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The map label for this gene is zraR [H]

Identifier: 116620971

GI number: 116620971

Start: 2306007

End: 2307311

Strand: Direct

Name: zraR [H]

Synonym: Acid_1852

Alternate gene names: 116620971

Gene position: 2306007-2307311 (Clockwise)

Preceding gene: 116620970

Following gene: 116620972

Centisome position: 23.14

GC content: 61.3

Gene sequence:

>1305_bases
ATGCAGAAAATTCTCTTAGTGGAAGATGATCCGGCGCTTCAATTCACCATCCAGACGTTTCTGGAGGCGAACGGATACGC
GGTTGACGCTGTGTCAACAACCGACGATGCGGCGGATCGTATTAACGAAAACTCGTACCCCATCATCGTCAGCGATATTT
ACATCGATCAGCGCACGGGGTTGTTCGTGCTGGACGCCGCCAAGAGCAAGGATGAAAAGTGCGCCGTGATCATCATGTCC
GGTAGGGGCACGATCGAAACTGCCGTGGCTGCGACCCGCGGAGGCGCCTTCGACTACATCGCCAAGCCGTTCGAGCTGGA
CGCGCTGCTTGAAGTCATCAAGCGGGCCGAGGCTGCCCGCAACGATACGGAAAAGCCGGCGGAAGAAGAGCAGCTGCCGG
AGAGCGAAATGATCGGCAGCTCGGCCGCCATGGTGGACGTCTATAAGAAGGTGTCGCGCGTGGCGCCCACCGACGCCACG
GTGATTATCGAGGGTGAAACCGGCACCGGCAAGGAAATGGTGGCGCGCATGATCCACCGCTATAGCCTGCGCGCCAAGCA
GCCGTTCGTGGTGGTGGATTGCACGGCGATCGCGCCCACCCTGCTCGAGAGCGAACTCTTTGGCGCGGTTCGCGGCGCGT
ACACTGGCGCGGATCGCGATCGCATGGGCGTCTTCGAGGCGGCCAACCGCGGAACGGTTTTCCTGGATGAGATCGGCGAG
ATCGATAAGAGCTTTCAGGCGAGCCTGCTGCGGTTTTTGCAGGAGCACGAGATCCGGCCCGTGGGTGCGTCGCGGTCCAA
GGAAGTGGACGTGCGCGTGATCACCGCGACCAACCGCGATCTGCAGACGCTGGTCGATGAAGGCAAATTCCGCGAGGATC
TCTGGTACCGGCTGAACACGGTGCGGATCGTGATGCCGCGGCTCCGCGAGCGCCGCGACGATATTCCCCTGCTGGCCTAC
TCCTTCCTGAACAAGTACAACGGGCGCTACGGGCGCGATGTGAAGCTGATGGATTCCGGAGTGCGGGCGCTCAAAGATCA
CATGTGGCCGGGCAACGTGCGCCAGTTGCAGCACGTGATCGAGCGGCTGACGATTTTGGCGGATCGCATCGACGGGGATG
CCGTGAAGCACGCGCTCACGGTGCTGGAGTCCCGTGAGAAGGAAGTCGAGACCATCGCCGACGCGGAGGAGGATCTGATC
CGCAAGACCCTGGAAGCGGTCGGCGGCAATAAGAGCAAGGCCGCCGAACGCCTGGGAATCGAACGCAAAACCCTGTACCG
CAAACTCGAACGCATGAAGCCGTAG

Upstream 100 bases:

>100_bases
AAATTGAAGTGACCAGCCGGCCGGGCGCCGGGAGTTGCTTCACGGTGGTGGTGCCGGCGCGAGCGCTTGCCCCGGTTTCG
ACGGCCGCGGAACGACATTG

Downstream 100 bases:

>100_bases
AACGAGAGTGCGGGGATCACTCATGATCGATATCCACAGCCACATCCTGCCAGGACTCGACGACGGCTCGAAGAGTCTGG
AGGAATCTGTCGCCATGCTG

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MQKILLVEDDPALQFTIQTFLEANGYAVDAVSTTDDAADRINENSYPIIVSDIYIDQRTGLFVLDAAKSKDEKCAVIIMS
GRGTIETAVAATRGGAFDYIAKPFELDALLEVIKRAEAARNDTEKPAEEEQLPESEMIGSSAAMVDVYKKVSRVAPTDAT
VIIEGETGTGKEMVARMIHRYSLRAKQPFVVVDCTAIAPTLLESELFGAVRGAYTGADRDRMGVFEAANRGTVFLDEIGE
IDKSFQASLLRFLQEHEIRPVGASRSKEVDVRVITATNRDLQTLVDEGKFREDLWYRLNTVRIVMPRLRERRDDIPLLAY
SFLNKYNGRYGRDVKLMDSGVRALKDHMWPGNVRQLQHVIERLTILADRIDGDAVKHALTVLESREKEVETIADAEEDLI
RKTLEAVGGNKSKAAERLGIERKTLYRKLERMKP

Sequences:

>Translated_434_residues
MQKILLVEDDPALQFTIQTFLEANGYAVDAVSTTDDAADRINENSYPIIVSDIYIDQRTGLFVLDAAKSKDEKCAVIIMS
GRGTIETAVAATRGGAFDYIAKPFELDALLEVIKRAEAARNDTEKPAEEEQLPESEMIGSSAAMVDVYKKVSRVAPTDAT
VIIEGETGTGKEMVARMIHRYSLRAKQPFVVVDCTAIAPTLLESELFGAVRGAYTGADRDRMGVFEAANRGTVFLDEIGE
IDKSFQASLLRFLQEHEIRPVGASRSKEVDVRVITATNRDLQTLVDEGKFREDLWYRLNTVRIVMPRLRERRDDIPLLAY
SFLNKYNGRYGRDVKLMDSGVRALKDHMWPGNVRQLQHVIERLTILADRIDGDAVKHALTVLESREKEVETIADAEEDLI
RKTLEAVGGNKSKAAERLGIERKTLYRKLERMKP
>Mature_434_residues
MQKILLVEDDPALQFTIQTFLEANGYAVDAVSTTDDAADRINENSYPIIVSDIYIDQRTGLFVLDAAKSKDEKCAVIIMS
GRGTIETAVAATRGGAFDYIAKPFELDALLEVIKRAEAARNDTEKPAEEEQLPESEMIGSSAAMVDVYKKVSRVAPTDAT
VIIEGETGTGKEMVARMIHRYSLRAKQPFVVVDCTAIAPTLLESELFGAVRGAYTGADRDRMGVFEAANRGTVFLDEIGE
IDKSFQASLLRFLQEHEIRPVGASRSKEVDVRVITATNRDLQTLVDEGKFREDLWYRLNTVRIVMPRLRERRDDIPLLAY
SFLNKYNGRYGRDVKLMDSGVRALKDHMWPGNVRQLQHVIERLTILADRIDGDAVKHALTVLESREKEVETIADAEEDLI
RKTLEAVGGNKSKAAERLGIERKTLYRKLERMKP

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=439, Percent_Identity=39.4077448747153, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1788550, Length=449, Percent_Identity=37.8619153674833, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1788905, Length=434, Percent_Identity=37.5576036866359, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=35.8208955223881, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=40.0630914826498, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789087, Length=308, Percent_Identity=43.1818181818182, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87082117, Length=426, Percent_Identity=36.3849765258216, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082152, Length=239, Percent_Identity=48.1171548117155, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786524, Length=311, Percent_Identity=41.1575562700965, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=35.3896103896104, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787583, Length=229, Percent_Identity=40.6113537117904, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789828, Length=278, Percent_Identity=34.8920863309352, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081858, Length=280, Percent_Identity=32.1428571428571, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790552, Length=126, Percent_Identity=32.5396825396825, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48629; Mature: 48629

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILLVEDDPALQFTIQTFLEANGYAVDAVSTTDDAADRINENSYPIIVSDIYIDQRTG
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCEEEEEEEEECCCC
LFVLDAAKSKDEKCAVIIMSGRGTIETAVAATRGGAFDYIAKPFELDALLEVIKRAEAAR
EEEEECCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHC
NDTEKPAEEEQLPESEMIGSSAAMVDVYKKVSRVAPTDATVIIEGETGTGKEMVARMIHR
CCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHH
YSLRAKQPFVVVDCTAIAPTLLESELFGAVRGAYTGADRDRMGVFEAANRGTVFLDEIGE
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEHHHHHH
IDKSFQASLLRFLQEHEIRPVGASRSKEVDVRVITATNRDLQTLVDEGKFREDLWYRLNT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHHHH
VRIVMPRLRERRDDIPLLAYSFLNKYNGRYGRDVKLMDSGVRALKDHMWPGNVRQLQHVI
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
ERLTILADRIDGDAVKHALTVLESREKEVETIADAEEDLIRKTLEAVGGNKSKAAERLGI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCC
ERKTLYRKLERMKP
HHHHHHHHHHHCCC
>Mature Secondary Structure
MQKILLVEDDPALQFTIQTFLEANGYAVDAVSTTDDAADRINENSYPIIVSDIYIDQRTG
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCEEEEEEEEECCCC
LFVLDAAKSKDEKCAVIIMSGRGTIETAVAATRGGAFDYIAKPFELDALLEVIKRAEAAR
EEEEECCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHC
NDTEKPAEEEQLPESEMIGSSAAMVDVYKKVSRVAPTDATVIIEGETGTGKEMVARMIHR
CCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHH
YSLRAKQPFVVVDCTAIAPTLLESELFGAVRGAYTGADRDRMGVFEAANRGTVFLDEIGE
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEHHHHHH
IDKSFQASLLRFLQEHEIRPVGASRSKEVDVRVITATNRDLQTLVDEGKFREDLWYRLNT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHHHH
VRIVMPRLRERRDDIPLLAYSFLNKYNGRYGRDVKLMDSGVRALKDHMWPGNVRQLQHVI
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
ERLTILADRIDGDAVKHALTVLESREKEVETIADAEEDLIRKTLEAVGGNKSKAAERLGI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCC
ERKTLYRKLERMKP
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]