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The map label for this gene is accC [H]

Identifier: 116620977

GI number: 116620977

Start: 2312928

End: 2314424

Strand: Direct

Name: accC [H]

Synonym: Acid_1858

Alternate gene names: 116620977

Gene position: 2312928-2314424 (Clockwise)

Preceding gene: 116620973

Following gene: 116620978

Centisome position: 23.21

GC content: 67.27

Gene sequence:

>1497_bases
ATGTTCCGTAAGGTCTTGATCGCCAACCGCGGAGAGATCGCCGTGCGCGTGATCCGCACGCTGCGCGAAATGGGAATCGG
CACAGTCGCCGTGTATTCCGACCCCGATCGTACTTCGCTGCACGTTCGCATGGCCGATGAAGCCGAGCGCCTGGGTCCGG
GCCCATCGGCGGAGAGTTACCTGAGAATCGATCGCATTCTGGATGCCGCGCGCAAGCACGGCGCGGAGGCGATTCACCCC
GGCTACGGATTCCTGAGCGAGAACGCGGATTTCGCGGCGGCCTGCGAGGACGCGGGGCTGGTGTTCATCGGACCTTCGGC
GGCCTCGATCCGCGCCATGGGGTCGAAGACCGCGGCACGGCGATCCGCCATCGCTGCCGGCGCGCCGGTGGTGCCCGGCA
CGGAGCAGGCGGTCACGCTTCAGGAGTTGCGCGAGTTTGCCGCGGCGCATGGCTATCCGGTGCTGCTCAAGGCGGTCGCC
GGAGGCGGCGGAAAAGGTATGCGGCGCGTGGACTCTCCCGGCGAGCTCGAATCGGCCTATCGCAACGCGGCCAGCGAGGC
GGAGCGCGCATTTCAGAGCGCCGAGATCTACGTGGAGAAGCTGATCGAGCGGCCGCGGCACATCGAGATTCAAGTGCTCG
GTGATCGCTACGGGAACATGGTGCACCTGGGCGAGCGCGAGTGCTCGATTCAGCGGCGGCATCAAAAGGTGATCGAAGAG
TGTCCCTCGCCCTTGATCGAACGGCACCCGGAGATGCGCGACGCGATGGGCCAGGCGGCGATCCGCGCGGCGCAGGCAGC
CGGGTATTACAACGCGGGCACGGTGGAGTTCCTGGTGGACCAGGAGCGCCGCTTCTACTTCCTCGAAATGAACACGCGCC
TGCAGGTGGAGCATCCGGTCACTGAGCTGGCGACCGGCCTCGACCTGGTGCGTCATCAGGTAGAAATAGCGAACGGCGGG
CGCCTGCCGTTCACGCAGGAGCAGGTTGCATGGCGCGGGGCGGCGATCGAATGCCGCATCTACGCGGAGGATCCGTACAA
CAATTTCCTGCCGTATCCGGGGAAGATCACCAGGCTGCGCCGGCCGCTGGGACCGGGCGTCCGCATCGATGGCTGCATCT
ACGAAGGCTGGACCGTGCCCATGGAATATGACCCGCTGCTCGCCAAGCTCACCGTGTGGGCAGGCACGCGCGAACACGCG
GCGGAGCGGGCCATCCGCGCCCTGCGCGAGTACGACGTGGGCGGCATCCGCACGAACATCGGCTTCTTCCGGCAGATTCT
GGAGGATCCCGAGTTTCGCGCCGCGAACCTGCACGCCGGCTTCATCGAGGAATTCTTCGCGCGGCGCAGGGAACGCGAGG
CGCCCGCGGCTTTCGAGGCAGTGGCGGCGCTGGTTGCGGCCCTCCACCGCGCGCGGAGCAAGCCCGCCGCCGATAGCGCG
CAGGCCGCGCAGTCGAGCCGCTGGCTGGAGACGGGAAGGAGCGACCTGCTGCGATGA

Upstream 100 bases:

>100_bases
GGATCCTTCAATTGAGTCGAGCGCCATAGTTCTTCCGGAGACTTTTCAATTCTAGCCCAGTGAGGCCCTGCCGTGCGGCG
GCTGCTACAATTCCTTCTGC

Downstream 100 bases:

>100_bases
AGCTGACCCTCACGATCAATGGCCGCGAAGAGCAGATCGAGCTTCTCGCTCCGGAGCCCGAGTGCCGCTTTCAACTCGGC
GGCGGCGTGGAGCGCGAGGC

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MFRKVLIANRGEIAVRVIRTLREMGIGTVAVYSDPDRTSLHVRMADEAERLGPGPSAESYLRIDRILDAARKHGAEAIHP
GYGFLSENADFAAACEDAGLVFIGPSAASIRAMGSKTAARRSAIAAGAPVVPGTEQAVTLQELREFAAAHGYPVLLKAVA
GGGGKGMRRVDSPGELESAYRNAASEAERAFQSAEIYVEKLIERPRHIEIQVLGDRYGNMVHLGERECSIQRRHQKVIEE
CPSPLIERHPEMRDAMGQAAIRAAQAAGYYNAGTVEFLVDQERRFYFLEMNTRLQVEHPVTELATGLDLVRHQVEIANGG
RLPFTQEQVAWRGAAIECRIYAEDPYNNFLPYPGKITRLRRPLGPGVRIDGCIYEGWTVPMEYDPLLAKLTVWAGTREHA
AERAIRALREYDVGGIRTNIGFFRQILEDPEFRAANLHAGFIEEFFARRREREAPAAFEAVAALVAALHRARSKPAADSA
QAAQSSRWLETGRSDLLR

Sequences:

>Translated_498_residues
MFRKVLIANRGEIAVRVIRTLREMGIGTVAVYSDPDRTSLHVRMADEAERLGPGPSAESYLRIDRILDAARKHGAEAIHP
GYGFLSENADFAAACEDAGLVFIGPSAASIRAMGSKTAARRSAIAAGAPVVPGTEQAVTLQELREFAAAHGYPVLLKAVA
GGGGKGMRRVDSPGELESAYRNAASEAERAFQSAEIYVEKLIERPRHIEIQVLGDRYGNMVHLGERECSIQRRHQKVIEE
CPSPLIERHPEMRDAMGQAAIRAAQAAGYYNAGTVEFLVDQERRFYFLEMNTRLQVEHPVTELATGLDLVRHQVEIANGG
RLPFTQEQVAWRGAAIECRIYAEDPYNNFLPYPGKITRLRRPLGPGVRIDGCIYEGWTVPMEYDPLLAKLTVWAGTREHA
AERAIRALREYDVGGIRTNIGFFRQILEDPEFRAANLHAGFIEEFFARRREREAPAAFEAVAALVAALHRARSKPAADSA
QAAQSSRWLETGRSDLLR
>Mature_498_residues
MFRKVLIANRGEIAVRVIRTLREMGIGTVAVYSDPDRTSLHVRMADEAERLGPGPSAESYLRIDRILDAARKHGAEAIHP
GYGFLSENADFAAACEDAGLVFIGPSAASIRAMGSKTAARRSAIAAGAPVVPGTEQAVTLQELREFAAAHGYPVLLKAVA
GGGGKGMRRVDSPGELESAYRNAASEAERAFQSAEIYVEKLIERPRHIEIQVLGDRYGNMVHLGERECSIQRRHQKVIEE
CPSPLIERHPEMRDAMGQAAIRAAQAAGYYNAGTVEFLVDQERRFYFLEMNTRLQVEHPVTELATGLDLVRHQVEIANGG
RLPFTQEQVAWRGAAIECRIYAEDPYNNFLPYPGKITRLRRPLGPGVRIDGCIYEGWTVPMEYDPLLAKLTVWAGTREHA
AERAIRALREYDVGGIRTNIGFFRQILEDPEFRAANLHAGFIEEFFARRREREAPAAFEAVAALVAALHRARSKPAADSA
QAAQSSRWLETGRSDLLR

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=50.5668934240363, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI189095269, Length=448, Percent_Identity=47.5446428571429, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=448, Percent_Identity=47.5446428571429, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=448, Percent_Identity=47.5446428571429, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.8841870824053, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.8841870824053, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.8841870824053, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI38679977, Length=538, Percent_Identity=31.0408921933086, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI38679967, Length=538, Percent_Identity=31.0408921933086, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI38679960, Length=538, Percent_Identity=31.0408921933086, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI38679974, Length=538, Percent_Identity=31.0408921933086, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI38679971, Length=538, Percent_Identity=31.0408921933086, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI134142062, Length=531, Percent_Identity=29.3785310734463, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=49.1031390134529, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=479, Percent_Identity=49.0605427974948, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567343, Length=473, Percent_Identity=48.8372093023256, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=49.3333333333333, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI133931226, Length=403, Percent_Identity=31.7617866004963, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=532, Percent_Identity=26.6917293233083, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=533, Percent_Identity=26.6416510318949, Blast_Score=195, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=44.5190156599553, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=469, Percent_Identity=42.8571428571429, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=469, Percent_Identity=43.7100213219616, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323863, Length=482, Percent_Identity=30.7053941908714, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=28.6527514231499, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=48.2062780269058, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=49.1111111111111, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=49.1111111111111, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=49.1111111111111, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=49.1111111111111, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=49.1111111111111, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=49.1111111111111, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=46.3414634146341, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI161076407, Length=549, Percent_Identity=30.9653916211293, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24586460, Length=549, Percent_Identity=30.9653916211293, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI161076409, Length=549, Percent_Identity=30.9653916211293, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24586458, Length=549, Percent_Identity=31.1475409836066, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 55109; Mature: 55109

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKVLIANRGEIAVRVIRTLREMGIGTVAVYSDPDRTSLHVRMADEAERLGPGPSAESY
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHCCCCCCHHHH
LRIDRILDAARKHGAEAIHPGYGFLSENADFAAACEDAGLVFIGPSAASIRAMGSKTAAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHCCHHHHH
RSAIAAGAPVVPGTEQAVTLQELREFAAAHGYPVLLKAVAGGGGKGMRRVDSPGELESAY
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCHHHHHHH
RNAASEAERAFQSAEIYVEKLIERPRHIEIQVLGDRYGNMVHLGERECSIQRRHQKVIEE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHH
CPSPLIERHPEMRDAMGQAAIRAAQAAGYYNAGTVEFLVDQERRFYFLEMNTRLQVEHPV
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCCH
TELATGLDLVRHQVEIANGGRLPFTQEQVAWRGAAIECRIYAEDPYNNFLPYPGKITRLR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
RPLGPGVRIDGCIYEGWTVPMEYDPLLAKLTVWAGTREHAAERAIRALREYDVGGIRTNI
CCCCCCCEEEEEEECCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHH
GFFRQILEDPEFRAANLHAGFIEEFFARRREREAPAAFEAVAALVAALHRARSKPAADSA
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
QAAQSSRWLETGRSDLLR
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRKVLIANRGEIAVRVIRTLREMGIGTVAVYSDPDRTSLHVRMADEAERLGPGPSAESY
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHCCCCCCHHHH
LRIDRILDAARKHGAEAIHPGYGFLSENADFAAACEDAGLVFIGPSAASIRAMGSKTAAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHCCHHHHH
RSAIAAGAPVVPGTEQAVTLQELREFAAAHGYPVLLKAVAGGGGKGMRRVDSPGELESAY
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCHHHHHHH
RNAASEAERAFQSAEIYVEKLIERPRHIEIQVLGDRYGNMVHLGERECSIQRRHQKVIEE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHH
CPSPLIERHPEMRDAMGQAAIRAAQAAGYYNAGTVEFLVDQERRFYFLEMNTRLQVEHPV
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCCH
TELATGLDLVRHQVEIANGGRLPFTQEQVAWRGAAIECRIYAEDPYNNFLPYPGKITRLR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
RPLGPGVRIDGCIYEGWTVPMEYDPLLAKLTVWAGTREHAAERAIRALREYDVGGIRTNI
CCCCCCCEEEEEEECCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHH
GFFRQILEDPEFRAANLHAGFIEEFFARRREREAPAAFEAVAALVAALHRARSKPAADSA
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
QAAQSSRWLETGRSDLLR
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]