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The map label for this gene is atoC [H]

Identifier: 116621041

GI number: 116621041

Start: 2384928

End: 2386280

Strand: Direct

Name: atoC [H]

Synonym: Acid_1922

Alternate gene names: 116621041

Gene position: 2384928-2386280 (Clockwise)

Preceding gene: 116621040

Following gene: 116621042

Centisome position: 23.93

GC content: 63.41

Gene sequence:

>1353_bases
ATGAAGAAACGCATTCTGGTCGTGGAAGACGAAGAGAAACTGCGGCGCGTGATCGAGCTGCAACTGTTGTCGGCCGGCTT
CGACGTGGACAAGGCGGCTAGCGCGGAAGAAGGCTTGAAGATCGTGGATCGGGCGGACATGGTGCTGACCGATCTCAAGC
TGCCGAACATGGACGGCCAGGAGTTTTTGTCCTTGATCCGGCGGCAGAATTCGCACGTGCCGGTGGTGATGATGACCGCG
TTCGGCAACGTGGAGACGGCGGTAGAGGCGATGAAGGCGGGGGCGACGGATTTTCTGCTCAAGCCGTTCTCGCTGGATCA
CCTGATGCAGGTGGTGGACAAGGCGCTCGAGGTGCGGGCGCTGCGAGAGGAGAATCGCGAGCTGAAGGCGGCGCTGGGGC
GGCGCTACGAGTTCGACAACATCGTGGGACGGAGTCCGGCGATGCAGGAGATTTTCGCGGCGATCGAGCGCGTGGGGCCG
TCGCGGGCGACAGTACTGTTGACGGGAGAGAGCGGCGTCGGAAAGGACCTGATCGCGCGCGCGATTCATTTTCACTCGCC
GCGCAAAGATCGCCCGCTGGTAAAGATCAACTGCACGGCGATCCCGGAGAACCTGATGGAGAGCGAGCTCTTCGGCTACG
AGAAGGGCGCGTTCACGGGGGCGCAGACCACCAAGCCGGGCAAGTTCGAACAGGCGGACACCGGGACGGTATTCCTGGAC
GAGATCGGCGACGTACCGGCGGCGATTCAGGTTAAGCTGCTGAGGGTGCTGCAGGAGAGGGAATTCGAGCGGCTGGGAAG
CAACGTGACGCGGCACATCGACGTGCGGCTGGTGGCGGCGACCAACCAGGATTTGCGGGCGGCGCTGGAGCAGGGGACGT
TTCGCGAGGACCTGTACTACCGGCTGAACGTAGTGCCGCTGAACATTCCGCCGCTGCGCGAGCGCAAGGTGGATATTCCT
TTCCTGGCGAATCATTTCGTCCACAAGCTGGCGCCCGATACCGGCTGCCAGGTGGAGAGCATCACGGACGCGGGCATGGA
GAAACTGATGGCGTACCACTGGCCGGGCAATGTGCGCGAACTGGAGAACGTGATCGAGCGCAGCCTGGTGATGGCCACTG
GAACGCAACTGGACGCCGACGATATCAAGCTGGAGAGCGCTCCGCGGCCGCGAGCGCAGGGCAACGACAACCACTTTCTG
CCCGAGGGCCTGAGTCTGGACCAGTACGAGCAGGAGATCATCCGGGAAGCGCTGCGGCGGGCCGATGGAAACAAGAGCCA
GGCGGCGCGCCTGCTGGGACTGACGCGGAACGCGCTGCGCTACAGGCTGACGCAGATGGGGCTGGAGAGCTAG

Upstream 100 bases:

>100_bases
TGGATGAACACGGCGGTAAGATAGCAGTGGAGAGCGAGCCGGGGAAAGGCAGCATTTTTTGCGTGTCGCTGCCCACAAAT
CCGACGCCCCAACCCACCGC

Downstream 100 bases:

>100_bases
AAGCTGATAACAATATGCTGACGGATCGGGAAGCTTACAAGAAACTGGCGGCGCACTTCGAACAGGTCAAGAATGTCCAC
CTGCGGGAATTGTTTGCGGC

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKKRILVVEDEEKLRRVIELQLLSAGFDVDKAASAEEGLKIVDRADMVLTDLKLPNMDGQEFLSLIRRQNSHVPVVMMTA
FGNVETAVEAMKAGATDFLLKPFSLDHLMQVVDKALEVRALREENRELKAALGRRYEFDNIVGRSPAMQEIFAAIERVGP
SRATVLLTGESGVGKDLIARAIHFHSPRKDRPLVKINCTAIPENLMESELFGYEKGAFTGAQTTKPGKFEQADTGTVFLD
EIGDVPAAIQVKLLRVLQEREFERLGSNVTRHIDVRLVAATNQDLRAALEQGTFREDLYYRLNVVPLNIPPLRERKVDIP
FLANHFVHKLAPDTGCQVESITDAGMEKLMAYHWPGNVRELENVIERSLVMATGTQLDADDIKLESAPRPRAQGNDNHFL
PEGLSLDQYEQEIIREALRRADGNKSQAARLLGLTRNALRYRLTQMGLES

Sequences:

>Translated_450_residues
MKKRILVVEDEEKLRRVIELQLLSAGFDVDKAASAEEGLKIVDRADMVLTDLKLPNMDGQEFLSLIRRQNSHVPVVMMTA
FGNVETAVEAMKAGATDFLLKPFSLDHLMQVVDKALEVRALREENRELKAALGRRYEFDNIVGRSPAMQEIFAAIERVGP
SRATVLLTGESGVGKDLIARAIHFHSPRKDRPLVKINCTAIPENLMESELFGYEKGAFTGAQTTKPGKFEQADTGTVFLD
EIGDVPAAIQVKLLRVLQEREFERLGSNVTRHIDVRLVAATNQDLRAALEQGTFREDLYYRLNVVPLNIPPLRERKVDIP
FLANHFVHKLAPDTGCQVESITDAGMEKLMAYHWPGNVRELENVIERSLVMATGTQLDADDIKLESAPRPRAQGNDNHFL
PEGLSLDQYEQEIIREALRRADGNKSQAARLLGLTRNALRYRLTQMGLES
>Mature_450_residues
MKKRILVVEDEEKLRRVIELQLLSAGFDVDKAASAEEGLKIVDRADMVLTDLKLPNMDGQEFLSLIRRQNSHVPVVMMTA
FGNVETAVEAMKAGATDFLLKPFSLDHLMQVVDKALEVRALREENRELKAALGRRYEFDNIVGRSPAMQEIFAAIERVGP
SRATVLLTGESGVGKDLIARAIHFHSPRKDRPLVKINCTAIPENLMESELFGYEKGAFTGAQTTKPGKFEQADTGTVFLD
EIGDVPAAIQVKLLRVLQEREFERLGSNVTRHIDVRLVAATNQDLRAALEQGTFREDLYYRLNVVPLNIPPLRERKVDIP
FLANHFVHKLAPDTGCQVESITDAGMEKLMAYHWPGNVRELENVIERSLVMATGTQLDADDIKLESAPRPRAQGNDNHFL
PEGLSLDQYEQEIIREALRRADGNKSQAARLLGLTRNALRYRLTQMGLES

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=44.3708609271523, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=45.2702702702703, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=39.2405063291139, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=41.4253897550111, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI87082117, Length=342, Percent_Identity=45.906432748538, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1789087, Length=351, Percent_Identity=46.7236467236467, Blast_Score=280, Evalue=9e-77,
Organism=Escherichia coli, GI1789233, Length=309, Percent_Identity=41.4239482200647, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87082152, Length=301, Percent_Identity=42.5249169435216, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI87081872, Length=314, Percent_Identity=40.4458598726115, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1786524, Length=380, Percent_Identity=36.8421052631579, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=39.2405063291139, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=35.6862745098039, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=330, Percent_Identity=28.7878787878788, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787375, Length=111, Percent_Identity=38.7387387387387, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=134, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786911, Length=106, Percent_Identity=36.7924528301887, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=34.5132743362832, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789402, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=31.9327731092437, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.0578512396694, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=129, Percent_Identity=31.0077519379845, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790552, Length=108, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50458; Mature: 50458

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRILVVEDEEKLRRVIELQLLSAGFDVDKAASAEEGLKIVDRADMVLTDLKLPNMDGQ
CCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCHHHCCHHHHHHHHHEEECCCCCCCHH
EFLSLIRRQNSHVPVVMMTAFGNVETAVEAMKAGATDFLLKPFSLDHLMQVVDKALEVRA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHH
LREENRELKAALGRRYEFDNIVGRSPAMQEIFAAIERVGPSRATVLLTGESGVGKDLIAR
HHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
AIHFHSPRKDRPLVKINCTAIPENLMESELFGYEKGAFTGAQTTKPGKFEQADTGTVFLD
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHH
EIGDVPAAIQVKLLRVLQEREFERLGSNVTRHIDVRLVAATNQDLRAALEQGTFREDLYY
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCCHHCCEE
RLNVVPLNIPPLRERKVDIPFLANHFVHKLAPDTGCQVESITDAGMEKLMAYHWPGNVRE
EEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
LENVIERSLVMATGTQLDADDIKLESAPRPRAQGNDNHFLPEGLSLDQYEQEIIREALRR
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADGNKSQAARLLGLTRNALRYRLTQMGLES
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKRILVVEDEEKLRRVIELQLLSAGFDVDKAASAEEGLKIVDRADMVLTDLKLPNMDGQ
CCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCHHHCCHHHHHHHHHEEECCCCCCCHH
EFLSLIRRQNSHVPVVMMTAFGNVETAVEAMKAGATDFLLKPFSLDHLMQVVDKALEVRA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHH
LREENRELKAALGRRYEFDNIVGRSPAMQEIFAAIERVGPSRATVLLTGESGVGKDLIAR
HHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHH
AIHFHSPRKDRPLVKINCTAIPENLMESELFGYEKGAFTGAQTTKPGKFEQADTGTVFLD
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHH
EIGDVPAAIQVKLLRVLQEREFERLGSNVTRHIDVRLVAATNQDLRAALEQGTFREDLYY
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCCHHCCEE
RLNVVPLNIPPLRERKVDIPFLANHFVHKLAPDTGCQVESITDAGMEKLMAYHWPGNVRE
EEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
LENVIERSLVMATGTQLDADDIKLESAPRPRAQGNDNHFLPEGLSLDQYEQEIIREALRR
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADGNKSQAARLLGLTRNALRYRLTQMGLES
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]