Click here to switch to the map view.

The map label for this gene is accB [C]

Identifier: 116620978

GI number: 116620978

Start: 2314421

End: 2314921

Strand: Direct

Name: accB [C]

Synonym: Acid_1859

Alternate gene names: 116620978

Gene position: 2314421-2314921 (Clockwise)

Preceding gene: 116620977

Following gene: 116620984

Centisome position: 23.22

GC content: 65.07

Gene sequence:

>501_bases
ATGAAGCTGACCCTCACGATCAATGGCCGCGAAGAGCAGATCGAGCTTCTCGCTCCGGAGCCCGAGTGCCGCTTTCAACT
CGGCGGCGGCGTGGAGCGCGAGGCCAACGTGGAATCTCCGCAGCACGGCGTATTCTCTGTGCTGCTGGAAGGTCGCAGCT
ACGACGCGTACCTCGAGGAGACGCCGGCCGGAATGCTGGTGGTCATGATCGATGGCTACCGTTTCGAGATCGAGGCCCGC
GATCCGCGCCGCTGGTCCCGCAAGTCGGCCGGGCGCGGCGCCGATGCGGTGCAATCGATTCTCAGTCCGATGCCCGGCAA
GGTGGTGCGCGTGTTGGCGAAGGTGGGCCAGGCTGTGGAAGCGGGGCAGGGAATCGTCGTGGTTGAAGCGATGAAGATGC
AGAATGAGATGAAGGCGAGCCGGGCGGGCACAGTCCTCACGCTTCCGGCGAAAGAGGGATCGACCGTGGCGGCCGGCGAG
CTGCTGGCGACCATCGAATAG

Upstream 100 bases:

>100_bases
TTGCGGCCCTCCACCGCGCGCGGAGCAAGCCCGCCGCCGATAGCGCGCAGGCCGCGCAGTCGAGCCGCTGGCTGGAGACG
GGAAGGAGCGACCTGCTGCG

Downstream 100 bases:

>100_bases
GGACGCTTACGCCTTCCGAACTTTGACTGTGCCTCGCGTGCCGATCGCGTCGTCCGTCGATACCGTGCCTTCCAGCGACC
GCGGCTCTGCCGAGGGAGCC

Product: biotin/lipoyl attachment domain-containing protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: Acetyl/Propionyl CoA Carboxylase Alpha Subunit; Acetyl-CoA Carboxylase Biotin Carboxylase; Biotin Carboxyl Carrier Protein; Pyruvate Carboxylase Subunit B; 3-Methylcrotonoyl-CoA Carboxylase Subunit Alpha; RimK-Like ATP-Grasp Domain Family; Methylmalonyl-CoA Decarboxylase Subunit Gamma; Acyl-CoA Carboxylase Biotin/Lipoyl Carrier Domain; Pyruvate Carboxylase Beta Chain; Pyruvate Carboxylase; Biotin/Lipoyl Attachment; Acetyl/Propionyl-CoA Carboxylase Alpha Subunit; Biotin/Lipoyl Attachment Protein; Biotin-Requiring Protein; Biotin/Lipoyl Attachment Domain Protein; Biotin-Requiring Domain Protein

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKLTLTINGREEQIELLAPEPECRFQLGGGVEREANVESPQHGVFSVLLEGRSYDAYLEETPAGMLVVMIDGYRFEIEAR
DPRRWSRKSAGRGADAVQSILSPMPGKVVRVLAKVGQAVEAGQGIVVVEAMKMQNEMKASRAGTVLTLPAKEGSTVAAGE
LLATIE

Sequences:

>Translated_166_residues
MKLTLTINGREEQIELLAPEPECRFQLGGGVEREANVESPQHGVFSVLLEGRSYDAYLEETPAGMLVVMIDGYRFEIEAR
DPRRWSRKSAGRGADAVQSILSPMPGKVVRVLAKVGQAVEAGQGIVVVEAMKMQNEMKASRAGTVLTLPAKEGSTVAAGE
LLATIE
>Mature_166_residues
MKLTLTINGREEQIELLAPEPECRFQLGGGVEREANVESPQHGVFSVLLEGRSYDAYLEETPAGMLVVMIDGYRFEIEAR
DPRRWSRKSAGRGADAVQSILSPMPGKVVRVLAKVGQAVEAGQGIVVVEAMKMQNEMKASRAGTVLTLPAKEGSTVAAGE
LLATIE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI65506442, Length=72, Percent_Identity=50, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI189095269, Length=72, Percent_Identity=50, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=130, Percent_Identity=33.8461538461538, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 17911; Mature: 17911

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTLTINGREEQIELLAPEPECRFQLGGGVEREANVESPQHGVFSVLLEGRSYDAYLEE
CEEEEEECCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
TPAGMLVVMIDGYRFEIEARDPRRWSRKSAGRGADAVQSILSPMPGKVVRVLAKVGQAVE
CCCCEEEEEECCEEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
AGQGIVVVEAMKMQNEMKASRAGTVLTLPAKEGSTVAAGELLATIE
CCCCEEEEEHHHHHHHHHHHHCCEEEEEECCCCCEEECCEEEEECC
>Mature Secondary Structure
MKLTLTINGREEQIELLAPEPECRFQLGGGVEREANVESPQHGVFSVLLEGRSYDAYLEE
CEEEEEECCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
TPAGMLVVMIDGYRFEIEARDPRRWSRKSAGRGADAVQSILSPMPGKVVRVLAKVGQAVE
CCCCEEEEEECCEEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
AGQGIVVVEAMKMQNEMKASRAGTVLTLPAKEGSTVAAGELLATIE
CCCCEEEEEHHHHHHHHHHHHCCEEEEEECCCCCEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA