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The map label for this gene is pgi [H]

Identifier: 116621042

GI number: 116621042

Start: 2386295

End: 2387893

Strand: Direct

Name: pgi [H]

Synonym: Acid_1923

Alternate gene names: 116621042

Gene position: 2386295-2387893 (Clockwise)

Preceding gene: 116621041

Following gene: 116621047

Centisome position: 23.95

GC content: 63.16

Gene sequence:

>1599_bases
ATGCTGACGGATCGGGAAGCTTACAAGAAACTGGCGGCGCACTTCGAACAGGTCAAGAATGTCCACCTGCGGGAATTGTT
TGCGGCGGACAGCCGGCGCGGGGAGCGGCTGACGGCGGAAGCGGCGGGACTGTATCTGGACTACTCGAAGAACCGGGTGA
CGGATGAGACGCTCGGCCTGCTGCTGGCTCTGGCGGAAGAGTGCGGGCTGCGGGGGCGAATCGACGCCATGTTCCGCGGC
GACAAGATCAACACGACGGAGGGGCGCGCGGTGCTGCATACGGCGCTGCGAGCGCCGCGCGGCAAATCGCCGGCGGCGGC
GCAGGTGCCCGAGGCCGGGGAGCCGGTCCAGGCGGTGCTGGAGCAGATGAGCGTCTTCGCCACCAGCGTGCGGGAGGGCC
GGTGGGCAGGGTTCACGGGGAAGCCGATCCGCAACGTGGTGAACATCGGGATCGGCGGCAGCGACCTGGGGCCGGTCATG
GCCTTCGAGGCGCTGCGGTATTACAGCCAGCGCAATCTCACGTTCCGCTTCGTTTCGAACGTGGACGGCACGGATTTCCG
CGAGGCTACTCGCGATCTGGATCCGGCCGAGACGCTCTTCATCGTGGCGTCGAAGACTTTCACGACGCTGGAGACGATGG
CGAACGCGCAATCGGCGCGCGCGTGGACGCTGGCGGCGCTGGGAGACCCGGCGGCGGTCGCGAGGCACTTTGTCGCGGTG
TCTACGGCGGCGGAGAAGGTCGCTAAGTTTGGAATCGACACGGCGAACATGTTCGGGTTCTGGGATTGGGTGGGCGGCCG
CTACTCGATGGAATCGGCGATCGGACTTTCGACGATGATCGCGATCGGGCCGGAGAATTTCCTGGAGATGCTGGGCGGAT
CTTACGCGATGGACGAGCATTTCCGTACGGCTCCGTTCGCGAAGAATCTGCCGGTGCTGATGGGGCTGCTAACTGTTTGG
TACAACAATCTGTTTAAGGCGCAAACGGTGGCGGTGCTGCCGTACGATCAATACCTGAAGCGCTTTCCGGCGTACCTGCA
ACAGCTGACGATGGAGAGCTGCGGCAAGCACGTCACGCTGGGCGGGGAGCCGATCACGACGTATGAAACGGGCCCGATTT
TTTGGGGTGAGCCGGGGACCAACGGGCAGCACTCGTTCTACCAGTTGATTCATCAGGGGACGAAACTGATTCCCTGCGAC
TTCATCGGTTTCCGGCAGACGTTGAATCCGCTGCCGAGTCCGATGGGGAATCATCACGACCTGCTGATGGCCAACGTGTT
CGCGCAGAGCAAGGCGCTCGCATTCGGAAAGGCGGCGCCTGCCGGGCAGCCCTACCGGGAGTTCGATGGCAACCGGCCGA
GCAATACGATTCTGGCGGAGCGGTTGACGCCCGCGGTGCTGGGAGCGCTGGTGACGCTGTACGAGCACAGCGTACTCACG
CAGGCGACGATCTGGGATATCAACCCGTTCGATCAGTTCGGCGTCGAATTGGGCAAAGTGCTGGCCGCGGAGATTTTGCC
ATCTCTGGCGAAGGATGCGCCTCTGCCGGATGACGACAGCTCGACGGTGGCGCTGATTAAGAGGTACAAGAAGCAATAA

Upstream 100 bases:

>100_bases
GAAACAAGAGCCAGGCGGCGCGCCTGCTGGGACTGACGCGGAACGCGCTGCGCTACAGGCTGACGCAGATGGGGCTGGAG
AGCTAGAAGCTGATAACAAT

Downstream 100 bases:

>100_bases
GTGGACACGGTTGAAAGCCCCGCTGCCAAGCGTTGACCGTCTCCGCGGAGCCAGGATTGGGTTGCCCCACGTGCGGCAAG
CCGCAAACTGAGGTCGTGGT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MLTDREAYKKLAAHFEQVKNVHLRELFAADSRRGERLTAEAAGLYLDYSKNRVTDETLGLLLALAEECGLRGRIDAMFRG
DKINTTEGRAVLHTALRAPRGKSPAAAQVPEAGEPVQAVLEQMSVFATSVREGRWAGFTGKPIRNVVNIGIGGSDLGPVM
AFEALRYYSQRNLTFRFVSNVDGTDFREATRDLDPAETLFIVASKTFTTLETMANAQSARAWTLAALGDPAAVARHFVAV
STAAEKVAKFGIDTANMFGFWDWVGGRYSMESAIGLSTMIAIGPENFLEMLGGSYAMDEHFRTAPFAKNLPVLMGLLTVW
YNNLFKAQTVAVLPYDQYLKRFPAYLQQLTMESCGKHVTLGGEPITTYETGPIFWGEPGTNGQHSFYQLIHQGTKLIPCD
FIGFRQTLNPLPSPMGNHHDLLMANVFAQSKALAFGKAAPAGQPYREFDGNRPSNTILAERLTPAVLGALVTLYEHSVLT
QATIWDINPFDQFGVELGKVLAAEILPSLAKDAPLPDDDSSTVALIKRYKKQ

Sequences:

>Translated_532_residues
MLTDREAYKKLAAHFEQVKNVHLRELFAADSRRGERLTAEAAGLYLDYSKNRVTDETLGLLLALAEECGLRGRIDAMFRG
DKINTTEGRAVLHTALRAPRGKSPAAAQVPEAGEPVQAVLEQMSVFATSVREGRWAGFTGKPIRNVVNIGIGGSDLGPVM
AFEALRYYSQRNLTFRFVSNVDGTDFREATRDLDPAETLFIVASKTFTTLETMANAQSARAWTLAALGDPAAVARHFVAV
STAAEKVAKFGIDTANMFGFWDWVGGRYSMESAIGLSTMIAIGPENFLEMLGGSYAMDEHFRTAPFAKNLPVLMGLLTVW
YNNLFKAQTVAVLPYDQYLKRFPAYLQQLTMESCGKHVTLGGEPITTYETGPIFWGEPGTNGQHSFYQLIHQGTKLIPCD
FIGFRQTLNPLPSPMGNHHDLLMANVFAQSKALAFGKAAPAGQPYREFDGNRPSNTILAERLTPAVLGALVTLYEHSVLT
QATIWDINPFDQFGVELGKVLAAEILPSLAKDAPLPDDDSSTVALIKRYKKQ
>Mature_532_residues
MLTDREAYKKLAAHFEQVKNVHLRELFAADSRRGERLTAEAAGLYLDYSKNRVTDETLGLLLALAEECGLRGRIDAMFRG
DKINTTEGRAVLHTALRAPRGKSPAAAQVPEAGEPVQAVLEQMSVFATSVREGRWAGFTGKPIRNVVNIGIGGSDLGPVM
AFEALRYYSQRNLTFRFVSNVDGTDFREATRDLDPAETLFIVASKTFTTLETMANAQSARAWTLAALGDPAAVARHFVAV
STAAEKVAKFGIDTANMFGFWDWVGGRYSMESAIGLSTMIAIGPENFLEMLGGSYAMDEHFRTAPFAKNLPVLMGLLTVW
YNNLFKAQTVAVLPYDQYLKRFPAYLQQLTMESCGKHVTLGGEPITTYETGPIFWGEPGTNGQHSFYQLIHQGTKLIPCD
FIGFRQTLNPLPSPMGNHHDLLMANVFAQSKALAFGKAAPAGQPYREFDGNRPSNTILAERLTPAVLGALVTLYEHSVLT
QATIWDINPFDQFGVELGKVLAAEILPSLAKDAPLPDDDSSTVALIKRYKKQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=553, Percent_Identity=49.5479204339964, Blast_Score=527, Evalue=1e-150,
Organism=Homo sapiens, GI296080693, Length=553, Percent_Identity=45.750452079566, Blast_Score=471, Evalue=1e-132,
Organism=Escherichia coli, GI1790457, Length=546, Percent_Identity=53.8461538461538, Blast_Score=582, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71996703, Length=553, Percent_Identity=49.005424954792, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71996708, Length=553, Percent_Identity=49.005424954792, Blast_Score=508, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=50.091407678245, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24651916, Length=552, Percent_Identity=51.4492753623188, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24651914, Length=552, Percent_Identity=51.4492753623188, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17737445, Length=552, Percent_Identity=51.4492753623188, Blast_Score=542, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58383; Mature: 58383

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDREAYKKLAAHFEQVKNVHLRELFAADSRRGERLTAEAAGLYLDYSKNRVTDETLGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCEEEECCCCCCCHHHHHH
LLALAEECGLRGRIDAMFRGDKINTTEGRAVLHTALRAPRGKSPAAAQVPEAGEPVQAVL
HHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
EQMSVFATSVREGRWAGFTGKPIRNVVNIGIGGSDLGPVMAFEALRYYSQRNLTFRFVSN
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
VDGTDFREATRDLDPAETLFIVASKTFTTLETMANAQSARAWTLAALGDPAAVARHFVAV
CCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCHHCCEEEEEECCCHHHHHHHHHHH
STAAEKVAKFGIDTANMFGFWDWVGGRYSMESAIGLSTMIAIGPENFLEMLGGSYAMDEH
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCHHHHEEECHHHHHHHHCCCCHHHHH
FRTAPFAKNLPVLMGLLTVWYNNLFKAQTVAVLPYDQYLKRFPAYLQQLTMESCGKHVTL
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEE
GGEPITTYETGPIFWGEPGTNGQHSFYQLIHQGTKLIPCDFIGFRQTLNPLPSPMGNHHD
CCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCH
LLMANVFAQSKALAFGKAAPAGQPYREFDGNRPSNTILAERLTPAVLGALVTLYEHSVLT
HHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QATIWDINPFDQFGVELGKVLAAEILPSLAKDAPLPDDDSSTVALIKRYKKQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLTDREAYKKLAAHFEQVKNVHLRELFAADSRRGERLTAEAAGLYLDYSKNRVTDETLGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCEEEECCCCCCCHHHHHH
LLALAEECGLRGRIDAMFRGDKINTTEGRAVLHTALRAPRGKSPAAAQVPEAGEPVQAVL
HHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
EQMSVFATSVREGRWAGFTGKPIRNVVNIGIGGSDLGPVMAFEALRYYSQRNLTFRFVSN
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
VDGTDFREATRDLDPAETLFIVASKTFTTLETMANAQSARAWTLAALGDPAAVARHFVAV
CCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCHHCCEEEEEECCCHHHHHHHHHHH
STAAEKVAKFGIDTANMFGFWDWVGGRYSMESAIGLSTMIAIGPENFLEMLGGSYAMDEH
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCHHHHEEECHHHHHHHHCCCCHHHHH
FRTAPFAKNLPVLMGLLTVWYNNLFKAQTVAVLPYDQYLKRFPAYLQQLTMESCGKHVTL
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEE
GGEPITTYETGPIFWGEPGTNGQHSFYQLIHQGTKLIPCDFIGFRQTLNPLPSPMGNHHD
CCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCH
LLMANVFAQSKALAFGKAAPAGQPYREFDGNRPSNTILAERLTPAVLGALVTLYEHSVLT
HHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QATIWDINPFDQFGVELGKVLAAEILPSLAKDAPLPDDDSSTVALIKRYKKQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA