARVKVTVKNGTETRAVYRTVGSGGSFGASPLEQHMGLGKSAEIVGLEIQ
WPGDAQAQRFASVPKNQAIEIRQSASDYRVIERHRFKLGGDQLGGDHGQ

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI47777317, Length=502, Percent_Identity=25.6972111553785, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 91442; Mature: 91311

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLLCALFALVVFAPGQLRTSTGIPLRILVLNSAEESARVRAQLANGADFAVLAREKS
CCHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCC
VDATSLDGGLLGNVDPSTLREEIRTALQGLAPGQISPVFRLPTGFAIVKVLAPDELAGIA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEECCHHHHHHH
EFQRSRQAAIRAEGSIRFDVNVSGFSEAAAALASYAKPANWNTDLRQSCAMRKQSFADLK
HHHHHHHHHEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ARAEKLAAGADDPGHSPADGVALHLGVAQVYAYQGDMDRAIAQFEAALRTASAGAPKLLP
HHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHEECCCHHHHHHHHHHHHHHCCCCCCHHHH
EVEEMLGVGYLHRAGAVNDVYRHPGERCLFPIRPEFSYTKGADSQKAIQHFLASLKLRPN
HHHHHHCCCHHHHCCCHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DLETRWLLNLAYMTLGKYPAGVPKEHLLAPSHFDSAEDIGRFTDVAPRVGLGAVNFEVGG
CCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECC
LIVDDFDNDGLFDIVTSNWDFCAPMHFFHNNGDGTFADRSAQSGLATQFGGNNITQTDYN
EEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
NDGCLDVLVLRGGWETAMRKSLLRNNCNGTFTDVTVEAGLGTPTTTEFAVWVDINNDGFL
CCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCEE
DLYVGNENEPNQLFLNNGNGTFKDISRSSGTDLSVLSKAVVAADYDNDGYADLFVSNYRG
EEEECCCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHEEEECCCCCCEEEEEECCCC
DSVLFHNNHDGTFTNVAPQAGVQASGHGFAAWFFDYDNDGWPDLLASSYAMSIDESVRTY
CEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LGLPHLSPTMKLYRNLGNGAFRDVTEETGLNKVFMPMGANFGDVDNDGYPDIYFGTGELS
HCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCC
FASLLPNVLLHNKGGKKFVDITTSSGTGELHKGHGVAFADIDNDGDEDLLEVVGGGVPGD
HHHHHHHHEEECCCCCEEEEEEECCCCCCEECCCCEEEEECCCCCHHHHHHHHCCCCCCC
PHTFRLFENPGHGNDWISVRLVGVKANRAAIGARVKVTVKNGTETRAVYRTVGSGGSFGA
CCEEEEECCCCCCCCEEEEEEEEEECCCEEECEEEEEEECCCCCHHHHHHHHCCCCCCCC
SPLEQHMGLGKSAEIVGLEIQWPGDAQAQRFASVPKNQAIEIRQSASDYRVIERHRFKLG
CHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCEEEHHCCCHHHHHHHHHHCCC
GDQLGGDHGQ
CCCCCCCCCC
>Mature Secondary Structure 
SRVLLCALFALVVFAPGQLRTSTGIPLRILVLNSAEESARVRAQLANGADFAVLAREKS
CHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCC
VDATSLDGGLLGNVDPSTLREEIRTALQGLAPGQISPVFRLPTGFAIVKVLAPDELAGIA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEECCHHHHHHH
EFQRSRQAAIRAEGSIRFDVNVSGFSEAAAALASYAKPANWNTDLRQSCAMRKQSFADLK
HHHHHHHHHEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ARAEKLAAGADDPGHSPADGVALHLGVAQVYAYQGDMDRAIAQFEAALRTASAGAPKLLP
HHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHEECCCHHHHHHHHHHHHHHCCCCCCHHHH
EVEEMLGVGYLHRAGAVNDVYRHPGERCLFPIRPEFSYTKGADSQKAIQHFLASLKLRPN
HHHHHHCCCHHHHCCCHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DLETRWLLNLAYMTLGKYPAGVPKEHLLAPSHFDSAEDIGRFTDVAPRVGLGAVNFEVGG
CCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECC
LIVDDFDNDGLFDIVTSNWDFCAPMHFFHNNGDGTFADRSAQSGLATQFGGNNITQTDYN
EEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
NDGCLDVLVLRGGWETAMRKSLLRNNCNGTFTDVTVEAGLGTPTTTEFAVWVDINNDGFL
CCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCEE
DLYVGNENEPNQLFLNNGNGTFKDISRSSGTDLSVLSKAVVAADYDNDGYADLFVSNYRG
EEEECCCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHEEEECCCCCCEEEEEECCCC
DSVLFHNNHDGTFTNVAPQAGVQASGHGFAAWFFDYDNDGWPDLLASSYAMSIDESVRTY
CEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LGLPHLSPTMKLYRNLGNGAFRDVTEETGLNKVFMPMGANFGDVDNDGYPDIYFGTGELS
HCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCC
FASLLPNVLLHNKGGKKFVDITTSSGTGELHKGHGVAFADIDNDGDEDLLEVVGGGVPGD
HHHHHHHHEEECCCCCEEEEEEECCCCCCEECCCCEEEEECCCCCHHHHHHHHCCCCCCC
PHTFRLFENPGHGNDWISVRLVGVKANRAAIGARVKVTVKNGTETRAVYRTVGSGGSFGA
CCEEEEECCCCCCCCEEEEEEEEEECCCEEECEEEEEEECCCCCHHHHHHHHCCCCCCCC
SPLEQHMGLGKSAEIVGLEIQWPGDAQAQRFASVPKNQAIEIRQSASDYRVIERHRFKLG
CHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCEEEHHCCCHHHHHHHHHHCCC
GDQLGGDHGQ
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA